JP2014523330A5 - - Google Patents
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- Publication number
- JP2014523330A5 JP2014523330A5 JP2014521814A JP2014521814A JP2014523330A5 JP 2014523330 A5 JP2014523330 A5 JP 2014523330A5 JP 2014521814 A JP2014521814 A JP 2014521814A JP 2014521814 A JP2014521814 A JP 2014521814A JP 2014523330 A5 JP2014523330 A5 JP 2014523330A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- tyrosine
- derived
- lactide
- pga
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 claims description 20
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 18
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 13
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims description 13
- 229960001225 rifampicin Drugs 0.000 claims description 13
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 12
- 229920000954 Polyglycolide Polymers 0.000 claims description 12
- 229960004023 minocycline Drugs 0.000 claims description 12
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 229920000642 polymer Polymers 0.000 claims description 10
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims description 8
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 8
- 229920001610 polycaprolactone Polymers 0.000 claims description 8
- 239000004632 polycaprolactone Substances 0.000 claims description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 6
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 6
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 230000003115 biocidal effect Effects 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 5
- -1 Polypropylene fumarate Polymers 0.000 claims description 4
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 claims description 4
- 239000004633 polyglycolic acid Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 3
- 239000003805 procoagulant Substances 0.000 claims description 3
- HCZQSLKOEQURLM-ZETCQYMHSA-N (4S)-4-amino-5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-oxopentanoic acid Chemical compound CC(C)(C)OC(=O)COC(=O)[C@@H](N)CCC(O)=O HCZQSLKOEQURLM-ZETCQYMHSA-N 0.000 claims description 2
- JRFXQKZEGILCCO-UHFFFAOYSA-N 5,5-dimethyl-1,3-dioxan-2-one Chemical compound CC1(C)COC(=O)OC1 JRFXQKZEGILCCO-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229930182555 Penicillin Natural products 0.000 claims description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 2
- 229920001710 Polyorthoester Polymers 0.000 claims description 2
- 239000004098 Tetracycline Substances 0.000 claims description 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000003899 bactericide agent Substances 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000007913 intrathecal administration Methods 0.000 claims description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 229940049954 penicillin Drugs 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 claims description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 2
- 229920006210 poly(glycolide-co-caprolactone) Polymers 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 239000000622 polydioxanone Substances 0.000 claims description 2
- 229920002643 polyglutamic acid Polymers 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 229920001299 polypropylene fumarate Polymers 0.000 claims description 2
- 210000000278 spinal cord Anatomy 0.000 claims description 2
- 229960002180 tetracycline Drugs 0.000 claims description 2
- 229930101283 tetracycline Natural products 0.000 claims description 2
- 235000019364 tetracycline Nutrition 0.000 claims description 2
- 150000003522 tetracyclines Chemical class 0.000 claims description 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 2
- 210000001186 vagus nerve Anatomy 0.000 claims description 2
- 230000002861 ventricular Effects 0.000 claims description 2
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 5
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229960003085 meticillin Drugs 0.000 description 2
- 239000006071 cream Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161509843P | 2011-07-20 | 2011-07-20 | |
| US61/509,843 | 2011-07-20 | ||
| PCT/US2012/047542 WO2013013123A1 (en) | 2011-07-20 | 2012-07-20 | Drug eluting mesh to prevent infection of indwelling transdermal devices |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137619A Division JP2016221297A (ja) | 2011-07-20 | 2016-07-12 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014523330A JP2014523330A (ja) | 2014-09-11 |
| JP2014523330A5 true JP2014523330A5 (enExample) | 2015-08-20 |
Family
ID=46650881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521814A Pending JP2014523330A (ja) | 2011-07-20 | 2012-07-20 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
| JP2016137619A Pending JP2016221297A (ja) | 2011-07-20 | 2016-07-12 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137619A Pending JP2016221297A (ja) | 2011-07-20 | 2016-07-12 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9381281B2 (enExample) |
| EP (1) | EP2734248B1 (enExample) |
| JP (2) | JP2014523330A (enExample) |
| AU (1) | AU2012283875B2 (enExample) |
| CA (1) | CA2842107C (enExample) |
| WO (1) | WO2013013123A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014137454A1 (en) * | 2013-03-07 | 2014-09-12 | Tyrx, Inc. | Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices |
| GB201505527D0 (en) * | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| CN107743404A (zh) | 2015-06-18 | 2018-02-27 | 心脏起搏器股份公司 | 用于可植入医疗装置的包含生物可吸收聚合物和抗微生物剂的聚合物覆盖物及其生产方法 |
| WO2017011321A1 (en) | 2015-07-11 | 2017-01-19 | Cardiac Pacemakers, Inc. | Polymer coating with antimicrobial materials and methods for producing |
| US9999899B2 (en) | 2016-11-01 | 2018-06-19 | International Business Machines Corporation | Controlled exposure of in-vivo sensors |
| WO2019036759A1 (en) * | 2017-08-24 | 2019-02-28 | Boulos & Cooper Pharmaceuticals Pty Ltd | ANTIMICROBIAL COATING |
| CN111432807A (zh) | 2017-10-06 | 2020-07-17 | 铸造疗法股份有限公司 | 用于控制释放治疗剂的可植入贮库 |
| US9919080B1 (en) * | 2017-10-27 | 2018-03-20 | Tyrx, Inc. | Kits for local delivery of water soluble agents and methods of use |
| WO2019136490A1 (en) | 2018-01-08 | 2019-07-11 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| EP3793536A1 (en) | 2018-05-12 | 2021-03-24 | Foundry Therapeutics, Inc. | Implantable polymer depots for the controlled release of therapeutic agents |
| EP3843710A1 (en) | 2018-08-28 | 2021-07-07 | Foundry Therapeutics, Inc. | Polymer implants |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980449A (en) | 1988-07-14 | 1990-12-25 | Rutgers, The State University | Polyiminocarbonate synthesis |
| US5099060A (en) | 1990-06-12 | 1992-03-24 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| US5216115A (en) | 1990-06-12 | 1993-06-01 | Rutgers, The State University Of New Jersey | Polyarylate containing derivatives of the natural amino acid L-tyrosine |
| USRE37160E1 (en) | 1990-06-12 | 2001-05-01 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5587507A (en) | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5658995A (en) | 1995-11-27 | 1997-08-19 | Rutgers, The State University | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
| US6319492B1 (en) | 1996-11-27 | 2001-11-20 | Rutgers, The State University | Copolymers of tyrosine-based polyarylates and poly(alkylene oxides) |
| US6048521A (en) | 1997-11-07 | 2000-04-11 | Rutgers, The State University | Copolymers of tyrosine-based polyarlates and poly(alkylene oxides) |
| US6120491A (en) | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
| US6475477B1 (en) | 1997-11-07 | 2002-11-05 | Rutgers, The State University | Radio-opaque polymer biomaterials |
| US6602497B1 (en) | 1997-11-07 | 2003-08-05 | Rutgers, The State University | Strictly alternating poly(alkylene oxide ether) copolymers |
| WO1999052962A1 (en) | 1998-04-13 | 1999-10-21 | Rutgers, The State University | The construction of copolymer libraries |
| US7521061B2 (en) | 1999-12-31 | 2009-04-21 | Rutgers, The State University Of New Jersey | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| AU784226B2 (en) | 1999-12-31 | 2006-02-23 | Rutgers, The State University | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| CA2395892C (en) | 1999-12-31 | 2014-06-03 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
| US7271234B2 (en) | 2002-04-24 | 2007-09-18 | Rutgers, The State University Of New Jersey | Polyarylates for drug delivery and tissue engineering |
| MX2008010126A (es) | 2006-02-08 | 2010-02-22 | Tyrx Pharma Inc | Protesis de malla temporalmente rigidizadas. |
| US8591531B2 (en) * | 2006-02-08 | 2013-11-26 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| US9486560B2 (en) * | 2006-02-08 | 2016-11-08 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| US8315700B2 (en) | 2006-02-08 | 2012-11-20 | Tyrx, Inc. | Preventing biofilm formation on implantable medical devices |
| EP2079491B1 (en) * | 2006-10-17 | 2013-02-27 | Reva Medical, Inc. | N-substituted monomers and polymers |
| US20080146869A1 (en) * | 2006-10-30 | 2008-06-19 | Hector Chow | Adjustable Gastric Band Having Anti-Microbial Coatings |
| WO2008127411A1 (en) * | 2006-11-06 | 2008-10-23 | Tyrx Pharma, Inc. | Mesh pouches for implantable medical devices |
| JP5847706B2 (ja) * | 2009-06-01 | 2016-01-27 | タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． | 胸骨創感染症を予防するための組成物および方法 |
| US9080015B2 (en) * | 2009-07-31 | 2015-07-14 | Rutgers, The State University Of New Jersey | Biocompatible polymers for medical devices |
| CA2816343C (en) * | 2010-11-12 | 2017-01-17 | Tyrx, Inc. | Anchorage devices comprising an active pharmaceutical ingredient |
-
2012
- 2012-07-20 AU AU2012283875A patent/AU2012283875B2/en active Active
- 2012-07-20 JP JP2014521814A patent/JP2014523330A/ja active Pending
- 2012-07-20 US US14/233,856 patent/US9381281B2/en active Active
- 2012-07-20 WO PCT/US2012/047542 patent/WO2013013123A1/en not_active Ceased
- 2012-07-20 CA CA2842107A patent/CA2842107C/en active Active
- 2012-07-20 EP EP12746171.3A patent/EP2734248B1/en active Active
-
2016
- 2016-07-12 JP JP2016137619A patent/JP2016221297A/ja active Pending
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