JP2014527073A5 - - Google Patents
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- Publication number
- JP2014527073A5 JP2014527073A5 JP2014530158A JP2014530158A JP2014527073A5 JP 2014527073 A5 JP2014527073 A5 JP 2014527073A5 JP 2014530158 A JP2014530158 A JP 2014530158A JP 2014530158 A JP2014530158 A JP 2014530158A JP 2014527073 A5 JP2014527073 A5 JP 2014527073A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- group
- alkoxy
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 229910052799 carbon Inorganic materials 0.000 description 7
- 229910052736 halogen Inorganic materials 0.000 description 7
- 150000002367 halogens Chemical class 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 description 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- ICCBZGUDUOMNOF-UHFFFAOYSA-N azidoamine Chemical compound NN=[N+]=[N-] ICCBZGUDUOMNOF-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 125000001963 4 membered heterocyclic group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11180929.9 | 2011-09-12 | ||
| EP11180929 | 2011-09-12 | ||
| PCT/EP2012/067469 WO2013037703A1 (en) | 2011-09-12 | 2012-09-07 | 3 -pyridine carboxylic acid hydrazides as hdl-cholesterol raising agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527073A JP2014527073A (ja) | 2014-10-09 |
| JP2014527073A5 true JP2014527073A5 (enExample) | 2015-07-16 |
| JP5815874B2 JP5815874B2 (ja) | 2015-11-17 |
Family
ID=46796631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530158A Expired - Fee Related JP5815874B2 (ja) | 2011-09-12 | 2012-09-07 | Ｈｄｌコレステロール上昇剤としての３−ピリジンカルボン酸ヒドラジド |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8648099B2 (enExample) |
| EP (1) | EP2755953A1 (enExample) |
| JP (1) | JP5815874B2 (enExample) |
| KR (1) | KR20140057652A (enExample) |
| CN (1) | CN103781765A (enExample) |
| BR (1) | BR112014005634A2 (enExample) |
| CA (1) | CA2844865A1 (enExample) |
| MX (1) | MX2014001860A (enExample) |
| RU (1) | RU2014111321A (enExample) |
| WO (1) | WO2013037703A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107056749A (zh) * | 2015-03-12 | 2017-08-18 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺和哌啶结构ptp1b抑制剂及其用途 |
| US20200085810A1 (en) * | 2018-07-26 | 2020-03-19 | Hoffmann-La Roche Inc. | Compounds for use in treating kidney disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1492784A4 (en) * | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
| ES2326280T3 (es) * | 2005-04-06 | 2009-10-06 | F. Hoffmann-La Roche Ag | Derivados de piridin-3-carboxamida como agonistas inversos de cb1. |
| WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| US7629346B2 (en) * | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
| EP2074096B1 (en) * | 2006-10-04 | 2012-06-27 | F. Hoffmann-La Roche AG | 3-pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as hdl-cholesterol raising agents |
| TW200940537A (en) * | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
-
2012
- 2012-09-07 CA CA2844865A patent/CA2844865A1/en not_active Abandoned
- 2012-09-07 WO PCT/EP2012/067469 patent/WO2013037703A1/en not_active Ceased
- 2012-09-07 KR KR1020147008882A patent/KR20140057652A/ko not_active Ceased
- 2012-09-07 MX MX2014001860A patent/MX2014001860A/es unknown
- 2012-09-07 RU RU2014111321/04A patent/RU2014111321A/ru not_active Application Discontinuation
- 2012-09-07 EP EP12754017.7A patent/EP2755953A1/en not_active Withdrawn
- 2012-09-07 BR BR112014005634A patent/BR112014005634A2/pt not_active IP Right Cessation
- 2012-09-07 CN CN201280044104.1A patent/CN103781765A/zh active Pending
- 2012-09-07 JP JP2014530158A patent/JP5815874B2/ja not_active Expired - Fee Related
- 2012-09-11 US US13/609,429 patent/US8648099B2/en not_active Expired - Fee Related
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