JP2014520077A5 - - Google Patents
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- Publication number
- JP2014520077A5 JP2014520077A5 JP2014510546A JP2014510546A JP2014520077A5 JP 2014520077 A5 JP2014520077 A5 JP 2014520077A5 JP 2014510546 A JP2014510546 A JP 2014510546A JP 2014510546 A JP2014510546 A JP 2014510546A JP 2014520077 A5 JP2014520077 A5 JP 2014520077A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline salt
- salt
- crystalline
- synthesis
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 40
- 230000015572 biosynthetic process Effects 0.000 claims 9
- 238000003786 synthesis reaction Methods 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 3
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 3
- 238000004128 high performance liquid chromatography Methods 0.000 claims 3
- 238000001757 thermogravimetry curve Methods 0.000 claims 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 241000186427 Cutibacterium acnes Species 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241001303601 Rosacea Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- -1 methoxy (methyl) amino Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940055019 propionibacterium acne Drugs 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485179P | 2011-05-12 | 2011-05-12 | |
| US61/485,179 | 2011-05-12 | ||
| PCT/US2012/037838 WO2012155146A1 (en) | 2011-05-12 | 2012-05-14 | Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017032823A Division JP2017132775A (ja) | 2011-05-12 | 2017-02-24 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2019043868A Division JP6876082B2 (ja) | 2011-05-12 | 2019-03-11 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520077A JP2014520077A (ja) | 2014-08-21 |
| JP2014520077A5 true JP2014520077A5 (enExample) | 2015-06-25 |
| JP6574572B2 JP6574572B2 (ja) | 2019-09-11 |
Family
ID=47139728
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510546A Active JP6574572B2 (ja) | 2011-05-12 | 2012-05-14 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2017032823A Withdrawn JP2017132775A (ja) | 2011-05-12 | 2017-02-24 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2019043868A Active JP6876082B2 (ja) | 2011-05-12 | 2019-03-11 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2021017922A Pending JP2021098695A (ja) | 2011-05-12 | 2021-02-08 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2023060582A Pending JP2023093519A (ja) | 2011-05-12 | 2023-04-04 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）－４－ジメチルアミノ－３，１０，１２，１２ａ－テトラヒドロキシ－７－［（メトキシ（メチル）アミノ）－メチル］－１，１１－ジオキソ－１，４，４ａ，５，５ａ，６，１１，１２ａ－オクタヒドロ－ナフタセン－２－カルボン酸アミドの結晶塩及びそれを使用する方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017032823A Withdrawn JP2017132775A (ja) | 2011-05-12 | 2017-02-24 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2019043868A Active JP6876082B2 (ja) | 2011-05-12 | 2019-03-11 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2021017922A Pending JP2021098695A (ja) | 2011-05-12 | 2021-02-08 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法 |
| JP2023060582A Pending JP2023093519A (ja) | 2011-05-12 | 2023-04-04 | （４ｓ，４ａｓ，５ａｒ，１２ａｓ）－４－ジメチルアミノ－３，１０，１２，１２ａ－テトラヒドロキシ－７－［（メトキシ（メチル）アミノ）－メチル］－１，１１－ジオキソ－１，４，４ａ，５，５ａ，６，１１，１２ａ－オクタヒドロ－ナフタセン－２－カルボン酸アミドの結晶塩及びそれを使用する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9255068B2 (enExample) |
| EP (2) | EP2707003B1 (enExample) |
| JP (5) | JP6574572B2 (enExample) |
| CA (1) | CA2835876C (enExample) |
| DK (1) | DK2707003T3 (enExample) |
| ES (2) | ES2739626T3 (enExample) |
| HR (1) | HRP20191295T8 (enExample) |
| HU (1) | HUE044536T2 (enExample) |
| LT (1) | LT2707003T (enExample) |
| PL (1) | PL2707003T3 (enExample) |
| PT (1) | PT2707003T (enExample) |
| SI (1) | SI2707003T1 (enExample) |
| TR (1) | TR201911086T4 (enExample) |
| WO (1) | WO2012155146A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8856782B2 (en) | 2007-03-01 | 2014-10-07 | George Mason Research Foundation, Inc. | On-demand disposable virtual work system |
| US9098698B2 (en) | 2008-09-12 | 2015-08-04 | George Mason Research Foundation, Inc. | Methods and apparatus for application isolation |
| WO2012155146A1 (en) * | 2011-05-12 | 2012-11-15 | Paratek Pharmaceuticals, Inc. | Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same |
| WO2013082437A1 (en) | 2011-12-02 | 2013-06-06 | Invincia, Inc. | Methods and apparatus for control and detection of malicious content using a sandbox environment |
| JP2015517524A (ja) * | 2012-05-14 | 2015-06-22 | パラテック ファーマシューティカルズ インコーポレイテッド | （４Ｓ，４ａＳ，５ａＲ，１２ａＳ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの使用方法 |
| ES2978198T3 (es) * | 2016-10-19 | 2024-09-06 | Tetraphase Pharmaceuticals Inc | Formas cristalinas de eravaciclina |
| EP3654988B1 (en) * | 2017-07-21 | 2023-09-06 | Almirall, LLC | Sarecycline for the treatment of non-inflammatory acne lesions |
| US12297161B2 (en) | 2018-04-06 | 2025-05-13 | Almirall, Llc | Process for making sarecycline hydrochloride |
| EP4357798A4 (en) | 2021-06-14 | 2025-05-21 | Hioki E.E. Corporation | SHORT-CIRCUIT DETECTION DEVICE AND SHORT-CIRCUIT DETECTION METHOD |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| NL6607516A (enExample) | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| CA2103189C (en) | 1992-11-17 | 2005-05-03 | Lorne M. Golub | Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes |
| US5834450A (en) | 1994-02-17 | 1998-11-10 | Pfizer Inc. | 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| ES2548261T3 (es) * | 2006-12-21 | 2015-10-15 | Paratek Pharmaceuticals, Inc. | Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias |
| AU2007338681B2 (en) | 2006-12-21 | 2013-09-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| WO2009111064A2 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| TW202021946A (zh) * | 2008-05-19 | 2020-06-16 | 美商派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| WO2012155146A1 (en) * | 2011-05-12 | 2012-11-15 | Paratek Pharmaceuticals, Inc. | Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same |
| JP2015517524A (ja) * | 2012-05-14 | 2015-06-22 | パラテック ファーマシューティカルズ インコーポレイテッド | （４Ｓ，４ａＳ，５ａＲ，１２ａＳ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの使用方法 |
-
2012
- 2012-05-14 WO PCT/US2012/037838 patent/WO2012155146A1/en not_active Ceased
- 2012-05-14 ES ES12782600T patent/ES2739626T3/es active Active
- 2012-05-14 PL PL12782600T patent/PL2707003T3/pl unknown
- 2012-05-14 ES ES19167006T patent/ES2985493T3/es active Active
- 2012-05-14 HU HUE12782600 patent/HUE044536T2/hu unknown
- 2012-05-14 JP JP2014510546A patent/JP6574572B2/ja active Active
- 2012-05-14 EP EP12782600.6A patent/EP2707003B1/en active Active
- 2012-05-14 EP EP19167006.6A patent/EP3574908B8/en active Active
- 2012-05-14 SI SI201231639T patent/SI2707003T1/sl unknown
- 2012-05-14 CA CA2835876A patent/CA2835876C/en active Active
- 2012-05-14 PT PT12782600T patent/PT2707003T/pt unknown
- 2012-05-14 TR TR2019/11086T patent/TR201911086T4/tr unknown
- 2012-05-14 HR HRP20191295TT patent/HRP20191295T8/hr unknown
- 2012-05-14 US US13/471,275 patent/US9255068B2/en active Active
- 2012-05-14 DK DK12782600.6T patent/DK2707003T3/da active
- 2012-05-14 LT LTEP12782600.6T patent/LT2707003T/lt unknown
-
2015
- 2015-12-18 US US14/974,813 patent/US20160200671A1/en not_active Abandoned
-
2017
- 2017-02-24 JP JP2017032823A patent/JP2017132775A/ja not_active Withdrawn
-
2018
- 2018-03-06 US US15/913,504 patent/US20190040002A1/en not_active Abandoned
-
2019
- 2019-03-11 JP JP2019043868A patent/JP6876082B2/ja active Active
- 2019-05-15 US US16/412,986 patent/US20200024223A1/en not_active Abandoned
-
2021
- 2021-02-08 JP JP2021017922A patent/JP2021098695A/ja active Pending
-
2023
- 2023-04-04 JP JP2023060582A patent/JP2023093519A/ja active Pending
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