JP2014525429A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014525429A5 JP2014525429A5 JP2014527686A JP2014527686A JP2014525429A5 JP 2014525429 A5 JP2014525429 A5 JP 2014525429A5 JP 2014527686 A JP2014527686 A JP 2014527686A JP 2014527686 A JP2014527686 A JP 2014527686A JP 2014525429 A5 JP2014525429 A5 JP 2014525429A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition according
- aureus
- polypeptide
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 63
- 239000000427 antigen Substances 0.000 claims description 42
- 102000036639 antigens Human genes 0.000 claims description 42
- 108091007433 antigens Proteins 0.000 claims description 42
- 229920001184 polypeptide Polymers 0.000 claims description 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
- 150000003839 salts Chemical class 0.000 claims description 32
- 125000003275 alpha amino acid group Chemical class 0.000 claims description 24
- 229910052751 metal Inorganic materials 0.000 claims description 22
- 239000002184 metal Substances 0.000 claims description 22
- 230000002163 immunogen Effects 0.000 claims description 20
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 11
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 108010006464 Hemolysin Proteins Proteins 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 6
- 239000003228 hemolysin Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 231100000252 nontoxic Toxicity 0.000 claims description 4
- 230000003000 nontoxic effect Effects 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 2
- 229940124615 TLR 7 agonist Drugs 0.000 claims 5
- 241000201788 Staphylococcus aureus subsp. aureus Species 0.000 claims 3
- 229940125904 compound 1 Drugs 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 239000000556 agonist Substances 0.000 description 25
- 102000002689 Toll-like receptor Human genes 0.000 description 23
- 108020000411 Toll-like receptor Proteins 0.000 description 23
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 102000045715 human TLR7 Human genes 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161530162P | 2011-09-01 | 2011-09-01 | |
| US61/530,162 | 2011-09-01 | ||
| US201261607999P | 2012-03-07 | 2012-03-07 | |
| US61/607,999 | 2012-03-07 | ||
| PCT/EP2012/067032 WO2013030378A1 (en) | 2011-09-01 | 2012-08-31 | Adjuvanted formulations of staphylococcus aureus antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014525429A JP2014525429A (ja) | 2014-09-29 |
| JP2014525429A5 true JP2014525429A5 (cg-RX-API-DMAC7.html) | 2015-10-01 |
Family
ID=46763095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527686A Pending JP2014525429A (ja) | 2011-09-01 | 2012-08-31 | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ抗原のアジュバント添加処方物 |
Country Status (14)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8859489B2 (en) * | 2009-04-03 | 2014-10-14 | Momenta Pharmaceuticals, Inc. | Water-mediated control of depolymerization step of glatiramer acetate synthesis |
| EA026401B1 (ru) | 2009-09-02 | 2017-04-28 | Новартис Аг | Иммуногенные композиции, содержащие модуляторы активности tlr |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| AU2012214677B2 (en) * | 2011-02-08 | 2016-11-10 | Abvacc, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| BR112013022397A2 (pt) | 2011-03-02 | 2017-09-26 | Derek OHagan | vacinas combinadas com doses menores de antígeno e/ou adjuvante |
| WO2013030378A1 (en) * | 2011-09-01 | 2013-03-07 | Novartis Ag | Adjuvanted formulations of staphylococcus aureus antigens |
| RU2014140336A (ru) * | 2012-03-07 | 2016-04-27 | Новартис Аг | Иммунологически полезные соли аргинина |
| RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
| ES2737024T3 (es) * | 2012-08-31 | 2020-01-09 | Glaxosmithkline Biologicals Sa | Proteínas estabilizadas para inmunización contra Staphylococcus aureus |
| EP2890387A1 (en) * | 2012-08-31 | 2015-07-08 | Novartis AG | Stabilised proteins for immunising against staphylococcus aureus |
| WO2014033193A1 (en) * | 2012-08-31 | 2014-03-06 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| BE1022359B1 (fr) * | 2014-03-17 | 2016-03-25 | Glaxosmithkline Biologicals Sa | Immunisation contre des infections staphylococciques des os et des articulations |
| JP6894237B2 (ja) * | 2014-03-26 | 2021-06-30 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 変異体ブドウ球菌抗原 |
| BE1022875B1 (fr) * | 2014-03-26 | 2016-09-30 | Glaxosmithkline Biologicals S.A. | Compositions pour une immunisation contre staphylococcus aureus |
| CN105646681B (zh) * | 2016-01-21 | 2021-07-16 | 浙江海隆生物科技有限公司 | 一种奶牛金黄色葡萄球菌α-溶血素亚单位疫苗的制备方法及应用 |
| CA3029902A1 (en) | 2016-07-07 | 2018-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody adjuvant conjugates |
| AR111760A1 (es) * | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
| EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3485094D1 (de) | 1983-01-25 | 1991-10-31 | Ciba Geigy Ag | Neue peptidderivate. |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| ES2162139T5 (es) | 1993-03-23 | 2008-05-16 | Smithkline Beecham Biologicals S.A. | Composiciones de vacuna que contienen monofosforil-lipido a 3-o-desacilado. |
| NZ544542A (en) | 2003-07-24 | 2009-01-31 | Merck & Co Inc | Polypeptides for inducing a protective immune response against staphylococcus aureus |
| US20060188515A1 (en) | 2003-07-24 | 2006-08-24 | Anderson Annaliesa S | Polypeptides for inducing a protective immune response against staphylococcus aureus |
| CA2555342A1 (en) | 2004-02-18 | 2005-09-01 | Merck & Co., Inc. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯 |
| TW200801003A (en) | 2005-09-16 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| EP1939202A4 (en) | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW COMPOUND OF ADENINE |
| US20090192153A1 (en) | 2005-09-22 | 2009-07-30 | Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan | Novel adenine compound |
| TW200745114A (en) | 2005-09-22 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| US20090099216A1 (en) | 2005-09-22 | 2009-04-16 | Astrazeneca Aktiebolag A Corporation Of Sweden | Novel adenine compound |
| EP1939201A4 (en) | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| WO2007093901A1 (en) | 2006-02-17 | 2007-08-23 | Pfizer Limited | 3 -deazapurine derivatives as tlr7 modulators |
| EP2043690A1 (en) | 2006-06-12 | 2009-04-08 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
| US8138172B2 (en) | 2006-07-05 | 2012-03-20 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of TLR7 |
| US8338593B2 (en) | 2006-07-07 | 2012-12-25 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
| WO2008152447A2 (en) | 2006-10-30 | 2008-12-18 | The University Of Western Ontario | Staphylococcus aureus specific anti-infectives |
| PT2125792E (pt) | 2007-02-19 | 2011-03-01 | Glaxosmithkline Llc | Derivados de purina como imunomoduladores |
| TW200902018A (en) | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Novel adenine compound |
| JP5400763B2 (ja) | 2007-05-08 | 2014-01-29 | アストラゼネカ・アクチエボラーグ | 免疫調節特性を有するイミダゾキノリン類 |
| ATE501136T1 (de) | 2007-08-03 | 2011-03-15 | Pfizer Ltd | Imidazopyridinone |
| EP2666784B1 (en) | 2007-08-31 | 2017-04-05 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
| PE20091236A1 (es) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| JP5380465B2 (ja) | 2008-03-03 | 2014-01-08 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｔｌｒ活性モジュレーターとしての化合物および組成物 |
| EA023556B1 (ru) | 2008-03-24 | 2016-06-30 | 4ЭсЦэ АГ | 1,2-дизамещенные-4-аминоимидазохинолины |
| PT2313111E (pt) | 2008-08-01 | 2013-12-05 | Ventirx Pharmaceuticals Inc | Formulações de agonista de receptor do tipo toll e seus usos |
| EA021377B9 (ru) | 2008-12-09 | 2015-09-30 | Джилид Сайэнс, Инк. | Модуляторы толл-подобных рецепторов |
| ES2565377T3 (es) | 2009-04-14 | 2016-04-04 | Glaxosmithkline Biologicals Sa | Composiciones para inmunización contra Staphylococcus aureus |
| PE20110023A1 (es) * | 2009-06-22 | 2011-01-31 | Wyeth Llc | Composiciones inmunogenicas de antigenos de staphylococcus aureus |
| AU2010272505B2 (en) | 2009-07-16 | 2015-09-17 | Glaxosmithkline Biologicals S.A. | Treatment of infections |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913681D0 (en) * | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| EA026401B1 (ru) | 2009-09-02 | 2017-04-28 | Новартис Аг | Иммуногенные композиции, содержащие модуляторы активности tlr |
| TWI445708B (zh) * | 2009-09-02 | 2014-07-21 | Irm Llc | 作為ｔｌｒ活性調節劑之化合物及組合物 |
| CA2792938C (en) | 2010-03-23 | 2018-07-31 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| BR112013022397A2 (pt) * | 2011-03-02 | 2017-09-26 | Derek OHagan | vacinas combinadas com doses menores de antígeno e/ou adjuvante |
| WO2013030378A1 (en) * | 2011-09-01 | 2013-03-07 | Novartis Ag | Adjuvanted formulations of staphylococcus aureus antigens |
| JP2015510872A (ja) * | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Ｓｔｒｅｐｔｏｃｏｃｃｕｓｐｎｅｕｍｏｎｉａｅ抗原の増強された製剤 |
| RU2014140521A (ru) * | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
| EP2822584A1 (en) * | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| WO2014033191A1 (en) * | 2012-08-31 | 2014-03-06 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| ES2737024T3 (es) * | 2012-08-31 | 2020-01-09 | Glaxosmithkline Biologicals Sa | Proteínas estabilizadas para inmunización contra Staphylococcus aureus |
| EP2890387A1 (en) * | 2012-08-31 | 2015-07-08 | Novartis AG | Stabilised proteins for immunising against staphylococcus aureus |
| WO2014033193A1 (en) * | 2012-08-31 | 2014-03-06 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| RU2015106930A (ru) * | 2012-09-06 | 2016-10-20 | Новартис Аг | Комбинированные вакцины с менингококком серогруппы в и к/д/с |
| GB201219420D0 (en) * | 2012-10-29 | 2012-12-12 | Novartis Ag | Staphyloccal immunogens |
| WO2014118305A1 (en) * | 2013-02-01 | 2014-08-07 | Novartis Ag | Intradermal delivery of immunological compositions comprising toll-like receptor agonists |
| BE1022359B1 (fr) * | 2014-03-17 | 2016-03-25 | Glaxosmithkline Biologicals Sa | Immunisation contre des infections staphylococciques des os et des articulations |
| JP6894237B2 (ja) * | 2014-03-26 | 2021-06-30 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 変異体ブドウ球菌抗原 |
| BE1022875B1 (fr) * | 2014-03-26 | 2016-09-30 | Glaxosmithkline Biologicals S.A. | Compositions pour une immunisation contre staphylococcus aureus |
-
2012
- 2012-08-31 WO PCT/EP2012/067032 patent/WO2013030378A1/en not_active Ceased
- 2012-08-31 SG SG11201400210RA patent/SG11201400210RA/en unknown
- 2012-08-31 CN CN201280053918.1A patent/CN104093418A/zh active Pending
- 2012-08-31 IN IN2152CHN2014 patent/IN2014CN02152A/en unknown
- 2012-08-31 JP JP2014527686A patent/JP2014525429A/ja active Pending
- 2012-08-31 CA CA2847204A patent/CA2847204A1/en not_active Abandoned
- 2012-08-31 AU AU2012300765A patent/AU2012300765A1/en not_active Abandoned
- 2012-08-31 EP EP12753488.1A patent/EP2763695A1/en not_active Withdrawn
- 2012-08-31 RU RU2014112343/10A patent/RU2014112343A/ru not_active Application Discontinuation
- 2012-08-31 US US14/240,616 patent/US20140363461A1/en not_active Abandoned
- 2012-08-31 KR KR1020147008622A patent/KR20140066212A/ko not_active Withdrawn
- 2012-08-31 MX MX2014002363A patent/MX2014002363A/es unknown
- 2012-08-31 BR BR112014004782A patent/BR112014004782A2/pt not_active IP Right Cessation
-
2014
- 2014-02-24 IL IL231104A patent/IL231104A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014525429A5 (cg-RX-API-DMAC7.html) | ||
| US10975127B2 (en) | Flagellin-based agents and uses including effective vaccination | |
| RU2014112343A (ru) | Оставы антигенов staphylococcus aureus, содержащие адъюванты | |
| JP2015509522A5 (cg-RX-API-DMAC7.html) | ||
| JP5425642B2 (ja) | 合成ｔｌｒアゴニストの結合体およびそのための使用 | |
| US10188733B2 (en) | Vaccines comprising bisphosphonate and methods of use thereof | |
| Tonnis et al. | Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars | |
| JP2013519645A5 (cg-RX-API-DMAC7.html) | ||
| JP2012523246A5 (cg-RX-API-DMAC7.html) | ||
| JP2013543505A5 (cg-RX-API-DMAC7.html) | ||
| RU2014140521A (ru) | Адъювантные составы бустерных вакцин | |
| CN106163551A (zh) | 单瓶疫苗制剂 | |
| JP2013501071A5 (cg-RX-API-DMAC7.html) | ||
| JPWO2020022272A5 (cg-RX-API-DMAC7.html) | ||
| JP2015511957A5 (cg-RX-API-DMAC7.html) | ||
| JP2015509075A5 (cg-RX-API-DMAC7.html) | ||
| JP2013503148A5 (cg-RX-API-DMAC7.html) | ||
| US20130011430A1 (en) | HUMAN CHORIONIC GONADOTROPIN (hCG) BASED VACCINE FOR PREVENTION AND TREATMENT OF CANCER | |
| US20160263214A1 (en) | Calcium fluoride compositions | |
| US20160235839A1 (en) | Calcium fluoride compositions | |
| CN118215475A (zh) | 包含sting激动剂的佐剂组合物 | |
| JP2012506412A (ja) | 定方向性増殖および成熟のための免疫処置プロトコル |