JP2014530838A5 - - Google Patents
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- Publication number
- JP2014530838A5 JP2014530838A5 JP2014536253A JP2014536253A JP2014530838A5 JP 2014530838 A5 JP2014530838 A5 JP 2014530838A5 JP 2014536253 A JP2014536253 A JP 2014536253A JP 2014536253 A JP2014536253 A JP 2014536253A JP 2014530838 A5 JP2014530838 A5 JP 2014530838A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- aryl
- cycloalkyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000003612 virological effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 4
- 206010022000 influenza Diseases 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 241000712892 Arenaviridae Species 0.000 claims 2
- 241000711573 Coronaviridae Species 0.000 claims 2
- 241000711950 Filoviridae Species 0.000 claims 2
- 241000710781 Flaviviridae Species 0.000 claims 2
- 241000700586 Herpesviridae Species 0.000 claims 2
- 241000712464 Orthomyxoviridae Species 0.000 claims 2
- 241000711504 Paramyxoviridae Species 0.000 claims 2
- 241000150350 Peribunyaviridae Species 0.000 claims 2
- 241000709664 Picornaviridae Species 0.000 claims 2
- 241000712907 Retroviridae Species 0.000 claims 2
- 241000711931 Rhabdoviridae Species 0.000 claims 2
- 241000710924 Togaviridae Species 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 1
- 101800004538 Bradykinin Proteins 0.000 claims 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 1
- 102100035792 Kininogen-1 Human genes 0.000 claims 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 claims 1
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 1
- 229940123066 Polymerase inhibitor Drugs 0.000 claims 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 claims 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 229930003827 cannabinoid Natural products 0.000 claims 1
- 239000003557 cannabinoid Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229940125400 channel inhibitor Drugs 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002911 sialidase inhibitor Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550057P | 2011-10-21 | 2011-10-21 | |
| US61/550,057 | 2011-10-21 | ||
| PCT/EP2012/070760 WO2013057253A1 (en) | 2011-10-21 | 2012-10-19 | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530838A JP2014530838A (ja) | 2014-11-20 |
| JP2014530838A5 true JP2014530838A5 (cg-RX-API-DMAC10.html) | 2015-12-03 |
| JP6033873B2 JP6033873B2 (ja) | 2016-11-30 |
Family
ID=47189887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014536253A Expired - Fee Related JP6033873B2 (ja) | 2011-10-21 | 2012-10-19 | ピリミジン−４−オン誘導体及びウイルス性疾患の治療、改善又は予防におけるその使用 |
Country Status (11)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017521424A (ja) | 2014-07-07 | 2017-08-03 | ザヴィラ ファーマシューティカルズ ゲーエムベーハー | ウイルス疾患の治療、改善又は予防におけるジヒドロピリドピラジン−１，８−ジオン及びそれらの使用 |
| CN107074771B (zh) * | 2014-08-28 | 2020-03-20 | X-化学有限公司 | 可溶性环氧化物水解酶抑制剂及其用途 |
| WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
| EP3428170B1 (en) | 2015-04-28 | 2021-01-06 | Shionogi & Co., Ltd | Anti-influenza polycyclic pyridone derivative and prodrug thereof |
| US20170081331A1 (en) | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease |
| CA3008607A1 (en) | 2015-12-15 | 2017-06-22 | Shionogi & Co., Ltd. | A medicament for treating influenza characterized by combining a cap-dependent endonuclease inhibitor and an anti-influenza drug |
| EP3478671B1 (en) | 2016-06-29 | 2020-05-13 | H. Hoffnabb-La Roche Ag | Pyridazinone-based broad spectrum anti-influenza inhibitors |
| UA125218C2 (uk) | 2016-08-10 | 2022-02-02 | Сіоногі Енд Ко., Лтд. | Фармацевтичні композиції, що містять заміщені поліциклічні піридонові похідні та їх проліки |
| UA125318C2 (uk) | 2017-08-01 | 2022-02-16 | Тереванс Байофарма Ар Енд Ді Айпі, Елелсі | Піразоло- і триазолобіциклічні сполуки як інгібітори jak-кінази |
| CA3125039A1 (en) | 2019-01-23 | 2020-07-30 | Theravance Biopharma R&D Ip, Llc | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
| AU2021253571A1 (en) * | 2020-04-08 | 2022-11-10 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| JP2024510004A (ja) * | 2021-03-17 | 2024-03-05 | エフ． ホフマン－ラ ロシュ アーゲー | 新規チエノピリミジノン誘導体 |
| US11932656B1 (en) | 2023-10-06 | 2024-03-19 | King Faisal University | Thieno[2,3-d]pyrimidines as COX-2 inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| AU2003210388B2 (en) * | 2002-03-07 | 2007-05-17 | F. Hoffmann-La Roche Ag | Bicyclic pyridine and pyrimidine P38 Kinase inhibitors |
| CN101014572B (zh) | 2004-09-15 | 2011-07-06 | 盐野义制药株式会社 | 具有hiv整合酶抑制活性的氨基甲酰基吡啶酮衍生物 |
| WO2009062258A1 (en) * | 2007-11-15 | 2009-05-22 | Cytopia Research Pty Ltd | N-containing heterocyclic compounds |
| JP5647998B2 (ja) | 2009-03-13 | 2015-01-07 | カトリーケ ユニバーシテイト ルーヴェン、ケー．ユー． ルーヴェン アール アンド ディー | 免疫抑制剤としてのチアゾロピリミジン調節因子 |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| WO2010110231A1 (ja) | 2009-03-26 | 2010-09-30 | 塩野義製薬株式会社 | 置換された３－ヒドロキシ－４－ピリドン誘導体 |
| WO2011000566A2 (en) | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
-
2012
- 2012-10-18 US US13/655,418 patent/US20130102601A1/en not_active Abandoned
- 2012-10-19 JP JP2014536253A patent/JP6033873B2/ja not_active Expired - Fee Related
- 2012-10-19 CA CA2852843A patent/CA2852843A1/en not_active Abandoned
- 2012-10-19 EP EP12787384.2A patent/EP2794616B1/en not_active Not-in-force
- 2012-10-19 RU RU2014120477/04A patent/RU2014120477A/ru not_active Application Discontinuation
- 2012-10-19 KR KR1020147013721A patent/KR20140097197A/ko not_active Withdrawn
- 2012-10-19 BR BR112014008412A patent/BR112014008412A2/pt not_active IP Right Cessation
- 2012-10-19 CN CN201280051684.7A patent/CN103958521B/zh not_active Expired - Fee Related
- 2012-10-19 WO PCT/EP2012/070760 patent/WO2013057253A1/en not_active Ceased
- 2012-10-19 ES ES12787384.2T patent/ES2589459T3/es active Active
- 2012-10-19 MX MX2014003801A patent/MX342176B/es active IP Right Grant
-
2016
- 2016-06-15 US US15/182,705 patent/US20160376286A1/en not_active Abandoned