JP2016221297A5 - - Google Patents
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- Publication number
- JP2016221297A5 JP2016221297A5 JP2016137619A JP2016137619A JP2016221297A5 JP 2016221297 A5 JP2016221297 A5 JP 2016221297A5 JP 2016137619 A JP2016137619 A JP 2016137619A JP 2016137619 A JP2016137619 A JP 2016137619A JP 2016221297 A5 JP2016221297 A5 JP 2016221297A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- tyrosine
- derived
- gastric
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- 230000002496 gastric effect Effects 0.000 claims description 10
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 239000003805 procoagulant Substances 0.000 claims description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 9
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 229920000954 Polyglycolide Polymers 0.000 claims 6
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 229920001432 poly(L-lactide) Polymers 0.000 claims 4
- 229920001610 polycaprolactone Polymers 0.000 claims 4
- 239000004632 polycaprolactone Substances 0.000 claims 4
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 4
- 229960001225 rifampicin Drugs 0.000 claims 4
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 3
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 3
- 229960004023 minocycline Drugs 0.000 claims 3
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 3
- -1 Polypropylene fumarate Polymers 0.000 claims 2
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- HCZQSLKOEQURLM-ZETCQYMHSA-N (4S)-4-amino-5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-oxopentanoic acid Chemical compound CC(C)(C)OC(=O)COC(=O)[C@@H](N)CCC(O)=O HCZQSLKOEQURLM-ZETCQYMHSA-N 0.000 claims 1
- JRFXQKZEGILCCO-UHFFFAOYSA-N 5,5-dimethyl-1,3-dioxan-2-one Chemical compound CC1(C)COC(=O)OC1 JRFXQKZEGILCCO-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 claims 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 229920006210 poly(glycolide-co-caprolactone) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 239000000622 polydioxanone Substances 0.000 claims 1
- 229920002643 polyglutamic acid Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920001299 polypropylene fumarate Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 229960002180 tetracycline Drugs 0.000 claims 1
- 229930101283 tetracycline Natural products 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 229940035674 anesthetics Drugs 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161509843P | 2011-07-20 | 2011-07-20 | |
| US61/509,843 | 2011-07-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521814A Division JP2014523330A (ja) | 2011-07-20 | 2012-07-20 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016221297A JP2016221297A (ja) | 2016-12-28 |
| JP2016221297A5 true JP2016221297A5 (enExample) | 2019-10-10 |
Family
ID=46650881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521814A Pending JP2014523330A (ja) | 2011-07-20 | 2012-07-20 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
| JP2016137619A Pending JP2016221297A (ja) | 2011-07-20 | 2016-07-12 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521814A Pending JP2014523330A (ja) | 2011-07-20 | 2012-07-20 | 留置型経皮的デバイスの感染を予防するための薬物溶出メッシュ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9381281B2 (enExample) |
| EP (1) | EP2734248B1 (enExample) |
| JP (2) | JP2014523330A (enExample) |
| AU (1) | AU2012283875B2 (enExample) |
| CA (1) | CA2842107C (enExample) |
| WO (1) | WO2013013123A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014137454A1 (en) * | 2013-03-07 | 2014-09-12 | Tyrx, Inc. | Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices |
| GB201505527D0 (en) * | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| CN107743404A (zh) | 2015-06-18 | 2018-02-27 | 心脏起搏器股份公司 | 用于可植入医疗装置的包含生物可吸收聚合物和抗微生物剂的聚合物覆盖物及其生产方法 |
| WO2017011321A1 (en) | 2015-07-11 | 2017-01-19 | Cardiac Pacemakers, Inc. | Polymer coating with antimicrobial materials and methods for producing |
| US9999899B2 (en) | 2016-11-01 | 2018-06-19 | International Business Machines Corporation | Controlled exposure of in-vivo sensors |
| WO2019036759A1 (en) * | 2017-08-24 | 2019-02-28 | Boulos & Cooper Pharmaceuticals Pty Ltd | ANTIMICROBIAL COATING |
| CN111432807A (zh) | 2017-10-06 | 2020-07-17 | 铸造疗法股份有限公司 | 用于控制释放治疗剂的可植入贮库 |
| US9919080B1 (en) * | 2017-10-27 | 2018-03-20 | Tyrx, Inc. | Kits for local delivery of water soluble agents and methods of use |
| WO2019136490A1 (en) | 2018-01-08 | 2019-07-11 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| EP3793536A1 (en) | 2018-05-12 | 2021-03-24 | Foundry Therapeutics, Inc. | Implantable polymer depots for the controlled release of therapeutic agents |
| EP3843710A1 (en) | 2018-08-28 | 2021-07-07 | Foundry Therapeutics, Inc. | Polymer implants |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980449A (en) | 1988-07-14 | 1990-12-25 | Rutgers, The State University | Polyiminocarbonate synthesis |
| US5099060A (en) | 1990-06-12 | 1992-03-24 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| US5216115A (en) | 1990-06-12 | 1993-06-01 | Rutgers, The State University Of New Jersey | Polyarylate containing derivatives of the natural amino acid L-tyrosine |
| USRE37160E1 (en) | 1990-06-12 | 2001-05-01 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5587507A (en) | 1995-03-31 | 1996-12-24 | Rutgers, The State University | Synthesis of tyrosine derived diphenol monomers |
| US5658995A (en) | 1995-11-27 | 1997-08-19 | Rutgers, The State University | Copolymers of tyrosine-based polycarbonate and poly(alkylene oxide) |
| US6319492B1 (en) | 1996-11-27 | 2001-11-20 | Rutgers, The State University | Copolymers of tyrosine-based polyarylates and poly(alkylene oxides) |
| US6048521A (en) | 1997-11-07 | 2000-04-11 | Rutgers, The State University | Copolymers of tyrosine-based polyarlates and poly(alkylene oxides) |
| US6120491A (en) | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
| US6475477B1 (en) | 1997-11-07 | 2002-11-05 | Rutgers, The State University | Radio-opaque polymer biomaterials |
| US6602497B1 (en) | 1997-11-07 | 2003-08-05 | Rutgers, The State University | Strictly alternating poly(alkylene oxide ether) copolymers |
| WO1999052962A1 (en) | 1998-04-13 | 1999-10-21 | Rutgers, The State University | The construction of copolymer libraries |
| US7521061B2 (en) | 1999-12-31 | 2009-04-21 | Rutgers, The State University Of New Jersey | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| AU784226B2 (en) | 1999-12-31 | 2006-02-23 | Rutgers, The State University | Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix |
| CA2395892C (en) | 1999-12-31 | 2014-06-03 | Rutgers, The State University | Pharmaceutical formulation composed of a polymer blend and an active compound for time-controlled release |
| US7271234B2 (en) | 2002-04-24 | 2007-09-18 | Rutgers, The State University Of New Jersey | Polyarylates for drug delivery and tissue engineering |
| MX2008010126A (es) | 2006-02-08 | 2010-02-22 | Tyrx Pharma Inc | Protesis de malla temporalmente rigidizadas. |
| US8591531B2 (en) * | 2006-02-08 | 2013-11-26 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| US9486560B2 (en) * | 2006-02-08 | 2016-11-08 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| US8315700B2 (en) | 2006-02-08 | 2012-11-20 | Tyrx, Inc. | Preventing biofilm formation on implantable medical devices |
| EP2079491B1 (en) * | 2006-10-17 | 2013-02-27 | Reva Medical, Inc. | N-substituted monomers and polymers |
| US20080146869A1 (en) * | 2006-10-30 | 2008-06-19 | Hector Chow | Adjustable Gastric Band Having Anti-Microbial Coatings |
| WO2008127411A1 (en) * | 2006-11-06 | 2008-10-23 | Tyrx Pharma, Inc. | Mesh pouches for implantable medical devices |
| JP5847706B2 (ja) * | 2009-06-01 | 2016-01-27 | タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． | 胸骨創感染症を予防するための組成物および方法 |
| US9080015B2 (en) * | 2009-07-31 | 2015-07-14 | Rutgers, The State University Of New Jersey | Biocompatible polymers for medical devices |
| CA2816343C (en) * | 2010-11-12 | 2017-01-17 | Tyrx, Inc. | Anchorage devices comprising an active pharmaceutical ingredient |
-
2012
- 2012-07-20 AU AU2012283875A patent/AU2012283875B2/en active Active
- 2012-07-20 JP JP2014521814A patent/JP2014523330A/ja active Pending
- 2012-07-20 US US14/233,856 patent/US9381281B2/en active Active
- 2012-07-20 WO PCT/US2012/047542 patent/WO2013013123A1/en not_active Ceased
- 2012-07-20 CA CA2842107A patent/CA2842107C/en active Active
- 2012-07-20 EP EP12746171.3A patent/EP2734248B1/en active Active
-
2016
- 2016-07-12 JP JP2016137619A patent/JP2016221297A/ja active Pending
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