CN103781484A - 治疗疼痛的方法 - Google Patents

治疗疼痛的方法 Download PDF

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Publication number
CN103781484A
CN103781484A CN201280042680.2A CN201280042680A CN103781484A CN 103781484 A CN103781484 A CN 103781484A CN 201280042680 A CN201280042680 A CN 201280042680A CN 103781484 A CN103781484 A CN 103781484A
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CN
China
Prior art keywords
diclofenac
patients
pain
hpβcd
study
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280042680.2A
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English (en)
Chinese (zh)
Inventor
P·拉库图尔
M·加西亚德罗查
D·B·卡尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospira Inc
Original Assignee
Hospira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hospira Inc filed Critical Hospira Inc
Publication of CN103781484A publication Critical patent/CN103781484A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280042680.2A 2011-07-20 2012-07-19 治疗疼痛的方法 Pending CN103781484A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161509886P 2011-07-20 2011-07-20
US61/509,886 2011-07-20
PCT/US2012/047453 WO2013013076A1 (en) 2011-07-20 2012-07-19 Methods of treating pain

Publications (1)

Publication Number Publication Date
CN103781484A true CN103781484A (zh) 2014-05-07

Family

ID=47558482

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280042680.2A Pending CN103781484A (zh) 2011-07-20 2012-07-19 治疗疼痛的方法

Country Status (16)

Country Link
US (1) US20140221490A1 (enExample)
EP (2) EP2734212B1 (enExample)
JP (2) JP6320917B2 (enExample)
KR (1) KR20140063583A (enExample)
CN (1) CN103781484A (enExample)
AU (1) AU2012283915B2 (enExample)
BR (1) BR112014001335A2 (enExample)
CA (1) CA2841964A1 (enExample)
DK (1) DK2734212T3 (enExample)
ES (1) ES2646226T3 (enExample)
IL (1) IL230433A0 (enExample)
IN (1) IN2014CN00315A (enExample)
MX (1) MX350463B (enExample)
MY (1) MY166036A (enExample)
NO (1) NO2854815T3 (enExample)
WO (1) WO2013013076A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2522344A1 (en) * 2006-03-28 2012-11-14 Javelin Pharmaceuticals, Inc. Formulations of Low Dose Diclofenac and Beta-Cyclodextrin
US7943591B2 (en) 2007-05-11 2011-05-17 Adynxx, Inc. Gene expression and pain
EA038941B1 (ru) 2007-11-06 2021-11-12 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
PT2846839T (pt) 2012-05-10 2019-05-29 Adynxx Inc Formulações para a administração de ingredientes ativos
US20140275261A1 (en) 2013-03-15 2014-09-18 Dr. Reddy's Laboratories, Inc. Diclofenac parenteral compositions
AU2015301491A1 (en) 2014-08-15 2017-02-02 Adynxx, Inc. Oligonucleotide decoys for the treatment of pain
US20200017853A1 (en) * 2016-02-29 2020-01-16 Adynxx, Inc. Compositions and methods for pain amelioration via modification of gene expression
US20180025116A1 (en) * 2016-07-22 2018-01-25 Arizona Board Of Regents On Behalf Of University Of Arizona Clinical Event Management and Communication System
CN118903386A (zh) 2017-08-24 2024-11-08 诺和诺德股份有限公司 Glp-1组合物及其用途
US20200027555A1 (en) * 2018-07-17 2020-01-23 Lewis Pharmaceutical Information, Inc. Patient centric drug analysis platform
KR20220143036A (ko) * 2020-02-18 2022-10-24 노보 노르디스크 에이/에스 약학적 제형
CN111494446B (zh) * 2020-05-18 2021-08-17 深圳市宝安中医院（集团） 治疗胆绞痛的中药组合物及其应用
MX2024002602A (es) * 2021-08-31 2024-04-19 Ethismos Res Inc Métodos para prevenir y tratar el dolor y síntomas asociados.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070232566A1 (en) * 2006-03-28 2007-10-04 Curtis Wright Formulations Of Low Dose Diclofenac And Beta-Cyclodextrin
US20090292022A1 (en) * 2008-05-23 2009-11-26 Aaipharma Inc. Method of Treating Post-Surgical Acute Pain

Family Cites Families (15)

* Cited by examiner, † Cited by third party
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US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
US6407079B1 (en) 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5389681A (en) 1992-10-22 1995-02-14 Ciba-Geigy Corporation Parenteral solutions for diclofenac salts
IL111184A (en) 1993-10-08 2000-08-13 Farmarc Nederland B V Of Cito Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin
ZA949182B (en) 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US20050171057A1 (en) 2002-01-15 2005-08-04 Altana Pharma Ag Pantoprazole cyclodextrin inclusion complexes
US6869939B2 (en) 2002-05-04 2005-03-22 Cydex, Inc. Formulations containing amiodarone and sulfoalkyl ether cyclodextrin
ES2366436T3 (es) * 2003-11-04 2011-10-20 Otis Elevator Company Funcionamiento automático de un transportador de pasajeros a baja velocidad.
JP2007528384A (ja) * 2004-03-10 2007-10-11 シモダ、バイオテック（プロプライエタリー）リミテッド 安定な注射可能なジクロフェナク組成物
JP2009531451A (ja) * 2006-03-28 2009-09-03 ジャヴェリン ファーマシューティカルズ インコーポレイテッド 低投与量の非ステロイド系抗炎症薬及びβ−シクロデキストリンの配合物
CN101264086A (zh) 2007-03-14 2008-09-17 南京师范大学 含有头孢克肟环糊精包合物的药物组合物及其制备方法
WO2009089269A1 (en) * 2008-01-07 2009-07-16 Javelin Pharmaceuticals, Inc. Methods of treating pain while minimizing adverse effects on platelet function

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070232566A1 (en) * 2006-03-28 2007-10-04 Curtis Wright Formulations Of Low Dose Diclofenac And Beta-Cyclodextrin
US20090292022A1 (en) * 2008-05-23 2009-11-26 Aaipharma Inc. Method of Treating Post-Surgical Acute Pain

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AMMON ET AL: "《diclofenac does not interact with codeine metabolism in vivo:a study of healthy volunteers》", 《BMC CLINICAL PHARMACOLOGY》 *
CHRISTENSEN ET AL: "《a double-blind placebo-controlled comparison of a novel formulation of intravenous diclofenac and ketorolac for postoperative third molar extraction pain》", 《ANESTH. PROG.》 *

Also Published As

Publication number Publication date
AU2012283915B2 (en) 2016-11-24
AU2012283915A1 (en) 2014-02-06
JP2014520893A (ja) 2014-08-25
NO2854815T3 (enExample) 2018-04-21
WO2013013076A1 (en) 2013-01-24
US20140221490A1 (en) 2014-08-07
JP6320917B2 (ja) 2018-05-09
IL230433A0 (en) 2014-03-31
MX2014000744A (es) 2014-05-14
EP2734212A1 (en) 2014-05-28
EP2734212A4 (en) 2014-12-24
EP2734212B1 (en) 2017-09-06
BR112014001335A2 (pt) 2017-02-21
MX350463B (es) 2017-09-06
IN2014CN00315A (enExample) 2015-04-03
KR20140063583A (ko) 2014-05-27
EP3257505A1 (en) 2017-12-20
ES2646226T3 (es) 2017-12-12
CA2841964A1 (en) 2013-01-24
DK2734212T3 (da) 2017-11-06
MY166036A (en) 2018-05-21
JP2017110022A (ja) 2017-06-22

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