DK2707003T3 - Krystallinske salte af (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carboxylsyreamid og fremgangsmåder til anvendelse deraf - Google Patents
Krystallinske salte af (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carboxylsyreamid og fremgangsmåder til anvendelse deraf Download PDFInfo
- Publication number
- DK2707003T3 DK2707003T3 DK12782600.6T DK12782600T DK2707003T3 DK 2707003 T3 DK2707003 T3 DK 2707003T3 DK 12782600 T DK12782600 T DK 12782600T DK 2707003 T3 DK2707003 T3 DK 2707003T3
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- naphthacen
- tetrahydroxy
- octahydro
- dioxo
- Prior art date
Links
- -1 METHOXY (METHYL) AMINO Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
- C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485179P | 2011-05-12 | 2011-05-12 | |
| PCT/US2012/037838 WO2012155146A1 (en) | 2011-05-12 | 2012-05-14 | Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2707003T3 true DK2707003T3 (da) | 2019-08-05 |
Family
ID=47139728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12782600.6T DK2707003T3 (da) | 2011-05-12 | 2012-05-14 | Krystallinske salte af (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carboxylsyreamid og fremgangsmåder til anvendelse deraf |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9255068B2 (enExample) |
| EP (2) | EP2707003B1 (enExample) |
| JP (5) | JP6574572B2 (enExample) |
| CA (1) | CA2835876C (enExample) |
| DK (1) | DK2707003T3 (enExample) |
| ES (2) | ES2739626T3 (enExample) |
| HR (1) | HRP20191295T8 (enExample) |
| HU (1) | HUE044536T2 (enExample) |
| LT (1) | LT2707003T (enExample) |
| PL (1) | PL2707003T3 (enExample) |
| PT (1) | PT2707003T (enExample) |
| SI (1) | SI2707003T1 (enExample) |
| TR (1) | TR201911086T4 (enExample) |
| WO (1) | WO2012155146A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8856782B2 (en) | 2007-03-01 | 2014-10-07 | George Mason Research Foundation, Inc. | On-demand disposable virtual work system |
| US9098698B2 (en) | 2008-09-12 | 2015-08-04 | George Mason Research Foundation, Inc. | Methods and apparatus for application isolation |
| WO2012155146A1 (en) * | 2011-05-12 | 2012-11-15 | Paratek Pharmaceuticals, Inc. | Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same |
| WO2013082437A1 (en) | 2011-12-02 | 2013-06-06 | Invincia, Inc. | Methods and apparatus for control and detection of malicious content using a sandbox environment |
| JP2015517524A (ja) * | 2012-05-14 | 2015-06-22 | パラテック ファーマシューティカルズ インコーポレイテッド | （４Ｓ，４ａＳ，５ａＲ，１２ａＳ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの使用方法 |
| ES2978198T3 (es) * | 2016-10-19 | 2024-09-06 | Tetraphase Pharmaceuticals Inc | Formas cristalinas de eravaciclina |
| EP3654988B1 (en) * | 2017-07-21 | 2023-09-06 | Almirall, LLC | Sarecycline for the treatment of non-inflammatory acne lesions |
| US12297161B2 (en) | 2018-04-06 | 2025-05-13 | Almirall, Llc | Process for making sarecycline hydrochloride |
| EP4357798A4 (en) | 2021-06-14 | 2025-05-21 | Hioki E.E. Corporation | SHORT-CIRCUIT DETECTION DEVICE AND SHORT-CIRCUIT DETECTION METHOD |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| NL6607516A (enExample) | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| CA2103189C (en) | 1992-11-17 | 2005-05-03 | Lorne M. Golub | Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive collagen crosslinking during diabetes |
| US5834450A (en) | 1994-02-17 | 1998-11-10 | Pfizer Inc. | 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5789395A (en) | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| ES2548261T3 (es) * | 2006-12-21 | 2015-10-15 | Paratek Pharmaceuticals, Inc. | Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias |
| AU2007338681B2 (en) | 2006-12-21 | 2013-09-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| WO2009111064A2 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| TW202021946A (zh) * | 2008-05-19 | 2020-06-16 | 美商派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| WO2012155146A1 (en) * | 2011-05-12 | 2012-11-15 | Paratek Pharmaceuticals, Inc. | Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same |
| JP2015517524A (ja) * | 2012-05-14 | 2015-06-22 | パラテック ファーマシューティカルズ インコーポレイテッド | （４Ｓ，４ａＳ，５ａＲ，１２ａＳ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの使用方法 |
-
2012
- 2012-05-14 WO PCT/US2012/037838 patent/WO2012155146A1/en not_active Ceased
- 2012-05-14 ES ES12782600T patent/ES2739626T3/es active Active
- 2012-05-14 PL PL12782600T patent/PL2707003T3/pl unknown
- 2012-05-14 ES ES19167006T patent/ES2985493T3/es active Active
- 2012-05-14 HU HUE12782600 patent/HUE044536T2/hu unknown
- 2012-05-14 JP JP2014510546A patent/JP6574572B2/ja active Active
- 2012-05-14 EP EP12782600.6A patent/EP2707003B1/en active Active
- 2012-05-14 EP EP19167006.6A patent/EP3574908B8/en active Active
- 2012-05-14 SI SI201231639T patent/SI2707003T1/sl unknown
- 2012-05-14 CA CA2835876A patent/CA2835876C/en active Active
- 2012-05-14 PT PT12782600T patent/PT2707003T/pt unknown
- 2012-05-14 TR TR2019/11086T patent/TR201911086T4/tr unknown
- 2012-05-14 HR HRP20191295TT patent/HRP20191295T8/hr unknown
- 2012-05-14 US US13/471,275 patent/US9255068B2/en active Active
- 2012-05-14 DK DK12782600.6T patent/DK2707003T3/da active
- 2012-05-14 LT LTEP12782600.6T patent/LT2707003T/lt unknown
-
2015
- 2015-12-18 US US14/974,813 patent/US20160200671A1/en not_active Abandoned
-
2017
- 2017-02-24 JP JP2017032823A patent/JP2017132775A/ja not_active Withdrawn
-
2018
- 2018-03-06 US US15/913,504 patent/US20190040002A1/en not_active Abandoned
-
2019
- 2019-03-11 JP JP2019043868A patent/JP6876082B2/ja active Active
- 2019-05-15 US US16/412,986 patent/US20200024223A1/en not_active Abandoned
-
2021
- 2021-02-08 JP JP2021017922A patent/JP2021098695A/ja active Pending
-
2023
- 2023-04-04 JP JP2023060582A patent/JP2023093519A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20191295T8 (hr) | 2020-02-07 |
| JP6876082B2 (ja) | 2021-05-26 |
| US20200024223A1 (en) | 2020-01-23 |
| JP2019142867A (ja) | 2019-08-29 |
| US20160200671A1 (en) | 2016-07-14 |
| HRP20191295T1 (hr) | 2019-10-18 |
| ES2739626T3 (es) | 2020-02-03 |
| JP2023093519A (ja) | 2023-07-04 |
| EP2707003A4 (en) | 2014-11-12 |
| US9255068B2 (en) | 2016-02-09 |
| PT2707003T (pt) | 2019-08-05 |
| CA2835876A1 (en) | 2012-11-15 |
| SI2707003T1 (sl) | 2019-10-30 |
| TR201911086T4 (tr) | 2019-08-21 |
| EP2707003B1 (en) | 2019-05-01 |
| ES2985493T3 (es) | 2024-11-06 |
| LT2707003T (lt) | 2019-10-10 |
| PL2707003T3 (pl) | 2019-11-29 |
| EP2707003A1 (en) | 2014-03-19 |
| HUE044536T2 (hu) | 2019-10-28 |
| JP2014520077A (ja) | 2014-08-21 |
| EP3574908A1 (en) | 2019-12-04 |
| JP6574572B2 (ja) | 2019-09-11 |
| EP3574908B8 (en) | 2024-09-11 |
| CA2835876C (en) | 2020-04-14 |
| JP2017132775A (ja) | 2017-08-03 |
| US20130012480A1 (en) | 2013-01-10 |
| WO2012155146A1 (en) | 2012-11-15 |
| EP3574908B1 (en) | 2024-07-31 |
| US20190040002A1 (en) | 2019-02-07 |
| JP2021098695A (ja) | 2021-07-01 |
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