JP2014530877A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014530877A5 JP2014530877A5 JP2014537337A JP2014537337A JP2014530877A5 JP 2014530877 A5 JP2014530877 A5 JP 2014530877A5 JP 2014537337 A JP2014537337 A JP 2014537337A JP 2014537337 A JP2014537337 A JP 2014537337A JP 2014530877 A5 JP2014530877 A5 JP 2014530877A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- cells
- lymphoma
- relapsed
- refractory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 24
- 239000000090 biomarker Substances 0.000 claims 21
- 229940124291 BTK inhibitor Drugs 0.000 claims 19
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 17
- 230000002427 irreversible effect Effects 0.000 claims 15
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 14
- 238000011282 treatment Methods 0.000 claims 14
- 206010066476 Haematological malignancy Diseases 0.000 claims 11
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 11
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 11
- 230000035772 mutation Effects 0.000 claims 11
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 9
- 201000005787 hematologic cancer Diseases 0.000 claims 8
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 8
- 210000005259 peripheral blood Anatomy 0.000 claims 8
- 239000011886 peripheral blood Substances 0.000 claims 8
- 229960004641 rituximab Drugs 0.000 claims 8
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 6
- 201000003444 follicular lymphoma Diseases 0.000 claims 6
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 5
- 230000011664 signaling Effects 0.000 claims 5
- 230000004083 survival effect Effects 0.000 claims 5
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 4
- 229960002707 bendamustine Drugs 0.000 claims 4
- 229960004397 cyclophosphamide Drugs 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 4
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 4
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 3
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 3
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 3
- 101000818543 Homo sapiens Tyrosine-protein kinase ZAP-70 Proteins 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 3
- 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims 3
- 102100021125 Tyrosine-protein kinase ZAP-70 Human genes 0.000 claims 3
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 3
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000001086 cytosolic effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229960001507 ibrutinib Drugs 0.000 claims 3
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- -1 4-amino-3- (4-phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl Chemical group 0.000 claims 2
- NHHQJBCNYHBUSI-UHFFFAOYSA-N 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound COC1=C(OC)C(OC)=CC(NC=2N=C(NC=3N=C4NC(=O)C(C)(C)OC4=CC=3)C(F)=CN=2)=C1 NHHQJBCNYHBUSI-UHFFFAOYSA-N 0.000 claims 2
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 2
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- 201000004085 CLL/SLL Diseases 0.000 claims 2
- MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 claims 2
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 2
- 206010025280 Lymphocytosis Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 2
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 238000011394 anticancer treatment Methods 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 2
- 229960001467 bortezomib Drugs 0.000 claims 2
- 229960004562 carboplatin Drugs 0.000 claims 2
- 190000008236 carboplatin Chemical compound 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000023738 chronic lymphocytic leukemia/small lymphocytic lymphoma Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 229960002918 doxorubicin hydrochloride Drugs 0.000 claims 2
- 229960000390 fludarabine Drugs 0.000 claims 2
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 208000021173 high grade B-cell lymphoma Diseases 0.000 claims 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 2
- 229960004942 lenalidomide Drugs 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- 210000000066 myeloid cell Anatomy 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 229960003347 obinutuzumab Drugs 0.000 claims 2
- 229960002450 ofatumumab Drugs 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 2
- 229960004618 prednisone Drugs 0.000 claims 2
- 229960003787 sorafenib Drugs 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229960000235 temsirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 2
- 229960004528 vincristine Drugs 0.000 claims 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 2
- AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 claims 2
- 229960002110 vincristine sulfate Drugs 0.000 claims 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549067P | 2011-10-19 | 2011-10-19 | |
| US61/549,067 | 2011-10-19 | ||
| PCT/US2012/061208 WO2013059738A2 (en) | 2011-10-19 | 2012-10-19 | Use of inhibitors of bruton's tyrosine kinase (btk) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017174407A Division JP6588515B2 (ja) | 2011-10-19 | 2017-09-11 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530877A JP2014530877A (ja) | 2014-11-20 |
| JP2014530877A5 true JP2014530877A5 (https=) | 2015-12-03 |
| JP6506555B2 JP6506555B2 (ja) | 2019-04-24 |
Family
ID=48141634
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537337A Active JP6506555B2 (ja) | 2011-10-19 | 2012-10-19 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
| JP2017174407A Active JP6588515B2 (ja) | 2011-10-19 | 2017-09-11 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
| JP2019087022A Active JP6909255B2 (ja) | 2011-10-19 | 2019-04-29 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
| JP2021110943A Active JP7366084B2 (ja) | 2011-10-19 | 2021-07-02 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
| JP2023175486A Pending JP2024020199A (ja) | 2011-10-19 | 2023-10-10 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017174407A Active JP6588515B2 (ja) | 2011-10-19 | 2017-09-11 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
| JP2019087022A Active JP6909255B2 (ja) | 2011-10-19 | 2019-04-29 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
| JP2021110943A Active JP7366084B2 (ja) | 2011-10-19 | 2021-07-02 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
| JP2023175486A Pending JP2024020199A (ja) | 2011-10-19 | 2023-10-10 | ブルトン型チロシンキナーゼ（Ｂｔｋ）阻害剤の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US20140303191A1 (https=) |
| EP (1) | EP2771010A4 (https=) |
| JP (5) | JP6506555B2 (https=) |
| KR (5) | KR102054468B1 (https=) |
| CN (2) | CN104039325A (https=) |
| AU (5) | AU2012325804B2 (https=) |
| BR (1) | BR112014009276A8 (https=) |
| CA (2) | CA3110966A1 (https=) |
| EA (2) | EA201892766A1 (https=) |
| IL (4) | IL317457A (https=) |
| MX (2) | MX361772B (https=) |
| SG (2) | SG11201401625TA (https=) |
| WO (1) | WO2013059738A2 (https=) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613743B1 (en) | 2008-01-04 | 2022-03-16 | Intellikine, LLC | Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| TWI546290B (zh) | 2008-06-27 | 2016-08-21 | 賽基艾維洛米斯研究股份有限公司 | 雜芳基化合物及其用途 |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| ES2660418T3 (es) | 2008-07-16 | 2018-03-22 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos |
| KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Ｅｇｆｒ 억제제 및 질환 치료방법 |
| BR112012030711B1 (pt) | 2010-05-31 | 2020-10-13 | Ono Pharmaceutical Co. Ltd | derivado de purinona |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| CN105566229A (zh) | 2010-08-10 | 2016-05-11 | 西建阿维拉米斯研究公司 | Btk抑制剂的苯磺酸盐及其用途和制备方法 |
| EP2635285B1 (en) | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| MX382354B (es) | 2010-11-01 | 2025-03-13 | Celgene Car Llc | Compuestos heterocíclicos y usos de los mismos. |
| JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ， インコーポレイテッド | 変異体選択的ｅｇｆｒ阻害剤およびその使用 |
| TWI674262B (zh) | 2011-01-10 | 2019-10-11 | 美商英菲尼提製藥股份有限公司 | 製備異喹啉酮之方法及異喹啉酮之固體形式 |
| US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| EA025496B1 (ru) | 2011-05-17 | 2016-12-30 | Принсипиа Биофарма Инк. | Ингибиторы тирозинкиназы |
| KR20140058543A (ko) | 2011-07-08 | 2014-05-14 | 노파르티스 아게 | 신규 피롤로 피리미딘 유도체 |
| US9138436B2 (en) | 2011-07-13 | 2015-09-22 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| BR112014001255B1 (pt) | 2011-07-19 | 2019-07-02 | Merck Sharp & Dohme B.V. | Composto, uso de um composto, combinação, composição farmacêutica, e, sal farmaceuticamente aceitável de um composto |
| EP2734205B1 (en) | 2011-07-21 | 2018-03-21 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
| WO2013059738A2 (en) * | 2011-10-19 | 2013-04-25 | Pharmacyclics, Inc. | Use of inhibitors of bruton's tyrosine kinase (btk) |
| AR088570A1 (es) | 2011-10-28 | 2014-06-18 | Celgene Avilomics Res Inc | Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton |
| DK2786996T3 (en) | 2011-11-29 | 2016-12-19 | Ono Pharmaceutical Co | Hydrochloride PURINONDERIVAT |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| WO2014004707A1 (en) * | 2012-06-29 | 2014-01-03 | Principia Biopharma Inc. | Formulations comprising ibrutinib |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| ME03455B (me) | 2012-09-10 | 2020-01-20 | Principia Biopharma Inc | Jedinjenja pirazolopirimidina kao inhibitori kinaze |
| EP2914296B2 (en) | 2012-11-01 | 2021-09-29 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| US9126950B2 (en) | 2012-12-21 | 2015-09-08 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| AU2014214846A1 (en) | 2013-02-08 | 2015-07-23 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
| MX394360B (es) | 2013-03-14 | 2025-03-24 | Sumitomo Pharma Oncology Inc | Inhibidores de jak2 y alk2 y metodos para su uso. |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| SG11201509842SA (en) * | 2013-05-30 | 2015-12-30 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| EP3054954A4 (en) * | 2013-10-10 | 2017-12-13 | Acetylon Pharmaceuticals, Inc. | Hdac inhibitors, alone or in combination with btk inhibitors, for treating non-hodgkin's lymphoma |
| US9795604B2 (en) * | 2013-10-25 | 2017-10-24 | Pharmacyclics Llc | Methods of treating and preventing graft versus host disease |
| PL3065828T3 (pl) | 2013-11-06 | 2019-06-28 | Mayo Foundation For Medical Education And Research | Sposoby i materiały do leczenia złośliwych nowotworów hematologicznych |
| CN113995843A (zh) * | 2013-11-07 | 2022-02-01 | 豪夫迈·罗氏有限公司 | 抗cd20抗体与btk抑制剂的组合疗法 |
| WO2015071432A1 (en) * | 2013-11-14 | 2015-05-21 | Sandoz Ag | Pharmaceutical compositions of ibrutinib |
| US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
| WO2015084892A1 (en) * | 2013-12-02 | 2015-06-11 | Cornell University | Methods for treating b cell proliferative disorders |
| EA201691169A1 (ru) | 2013-12-05 | 2016-09-30 | Асерта Фарма Б.В. | Терапевтическая комбинация ингибитора pi3k и ингибитора btk |
| US10272083B2 (en) | 2014-01-21 | 2019-04-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor |
| PT3107544T (pt) | 2014-02-21 | 2021-01-05 | Principia Biopharma Inc | Sais e forma sólida de um inibidor de btk |
| WO2015127261A1 (en) * | 2014-02-21 | 2015-08-27 | Pharmacyclics, Inc. | Biomarkers for predicting response of dlbcl to treatment with ibrutinib |
| WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| JP6528779B2 (ja) | 2014-03-25 | 2019-06-12 | 小野薬品工業株式会社 | びまん性大細胞型ｂ細胞リンパ腫の予防および／または治療剤 |
| AU2015244039B2 (en) * | 2014-04-07 | 2021-10-21 | Novartis Ag | Treatment of cancer using anti-CD19 chimeric antigen receptor |
| WO2015185998A2 (en) * | 2014-04-11 | 2015-12-10 | Acerta Pharma B.V. | Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase |
| US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CN104825455B (zh) * | 2014-06-11 | 2017-08-15 | 中国科学院合肥物质科学研究院 | 依鲁替尼的用途 |
| WO2015192081A1 (en) * | 2014-06-13 | 2015-12-17 | Byrd, John C. | Biomarker for predicting response of cll to treatment with a btk inhibitor |
| US9949971B2 (en) | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
| WO2016010961A1 (en) * | 2014-07-15 | 2016-01-21 | Abbvie Inc. | Enzyme occupancy assay |
| WO2016014859A1 (en) * | 2014-07-25 | 2016-01-28 | Pharmacyclics Llc | Bet inhibitor and bruton's tyrosine kinase inhibitor combinations |
| MX2017001302A (es) * | 2014-08-01 | 2017-10-11 | Pharmacyclics Llc | Biomarcadores para predecir la respuesta del dlbcl al tratamiento con un inhibidor de la btk. |
| CA2956550A1 (en) * | 2014-08-08 | 2016-02-11 | Pharmacyclics Llc | Bruton's tyrosine kinase inhibitor combinations and uses thereof |
| MA40596B1 (fr) | 2014-08-11 | 2021-12-31 | Acerta Pharma Bv | Combinaisons thérapeutiques d'un inhibiteur de btk et d'un inhibiteur de bcl-2 |
| US10005760B2 (en) | 2014-08-13 | 2018-06-26 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| CN104873515B (zh) * | 2014-10-30 | 2017-04-05 | 中国科学院合肥物质科学研究院 | 依鲁替尼对flt3‑itd突变的急性白血病的应用 |
| WO2016071770A2 (en) * | 2014-11-05 | 2016-05-12 | Janssen Pharmaceutica Nv | Biological markers for identifying ibrutinib resistance in patients having mantle cell lymphoma and methods of using the same |
| CN104407067B (zh) * | 2014-11-17 | 2016-01-20 | 广东东阳光药业有限公司 | 依鲁替尼及其异构体的检测方法 |
| WO2016090255A1 (en) * | 2014-12-05 | 2016-06-09 | Sriram Balasubramanian | Biological markers for predicting responsiveness to ibrutinib and r-chop combination therapy and methods of using the same |
| US10485797B2 (en) | 2014-12-18 | 2019-11-26 | Principia Biopharma Inc. | Treatment of pemphigus |
| WO2016106381A1 (en) * | 2014-12-23 | 2016-06-30 | Pharmacyclics Llc | Btk inhibitor combinations and dosing regimen |
| DK3236943T3 (da) * | 2014-12-24 | 2023-04-11 | Principia Biopharma Inc | Sammensætninger til ileo-jejunal lægemiddeladministration |
| RS64653B1 (sr) * | 2015-04-06 | 2023-10-31 | Janssen Pharmaceutica Nv | Kompozicije koje sadrže ibrutinib |
| ES2955554T3 (es) | 2015-04-09 | 2023-12-04 | Ono Pharmaceutical Co | Proceso para producir un derivado de purinona |
| HK1251165A1 (en) | 2015-04-13 | 2019-01-25 | Daiichi Sankyo Company, Limited | Treatment method combining mdm2 inhibitor and btk inhibitor |
| KR101776238B1 (ko) * | 2015-06-12 | 2017-09-12 | 사회복지법인 삼성생명공익재단 | 교모세포종 환자에서 이브루티닙 감수성과 관련된 유전자 및 그 용도 |
| TW201718572A (zh) | 2015-06-24 | 2017-06-01 | 普林斯匹亞生物製藥公司 | 酪胺酸激酶抑制劑 |
| PL3954690T3 (pl) | 2015-07-02 | 2023-08-14 | Acerta Pharma B.V. | Postacie stałe i formulacje (s)-4-(8-amino-3-(1-(but-2-ynoilo)pirolidyn-2-ylo)imidazo[1,5-a]-pirazyn-1-ylo)-n-(pirydyn-2-ylo)benzamidu |
| ES2980794T3 (es) * | 2015-09-15 | 2024-10-03 | Acerta Pharma Bv | Combinaciones terapéuticas de un inhibidor de CD19 y un inhibidor de BTK |
| KR20250025518A (ko) * | 2016-01-19 | 2025-02-21 | 얀센 파마슈티카 엔브이 | Btk 저해제를 포함하는 제형/조성물 |
| EP3445364A4 (en) | 2016-04-19 | 2019-11-27 | Acetylon Pharmaceuticals, Inc. | HDAC INHIBITORS, ONLY OR IN COMBINATION WITH BTK INHIBITORS, FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA |
| RU2754507C2 (ru) | 2016-06-24 | 2021-09-02 | Инфинити Фармасьютикалз, Инк. | Комбинированная терапия |
| IL299099B2 (en) | 2016-06-27 | 2025-07-01 | Univ California | Cancer treatment combinations |
| MA45547A (fr) | 2016-06-29 | 2019-05-08 | Principia Biopharma Inc | Formulations à libération modifiée à base de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl)pipérazine-1-yl]pent-2-ènenitrile |
| US20190240210A1 (en) | 2016-10-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor |
| JP6782855B2 (ja) * | 2016-11-15 | 2020-11-11 | 杭州和正医薬有限公司 | 選択性ブルトン型チロシンキナーゼ阻害剤及びその使用 |
| KR102867725B1 (ko) | 2017-07-28 | 2025-10-13 | 제론 코포레이션 | 골수형성이상 증후군의 치료 방법 |
| CN112533602A (zh) | 2018-04-05 | 2021-03-19 | 大日本住友制药肿瘤公司 | Axl激酶抑制剂及其用途 |
| CN117838695A (zh) | 2018-04-13 | 2024-04-09 | 住友制药肿瘤公司 | 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 |
| MX2021000977A (es) | 2018-07-26 | 2021-04-12 | Sumitomo Pharma Oncology Inc | Metodos para tratar enfermedades asociadas con expresion anormal de receptor de activina a tipo 1 (acvr1) e inhibidores de acvr1 para uso en los mismos. |
| UA130012C2 (uk) | 2018-11-29 | 2025-10-15 | Джерон Корпорейшн | Спосіб лікування мієлодиспластичного синдрому |
| NZ778055A (en) | 2019-02-12 | 2025-11-28 | Sumitomo Pharma America Inc | Formulations comprising heterocyclic protein kinase inhibitors |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| US20220184086A1 (en) * | 2019-03-28 | 2022-06-16 | Cardiff Oncology, Inc. | Plk1 inhibitors and psa levels in prostate cancer |
| TWI877239B (zh) | 2019-10-14 | 2025-03-21 | 美商普林斯匹亞生物製藥公司 | 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法 |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| JP2023511105A (ja) | 2020-01-22 | 2023-03-16 | プリンシピア バイオファーマ インコーポレイテッド | ２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）－１ｈ－ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペンタ－２－エンニトリルの結晶形態 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| MX2023006418A (es) * | 2020-12-02 | 2023-06-13 | Telios Pharma Inc | Metodos y composiciones para el tratamiento de una afeccion oftalmica. |
| CN114681459B (zh) * | 2020-12-29 | 2024-02-27 | 上海云晟研新生物科技有限公司 | 伊布替尼药物组合物、其制备方法及应用 |
| US20250041308A1 (en) * | 2022-01-07 | 2025-02-06 | University Of Florida Research Foundation, Incorporated | Bruton's tyrosine kinase inhibitors as antiviral agents |
| EP4611753A1 (en) | 2022-10-31 | 2025-09-10 | Sumitomo Pharma America, Inc. | Pim1 inhibitor for treating myeloproliferative neoplasms |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| US6326469B1 (en) | 1994-04-22 | 2001-12-04 | Sugen, Inc. | Megakaryocytic protein tyrosine kinases |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| AU8322401A (en) * | 2000-08-09 | 2002-02-18 | Univ California | Indole compounds useful for the treatment of cancer |
| US7329502B2 (en) | 2002-04-25 | 2008-02-12 | The United States Of America As Represented By The Department Of Health And Human Services | ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) |
| BRPI0622054B8 (pt) * | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| CN101475632B (zh) * | 2008-01-03 | 2012-01-04 | 张喜田 | 具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 |
| AU2009228616B2 (en) * | 2008-03-25 | 2014-07-24 | Roche Glycart Ag | Use of a type II anti-CD20 antibody with increased antibody dependent cellular cytotoxicity (ADCC) in combination with cyclophosphamide, vincristine and doxorubicine for treating non-Hodgkin' s lymphomas |
| UA108193C2 (uk) * | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| US20100160322A1 (en) * | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| BR112012022243A8 (pt) * | 2010-03-08 | 2021-11-09 | Spectrum Pharmaceuticals Inc | Uso de um inibidor de autofagia baseado em tioxantona e de um composto indutor de autofagia para terapia de câncer, composição farmacêutica e kit farmacêutico |
| CN107898791A (zh) * | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| WO2013059738A2 (en) * | 2011-10-19 | 2013-04-25 | Pharmacyclics, Inc. | Use of inhibitors of bruton's tyrosine kinase (btk) |
-
2012
- 2012-10-19 WO PCT/US2012/061208 patent/WO2013059738A2/en not_active Ceased
- 2012-10-19 SG SG11201401625TA patent/SG11201401625TA/en unknown
- 2012-10-19 IL IL317457A patent/IL317457A/en unknown
- 2012-10-19 CN CN201280062429.2A patent/CN104039325A/zh active Pending
- 2012-10-19 KR KR1020147013035A patent/KR102054468B1/ko active Active
- 2012-10-19 EA EA201892766A patent/EA201892766A1/ru unknown
- 2012-10-19 EA EA201490798A patent/EA032463B1/ru unknown
- 2012-10-19 JP JP2014537337A patent/JP6506555B2/ja active Active
- 2012-10-19 AU AU2012325804A patent/AU2012325804B2/en active Active
- 2012-10-19 KR KR1020217015880A patent/KR20210065203A/ko not_active Abandoned
- 2012-10-19 KR KR1020197035965A patent/KR102258778B1/ko active Active
- 2012-10-19 CA CA3110966A patent/CA3110966A1/en active Pending
- 2012-10-19 MX MX2014004647A patent/MX361772B/es active IP Right Grant
- 2012-10-19 KR KR1020237023005A patent/KR20230109775A/ko not_active Ceased
- 2012-10-19 CA CA2851808A patent/CA2851808C/en active Active
- 2012-10-19 CN CN201911076512.5A patent/CN110801454A/zh active Pending
- 2012-10-19 IL IL288009A patent/IL288009B1/en unknown
- 2012-10-19 SG SG10201702913XA patent/SG10201702913XA/en unknown
- 2012-10-19 MX MX2017014058A patent/MX391121B/es unknown
- 2012-10-19 US US14/353,011 patent/US20140303191A1/en not_active Abandoned
- 2012-10-19 KR KR1020257018513A patent/KR20250086805A/ko active Pending
- 2012-10-19 EP EP12841068.5A patent/EP2771010A4/en active Pending
- 2012-10-19 BR BR112014009276A patent/BR112014009276A8/pt not_active Application Discontinuation
-
2014
- 2014-04-10 IL IL232059A patent/IL232059B/en unknown
-
2016
- 2016-12-29 US US15/393,821 patent/US20170266186A1/en not_active Abandoned
-
2017
- 2017-09-11 JP JP2017174407A patent/JP6588515B2/ja active Active
- 2017-12-07 AU AU2017272271A patent/AU2017272271A1/en not_active Abandoned
-
2019
- 2019-04-29 JP JP2019087022A patent/JP6909255B2/ja active Active
- 2019-09-12 AU AU2019229398A patent/AU2019229398B2/en active Active
-
2020
- 2020-02-12 IL IL272622A patent/IL272622A/en unknown
- 2020-12-16 US US17/123,736 patent/US20210361657A1/en not_active Abandoned
-
2021
- 2021-07-02 JP JP2021110943A patent/JP7366084B2/ja active Active
- 2021-12-14 AU AU2021286264A patent/AU2021286264B2/en active Active
-
2023
- 2023-10-10 JP JP2023175486A patent/JP2024020199A/ja active Pending
-
2024
- 2024-05-29 US US18/677,696 patent/US20250127781A1/en active Pending
- 2024-08-09 AU AU2024205662A patent/AU2024205662A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014530877A5 (https=) | ||
| Das et al. | Early B cell changes predict autoimmunity following combination immune checkpoint blockade | |
| Valent et al. | Advances in the classification and treatment of mastocytosis: current status and outlook toward the future | |
| Campàs et al. | Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells | |
| Kreitman et al. | Cladribine with immediate rituximab for the treatment of patients with variant hairy cell leukemia | |
| Shanafelt et al. | Ofatumumab‐based chemoimmunotherapy is effective and well tolerated in patients with previously untreated chronic lymphocytic leukemia (CLL) | |
| Wang et al. | Elevated absolute NK cell counts in peripheral blood predict good prognosis in chronic lymphocytic leukemia | |
| Iriyama et al. | CD56 expression is an independent prognostic factor for relapse in acute myeloid leukemia with t (8; 21) | |
| Chihara et al. | Ki-67 is a strong predictor of central nervous system relapse in patients with mantle cell lymphoma (MCL) | |
| Péron et al. | CD4 lymphopenia to identify end-of-life metastatic cancer patients | |
| JP2016501843A5 (https=) | ||
| Mick et al. | Statistical challenges in the design of late-stage cancer immunotherapy studies | |
| CA2762783A1 (en) | Methods for providing personalized medicine tests ex vivo for hematological neoplasms | |
| EA201691144A1 (ru) | Способы определения эффективности лекарственного средства для лечения диффузной крупноклеточной b-клеточной лимфомы, множественной миеломы и злокачественных новообразований миелоидного ростка | |
| JP2016500110A5 (https=) | ||
| AU2016252609A1 (en) | Predicting response to alvocidib by mitochondrial profiling | |
| ZA202100296B (en) | Methods for predicting therapeutic benefit of anti-cd19 therapy in patients | |
| Johnson et al. | Exploration of BRAFV600E as a diagnostic adjuvant in the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) | |
| Chang et al. | MHC-I upregulation safeguards neoplastic T cells in the skin against NK cell-mediated eradication in mycosis fungoides | |
| Yokosuka et al. | Flow cytometric chemosensitivity assay using JC-1, a sensor of mitochondrial transmembrane potential, in acute leukemia | |
| Harrer et al. | Lymphocyte subsets show different response patterns to in vivo bound natalizumab—a flow cytometric study on patients with multiple sclerosis | |
| Tse et al. | Expert consensus on the management of chronic lymphocytic leukaemia in Asia | |
| Ahn et al. | Patterns of relapse or progression after bortezomib-based salvage therapy in patients with relapsed/refractory multiple myeloma | |
| Sośnia et al. | Accelerated chronic lymphocytic leukemia–characteristics and retrospective analysis of the Polish Adult Leukemia Study Group | |
| Sebejova et al. | Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to ofatumumab and rituximab |