JP2014520111A5 - - Google Patents
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- JP2014520111A5 JP2014520111A5 JP2014514605A JP2014514605A JP2014520111A5 JP 2014520111 A5 JP2014520111 A5 JP 2014520111A5 JP 2014514605 A JP2014514605 A JP 2014514605A JP 2014514605 A JP2014514605 A JP 2014514605A JP 2014520111 A5 JP2014520111 A5 JP 2014520111A5
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- Prior art keywords
- syndrome
- delivery device
- drug delivery
- chronic
- disease
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Claims (24)
- 第1活性医薬成分(API)を含む少なくとも1つのコア;
上記少なくとも1つのコアの少なくとも一部を覆っている、APIに対して浸透性および/または半浸透性である第1コーティング層;
第1コーティング層の少なくとも一部を覆っている、APIに対して不浸透性である第2コーティング層;および
APIが第2コーティング層を通り抜けるための通路を与えるデリバリーウィンドウ
を含む、薬剤デリバリーデバイス。 - 少なくとも2つのコアを含み、上記少なくとも2つのコアのうち第1のコアが、第1APIを含み、上記少なくとも2つのコアのうち第2のコアが、第2APIを含むことを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- 少なくとも1つのコアが第2APIを含むことを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- さらに、デリバリーウィンドウを通るAPIの移動速度を改変するためのウィッキング材料を含むことを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- デリバリーウィンドウが、ウィッキング材料により完全に満たされていることを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- デリバリーウィンドウが、ウィッキング材料により部分的に満たされていることを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- ウィッキング材料が、デリバリーウィンドウの通路を通って配置されていることを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- ウィッキング材料が、1つまたはそれ以上のデリバリーウィンドウの内壁をコートしていることを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- ウィッキング材料が、第2コーティング層の少なくとも1部に化学的に結合していることを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- さらに、第1コーティング層と第2コーティング層の間に第3コーティング層を含み、該第3コーティング層が、第1コーティング層の少なくとも一部分を覆って、APIの放出を遅くすることを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- 第1コーティング層が、ポリ乳酸重合体、ポリビニルアルコールまたはそれらの組み合わせを含むことを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- 第2コーティング層が、シリコーン、ポリエチレン(PE)、エチレン酢酸ビニル(EVA)およびそれらの組み合わせからなる群から選択されることを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- ウィッキング材料が、親水性ポリマーまたは繊維材料を含むことを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- ウィッキング材料が、カルボキシメチルセルロース−ヒドロキシエチルセルロース(CMC−HEC)共重合体を含むことを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- ウィッキング材料が、ポリビニルアルコール−アクリレート(PVA−MA)共重合体を含むことを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- ウィッキング材料が、ポリエチレングリコール−メタクリレート共重合体であることを特徴とする、請求項4に記載の薬剤デリバリーデバイス。
- 繊維材料が、絹、綿、ナフィオンおよびそれらの組み合わせからなる群から選択されることを特徴とする、請求項13に記載の薬剤デリバリーデバイス。
- 膣内リング、ダイアフラム、ペッサリー、坐剤または涙点プラグとして構成されることを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- APIがテノホビルを含む膣内リングとして構成されることを特徴とする、請求項1に記載の薬剤デリバリーデバイス。
- 病状を治療または軽減するための請求項1〜19のいずれか1項に記載の薬剤デリバリーデバイス。
- 病状が、膣、子宮、骨盤、直腸、目、耳、膿瘻、鼻、前立腺および膀胱からなる群から選択されることを特徴とする、請求項20に記載の薬剤デリバリーデバイス。
- 活性医薬成分が、アタザナビル、ディダノシン、エファビレンツ、エムトリシタビン、ラミブジン、ロピナビル、ネビラピン、ラルテグラビル、リトナビル、サキナビル、スタブジン、テノホビル、フマル酸テノホビルジソプロキシル、ジドブジン、アシクロビル、ファムシクロビル、バラシクロビル、モルヒネ、ブプレノルフィン、エストロゲン、プロゲスチン、プロゲステロン、シクロスポリン、カルシニューリン阻害剤、プロスタグランジン、ベータ遮断剤、ゲンタマイシン、コルチコステロイド、フルオロキノロン、インスリン、抗腫瘍剤、制嘔吐剤、コルチコステロイド、抗生物質、モルヒネブプレノルフィン、VEGF阻害剤、およびそれらの組み合わせからなる群から選択されることを特徴とする、請求項20に記載の薬剤デリバリーデバイス。
- 薬剤デリバリーデバイスが、真皮下、皮下、全身、局所、硬膜外、病変内、腫瘍内、涙点内およびそれらの組み合わせからなる群から選択される投与経路に適合することを特徴とする、請求項20に記載の薬剤デリバリーデバイス。
- 病状が、高ホモシステイン血症、慢性腎不全、末期腎不全、血液透析、腹膜透析、血管性認知症、循環器疾患、卒中、脳血管障害、血栓疾患、凝固能亢進状態、静脈血栓症、深部静脈血栓症、血栓性静脈炎、血栓塞栓性疾患、虚血性卒中、経皮的冠動脈形成術後再狭窄(PTCA)、子癇前症、血管炎、指虚血、多発性骨壊死、網膜静脈閉塞、緑内障、流産、妊娠合併症、胎盤早期剥離、移植、糖尿病性網膜症、虚血性腸疾患、大脳静脈血栓症、アテローム性動脈硬化、冠動脈疾患、陰茎静脈血栓症、インポテンス、中央静脈血栓症、末梢動脈障害、間欠性跛行、出血性大腸炎、放射線腸炎、放射線性大腸炎、内臓虚血、急性腸間膜虚血、慢性腸間膜虚血、高血圧、細小血管障害、大血管障害、再発性下腿潰瘍、頸動脈狭窄症、血管閉塞性疾患、動脈瘤、腹部大動脈瘤、鬱血性心不全、肝肺症候群、慢性肝疾患に付随する高流量状態、片頭痛、血管性頭痛、目まい、立ちくらみ、起立不耐症、起立性低血圧、起立性低血圧、体位性起立性頻拍症候群、特発性肺線維症、肺性高血圧、血管性浮腫、血管迷走神経性失神、神経弛緩薬性悪性症候群、学習障害、学習能障害、不眠症、認知症、加齢記憶障害、注意欠陥多動性障害(ADHD)、軽度認識障害、アルツハイマー病、ダウン症、自閉症、パーキンソン病、うつ病、不安または不安症、アスペルガー症候群、耐糖能異常、糖尿病、活動性低血糖症、メタボリック・シンドローム、低コルチゾール血症、視床下部−下垂体−副腎系機能不全、重症筋無力症候群、骨粗鬆症、自己免疫性多内分泌症候群、慢性疲労症候群(CFS)、中枢性過敏症候群、狭心症、X症候群、慢性首痛症候群、慢性神経筋痛、変形性関節症、筋肉緊張性頭痛、慢性頭痛、群発性頭痛、側頭筋腱炎、副鼻腔炎、非定型顔面痛、三叉神経痛、顔面および首の疼痛症候群、顎関節症候群、突発性慢性下背部痛、子宮内膜症、有痛性腹部癒着、慢性腹痛症候群、尾骨痛、骨盤底筋痛(肛門挙筋痙攣)、多発性筋炎、ヘルペス後神経痛、多発神経根障害、多発単神経炎、反射性交感神経性ジストロフィー、神経因性疼痛、外陰部前庭炎、外陰部痛、慢性局所疼痛症候群、変形性関節症、結合組織炎、慢性内臓痛症候群、女性尿道症候群、有痛性憩室症、機能性消化不良、非潰瘍性消化不良、非びらん性胃食道逆流疾患、酸過敏食道、間質性膀胱炎、慢性骨盤痛症候群、慢性尿道症候群、慢性前立腺炎、1次性月経困難、性交疼痛、月経前症候群(PMS)、外陰部痛、卵巣残遺物症候群、排卵痛、骨盤鬱血症候群、筋膜性疼痛症候群、線維筋痛多発筋痛リウマチ、ライター症候群(反応性関節炎)、関節リウマチ、脊椎関節症、機能性身体症候群、慢性局所疼痛症候群、ポリオ後症候群、機能性身体症候群、鼻炎、喘息、多種化学物質過敏症候群、反応性気道機能不全症候群、名詞想起困難症、シックハウス症候群、喘息、特発性肺線維症、特発性肺高血圧症高血圧、嚥下障害、胃不全まひ、機能性下痢、慢性便秘、慢性便秘、排尿障害、弛緩膀胱、過敏膀胱、過敏性腸症候群(IBS)、腸閉塞、慢性特発性大腸偽性腸閉塞症、オギルビー症候群、レストレスレッグス症候群、免疫機能不全症候群、多発性硬化症(MS)、湿疹、乾癬、アトピー性皮膚炎、皮膚炎、クローン病、潰瘍性大腸炎、潰瘍性直腸炎、回腸嚢炎、非特異性潰瘍性大腸炎、炎症性大腸炎(IBD)、セリアック病、空置大腸炎、コラーゲン蓄積大腸炎、リンパ球性大腸炎、盲管係蹄症候群、非アルコール性脂肪性肝炎(NASH)、脂肪肝、慢性肝疾患、肝硬変、突発性細菌性腹膜炎、術後イレウス、全身性エリテマトーデス、混合性結合組織障害、未分化結合組織障害、レイノー症候群、川崎症候群、多発性筋炎、皮膚筋炎、筋炎、多発性自己免疫症候群、シェーグレン症候群、扁平苔癬、特発性ブドウ膜炎、歯肉炎、口内炎、耳炎、壊死性腸炎、集中治療室(ICU)多臓器不全、原発性胆汁性肝硬変、特発性骨髄線維症、結節性多発動脈炎、好酸球性胸水、好酸球性胃腸炎、好酸球性食道炎、移植片対宿主疾患、グレーブス病、突発性甲状腺不全、橋本甲状腺炎、自己免疫性肝炎、膵臓炎、CREST症候群、自己免疫性胆管炎、強直性脊椎炎、アトピー性皮膚炎、白斑、強皮症、自己免疫性耳疾患、多発性血管炎重複症候群、原発性硬化性胆管炎、湾岸戦争症候群、筋痛性脳脊髄炎、食物過敏症、異常調節スペクトラム症候群、心的外傷後ストレス障害(PTSD)、良性腫瘍、悪性腫瘍、癌およびそれらの組み合わせからなる群から選択されることを特徴とする、請求項20に記載の薬剤デリバリーデバイス。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7170070B2 (ja) | 2015-01-30 | 2022-11-11 | リ・ガリ・ベスローテン・フエンノートシャップ | 膣用薬物送達デバイス |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010141729A1 (en) | 2009-06-03 | 2010-12-09 | Forsight Labs, Llc | Anterior segment drug delivery |
AU2012268068B2 (en) | 2011-06-06 | 2016-10-13 | Auritec Pharmaceuticals | Drug delivery device employing wicking release window |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
EP2945686A4 (en) | 2013-01-15 | 2016-08-31 | Univ Colorado Regents | APPARATUS FOR DRUG DELIVERY IN THE TISSUE SYSTEM |
RU2015136769A (ru) * | 2013-02-05 | 2017-03-13 | Дзе Попьюлейшн Каунсил, Инк. | Внутривагинальное кольцо для доставки уникальных комбинаций противомикробных композиций |
US9974759B2 (en) | 2013-05-31 | 2018-05-22 | Indiana University Research And Technology Corporation | Beta 2 adrenoceptor antagonists for treating orthostatic hypotension |
SE539540C2 (sv) | 2013-09-12 | 2017-10-10 | Qpharma Ab | Ett läkemedelsavgivningssystem för en eller flera aktiva beståndsdelar |
JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
EP2982352B1 (en) * | 2014-06-28 | 2018-10-03 | Laboratorios Andrómaco S.A. | Cervical pessary containing progesterone for prolonged, sustained and continuous release, used to prevent premature birth |
US10912933B2 (en) | 2014-08-19 | 2021-02-09 | The Regents Of The University Of California | Implants for localized drug delivery and methods of use thereof |
KR101656170B1 (ko) * | 2015-01-16 | 2016-09-09 | 이화여자대학교 산학협력단 | 골반장기탈출증 치료용 페서리 |
US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017027376A1 (en) * | 2015-08-07 | 2017-02-16 | Massachusetts Institute Of Technology | Subcutaneous drug delivery device with manual activation and deactivation of drug release |
EP3380040B1 (en) * | 2015-11-23 | 2023-04-19 | The Regents of The University of Colorado, A Body Corporate | Lacrimal system for drug delivery |
BR112018012743A2 (pt) * | 2015-12-21 | 2018-12-04 | Bayer Oy | método para fabricar um dispositivo de administração de medicamento e um dispositivo de administração de medicamento fabricado de acordo com o método |
RU2018133932A (ru) | 2016-04-01 | 2020-05-12 | Терапьютиксмд, Инк. | Фармацевтическая композиция стероидного гормона |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
WO2017201255A1 (en) * | 2016-05-20 | 2017-11-23 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal drug delivery device |
US11213430B2 (en) | 2016-05-26 | 2022-01-04 | Cochlear Limited | Inner ear plug |
BR112019021998A2 (pt) * | 2017-04-19 | 2020-05-05 | Auritec Pharmaceuticals | dispositivo de distribuição de fármaco com cápsulas removíveis e cápsulas métodos e sistemas relacionados |
WO2019176890A1 (en) | 2018-03-15 | 2019-09-19 | Canon Kabushiki Kaisha | Packing member and packing unit |
BR112021000537A2 (pt) | 2018-07-12 | 2021-04-06 | Prima-Temp, Inc. | Aparelho e métodos de detecção de temperatura vaginal |
CN109793980B (zh) * | 2019-03-15 | 2021-03-02 | 丽水学院 | 一种多功能的口腔溃疡治疗仪及其使用方法 |
WO2021108722A1 (en) | 2019-11-27 | 2021-06-03 | Oak Crest Institute Of Science | Sustained release drug delivery device |
US11344526B2 (en) | 2020-03-20 | 2022-05-31 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
US11338119B2 (en) | 2020-03-20 | 2022-05-24 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
US11173291B2 (en) | 2020-03-20 | 2021-11-16 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
CN111557656B (zh) * | 2020-05-26 | 2020-11-24 | 魏月玲 | 一种紧急状况供药急救装置 |
US20240091410A1 (en) * | 2020-11-25 | 2024-03-21 | Oak Crest Institute Of Science | Vaginal Encapsulation Devices |
KR102571791B1 (ko) * | 2021-03-22 | 2023-08-28 | 가톨릭대학교 산학협력단 | 산모 맞춤형 조산 예방용 페서리 및 이의 제조방법 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
US3630200A (en) * | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
DE3040978A1 (de) * | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Vaginalring |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
US5660848A (en) * | 1994-11-02 | 1997-08-26 | The Population Council, Center For Biomedical Research | Subdermally implantable device |
US5972372A (en) | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
BRPI9802144B1 (pt) | 1997-05-30 | 2017-03-28 | Ezequiel Mayorga Jorge | dispositivo osmótico multicapa aperfeiçoado |
US20050276836A1 (en) * | 1997-06-11 | 2005-12-15 | Michelle Wilson | Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents |
US6342250B1 (en) | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
US6387403B1 (en) * | 1999-09-15 | 2002-05-14 | Alza Corporation | Dosage forms and methods for providing effective reboxetine therapy with once-a-day dosing |
EP1345588A2 (en) * | 2000-12-29 | 2003-09-24 | Bausch & Lomb Incorporated | Sustained release drug delivery devices |
US20050197651A1 (en) * | 2001-04-25 | 2005-09-08 | Chen Hai L. | Vaginal ring preparation and its application |
MXPA04002980A (es) | 2001-09-28 | 2005-06-20 | Johnson & Johnson | Formas de dosificacion que tienen un nucleo interior y coraza exterior con diferentes formas. |
US7303538B2 (en) * | 2002-07-23 | 2007-12-04 | Ossur Hf | Versatile orthopaedic leg mounted walkers |
US20060127483A1 (en) * | 2004-12-10 | 2006-06-15 | Alan Drizen | Topical drug delivery system |
US20060280795A1 (en) * | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
DE102006044109A1 (de) | 2006-09-20 | 2008-03-27 | Zf Friedrichshafen Ag | Verbindung eines ersten mit einem zweiten zylindrischen Bauteil und Verfahren zur Montage des ersten und des zweiten Bauteiles |
CN105581976A (zh) * | 2007-06-26 | 2016-05-18 | 沃纳奇尔科特有限责任公司 | 用于递送大分子和水溶性药物的阴道内药物递送装置 |
AR066166A1 (es) * | 2007-09-21 | 2009-07-29 | Organon Nv | Sistema de suministro de droga |
EP2062568A1 (en) * | 2007-11-22 | 2009-05-27 | Bayer Schering Pharma Oy | Vaginal delivery system |
TW200927141A (en) | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
US20110045076A1 (en) * | 2008-01-25 | 2011-02-24 | Kiser Patrick F | Linear order release polymer |
CN101703488B (zh) * | 2008-12-16 | 2013-02-20 | 北京科信必成医药科技发展有限公司 | 具有润滑层结构的双层渗透泵控释片及其制备方法 |
FI20095563A (fi) * | 2009-05-20 | 2010-11-21 | Bayer Schering Pharma Oy | Vaginaalinen antojärjestelmä |
WO2010146591A2 (en) * | 2009-06-18 | 2010-12-23 | Rdd Pharma Ltd. | Methods and devices for delivery of pharmaceutical agents within orifices of the body |
AU2012268068B2 (en) | 2011-06-06 | 2016-10-13 | Auritec Pharmaceuticals | Drug delivery device employing wicking release window |
-
2012
- 2012-06-06 AU AU2012268068A patent/AU2012268068B2/en not_active Ceased
- 2012-06-06 KR KR1020147000345A patent/KR102059698B1/ko active IP Right Grant
- 2012-06-06 CN CN201610143145.6A patent/CN105853445A/zh active Pending
- 2012-06-06 JP JP2014514605A patent/JP6068454B2/ja active Active
- 2012-06-06 CA CA2838402A patent/CA2838402C/en active Active
- 2012-06-06 CN CN201280038214.7A patent/CN103747765B/zh active Active
- 2012-06-06 WO PCT/US2012/041159 patent/WO2012170578A1/en active Application Filing
- 2012-06-06 US US14/124,517 patent/US9937335B2/en active Active
- 2012-06-06 EP EP12796540.8A patent/EP2717813B1/en active Active
-
2016
- 2016-12-22 JP JP2016249634A patent/JP6254248B2/ja not_active Expired - Fee Related
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2017
- 2017-01-13 AU AU2017200240A patent/AU2017200240B2/en active Active
- 2017-11-29 JP JP2017228775A patent/JP2018048198A/ja active Pending
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2018
- 2018-02-26 US US15/905,565 patent/US20190030306A1/en not_active Abandoned
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2019
- 2019-09-13 US US16/570,772 patent/US20200001062A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7170070B2 (ja) | 2015-01-30 | 2022-11-11 | リ・ガリ・ベスローテン・フエンノートシャップ | 膣用薬物送達デバイス |
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