JP2014517004A - 複素環スルホンアミド誘導体 - Google Patents

複素環スルホンアミド誘導体 Download PDF

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Publication number
JP2014517004A
JP2014517004A JP2014514204A JP2014514204A JP2014517004A JP 2014517004 A JP2014517004 A JP 2014517004A JP 2014514204 A JP2014514204 A JP 2014514204A JP 2014514204 A JP2014514204 A JP 2014514204A JP 2014517004 A JP2014517004 A JP 2014517004A
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JP
Japan
Prior art keywords
compound
compounds
fluoro
difluoro
iodophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2014514204A
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English (en)
Japanese (ja)
Inventor
ラムル・ポデュトゥーリ
ワン・ツァン
ジャオ・シャンリン
Original Assignee
ノバルティス アーゲー
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Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2014517004A publication Critical patent/JP2014517004A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2014514204A 2011-06-09 2012-06-06 複素環スルホンアミド誘導体 Pending JP2014517004A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN1634DE2011 2011-06-09
IN1634/DEL/11 2011-06-09
CN201210175145 2012-05-31
CN201210175145.6 2012-05-31
PCT/IB2012/052860 WO2012168884A1 (en) 2011-06-09 2012-06-06 Heterocyclic sulfonamide derivatives

Publications (1)

Publication Number Publication Date
JP2014517004A true JP2014517004A (ja) 2014-07-17

Family

ID=46384435

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014514204A Pending JP2014517004A (ja) 2011-06-09 2012-06-06 複素環スルホンアミド誘導体

Country Status (10)

Country Link
EP (1) EP2718276A1 (ru)
JP (1) JP2014517004A (ru)
KR (1) KR20140034898A (ru)
AU (1) AU2012265844A1 (ru)
BR (1) BR112013031201A2 (ru)
CA (1) CA2838029A1 (ru)
EA (1) EA201391820A1 (ru)
IN (1) IN2014DN00123A (ru)
MX (1) MX2013014398A (ru)
WO (1) WO2012168884A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020521741A (ja) * 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー がんの処置のための化合物およびその使用の方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2796455A4 (en) * 2011-12-19 2015-08-19 Sumitomo Chemical Co PROCESS FOR PRODUCING SULFONATE
EP3251673A1 (en) 2012-12-13 2017-12-06 IP Gesellschaft für Management mbH Combination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer
CN104886052B (zh) * 2015-06-02 2016-08-31 吉林省八达农药有限公司 一种环丙磺酰胺的应用
WO2019183385A1 (en) * 2018-03-22 2019-09-26 University Of Rochester Mapk/erk inhibition for ovarian and other cancers

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JP2006083137A (ja) * 2004-09-17 2006-03-30 Sankyo Co Ltd 免疫抑制剤
WO2009018238A1 (en) * 2007-07-30 2009-02-05 Ardea Biosciences, Inc. Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
WO2009112490A1 (en) * 2008-03-11 2009-09-17 Cellzome Limited Sulfonamides as zap-70 inhibitors
JP2010516698A (ja) * 2007-01-19 2010-05-20 アルデア バイオサイエンシズ，インコーポレイティド Ｍｅｋのインヒビター
WO2010121646A1 (en) * 2009-04-21 2010-10-28 Novartis Ag Heterocyclic compounds as mek inhibitors
WO2010145197A1 (en) * 2009-06-15 2010-12-23 Chemizon (Beijing), Ltd. Novel 6-arylamino pyridone sulfonamides and 6-arylamino pyrazinone sulfonamdies as mek inhibitors
WO2011054828A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Heterocyclic sulfonamide derivatives useful as mek inhibitors
JP2011526926A (ja) * 2008-07-01 2011-10-20 ジェネンテック， インコーポレイテッド 置換二環式ヘテロ環化合物と使用方法
JP5456908B2 (ja) * 2009-12-08 2014-04-02 ノバルティス アーゲー ヘテロ環式スルホンアミド誘導体

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Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006083137A (ja) * 2004-09-17 2006-03-30 Sankyo Co Ltd 免疫抑制剤
JP2010516698A (ja) * 2007-01-19 2010-05-20 アルデア バイオサイエンシズ，インコーポレイティド Ｍｅｋのインヒビター
WO2009018238A1 (en) * 2007-07-30 2009-02-05 Ardea Biosciences, Inc. Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
WO2009112490A1 (en) * 2008-03-11 2009-09-17 Cellzome Limited Sulfonamides as zap-70 inhibitors
JP2011526926A (ja) * 2008-07-01 2011-10-20 ジェネンテック， インコーポレイテッド 置換二環式ヘテロ環化合物と使用方法
WO2010121646A1 (en) * 2009-04-21 2010-10-28 Novartis Ag Heterocyclic compounds as mek inhibitors
WO2010145197A1 (en) * 2009-06-15 2010-12-23 Chemizon (Beijing), Ltd. Novel 6-arylamino pyridone sulfonamides and 6-arylamino pyrazinone sulfonamdies as mek inhibitors
WO2011054828A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Heterocyclic sulfonamide derivatives useful as mek inhibitors
JP5456908B2 (ja) * 2009-12-08 2014-04-02 ノバルティス アーゲー ヘテロ環式スルホンアミド誘導体

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020521741A (ja) * 2017-05-25 2020-07-27 アラクセス ファーマ エルエルシー がんの処置のための化合物およびその使用の方法

Also Published As

Publication number Publication date
KR20140034898A (ko) 2014-03-20
BR112013031201A2 (pt) 2017-01-31
IN2014DN00123A (ru) 2015-05-22
EA201391820A1 (ru) 2014-12-30
AU2012265844A1 (en) 2013-05-02
EP2718276A1 (en) 2014-04-16
CA2838029A1 (en) 2012-12-13
WO2012168884A1 (en) 2012-12-13
MX2013014398A (es) 2014-03-21

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