JP2014523884A5 - - Google Patents
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- JP2014523884A5 JP2014523884A5 JP2014517251A JP2014517251A JP2014523884A5 JP 2014523884 A5 JP2014523884 A5 JP 2014523884A5 JP 2014517251 A JP2014517251 A JP 2014517251A JP 2014517251 A JP2014517251 A JP 2014517251A JP 2014523884 A5 JP2014523884 A5 JP 2014523884A5
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- JP
- Japan
- Prior art keywords
- edc
- antibody
- targeting moiety
- composition
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000008685 targeting Effects 0.000 claims description 38
- 239000003814 drug Substances 0.000 claims description 34
- 229940124597 therapeutic agent Drugs 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- -1 Sel-1 Proteins 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 7
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims description 6
- 102100032412 Basigin Human genes 0.000 claims description 6
- 102100032912 CD44 antigen Human genes 0.000 claims description 6
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 claims description 6
- 101000798441 Homo sapiens Basigin Proteins 0.000 claims description 6
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 6
- 101000605020 Homo sapiens Large neutral amino acids transporter small subunit 1 Proteins 0.000 claims description 6
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 6
- 101000760337 Homo sapiens Urokinase plasminogen activator surface receptor Proteins 0.000 claims description 6
- 102100025818 Major prion protein Human genes 0.000 claims description 6
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 6
- 102100024689 Urokinase plasminogen activator surface receptor Human genes 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000008873 Angiotensin II receptor Human genes 0.000 claims description 4
- 108050000824 Angiotensin II receptor Proteins 0.000 claims description 4
- 102100026144 Transferrin receptor protein 1 Human genes 0.000 claims description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 claims description 2
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 claims description 2
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 102100024210 CD166 antigen Human genes 0.000 claims description 2
- 101000975407 Caenorhabditis elegans Inositol 1,4,5-trisphosphate receptor itr-1 Proteins 0.000 claims description 2
- 101000975393 Drosophila melanogaster Inositol 1,4,5-trisphosphate receptor Proteins 0.000 claims description 2
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims description 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims description 2
- 108091008794 FGF receptors Proteins 0.000 claims description 2
- 102000027484 GABAA receptors Human genes 0.000 claims description 2
- 108091008681 GABAA receptors Proteins 0.000 claims description 2
- 101000980840 Homo sapiens CD166 antigen Proteins 0.000 claims description 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 2
- 101001139093 Homo sapiens Klotho Proteins 0.000 claims description 2
- 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 claims description 2
- 101000590830 Homo sapiens Monocarboxylate transporter 1 Proteins 0.000 claims description 2
- 101000724418 Homo sapiens Neutral amino acid transporter B(0) Proteins 0.000 claims description 2
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims description 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims description 2
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims description 2
- 108010001127 Insulin Receptor Proteins 0.000 claims description 2
- 102100036721 Insulin receptor Human genes 0.000 claims description 2
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 2
- 102100020686 Klotho Human genes 0.000 claims description 2
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 claims description 2
- 101710138751 Major prion protein Proteins 0.000 claims description 2
- 102100027329 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Human genes 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 102100028267 Neutral amino acid transporter B(0) Human genes 0.000 claims description 2
- 208000034038 Pathologic Neovascularization Diseases 0.000 claims description 2
- 101710096328 Phospholipase A2 Proteins 0.000 claims description 2
- 102100026918 Phospholipase A2 Human genes 0.000 claims description 2
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims description 2
- 108010025832 RANK Ligand Proteins 0.000 claims description 2
- 102000014128 RANK Ligand Human genes 0.000 claims description 2
- 108091006232 SLC7A5 Proteins 0.000 claims description 2
- 102000019208 Serotonin Plasma Membrane Transport Proteins Human genes 0.000 claims description 2
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 claims description 2
- 108091008874 T cell receptors Proteins 0.000 claims description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims description 2
- 108050003222 Transferrin receptor protein 1 Proteins 0.000 claims description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 102000006495 integrins Human genes 0.000 claims description 2
- 108010044426 integrins Proteins 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 230000001404 mediated effect Effects 0.000 claims description 2
- 230000009401 metastasis Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 230000019491 signal transduction Effects 0.000 claims description 2
- 125000002345 steroid group Chemical group 0.000 claims description 2
- 229940126585 therapeutic drug Drugs 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 17
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500756P | 2011-06-24 | 2011-06-24 | |
| US61/500,756 | 2011-06-24 | ||
| US201161507882P | 2011-07-14 | 2011-07-14 | |
| US61/507,882 | 2011-07-14 | ||
| US201161551287P | 2011-10-25 | 2011-10-25 | |
| US61/551,287 | 2011-10-25 | ||
| PCT/US2012/044029 WO2012178173A1 (en) | 2011-06-24 | 2012-06-25 | Extracellular targeted drug conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014523884A JP2014523884A (ja) | 2014-09-18 |
| JP2014523884A5 true JP2014523884A5 (https=) | 2015-08-13 |
Family
ID=47423002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014517251A Pending JP2014523884A (ja) | 2011-06-24 | 2012-06-25 | 細胞外標的化薬物複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140193436A1 (https=) |
| EP (1) | EP2723393A4 (https=) |
| JP (1) | JP2014523884A (https=) |
| CN (2) | CN107080847A (https=) |
| WO (1) | WO2012178173A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2524124C (en) | 2003-04-30 | 2014-03-25 | Uwe Zangemeister-Wittke | Methods for treating cancer using an immunotoxin |
| WO2015048901A1 (en) | 2013-10-02 | 2015-04-09 | Viventia Bio Inc. | Anti-epcam antibodies and methods of use |
| ES3012974T3 (en) * | 2014-01-08 | 2025-04-10 | Univ Leland Stanford Junior | Targeted therapy for lung cancer |
| JP2017506640A (ja) * | 2014-02-14 | 2017-03-09 | セントローズ， エルエルシー | 細胞外標的化薬物共役体 |
| JP2017114763A (ja) * | 2014-03-26 | 2017-06-29 | 第一三共株式会社 | 抗ｃｄ９８抗体−薬物コンジュゲート |
| EP3268040A4 (en) | 2015-03-12 | 2018-09-12 | Viventia Bio Inc. | Methods of treatment for epcam positive bladder cancer |
| US10583198B2 (en) | 2015-03-12 | 2020-03-10 | Viventia Bio Inc. | Dosing strategies for targeting EPCAM positive bladder cancer |
| WO2017023760A1 (en) | 2015-07-31 | 2017-02-09 | Prudent James R | Extracellular drug conjugates targeting cd20 |
| WO2017142083A1 (ja) * | 2016-02-18 | 2017-08-24 | 国立大学法人京都大学 | エクソソームの遺伝子機能を抑制することができる複合体、がんの増殖及び／又は転移抑制剤 |
| KR101923624B1 (ko) * | 2016-07-28 | 2018-11-30 | 고려대학교 산학협력단 | 암세포 화학요법을 위한 agtr1 압타머-항암약물 복합체 |
| EP3735427A4 (en) * | 2018-01-05 | 2021-09-15 | Immunext Inc. | ANTI-MCT1 ANTIBODIES AND USES THEREOF |
| US12031991B2 (en) * | 2018-03-02 | 2024-07-09 | Evonik Operations Gmbh | In vitro method for detecting intestinal barrier failure in animals |
| WO2019183375A1 (en) * | 2018-03-22 | 2019-09-26 | Eureka Therapeutics, Inc. | Antibody agents specifically recognizing monocarboxylate transporter 4 and uses thereof |
| CN112543766A (zh) | 2018-04-03 | 2021-03-23 | 斯特里迪比奥公司 | 抗体逃避性病毒载体 |
| CA3094465A1 (en) | 2018-04-03 | 2019-10-10 | Stridebio, Inc. | Virus vectors for targeting ophthalmic tissues |
| US20210363191A1 (en) | 2018-04-03 | 2021-11-25 | Stridebio, Inc. | Antibody-evading virus vectors |
| JP7576542B2 (ja) * | 2018-08-02 | 2024-10-31 | ダイン セラピューティクス，インコーポレーテッド | 筋標的化複合体およびそれらの使用 |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| EP3829595A4 (en) | 2018-08-02 | 2022-08-24 | Dyne Therapeutics, Inc. | MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES |
| US20220193250A1 (en) | 2018-08-02 | 2022-06-23 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| EP3897657A2 (en) * | 2018-12-20 | 2021-10-27 | Universität Basel | <sup2/>? <sub2/>?+? ?na/k <ns1:sup>+</ns1:sup>?atpase inhibitors for use in the prevention or treatment of metastasis |
| CN114072514A (zh) | 2019-05-14 | 2022-02-18 | 杜克大学 | 用于治疗atp酶介导的疾病的组合物和方法 |
| WO2020236755A2 (en) * | 2019-05-17 | 2020-11-26 | Ionis Pharmaceuticals, Inc. | Angiotensin ii type 1 receptor targeted oligonucleotides and uses thereof |
| KR20220083714A (ko) | 2019-10-17 | 2022-06-20 | 스트라이드바이오 인코포레이티드 | 니만-피크 질환 c형의 치료를 위한 아데노-연관 바이러스 벡터 |
| EP4200408A1 (en) | 2020-08-19 | 2023-06-28 | Sarepta Therapeutics, Inc. | Adeno-associated virus vectors for treatment of rett syndrome |
| CN114920841B (zh) * | 2021-02-11 | 2023-06-09 | 兰州大学第二医院 | 抗cd87抗体及其特异性嵌合抗原受体 |
| WO2022178754A1 (en) * | 2021-02-25 | 2022-09-01 | Shanghai Allygen Biologics Co., Ltd. | Targeting conjugates with therapeutic agents and oligonucleotides and uses thereof |
| US11672872B2 (en) | 2021-07-09 | 2023-06-13 | Dyne Therapeutics, Inc. | Anti-transferrin receptor antibody and uses thereof |
| IL309936A (en) | 2021-07-09 | 2024-03-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of dystrophinopathy |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| AU2022324471A1 (en) * | 2021-08-05 | 2024-02-15 | Sanegene Bio Usa Inc. | 1'-alkyl modified ribose derivatives and methods of use |
| TWI842088B (zh) | 2021-09-14 | 2024-05-11 | 美商伊穆諾米塔博立森發展公司 | 人類單羧酸鹽轉運蛋白1抗體及其用途 |
| US20250339553A1 (en) | 2022-04-15 | 2025-11-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
| CN117430697A (zh) * | 2022-07-21 | 2024-01-23 | 佰舟生物科技(苏州)有限公司 | 抗mct1抗体及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002063299A1 (en) * | 2001-02-05 | 2002-08-15 | Graffinity Pharmaceuticals Ag | Low affinity screening method |
| CN109045307A (zh) * | 2004-06-01 | 2018-12-21 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
| JP2009529522A (ja) * | 2006-03-10 | 2009-08-20 | ディアト | 酵素で切断可能なリンカーを介して抗体に複合された抗癌剤 |
| EP2185188B1 (en) * | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| US8007808B2 (en) * | 2008-04-04 | 2011-08-30 | The Board Of Trustees Of The Univeristy Of Illinois | Composition and method for facilitating the internalization of a therapeutic agent into a cell |
| AU2009296937B2 (en) * | 2008-09-29 | 2015-02-12 | Centocor Ortho Biotech Inc. | Anti-CD147 antibodies, methods, and uses |
| CA2809819A1 (en) * | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
| JP2013505938A (ja) * | 2009-09-24 | 2013-02-21 | エックスバイオテク，インコーポレイテッド | 抗抗体応答を軽減する方法、組成物およびキット |
| TW201129384A (en) * | 2010-02-10 | 2011-09-01 | Immunogen Inc | CD20 antibodies and uses thereof |
-
2012
- 2012-06-25 JP JP2014517251A patent/JP2014523884A/ja active Pending
- 2012-06-25 WO PCT/US2012/044029 patent/WO2012178173A1/en not_active Ceased
- 2012-06-25 CN CN201610948368.XA patent/CN107080847A/zh active Pending
- 2012-06-25 CN CN201280039499.6A patent/CN103732259A/zh active Pending
- 2012-06-25 EP EP12803197.8A patent/EP2723393A4/en not_active Withdrawn
- 2012-06-25 US US14/128,429 patent/US20140193436A1/en not_active Abandoned
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