JP2014512387A5 - - Google Patents
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- Publication number
- JP2014512387A5 JP2014512387A5 JP2014506535A JP2014506535A JP2014512387A5 JP 2014512387 A5 JP2014512387 A5 JP 2014512387A5 JP 2014506535 A JP2014506535 A JP 2014506535A JP 2014506535 A JP2014506535 A JP 2014506535A JP 2014512387 A5 JP2014512387 A5 JP 2014512387A5
- Authority
- JP
- Japan
- Prior art keywords
- viscosity
- composition
- ophthalmic
- thermosensitive
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 70
- 239000003623 enhancer Substances 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 230000002708 enhancing effect Effects 0.000 claims description 17
- 230000007704 transition Effects 0.000 claims description 13
- -1 polyhydroxypropylene Polymers 0.000 claims description 12
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 8
- 229920001400 block copolymer Polymers 0.000 claims description 8
- 239000000499 gel Substances 0.000 claims description 8
- 229920001983 poloxamer Polymers 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 230000000699 topical effect Effects 0.000 claims description 8
- 229920000428 triblock copolymer Polymers 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 229920000896 Ethulose Polymers 0.000 claims description 4
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 230000036760 body temperature Effects 0.000 claims description 4
- 229920006184 cellulose methylcellulose Polymers 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 229960000502 poloxamer Drugs 0.000 claims description 4
- 229920002939 poly(N,N-dimethylacrylamides) Polymers 0.000 claims description 4
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 claims description 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920001451 polypropylene glycol Polymers 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000000043 antiallergic agent Substances 0.000 claims description 2
- 239000000030 antiglaucoma agent Substances 0.000 claims description 2
- 229960005475 antiinfective agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 229940023490 ophthalmic product Drugs 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003889 eye drop Substances 0.000 description 2
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478084P | 2011-04-22 | 2011-04-22 | |
| US61/478,084 | 2011-04-22 | ||
| PCT/US2012/034187 WO2012145470A2 (en) | 2011-04-22 | 2012-04-19 | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014512387A JP2014512387A (ja) | 2014-05-22 |
| JP2014512387A5 true JP2014512387A5 (enExample) | 2015-05-28 |
Family
ID=46026952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506535A Pending JP2014512387A (ja) | 2011-04-22 | 2012-04-19 | 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120270955A1 (enExample) |
| EP (2) | EP3045163A1 (enExample) |
| JP (1) | JP2014512387A (enExample) |
| KR (1) | KR20140022901A (enExample) |
| CN (1) | CN103491944A (enExample) |
| AU (1) | AU2012245454A1 (enExample) |
| BR (1) | BR112013026534A2 (enExample) |
| CA (1) | CA2833596A1 (enExample) |
| MX (1) | MX2013012308A (enExample) |
| RU (1) | RU2601115C2 (enExample) |
| WO (1) | WO2012145470A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016013993A1 (en) * | 2014-07-25 | 2016-01-28 | Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. | Stable preservative free ophthalmic formulations of opioid antagonists |
| WO2020175525A1 (ja) * | 2019-02-27 | 2020-09-03 | 参天製薬株式会社 | ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物 |
| CA3148362C (en) * | 2019-08-18 | 2024-02-13 | Bo Liang | In-situ gel forming ophthalmic formulations containing difluprednate |
| JP2023038930A (ja) * | 2021-09-07 | 2023-03-17 | 学校法人近畿大学 | 眼表面薬物滞留化剤およびこれを含む点眼剤、並びに、これらの剤を用いた眼表面薬物滞留方法および眼科疾患治療方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5037647A (en) | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
| US5252318A (en) * | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| US5540930A (en) * | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
| JP4167728B2 (ja) * | 1996-02-07 | 2008-10-22 | ロート製薬株式会社 | 粘度を調節した眼科用組成物 |
| DE69818675T2 (de) | 1997-07-29 | 2004-07-29 | Alcon Laboratories, Inc., Fort Worth | Galaktomannanpolymere und borat enthaltende augenarzneimittel |
| US6703039B2 (en) * | 2000-12-06 | 2004-03-09 | Bausch & Lomb Incorporated | Reversible gelling system for ocular drug delivery |
| EP1681065A4 (en) * | 2003-10-31 | 2011-12-28 | Wakamoto Pharma Co Ltd | WATER-BASED COMPOSITION SUBJECTED TO REVERSIBLE THERMOREGULATION |
| CN101073556A (zh) * | 2007-06-25 | 2007-11-21 | 苏州瑞桥医药科技有限公司 | 一种散瞳眼用制剂及其制备方法 |
| WO2009041549A1 (ja) * | 2007-09-28 | 2009-04-02 | Rohto Pharmaceutical Co., Ltd. | 眼科用組成物 |
| RU2600863C2 (ru) * | 2007-12-10 | 2016-10-27 | Сентисс Фарма Прайвит Лимитед | Офтальмическая композиция, включающая фенилэфрин |
| AU2009225931B9 (en) | 2008-03-17 | 2014-04-03 | Novartis Ag | Aqueous pharmaceutical compositions containing borate-polyol complexes |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
-
2012
- 2012-04-19 EP EP16156221.0A patent/EP3045163A1/en not_active Withdrawn
- 2012-04-19 AU AU2012245454A patent/AU2012245454A1/en not_active Abandoned
- 2012-04-19 BR BR112013026534A patent/BR112013026534A2/pt active Search and Examination
- 2012-04-19 EP EP12718822.5A patent/EP2699229A2/en not_active Withdrawn
- 2012-04-19 JP JP2014506535A patent/JP2014512387A/ja active Pending
- 2012-04-19 WO PCT/US2012/034187 patent/WO2012145470A2/en not_active Ceased
- 2012-04-19 US US13/450,731 patent/US20120270955A1/en not_active Abandoned
- 2012-04-19 CA CA2833596A patent/CA2833596A1/en not_active Abandoned
- 2012-04-19 KR KR1020137030489A patent/KR20140022901A/ko not_active Ceased
- 2012-04-19 MX MX2013012308A patent/MX2013012308A/es unknown
- 2012-04-19 RU RU2013152026/15A patent/RU2601115C2/ru not_active IP Right Cessation
- 2012-04-19 CN CN201280019679.8A patent/CN103491944A/zh active Pending
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