JP2014527508A - ハイパーフォリン類似物、合成方法、およびその使用 - Google Patents

ハイパーフォリン類似物、合成方法、およびその使用 Download PDF

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JP2014527508A
JP2014527508A JP2014513726A JP2014513726A JP2014527508A JP 2014527508 A JP2014527508 A JP 2014527508A JP 2014513726 A JP2014513726 A JP 2014513726A JP 2014513726 A JP2014513726 A JP 2014513726A JP 2014527508 A JP2014527508 A JP 2014527508A
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JP2014527508A5 (enExample
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シェア，マシュー，ディー．
スパーリング，ブライアン，エー．
メビウス，デビット
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Harvard University
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    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
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    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
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    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
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    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
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    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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JP2014513726A 2011-06-03 2012-06-01 ハイパーフォリン類似物、合成方法、およびその使用 Pending JP2014527508A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161493250P 2011-06-03 2011-06-03
US61/493,250 2011-06-03
PCT/US2012/040379 WO2012167021A2 (en) 2011-06-03 2012-06-01 Hyperforin analogs, methods of synthesis, and uses thereof

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JP2014527508A true JP2014527508A (ja) 2014-10-16
JP2014527508A5 JP2014527508A5 (enExample) 2015-08-20

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US (1) US9321713B2 (enExample)
EP (1) EP2714638A4 (enExample)
JP (1) JP2014527508A (enExample)
KR (1) KR20140041610A (enExample)
CN (1) CN103732568A (enExample)
AU (1) AU2012262084A1 (enExample)
BR (1) BR112013030986A2 (enExample)
CA (1) CA2837549A1 (enExample)
IL (1) IL229742A0 (enExample)
MX (1) MX2013014162A (enExample)
RU (1) RU2013157954A (enExample)
SG (1) SG195210A1 (enExample)
WO (1) WO2012167021A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103980231B (zh) * 2014-06-04 2016-03-30 中国科学院上海有机化学研究所 一种五氟苯基环氧丙烷的合成方法
US20180071269A1 (en) 2015-08-12 2018-03-15 Tianxin Wang Therapeutical methods, formulations and nutraceutical formulations
CN106496171B (zh) * 2016-10-20 2019-09-13 贵州省中国科学院天然产物化学重点实验室 具有抗肿瘤活性的多环多异戊烯基间苯三酚类化合物、其制备方法及应用
CN106967016B (zh) * 2017-04-25 2020-05-19 华中科技大学 贯叶连翘次生代谢产物中具有乙酰胆碱酯酶抑制作用化合物及分离制备和用途
CN109044999A (zh) * 2018-10-15 2018-12-21 上海市第六人民医院 贯叶金丝桃素在制备促进白色脂肪棕色化并且提高棕色脂肪活性的药物中的用途
DE102022129895A1 (de) * 2022-11-11 2024-05-16 Technische Universität Dresden, Körperschaft des öffentlichen Rechts 4-Hydroxybicyclo[3.3.1]non-3-en-2,9-dion-Derivate und deren Verwendung

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO2000054785A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Stabilized bicyclo[3.3.1]nonenes and methods of use
WO2000054760A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia
JP2002517478A (ja) * 1998-06-10 2002-06-18 インデナ エッセ ピ ア ハイパーフォリン誘導体、その利用及びこれを含む調剤
JP2005515979A (ja) * 2001-11-21 2005-06-02 ゼーバー，ジークフリート 活性な薬物成分としてのビシクロ［３．３．１］ノナン−２，４，９−トリオン置換体
JP2005523917A (ja) * 2002-04-23 2005-08-11 インデナ・ソチエタ・ペル・アチオニ ハイパーフォリン誘導体、それらの使用及びそれらを含有している製剤

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WO1999041220A1 (de) 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Stabile hyperforin-salze, verfahren zu ihrer herstellung und verwendung zur therapie der alzheimerschen krankheit
ITMI20020871A1 (it) 2002-04-23 2003-10-23 Indena Spa Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002517478A (ja) * 1998-06-10 2002-06-18 インデナ エッセ ピ ア ハイパーフォリン誘導体、その利用及びこれを含む調剤
WO2000054785A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Stabilized bicyclo[3.3.1]nonenes and methods of use
WO2000054760A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia
JP2005515979A (ja) * 2001-11-21 2005-06-02 ゼーバー，ジークフリート 活性な薬物成分としてのビシクロ［３．３．１］ノナン−２，４，９−トリオン置換体
JP2005523917A (ja) * 2002-04-23 2005-08-11 インデナ・ソチエタ・ペル・アチオニ ハイパーフォリン誘導体、それらの使用及びそれらを含有している製剤

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JPN6015049541; Ｍａ，　Ｓｈｕａｎｇ-Ｇａｎｇ　ｅｔ　ａｌ．: 'Ｐｒｅｎｙｌａｔｅｄ　Ｃ６-Ｃ３　ｃｏｍｐｏｕｎｄｓ　ｗｉｔｈ　ｍｏｌｅｃｕｌａｒ　ｄｉｖｅｒｓｉｔｙ　ｆｒｏｍ　ｔｈｅ　ｒｏｏｔｓ　ｏｆ　Ｉｌｌｉｃｉｕｍ　ｏｌｉｇａｎｄｒｕｍ' Ｐｈｙｔｏｃｈｅｍｉｓｔｒｙ　（Ｅｌｓｅｖｉｅｒ） ７２（１）, 2011, １１５-１２５ *
JPN6015049542; Ｔａｎｇ，　Ｗｅｎ-Ｚｈａｏ　ｅｔ　ａｌ．: 'Ｒｅａｒｒａｎｇｅｄ　ｐｒｅｎｙｌａｔｅｄ　Ｃ６-Ｃ３　ｃｏｍｐｏｕｎｄｓ　ａｎｄ　ａ　ｈｉｇｈｌｙ　ｏｘｙｇｅｎａｔｅｄ　ｓｅｃｏ-ｐｒｅｚｉｚａａｎｅ-ｔｙｐｅ　ｓｅｓｑｕｉｔｅｒｐｅｎｅ　ｆｒｏ' Ｊｏｕｒｎａｌ　ｏｆ　Ｎａｔｕｒａｌ　Ｐｒｏｄｕｃｔｓ ７２（６）, 2009, １０１７-１０２１ *
JPN6015049544; Ａｈｍａｄ，　Ｎａｄｉａ　Ｍ．　ｅｔ　ａｌ．: 'Ｓｙｎｔｈｅｔｉｃ　ｓｔｕｄｉｅｓ　ｔｏｗａｒｄｓ　ｇａｒｓｕｂｅｌｌｉｎ　Ａ：　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｍｏｄｅｌ　ｓｙｓｔｅｍｓ　ａｎｄ　ｐｏｔｅｎｔｉａｌ　ｍｉｍｉｃｓ　ｂｙ　ｒｅｇｉｏｓｅｌ' Ｏｒｇａｎｉｃ　＆　Ｂｉｏｍｏｌｅｃｕｌａｒ　Ｃｈｅｍｉｓｔｒｙ ５（１２）, 2007, １９２４-１９３４ *
JPN6015049546; Ｈａｓｈｉｄａ，　Ｋｏｈ；　Ｏｈａｒａ，　Ｓｅｉｊｉ；　Ｍａｋｉｎｏ，　Ｒｅｉ: 'Ｂａｓｅ-ｃａｔａｌｙｚｅｄ　ｒｅａｃｔｉｏｎｓ　ｏｆ　ｐｒｏｃｙａｎｉｄｉｎ　Ｂ３：　Ｆｏｒｍａｔｉｏｎ　ｏｆ　ａ　ｎｏｖｅｌ　ｃａｔｅｃｈｉｎｉｃ　ａｃｉｄ-ｃａｔｅｃｈｉｎ　ｄｉｍｅｒ' Ｊｏｕｒｎａｌ　ｏｆ　Ｗｏｏｄ　Ｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｔｅｃｈｎｏｌｏｇｙ ２６（２）, 2006, １２５-１４０ *
JPN6015049547; Ｈａｓｈｉｄａ，　Ｋｏｈ；　Ｏｈａｒａ，　Ｓｅｉｊｉ；　Ｍａｋｉｎｏ，　Ｒｅｉ: 'Ｂａｓｅ-Ｃａｔａｌｙｚｅｄ　Ｒｅａｃｔｉｏｎｓ　ｏｆ　（-）-Ｅｐｉｃａｔｅｃｈｉｎ：　Ｆｏｒｍａｔｉｏｎ　ｏｆ　Ｅｎａｎｔｉｏｍｅｒｓ　ｏｆ　Ｂａｓｅ-Ｃａｔａｌｙｚｅｄ　Ｒｅａｃｔｉｏｎ　Ｐｒｏ' Ｊｏｕｒｎａｌ　ｏｆ　Ｗｏｏｄ　Ｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｔｅｃｈｎｏｌｏｇｙ ２３（３　＆　４）, 2003, ２２７-２３２ *
JPN6015049548; Ｈａｓｈｉｄａ，　Ｋｏｈ；　Ｏｈａｒａ，　Ｓｅｉｊｉ: 'Ｆｏｒｍａｔｉｏｎ　ｏｆ　ａ　ｎｏｖｅｌ　ｃａｔｅｃｈｉｎｉｃ　ａｃｉｄ　ｓｔｅｒｅｏｉｓｏｍｅｒ　ｆｒｏｍ　ｂａｓｅ-ｃａｔａｌｙｚｅｄ　ｒｅａｃｔｉｏｎｓ　ｏｆ　（＋）-ｃａｔｅｃｈｉｎ' Ｊｏｕｒｎａｌ　ｏｆ　Ｗｏｏｄ　Ｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｔｅｃｈｎｏｌｏｇｙ ２２（１）, 2002, １１-２３ *
JPN6015049549; Ｏｈａｒａ， Ｓｅｉｊｉ； Ｈｅｍｉｎｇｗａｙ， Ｒｉｃｈａｒｄ Ｗ．: 'Ｃｏｎｄｅｎｓｅｄ ｔａｎｎｉｎｓ： ｔｈｅ ｆｏｒｍａｔｉｏｎ ｏｆ ａ ｄｉａｒｙｌｐｒｏｐａｎｏｌ-ｃａｔｅｃｈｉｎｉｃ ａｃｉｄ ｄｉｍｅｒ ｆｒｏｍ ｂａｓｅ-ｃａｔａｌｙｚｅｄ ｒｅａｃ' Ｊｏｕｒｎａｌ ｏｆ Ｗｏｏｄ Ｃｈｅｍｉｓｔｒｙ ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ １１（２）, 1991, １９５-２０８ *
JPN6015049550; Ｉｎｏｕｙｅ，　Ｙｏｓｈｉｎｏｂｕ；　Ｋｏｊｉｍａ，　Ｔｓｕｔｏｍｕ；　Ｏｗａｄａ，　Ｊｕｎ；　Ｋａｋｉｓａｗａ，　Ｈｉｒｏｓｈｉ: 'Ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　ｂｉｃｙｃｌｏ［３．３．１］ｎｏｎａｎｅ-２，４-ｄｉｏｎｅ　ｄｅｒｉｖａｔｉｖｅｓ' Ｂｕｌｌｅｔｉｎ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ　ｏｆ　Ｊａｐａｎ ６０（１２）, 1987, ４３６９-７５ *
JPN6015049551; Ｇｒａｖｅｌ，　Ｄ．；　Ｒａｈａｌ，　Ｓ．: 'Ｎｅｗ　ａｃｃｅｓｓ　ｔｏ　ｎｏｒａｄａｍａｎｔａｎｅｓ　ｖｉａ　ｇｅｎｅｒａｔｉｏｎ　ｏｆ　ｓｅｌｅｃｔｉｖｅｌｙ　ｐｒｏｔｅｃｔｅｄ　ｂｉｃｙｃｌｉｃ　beta-ｄｉｋｅｔｏｎｅｓ' Ｃａｎａｄｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｓｔｒｙ ５３（１７）, 1975, ２６７１-３ *
JPN6015049552; Ｓｉｍｐｋｉｎｓ，　Ｎｉｇｅｌ　Ｓ．　ｅｔ　ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｎｅｍｏｒｏｓｏｎｅ　ｖｉａ　ａ　ｄｉｆｆｉｃｕｌｔ　ｂｒｉｄｇｅｈｅａｄ　ｓｕｂｓｔｉｔｕｔｉｏｎ　ｒｅａｃｔｉｏｎ' Ｓｙｎｌｅｔｔ （４）, 2010, ６３９-６４３ *
JPN6015049553; Ｋｒａｕｓ，　Ｇｅｏｒｇｅ　Ａ．；　Ｎｇｕｙｅｎ，　Ｔｕａｎ　Ｈ．；　Ｊｅｏｎ，　Ｉｎｓｉｋ: 'Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　ｃｏｒｅ　ｂｉｃｙｃｌｉｃ　ｓｙｓｔｅｍ　ｏｆ　ｈｙｐｅｒｆｏｒｉｎ　ａｎｄ　ｎｅｍｏｒｏｓｏｎｅ' Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ ４４（４）, 2003, ６５９-６６１ *
JPN6015049554; Ａｒｅｄｏｖａ，　Ｅ．　Ｎ．　ｅｔ　ａｌ．: 'Ｄｅｒｉｖａｔｉｖｅｓ　ｏｆ　ｂｉｃｙｃｌｏ［３．３．１］ｎｏｎａｎｅ-２，９-ｄｉｏｎｅ' Ｉｚｖｅｓｔｉｙａ　Ａｋａｄｅｍｉｉ　Ｎａｕｋ　ＳＳＳＲ，　Ｓｅｒｉｙａ　Ｋｈｉｍｉｃｈｅｓｋａｙａ （６）, 1976, １４０８-１０ *

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AU2012262084A1 (en) 2014-01-09
BR112013030986A2 (pt) 2016-12-06
US9321713B2 (en) 2016-04-26
EP2714638A2 (en) 2014-04-09
CN103732568A (zh) 2014-04-16
RU2013157954A (ru) 2015-07-20
CA2837549A1 (en) 2012-12-06
US20140135287A1 (en) 2014-05-15
WO2012167021A2 (en) 2012-12-06
KR20140041610A (ko) 2014-04-04
SG195210A1 (en) 2013-12-30
EP2714638A4 (en) 2015-09-23
WO2012167021A3 (en) 2013-04-25
IL229742A0 (en) 2014-01-30

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