JP2014520893A5 - - Google Patents

Info

Publication number

JP2014520893A5

JP2014520893A5 JP2014521796A JP2014521796A JP2014520893A5 JP 2014520893 A5 JP2014520893 A5 JP 2014520893A5 JP 2014521796 A JP2014521796 A JP 2014521796A JP 2014521796 A JP2014521796 A JP 2014521796A JP 2014520893 A5 JP2014520893 A5 JP 2014520893A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

mammal

administration

pain

hours

Prior art date

2012-07-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims description 41
• 241000124008 Mammalia Species 0.000 claims description 33
• 239000008194 pharmaceutical composition Substances 0.000 claims description 30
• -1 diclofenac compound Chemical class 0.000 claims description 25
• 229960001259 diclofenac Drugs 0.000 claims description 20
• 229920000858 Cyclodextrin Polymers 0.000 claims description 19
• 208000002193 Pain Diseases 0.000 claims description 18
• 230000036407 pain Effects 0.000 claims description 17
• 239000001116 FEMA 4028 Substances 0.000 claims description 11
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 11
• 229960004853 betadex Drugs 0.000 claims description 11
• 208000004550 Postoperative Pain Diseases 0.000 claims description 10
• 239000003814 drug Substances 0.000 claims description 7
• 229940079593 drug Drugs 0.000 claims description 7
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 5
• 230000037396 body weight Effects 0.000 claims description 4
• 238000001356 surgical procedure Methods 0.000 claims description 4
• 206010067125 Liver injury Diseases 0.000 claims description 3
• 231100000234 hepatic damage Toxicity 0.000 claims description 3
• 208000017169 kidney disease Diseases 0.000 claims description 3
• 230000008818 liver damage Effects 0.000 claims description 3
• 206010067484 Adverse reaction Diseases 0.000 claims description 2
• 206010028980 Neoplasm Diseases 0.000 claims description 2
• 230000003187 abdominal effect Effects 0.000 claims description 2
• 230000006838 adverse reaction Effects 0.000 claims description 2
• 230000036592 analgesia Effects 0.000 claims description 2
• 201000011510 cancer Diseases 0.000 claims description 2
• 230000000399 orthopedic effect Effects 0.000 claims description 2
• 238000007911 parenteral administration Methods 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 208000019423 liver disease Diseases 0.000 claims 1
• 239000000902 placebo Substances 0.000 description 7
• 229940068196 placebo Drugs 0.000 description 7
• DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 6
• 238000011282 treatment Methods 0.000 description 5
• 229960004752 ketorolac Drugs 0.000 description 4
• OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 4
• 229940124645 emergency medicine Drugs 0.000 description 3
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 208000005298 acute pain Diseases 0.000 description 1
• 238000011256 aggressive treatment Methods 0.000 description 1
• 238000001647 drug administration Methods 0.000 description 1
• 230000002980 postoperative effect Effects 0.000 description 1