JP2014524918A5 - - Google Patents
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- Publication number
- JP2014524918A5 JP2014524918A5 JP2014520341A JP2014520341A JP2014524918A5 JP 2014524918 A5 JP2014524918 A5 JP 2014524918A5 JP 2014520341 A JP2014520341 A JP 2014520341A JP 2014520341 A JP2014520341 A JP 2014520341A JP 2014524918 A5 JP2014524918 A5 JP 2014524918A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- pharmaceutical composition
- alkyl
- optionally substituted
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052799 carbon Inorganic materials 0.000 claims 15
- 229910052757 nitrogen Inorganic materials 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 230000004054 inflammatory process Effects 0.000 claims 7
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 6
- 206010061218 Inflammation Diseases 0.000 claims 6
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 206010037660 Pyrexia Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000005171 Dysmenorrhea Diseases 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 230000004075 alteration Effects 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000006472 autoimmune response Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000016557 Acute basophilic leukemia Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000036487 Arthropathies Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010006811 Bursitis Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 206010048554 Endothelial dysfunction Diseases 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000003807 Graves Disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010020601 Hyperchlorhydria Diseases 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 208000036631 Metastatic pain Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000008469 Peptic Ulcer Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 206010038419 Renal colic Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 201000001880 Sexual dysfunction Diseases 0.000 claims 1
- 206010042220 Stress ulcer Diseases 0.000 claims 1
- 201000008736 Systemic mastocytosis Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010061577 Ulcer haemorrhage Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 230000003872 anastomosis Effects 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 230000008694 endothelial dysfunction Effects 0.000 claims 1
- 201000000052 gastrinoma Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 231100000414 gastrointestinal toxicity Toxicity 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 208000003243 intestinal obstruction Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000009826 neoplastic cell growth Effects 0.000 claims 1
- 231100000417 nephrotoxicity Toxicity 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000011906 peptic ulcer disease Diseases 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 231100000828 respiratory toxicity Toxicity 0.000 claims 1
- 230000002000 scavenging effect Effects 0.000 claims 1
- 231100000872 sexual dysfunction Toxicity 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 208000037816 tissue injury Diseases 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 208000014001 urinary system disease Diseases 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 0 CC1(*)C=NC(C)=C(*)C1CN Chemical compound CC1(*)C=NC(C)=C(*)C1CN 0.000 description 7
- RDIZEQKQZULQQV-MHLOZHTBSA-N CCC(/C=N\C(\C)=C(/CCN)\O)O Chemical compound CCC(/C=N\C(\C)=C(/CCN)\O)O RDIZEQKQZULQQV-MHLOZHTBSA-N 0.000 description 1
- KPRZOPQOBJRYSW-UHFFFAOYSA-N NCc1ccccc1O Chemical compound NCc1ccccc1O KPRZOPQOBJRYSW-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161506848P | 2011-07-12 | 2011-07-12 | |
| US61/506,848 | 2011-07-12 | ||
| PCT/US2012/046549 WO2013010034A2 (en) | 2011-07-12 | 2012-07-12 | Methods for treating inflammation and hypertension with gamma-ketoaldehyde skavengers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524918A JP2014524918A (ja) | 2014-09-25 |
| JP2014524918A5 true JP2014524918A5 (enExample) | 2015-09-03 |
| JP6280033B2 JP6280033B2 (ja) | 2018-02-14 |
Family
ID=47506934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520341A Active JP6280033B2 (ja) | 2011-07-12 | 2012-07-12 | ガンマ−ケトアルデヒド捕捉剤による炎症および高血圧の治療方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10975033B2 (enExample) |
| EP (1) | EP2731597B1 (enExample) |
| JP (1) | JP6280033B2 (enExample) |
| KR (2) | KR20140050661A (enExample) |
| CN (2) | CN103796648B (enExample) |
| AU (1) | AU2012281061B2 (enExample) |
| BR (1) | BR112014000810A8 (enExample) |
| CA (1) | CA2844150C (enExample) |
| ES (1) | ES2970814T3 (enExample) |
| HU (1) | HUE065757T2 (enExample) |
| MX (1) | MX383365B (enExample) |
| PL (1) | PL2731597T3 (enExample) |
| WO (1) | WO2013010034A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130018478A (ko) * | 2011-08-09 | 2013-02-25 | 주식회사 엘지화학 | 신규한 구조의 이차전지 팩 |
| US10166248B1 (en) * | 2015-12-21 | 2019-01-01 | Vanderbilt University | Methods of preventing platelet activation |
| US11400103B2 (en) * | 2015-12-21 | 2022-08-02 | Vanderbilt University | Methods of preventing platelet activation |
| CA3030036A1 (en) * | 2016-07-06 | 2018-01-11 | Vanderbilt University | Use of scavengers of reactive gamma-ketoaldehydes to extend cell lifespan and healthspan |
| PL3481505T3 (pl) * | 2016-07-07 | 2026-01-26 | Vanderbilt University | Zapobieganie i leczenie migotania/trzepotania przedsionków za pomocą środków wychwytujących gamma-ketoaldehyd |
| EP3510014B8 (en) * | 2016-09-06 | 2026-07-29 | MTI Biotech, Inc. | Compositions and methods of use of gamma-ketoaldehyde scavengers for treating, preventing or improving nash or ald |
| PT3512863T (pt) | 2016-09-07 | 2022-03-09 | Atea Pharmaceuticals Inc | Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna |
| EP4385576A3 (en) * | 2016-11-15 | 2024-09-04 | Vanderbilt University | Use of 2-hydroxybenzylamine in the treatment and prevention of pulmonary hypertension |
| HUE066390T2 (hu) | 2017-04-27 | 2024-07-28 | Univ Vanderbilt | Eljárások ateroszklerózis kezelésére gamma-ketoaldehid-szkevendzserekkel |
| US20210023032A1 (en) | 2017-09-05 | 2021-01-28 | Mti Biotech, Inc. | Compositions and methods of use of gamma-ketoaldheyde scavengers for treating, preventing or improving fibrosis of the liver |
| WO2019050967A1 (en) * | 2017-09-05 | 2019-03-14 | Metabolic Technologies, Inc. | COMPOSITIONS AND METHODS OF USING GAMMA-KETOALDEHYDE SENSORS TO TREAT, PREVENT, OR IMPROVE LIVER FIBROSIS |
| CN109836341B (zh) * | 2017-11-28 | 2021-08-27 | 江阴技源药业有限公司 | 一种水杨胺醋酸盐的制备方法 |
| US20200197323A1 (en) * | 2018-12-21 | 2020-06-25 | Vanderbilt University | Methods for suppressing accumulation of reflux-induced protein adducts |
| US20230069820A9 (en) * | 2019-09-24 | 2023-03-02 | Vanderbilt University | Use of 2-hydroxybenzylamine for the treatment of systemic lupus |
| WO2021154877A1 (en) * | 2020-01-27 | 2021-08-05 | Vanderbilt University | Mitochondria-targeted isoketal/isolevuglandin scavengers and uses thereof |
| CN118652245B (zh) * | 2024-08-21 | 2024-11-12 | 首都医科大学附属北京儿童医院 | 一种化合物及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740439A (en) * | 1968-06-24 | 1973-06-19 | Ciba Geigy Corp | Treating hypertension with beta-aminoalkane carboxylic acids |
| US3794734A (en) | 1971-03-03 | 1974-02-26 | Merck & Co Inc | Methods of treating edema and hypertension using certain 2-aminoethylphenols |
| US4123537A (en) * | 1977-05-26 | 1978-10-31 | Merck & Co., Inc. | 2-Halo-4-aminomethyl-6-alkyl-3-pyridinols useful as diuretics in treating hypertension and edema |
| US8178516B2 (en) * | 1992-06-30 | 2012-05-15 | Sylvan Labs, LLC | Compositions and method for treatment of chronic inflammatory diseases |
| US20050090553A1 (en) * | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
| AU5659796A (en) | 1995-05-19 | 1996-11-29 | Kissei Pharmaceutical Co. Ltd. | 2-hydroxyphenylalkylamine derivatives and maillard reaction inhibitors |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| ATE333868T1 (de) | 2000-11-02 | 2006-08-15 | Univ South Carolina | Verwendung von pyridoxamin für die behandlung und unterdrückung von komplikationen im zusammenhang mit adipositas |
| US6824786B2 (en) * | 2001-11-27 | 2004-11-30 | Ruey J. Yu | Compositions comprising phenyl-glycine derivatives |
| US7705054B1 (en) * | 2004-10-20 | 2010-04-27 | Vanderbilt University | Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases |
| EP2207555B1 (en) * | 2007-10-05 | 2013-07-24 | InDex Pharmaceuticals AB | Oligonucleotides for the treatment or alleviation of edema |
| KR100973343B1 (ko) * | 2008-02-01 | 2010-07-30 | 롯데칠성음료주식회사 | 기호성이 우수한 혼합차 조성물 및 그 제조방법 |
| CN101305759B (zh) * | 2008-06-19 | 2011-09-07 | 成都大学 | 一种苦荞保健茶及其制备方法 |
| CN101843671A (zh) * | 2009-03-25 | 2010-09-29 | 王文祥 | 苦荞托毒丸及其制备方法 |
| EP2477594A4 (en) * | 2009-07-15 | 2013-03-13 | Univ Vanderbilt | ISOKETAL CATCHER AND TREATMENT OF DISEASES WITH OXIDATIVE INJURY |
| CN101606986A (zh) * | 2009-07-29 | 2009-12-23 | 李钢 | 一种具有降糖作用的组合物及其药物 |
-
2012
- 2012-07-12 US US14/232,615 patent/US10975033B2/en active Active
- 2012-07-12 CA CA2844150A patent/CA2844150C/en active Active
- 2012-07-12 BR BR112014000810A patent/BR112014000810A8/pt not_active Application Discontinuation
- 2012-07-12 JP JP2014520341A patent/JP6280033B2/ja active Active
- 2012-07-12 WO PCT/US2012/046549 patent/WO2013010034A2/en not_active Ceased
- 2012-07-12 ES ES12811030T patent/ES2970814T3/es active Active
- 2012-07-12 CN CN201280044440.6A patent/CN103796648B/zh active Active
- 2012-07-12 MX MX2014000515A patent/MX383365B/es unknown
- 2012-07-12 AU AU2012281061A patent/AU2012281061B2/en active Active
- 2012-07-12 EP EP12811030.1A patent/EP2731597B1/en active Active
- 2012-07-12 HU HUE12811030A patent/HUE065757T2/hu unknown
- 2012-07-12 KR KR1020147003650A patent/KR20140050661A/ko not_active Ceased
- 2012-07-12 PL PL12811030.1T patent/PL2731597T3/pl unknown
- 2012-07-12 KR KR1020197016572A patent/KR102050700B1/ko active Active
- 2012-07-12 CN CN201910951171.5A patent/CN111494352A/zh active Pending
-
2021
- 2021-04-13 US US17/229,593 patent/US20210261508A1/en not_active Abandoned
-
2024
- 2024-10-16 US US18/917,759 patent/US20250034093A1/en active Pending
- 2024-10-16 US US18/917,789 patent/US20250214939A1/en active Pending
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