JP2014516034A5 - - Google Patents

Info

Publication number

JP2014516034A5

JP2014516034A5 JP2014511548A JP2014511548A JP2014516034A5 JP 2014516034 A5 JP2014516034 A5 JP 2014516034A5 JP 2014511548 A JP2014511548 A JP 2014511548A JP 2014511548 A JP2014511548 A JP 2014511548A JP 2014516034 A5 JP2014516034 A5 JP 2014516034A5

Authority

JP

Japan

Prior art keywords

use according

cells

hydrogel

umbilical cord

hanareshu

Prior art date

2012-05-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004027 cell Anatomy 0.000 claims 16
• 239000000017 hydrogel Substances 0.000 claims 9
• 210000001519 tissue Anatomy 0.000 claims 9
• 210000003954 umbilical cord Anatomy 0.000 claims 7
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 230000001228 trophic effect Effects 0.000 claims 3
• 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 2
• 108010049003 Fibrinogen Proteins 0.000 claims 2
• 102000008946 Fibrinogen Human genes 0.000 claims 2
• 206010061246 Intervertebral disc degeneration Diseases 0.000 claims 2
• 108090000190 Thrombin Proteins 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 229940012952 fibrinogen Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 229960004072 thrombin Drugs 0.000 claims 2
• 102100022464 5'-nucleotidase Human genes 0.000 claims 1
• 102100022749 Aminopeptidase N Human genes 0.000 claims 1
• 108010081589 Becaplermin Proteins 0.000 claims 1
• 102100032912 CD44 antigen Human genes 0.000 claims 1
• 102000009410 Chemokine receptor Human genes 0.000 claims 1
• 108050000299 Chemokine receptor Proteins 0.000 claims 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
• 108010090254 Growth Differentiation Factor 5 Proteins 0.000 claims 1
• 102100035379 Growth/differentiation factor 5 Human genes 0.000 claims 1
• 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
• 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
• 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
• 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
• 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 claims 1
• 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
• 102000004890 Interleukin-8 Human genes 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 1
• 102000003729 Neprilysin Human genes 0.000 claims 1
• 108090000028 Neprilysin Proteins 0.000 claims 1
• 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
• 102100022647 Reticulon-1 Human genes 0.000 claims 1
• 101710122684 Reticulon-1 Proteins 0.000 claims 1
• 108010017842 Telomerase Proteins 0.000 claims 1
• 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
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• 210000002798 bone marrow cell Anatomy 0.000 claims 1
• 230000003399 chemotactic effect Effects 0.000 claims 1
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• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 210000002950 fibroblast Anatomy 0.000 claims 1
• 210000003714 granulocyte Anatomy 0.000 claims 1
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• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
• 229940096397 interleukin-8 Drugs 0.000 claims 1
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• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
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• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1