JP2014513700A5 - - Google Patents
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- Publication number
- JP2014513700A5 JP2014513700A5 JP2014510613A JP2014510613A JP2014513700A5 JP 2014513700 A5 JP2014513700 A5 JP 2014513700A5 JP 2014510613 A JP2014510613 A JP 2014510613A JP 2014510613 A JP2014510613 A JP 2014510613A JP 2014513700 A5 JP2014513700 A5 JP 2014513700A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- alkynyl
- group
- biofilm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 17
- 244000005700 microbiome Species 0.000 claims description 15
- 230000003115 biocidal effect Effects 0.000 claims description 10
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 8
- 230000032770 biofilm formation Effects 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 4
- 239000006185 dispersion Substances 0.000 claims description 4
- 229960003405 ciprofloxacin Drugs 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000004306 triazinyl group Chemical group 0.000 claims 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- -1 ethoxy, methoxy, propoxy Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 108090000204 Dipeptidase 1 Proteins 0.000 claims 2
- 101100490139 Mus musculus Acer3 gene Proteins 0.000 claims 2
- 102000006635 beta-lactamase Human genes 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 1
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 229930186147 Cephalosporin Natural products 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 1
- 208000000913 Kidney Calculi Diseases 0.000 claims 1
- 206010029148 Nephrolithiasis Diseases 0.000 claims 1
- 206010033078 Otitis media Diseases 0.000 claims 1
- 108010087702 Penicillinase Proteins 0.000 claims 1
- 108090000279 Peptidyltransferases Proteins 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000009361 bacterial endocarditis Diseases 0.000 claims 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims 1
- 229940124587 cephalosporin Drugs 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000007119 infective endocarditis Diseases 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 239000002840 nitric oxide donor Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 229950009506 penicillinase Drugs 0.000 claims 1
- IPBVNPXQWQGGJP-UHFFFAOYSA-N phenyl acetate Chemical compound CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 239000002132 β-lactam antibiotic Substances 0.000 claims 1
- 229940124586 β-lactam antibiotics Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 229940088710 antibiotic agent Drugs 0.000 description 3
- MUMXDRRTIYLYMY-YJKCNMNRSA-N (Z)-[dodecyl-[6-(dodecylazaniumyl)hexyl]amino]-oxido-oxidoiminoazanium Chemical compound CCCCCCCCCCCC[NH2+]CCCCCCN(CCCCCCCCCCCC)[N+](\[O-])=N\[O-] MUMXDRRTIYLYMY-YJKCNMNRSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011901872 | 2011-05-16 | ||
| AU2011901872A AU2011901872A0 (en) | 2011-05-16 | Regulation of nitric oxide release and biofilm development | |
| PCT/AU2012/000542 WO2012155203A1 (en) | 2011-05-16 | 2012-05-16 | Regulation of nitric oxide release and biofilm development |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513700A JP2014513700A (ja) | 2014-06-05 |
| JP2014513700A5 true JP2014513700A5 (https=) | 2015-07-02 |
| JP5974083B2 JP5974083B2 (ja) | 2016-08-23 |
Family
ID=47176046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510613A Expired - Fee Related JP5974083B2 (ja) | 2011-05-16 | 2012-05-16 | 酸化窒素放出及びバイオフィルム発達の調節 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9156855B2 (https=) |
| EP (1) | EP2710016B1 (https=) |
| JP (1) | JP5974083B2 (https=) |
| KR (1) | KR101980285B1 (https=) |
| CN (2) | CN105820176A (https=) |
| AU (1) | AU2012255694B2 (https=) |
| BR (1) | BR112013029485B1 (https=) |
| CA (1) | CA2835642C (https=) |
| DK (1) | DK2710016T3 (https=) |
| IL (1) | IL229422A (https=) |
| WO (1) | WO2012155203A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| US10925689B2 (en) * | 2014-07-14 | 2021-02-23 | Novan, Inc. | Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same |
| WO2017019614A1 (en) | 2015-07-28 | 2017-02-02 | Novan, Inc. | Combinations and methods for the treatment and/or prevention of fungal infections |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| JP7645546B2 (ja) * | 2018-12-28 | 2025-03-14 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 一酸化窒素放出抗菌性ポリマーおよびそれから製造された足場、ならびにそれに関する方法 |
| WO2021159176A1 (en) * | 2020-02-12 | 2021-08-19 | The University Of Wollongong | Antimicrobial compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090131342A1 (en) * | 2004-01-22 | 2009-05-21 | Nitromed, Inc. | Nitrosated and/or nitrosylated compounds, compositions and methods of use |
| WO2006081619A1 (en) * | 2005-02-02 | 2006-08-10 | Newsouth Innovations Pty Limited | Improving survival and proliferation of cd4+ and cd25+ t cells |
| WO2006125262A1 (en) * | 2005-05-24 | 2006-11-30 | Environmental Biotechnology Crc Pty Limited | Methods and compositions for regulating biofilm development |
| DE102007035323A1 (de) * | 2007-07-25 | 2009-01-29 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- | Neue Ketoconazol-Derivate sowie deren Herstellung und Verwendung als antimikrobielle und antiinflammatorische Wirkstoffe |
| US8399005B2 (en) | 2007-10-12 | 2013-03-19 | University Of North Carolina At Chapel Hill | Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents |
| WO2009124379A1 (en) * | 2008-04-09 | 2009-10-15 | Enox Biopharma, Inc. | Biofilm-inhibiting catheters and tubings |
-
2012
- 2012-05-16 US US14/117,742 patent/US9156855B2/en active Active
- 2012-05-16 BR BR112013029485-0A patent/BR112013029485B1/pt not_active IP Right Cessation
- 2012-05-16 EP EP12786177.1A patent/EP2710016B1/en active Active
- 2012-05-16 KR KR1020137033167A patent/KR101980285B1/ko not_active Expired - Fee Related
- 2012-05-16 DK DK12786177.1T patent/DK2710016T3/en active
- 2012-05-16 JP JP2014510613A patent/JP5974083B2/ja not_active Expired - Fee Related
- 2012-05-16 AU AU2012255694A patent/AU2012255694B2/en not_active Ceased
- 2012-05-16 WO PCT/AU2012/000542 patent/WO2012155203A1/en not_active Ceased
- 2012-05-16 CN CN201610177023.9A patent/CN105820176A/zh active Pending
- 2012-05-16 CA CA2835642A patent/CA2835642C/en active Active
- 2012-05-16 CN CN201280035092.6A patent/CN103649098B/zh not_active Expired - Fee Related
-
2013
- 2013-11-13 IL IL229422A patent/IL229422A/en active IP Right Grant
-
2015
- 2015-09-25 US US14/865,518 patent/US20160009733A1/en not_active Abandoned
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