JP2014518289A5 - - Google Patents
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- Publication number
- JP2014518289A5 JP2014518289A5 JP2014515014A JP2014515014A JP2014518289A5 JP 2014518289 A5 JP2014518289 A5 JP 2014518289A5 JP 2014515014 A JP2014515014 A JP 2014515014A JP 2014515014 A JP2014515014 A JP 2014515014A JP 2014518289 A5 JP2014518289 A5 JP 2014518289A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- polymer
- trialkylamino
- polysaccharide
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052757 nitrogen Inorganic materials 0.000 claims 29
- 238000000034 method Methods 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229940100198 alkylating agent Drugs 0.000 claims 4
- 239000002168 alkylating agent Substances 0.000 claims 4
- 239000007810 chemical reaction solvent Substances 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 claims 2
- 230000002152 alkylating effect Effects 0.000 claims 2
- -1 amino polysaccharide Chemical class 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 230000006196 deacetylation Effects 0.000 claims 1
- 238000003381 deacetylation reaction Methods 0.000 claims 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 150000004679 hydroxides Chemical class 0.000 claims 1
- INQOMBQAUSQDDS-BJUDXGSMSA-N iodomethane Chemical group I[11CH3] INQOMBQAUSQDDS-BJUDXGSMSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000005956 quaternization reaction Methods 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161496225P | 2011-06-13 | 2011-06-13 | |
| US61/496,225 | 2011-06-13 | ||
| PCT/CA2012/050399 WO2012171125A1 (en) | 2011-06-13 | 2012-06-13 | N,n,n-trialkylpolymers, methods of their preparation and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017133777A Division JP2017222869A (ja) | 2011-06-13 | 2017-07-07 | Ｎ，ｎ，ｎ−トリアルキルポリマー、その調製方法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518289A JP2014518289A (ja) | 2014-07-28 |
| JP2014518289A5 true JP2014518289A5 (enExample) | 2015-07-30 |
| JP6346561B2 JP6346561B2 (ja) | 2018-06-20 |
Family
ID=47356469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014515014A Active JP6346561B2 (ja) | 2011-06-13 | 2012-06-13 | Ｎ，ｎ，ｎ−トリアルキルポリマー、その調製方法およびその使用 |
| JP2017133777A Pending JP2017222869A (ja) | 2011-06-13 | 2017-07-07 | Ｎ，ｎ，ｎ−トリアルキルポリマー、その調製方法およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017133777A Pending JP2017222869A (ja) | 2011-06-13 | 2017-07-07 | Ｎ，ｎ，ｎ−トリアルキルポリマー、その調製方法およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9505852B2 (enExample) |
| EP (1) | EP2718331B1 (enExample) |
| JP (2) | JP6346561B2 (enExample) |
| CA (1) | CA2869821C (enExample) |
| ES (1) | ES2644138T3 (enExample) |
| WO (1) | WO2012171125A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2869821C (en) * | 2011-06-13 | 2018-06-19 | Rival, Societe En Commandite | N,n,n-trialkylaminopolymers, methods of their preparation and uses thereof |
| WO2015022907A1 (ja) * | 2013-08-13 | 2015-02-19 | 生化学工業株式会社 | カチオン化キトサンを含有する医薬 |
| KR20160122828A (ko) * | 2014-02-19 | 2016-10-24 | 인스티튜트 바이오케미 아이 바이오피자이키 팬 | 생체고분자 유도체를 합성하기 위한 방법, 생체고분자 유도체 및 이의 용도 |
| CN106167532B (zh) * | 2016-09-27 | 2018-10-26 | 江南大学 | 一种壳聚糖季铵盐的制备方法 |
| CN107163165B (zh) * | 2017-06-14 | 2020-01-31 | 山东师范大学 | 一种o-羧甲基-n,n-双链长烷基化壳寡糖及制备方法与应用 |
| WO2019169478A1 (en) * | 2018-03-05 | 2019-09-12 | Ovensa Inc. | Treatment of protein aggregation diseases using n,n,n-trimethylchitosan |
| EP3841129A1 (en) * | 2018-08-23 | 2021-06-30 | Haskoli Islands | Chitosan derivatives and methods for preparing the same |
| JP7365279B2 (ja) * | 2020-03-25 | 2023-10-19 | 大日精化工業株式会社 | キトサン誘導体の製造方法 |
| JP2021172727A (ja) * | 2020-04-24 | 2021-11-01 | 大日精化工業株式会社 | キトサン誘導体及びその製造方法、ｏ／ｗ型乳化組成物、並びに化粧料 |
| KR102570766B1 (ko) * | 2020-12-04 | 2023-08-24 | 단국대학교 천안캠퍼스 산학협력단 | N,n,n-트리메틸 키토산을 포함하는 스프레이 조성물 |
| CN112651384B (zh) * | 2021-01-15 | 2022-08-16 | 芜湖美的厨卫电器制造有限公司 | 用于零冷水燃气热水器的方法、装置、存储介质及处理器 |
| WO2024259525A1 (en) * | 2023-06-19 | 2024-12-26 | Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sante Et Humaines, S.E.C. | Nanoparticles comprising n,n,n-trimethyl chitosan coated with peptide agonists of kinin b1 or b2 and/or peptide antagonists of kinin b1 for transvascular drug delivery across the blood-brain barrier |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744166A (en) | 1989-02-25 | 1998-04-28 | Danbiosyst Uk Limited | Drug delivery compositions |
| US6410046B1 (en) | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
| GB9710699D0 (en) | 1997-05-24 | 1997-07-16 | Danbiosyst Uk | Gastro-retentive controlled release system |
| US6328967B1 (en) | 1998-03-12 | 2001-12-11 | Allergenics, Inc. | Delivery system to modulate immune response |
| EP1035137A1 (en) | 1999-03-12 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Method for the reductive amination of polysaccharides |
| FR2804317B1 (fr) | 2000-01-28 | 2008-06-13 | Rhodia Chimie Sa | Compositions cosmetiques comprenant un melange polymere cationique/tensioactif et utilisation dudit melange comme agent structurant |
| JP3908444B2 (ja) | 2000-07-31 | 2007-04-25 | 花王株式会社 | 糖誘導体の製造法 |
| US6726920B1 (en) | 2000-09-22 | 2004-04-27 | Durect Corporation | Implantable drug delivery patch |
| US6444466B1 (en) | 2001-05-10 | 2002-09-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of helicase-moi expression |
| US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| US6824599B2 (en) | 2001-10-03 | 2004-11-30 | The University Of Alabama | Dissolution and processing of cellulose using ionic liquids |
| WO2003054208A2 (en) | 2001-12-13 | 2003-07-03 | Ism Biopolymer Inc. | Method of modulating release of saccharides and uses thereof |
| CA2507846A1 (en) | 2001-12-14 | 2003-06-26 | Ism Biopolymer Inc. | Chitosan oligosaccharides and uses thereof |
| US20040138119A1 (en) | 2002-09-18 | 2004-07-15 | Ingo Tamm | Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis |
| US20060058261A1 (en) | 2004-09-15 | 2006-03-16 | Andre Aube | Chitin derivatives for hyperlipidemia |
| US7282194B2 (en) | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7381716B2 (en) | 2005-11-21 | 2008-06-03 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7291598B2 (en) | 2005-01-04 | 2007-11-06 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| CA2623475A1 (en) | 2005-09-28 | 2007-04-05 | Dnp Canada Inc. | Combination of polychitosamine and fibrate for the prevention and treatment of hyperlipidemia |
| CN101336253A (zh) | 2005-12-16 | 2008-12-31 | Dnp加拿大公司 | 用于高脂血症的甲壳质衍生物 |
| WO2008067573A2 (en) * | 2006-12-01 | 2008-06-05 | Tshwane University Of Technology | Drug delivery system |
| DK2213678T3 (da) * | 2007-10-17 | 2013-12-02 | Nippon Steel & Sumikin Chem Co | Fremgangsmåde til fremstilling af opløst lignin, saccharidråmateriale og monosaccharidråmateriale såvel som opløst lignin |
| CN101157735B (zh) | 2007-11-27 | 2010-09-08 | 江南大学 | 一种n,n,n-三甲基壳聚糖硫酸甲酯铵的合成方法 |
| JP2010242020A (ja) | 2009-04-09 | 2010-10-28 | Kazuyuki Umemura | 脱ｎ−アセチル体の製造方法 |
| CA2869821C (en) * | 2011-06-13 | 2018-06-19 | Rival, Societe En Commandite | N,n,n-trialkylaminopolymers, methods of their preparation and uses thereof |
-
2012
- 2012-06-13 CA CA2869821A patent/CA2869821C/en active Active
- 2012-06-13 ES ES12800482.7T patent/ES2644138T3/es active Active
- 2012-06-13 JP JP2014515014A patent/JP6346561B2/ja active Active
- 2012-06-13 WO PCT/CA2012/050399 patent/WO2012171125A1/en not_active Ceased
- 2012-06-13 EP EP12800482.7A patent/EP2718331B1/en active Active
- 2012-06-13 US US14/125,759 patent/US9505852B2/en active Active
-
2017
- 2017-07-07 JP JP2017133777A patent/JP2017222869A/ja active Pending
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