JP2014515372A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014515372A5 JP2014515372A5 JP2014512145A JP2014512145A JP2014515372A5 JP 2014515372 A5 JP2014515372 A5 JP 2014515372A5 JP 2014512145 A JP2014512145 A JP 2014512145A JP 2014512145 A JP2014512145 A JP 2014512145A JP 2014515372 A5 JP2014515372 A5 JP 2014515372A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- cyclosporin
- ophthalmically acceptable
- crystalline
- diffraction pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930105110 Cyclosporin A Natural products 0.000 claims 5
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 5
- 108010036949 Cyclosporine Proteins 0.000 claims 5
- 229960001265 ciclosporin Drugs 0.000 claims 4
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 3
- 206010013774 Dry eye Diseases 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 claims 2
- 238000001565 modulated differential scanning calorimetry Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 206010046851 Uveitis Diseases 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 230000002052 anaphylactic effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010014801 endophthalmitis Diseases 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490887P | 2011-05-27 | 2011-05-27 | |
| US61/490,887 | 2011-05-27 | ||
| PCT/US2012/039611 WO2012166610A1 (en) | 2011-05-27 | 2012-05-25 | A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515372A JP2014515372A (ja) | 2014-06-30 |
| JP2014515372A5 true JP2014515372A5 (cg-RX-API-DMAC7.html) | 2015-04-30 |
| JP6163482B2 JP6163482B2 (ja) | 2017-07-12 |
Family
ID=46178866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512145A Active JP6163482B2 (ja) | 2011-05-27 | 2012-05-25 | シクロスポリンａの結晶形態、その調製方法、およびその使用のための方法 |
Country Status (19)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2779994T3 (da) * | 2011-11-15 | 2020-05-18 | Allergan Inc | Suspensioner af cyclosporin a form 2 |
| AU2012339695B2 (en) * | 2011-11-15 | 2017-10-05 | Allergan, Inc. | Sustained action formulation of cyclosporin Form 2 |
| RU2635547C2 (ru) | 2011-11-15 | 2017-11-14 | Аллерган, Инк. | Форма 2 циклоспорина а и способ ее получения |
| WO2013074616A1 (en) * | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Autoclavable suspensions of cyclosporin a form 2 |
| CN104487449A (zh) | 2012-06-01 | 2015-04-01 | 阿勒根公司 | 环孢菌素a类似物 |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| US10524661B2 (en) * | 2013-06-12 | 2020-01-07 | Proactive Live, Inc. | Sleep monitoring and stimulation |
| AU2015289387B2 (en) | 2014-07-18 | 2020-10-22 | Allergan, Inc. | Suspension compositions of cyclosporin A for subconjunctival and periocular injection |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| US10443292B2 (en) * | 2016-04-25 | 2019-10-15 | Magna Closures, Inc. | Non-contact obstacle detection system for motor vehicles |
| RU2766160C2 (ru) | 2017-05-17 | 2022-02-08 | Юю Фарма, Инк. | Новый пептид и фармацевтический состав для лечения глазного заболевания, содержащий пептид в качестве активного фармацевтического ингредиента |
| US11613558B2 (en) | 2018-11-14 | 2023-03-28 | Yuyu Pharma, Inc. | Peptides and pharmaceutical compositions for treating eye diseases |
| KR20250088544A (ko) | 2022-10-20 | 2025-06-17 | 추가이 세이야쿠 가부시키가이샤 | 고리형 펩티드 결정을 제조하는 방법 |
| JPWO2024195801A1 (cg-RX-API-DMAC7.html) | 2023-03-20 | 2024-09-26 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU203564B (en) * | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US6656504B1 (en) * | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
| CN101687013A (zh) * | 2007-05-04 | 2010-03-31 | 阿勒根公司 | 环孢菌素在治疗具有人工晶状体的患者中的用途 |
| BRPI0822221A2 (pt) * | 2008-01-04 | 2015-06-23 | Alcon Pharmaceuticals Ltd | Composições aquosas e estáveis de ciclosporina |
-
2012
- 2012-05-25 WO PCT/US2012/039611 patent/WO2012166610A1/en not_active Ceased
- 2012-05-25 AU AU2012262513A patent/AU2012262513B2/en not_active Ceased
- 2012-05-25 EP EP18211911.5A patent/EP3521302A1/en not_active Withdrawn
- 2012-05-25 UA UAA201314231A patent/UA113627C2/uk unknown
- 2012-05-25 RU RU2013155033/04A patent/RU2602062C2/ru active
- 2012-05-25 CA CA2836946A patent/CA2836946C/en active Active
- 2012-05-25 CN CN201280033382.7A patent/CN103649108B/zh active Active
- 2012-05-25 BR BR112013030554-1A patent/BR112013030554B1/pt active IP Right Grant
- 2012-05-25 MY MYPI2013004226A patent/MY180581A/en unknown
- 2012-05-25 SG SG10201607344UA patent/SG10201607344UA/en unknown
- 2012-05-25 KR KR1020137034444A patent/KR102079402B1/ko not_active Expired - Fee Related
- 2012-05-25 US US13/480,710 patent/US8772245B2/en active Active
- 2012-05-25 EP EP12724525.6A patent/EP2714720B1/en active Active
- 2012-05-25 MX MX2013013855A patent/MX362271B/es active IP Right Grant
- 2012-05-25 JP JP2014512145A patent/JP6163482B2/ja active Active
- 2012-05-28 TW TW101119051A patent/TWI554522B/zh not_active IP Right Cessation
- 2012-05-28 AR ARP120101878A patent/AR086586A1/es not_active Application Discontinuation
-
2013
- 2013-11-17 IL IL229475A patent/IL229475A0/en unknown
- 2013-11-19 ZA ZA2013/08665A patent/ZA201308665B/en unknown
- 2013-11-26 CL CL2013003400A patent/CL2013003400A1/es unknown
-
2014
- 2014-07-02 US US14/322,475 patent/US9206228B2/en active Active
-
2015
- 2015-12-07 US US14/961,132 patent/US20160083432A1/en not_active Abandoned
-
2016
- 2016-06-15 AU AU2016203990A patent/AU2016203990A1/en not_active Abandoned
-
2017
- 2017-11-21 AU AU2017265008A patent/AU2017265008A1/en not_active Abandoned
-
2019
- 2019-06-14 AU AU2019204192A patent/AU2019204192B2/en not_active Ceased
-
2021
- 2021-01-13 US US17/148,315 patent/US20210269484A1/en not_active Abandoned
-
2022
- 2022-01-27 IL IL290158A patent/IL290158A/en unknown