JP2014527826A5 - - Google Patents
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- Publication number
- JP2014527826A5 JP2014527826A5 JP2014531243A JP2014531243A JP2014527826A5 JP 2014527826 A5 JP2014527826 A5 JP 2014527826A5 JP 2014531243 A JP2014531243 A JP 2014531243A JP 2014531243 A JP2014531243 A JP 2014531243A JP 2014527826 A5 JP2014527826 A5 JP 2014527826A5
- Authority
- JP
- Japan
- Prior art keywords
- lab
- bifidobacteria
- ptcc
- trehalose
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000186000 Bifidobacterium Species 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 238000000034 method Methods 0.000 claims 9
- 241000894006 Bacteria Species 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 239000002778 food additive Substances 0.000 claims 7
- 235000013373 food additive Nutrition 0.000 claims 7
- 239000007858 starting material Substances 0.000 claims 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000006041 probiotic Substances 0.000 claims 5
- 230000000529 probiotic effect Effects 0.000 claims 5
- 235000018291 probiotics Nutrition 0.000 claims 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 101000662918 Lactococcus lactis subsp. lactis (strain IL1403) Trehalose 6-phosphate phosphorylase Proteins 0.000 claims 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 108020003272 trehalose-phosphatase Proteins 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 3
- 238000002156 mixing Methods 0.000 claims 3
- 101150089952 trePP gene Proteins 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 101150095512 otsB gene Proteins 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 241000194036 Lactococcus Species 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11182643 | 2011-09-23 | ||
| EP11182643.4 | 2011-09-23 | ||
| PCT/EP2012/068634 WO2013041673A1 (en) | 2011-09-23 | 2012-09-21 | Modified gram positive bacteria and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017195120A Division JP6669703B2 (ja) | 2011-09-23 | 2017-10-05 | 改変されたグラム陽性菌及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527826A JP2014527826A (ja) | 2014-10-23 |
| JP2014527826A5 true JP2014527826A5 (https=) | 2015-12-03 |
| JP6329903B2 JP6329903B2 (ja) | 2018-05-23 |
Family
ID=47040665
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531243A Active JP6329903B2 (ja) | 2011-09-23 | 2012-09-21 | 改変されたグラム陽性菌及びその使用 |
| JP2017195120A Expired - Fee Related JP6669703B2 (ja) | 2011-09-23 | 2017-10-05 | 改変されたグラム陽性菌及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017195120A Expired - Fee Related JP6669703B2 (ja) | 2011-09-23 | 2017-10-05 | 改変されたグラム陽性菌及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9347036B2 (https=) |
| EP (2) | EP3382006B1 (https=) |
| JP (2) | JP6329903B2 (https=) |
| KR (1) | KR102028771B1 (https=) |
| CN (1) | CN103917639B (https=) |
| AU (2) | AU2012311479B2 (https=) |
| BR (1) | BR112014006883A8 (https=) |
| CA (2) | CA2848471C (https=) |
| DK (1) | DK2758513T3 (https=) |
| ES (1) | ES2676270T3 (https=) |
| HU (1) | HUE038336T2 (https=) |
| RU (1) | RU2653757C2 (https=) |
| WO (1) | WO2013041673A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3382006B1 (en) | 2011-09-23 | 2021-02-17 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
| WO2013041672A1 (en) | 2011-09-23 | 2013-03-28 | Actogenix Nv | Modified gram positive bacteria and uses thereof |
| EP3237622B1 (en) | 2014-12-23 | 2021-02-24 | Ilya Pharma AB | Methods for wound healing |
| CA3011331C (en) | 2016-01-14 | 2025-05-13 | Intrexon Actobiotics N.V. | Compositions and methods for the treatment of type 1 diabetes |
| JP7016865B2 (ja) | 2016-09-02 | 2022-03-03 | イントレクソン・アクトバイオテイクス・エヌブイ | Ｉｌ－１０およびインスリンを安定的に発現する遺伝子改変された細菌 |
| CN109983028B (zh) * | 2016-09-13 | 2023-10-20 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 黏膜黏附性微生物 |
| IT201600122724A1 (it) * | 2016-12-02 | 2018-06-02 | Sofar Spa | Exopolysaccharides and uses thereof |
| CN113347983A (zh) * | 2018-10-09 | 2021-09-03 | 第二基因组股份有限公司 | 用于递送有效治疗上皮屏障功能障碍的蛋白质的乳酸乳球菌表达系统 |
| CN114854807B (zh) * | 2022-05-23 | 2024-05-17 | 中国科学院微生物研究所 | 一种生产海藻糖六磷酸的方法 |
| CN121204013A (zh) * | 2025-11-04 | 2025-12-26 | 大连理工大学 | 一种海藻糖-6-磷酸磷酸化酶及其突变体与应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9006400D0 (en) | 1990-03-22 | 1990-05-23 | Ciba Geigy Ag | Bacterial vectors |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| IT1270123B (it) | 1994-10-05 | 1997-04-28 | Dompe Spa | Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia |
| GB9521568D0 (en) | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| US6033376A (en) | 1998-09-30 | 2000-03-07 | Allergan Sales, Inc. | Wound shaper sleeve |
| AU770726B2 (en) | 1998-10-20 | 2004-02-26 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Use of a cytokine-producing lactococcus strain to treat colitis |
| PT1194554E (pt) | 1999-07-05 | 2007-01-31 | Vlaams Interuniv Inst Biotech | Libertação de péptidos trifólios |
| AT407730B (de) | 2000-01-14 | 2001-05-25 | Hoerbiger Hydraulik | Betätigungsanordnung für schwenkbare teile an fahrzeugen |
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| WO2002090551A2 (en) | 2001-05-03 | 2002-11-14 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Self-containing lactococcus strain |
| CA2506031A1 (en) | 2002-11-15 | 2004-06-03 | Vib Vzw | Self-containing lactobacillus strain comprising a thya mutation and therapeutic applications thereof |
| EP1720974B2 (en) | 2004-02-24 | 2021-12-22 | Chr. Hansen A/S | Frozen lactic acid bacteria culture of individual pellets |
| AU2005243441A1 (en) | 2004-05-18 | 2005-11-24 | Universiteit Gent | Self-containing lactobacillus strain |
| ES2439698T3 (es) * | 2004-08-20 | 2014-01-24 | Actogenix N.V. | Procedimiento para mejorar la conservación de lactococos |
| WO2007025977A2 (en) | 2005-08-30 | 2007-03-08 | Actogenix Nv | Anti-tnf alpha producing lactic acid bacteria for the treatment of chronic enterocolitis |
| AU2006319216B2 (en) | 2005-11-29 | 2012-09-13 | Intrexon Actobiotics Nv | Induction of mucosal tolerance to antigens |
| RU2008147398A (ru) | 2006-05-02 | 2010-06-10 | Актогеникс Н.В. (Be) | Доставка пептидов, связанных с ожирением, через кишечник посредством микроорганизмов |
| JP2010513245A (ja) | 2006-12-14 | 2010-04-30 | アクトジェニックス・エヌブイ | 免疫調節を誘起するための結合分子の送達 |
| EP2115146B1 (en) | 2007-01-12 | 2016-07-06 | Intrexon Actobiotics NV | Lactococcus promoters and uses thereof |
| CN103933563B (zh) | 2007-01-25 | 2016-09-28 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病 |
| DK3181682T3 (da) | 2008-09-29 | 2021-07-05 | Intrexon Actobiotics Nv | Reduceret kolonisering af mikrober på slimhinden |
| RU2393214C1 (ru) * | 2009-01-29 | 2010-06-27 | Общество с ограниченной ответственностью "ИнноПроб"(ООО"ИнноПроб") | Иммунобиологическое противоаллергическое средство (варианты), штамм lactobacillus acidophilus nkjc, штамм lactobacillus acidophilus jch, штамм lactobacillus acidophilus kaa |
| WO2010124855A1 (en) | 2009-04-30 | 2010-11-04 | Actogenix Nv | Cryoprotectants for freeze drying of lactic acid bacteria |
| EP3382006B1 (en) * | 2011-09-23 | 2021-02-17 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
| WO2013041672A1 (en) * | 2011-09-23 | 2013-03-28 | Actogenix Nv | Modified gram positive bacteria and uses thereof |
-
2012
- 2012-09-21 EP EP18172371.9A patent/EP3382006B1/en active Active
- 2012-09-21 WO PCT/EP2012/068634 patent/WO2013041673A1/en not_active Ceased
- 2012-09-21 CA CA2848471A patent/CA2848471C/en active Active
- 2012-09-21 US US14/346,488 patent/US9347036B2/en active Active
- 2012-09-21 ES ES12773253.5T patent/ES2676270T3/es active Active
- 2012-09-21 HU HUE12773253A patent/HUE038336T2/hu unknown
- 2012-09-21 KR KR1020147010661A patent/KR102028771B1/ko not_active Expired - Fee Related
- 2012-09-21 EP EP12773253.5A patent/EP2758513B1/en active Active
- 2012-09-21 AU AU2012311479A patent/AU2012311479B2/en not_active Ceased
- 2012-09-21 DK DK12773253.5T patent/DK2758513T3/en active
- 2012-09-21 JP JP2014531243A patent/JP6329903B2/ja active Active
- 2012-09-21 CA CA3131722A patent/CA3131722A1/en not_active Abandoned
- 2012-09-21 CN CN201280053876.1A patent/CN103917639B/zh not_active Expired - Fee Related
- 2012-09-21 BR BR112014006883A patent/BR112014006883A8/pt not_active Application Discontinuation
- 2012-09-21 RU RU2014116230A patent/RU2653757C2/ru active
-
2016
- 2016-01-21 US US15/003,426 patent/US9982228B2/en active Active
-
2017
- 2017-10-05 JP JP2017195120A patent/JP6669703B2/ja not_active Expired - Fee Related
- 2017-11-29 AU AU2017268593A patent/AU2017268593B9/en not_active Ceased
-
2018
- 2018-04-23 US US15/959,705 patent/US10519418B2/en active Active
-
2019
- 2019-12-13 US US16/713,737 patent/US10793825B2/en active Active
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