JP2014511885A5 - - Google Patents
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- Publication number
- JP2014511885A5 JP2014511885A5 JP2014505544A JP2014505544A JP2014511885A5 JP 2014511885 A5 JP2014511885 A5 JP 2014511885A5 JP 2014505544 A JP2014505544 A JP 2014505544A JP 2014505544 A JP2014505544 A JP 2014505544A JP 2014511885 A5 JP2014511885 A5 JP 2014511885A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazolo
- pyrimidin
- phenyl
- amine
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PQNUIDJXNXPHGG-UHFFFAOYSA-N Cc(cc1)cnc1N1CCCC1 Chemical compound Cc(cc1)cnc1N1CCCC1 PQNUIDJXNXPHGG-UHFFFAOYSA-N 0.000 description 1
- BZACBBRLMWHCNM-UHFFFAOYSA-N Cc1c[n](cccc2)c2n1 Chemical compound Cc1c[n](cccc2)c2n1 BZACBBRLMWHCNM-UHFFFAOYSA-N 0.000 description 1
- XKVUYEYANWFIJX-UHFFFAOYSA-N Cc1n[nH]cc1 Chemical compound Cc1n[nH]cc1 XKVUYEYANWFIJX-UHFFFAOYSA-N 0.000 description 1
- LDZYRENCLPUXAX-UHFFFAOYSA-N Cc1nc(cccc2)c2[nH]1 Chemical compound Cc1nc(cccc2)c2[nH]1 LDZYRENCLPUXAX-UHFFFAOYSA-N 0.000 description 1
- PJQIBTFOXWGAEN-UHFFFAOYSA-N Cc1nc(cccc2)c2[n]1C Chemical compound Cc1nc(cccc2)c2[n]1C PJQIBTFOXWGAEN-UHFFFAOYSA-N 0.000 description 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N Cc1nc(cccc2)c2[s]1 Chemical compound Cc1nc(cccc2)c2[s]1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161517582P | 2011-04-21 | 2011-04-21 | |
| US61/517,582 | 2011-04-21 | ||
| PCT/EP2012/001737 WO2012143144A1 (en) | 2011-04-21 | 2012-04-23 | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511885A JP2014511885A (ja) | 2014-05-19 |
| JP2014511885A5 true JP2014511885A5 (enExample) | 2016-09-29 |
| JP6222776B2 JP6222776B2 (ja) | 2017-11-01 |
Family
ID=46017783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505544A Active JP6222776B2 (ja) | 2011-04-21 | 2012-04-23 | キナ−ゼ・インヒビタ−として有用なピラゾロ［４，３−ｄ］ピリミジン |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9802937B2 (enExample) |
| EP (1) | EP2699579B1 (enExample) |
| JP (1) | JP6222776B2 (enExample) |
| KR (1) | KR101649611B1 (enExample) |
| CN (1) | CN103492389B (enExample) |
| AP (1) | AP2013007253A0 (enExample) |
| AU (1) | AU2012244550C1 (enExample) |
| BR (1) | BR112013026521A2 (enExample) |
| CA (1) | CA2831634C (enExample) |
| CL (1) | CL2013003051A1 (enExample) |
| CO (1) | CO6831982A2 (enExample) |
| CR (1) | CR20130536A (enExample) |
| CU (1) | CU20130143A7 (enExample) |
| EA (1) | EA029040B1 (enExample) |
| EC (1) | ECSP13012982A (enExample) |
| GT (1) | GT201300255A (enExample) |
| IL (1) | IL228968A (enExample) |
| MA (1) | MA35124B1 (enExample) |
| MX (1) | MX363696B (enExample) |
| PE (1) | PE20140928A1 (enExample) |
| PH (1) | PH12013502185A1 (enExample) |
| SG (1) | SG194549A1 (enExample) |
| TN (1) | TN2013000419A1 (enExample) |
| TW (1) | TWI606049B (enExample) |
| WO (1) | WO2012143144A1 (enExample) |
| ZA (1) | ZA201307839B (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2610840C2 (ru) * | 2011-03-28 | 2017-02-16 | Ф. Хоффманн-Ля Рош Аг | Тиазолопиримидины |
| WO2012143144A1 (en) | 2011-04-21 | 2012-10-26 | Origenis Gmbh | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors |
| SG194512A1 (en) | 2011-04-21 | 2013-12-30 | Gilead Sciences Inc | Benzothiazole compounds and their pharmaceutical use |
| WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| AR090650A1 (es) | 2012-04-12 | 2014-11-26 | Alcon Res Ltd | Tratamiento para respuestas inflamatorias inducidas por microbios en el ojo |
| US20120323214A1 (en) * | 2012-05-16 | 2012-12-20 | Totada R Shantha | Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis |
| EP2867236B1 (en) | 2012-06-29 | 2017-06-14 | Pfizer Inc | Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
| US9637491B2 (en) * | 2012-10-19 | 2017-05-02 | Origenis Gmbh | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors |
| US9440952B2 (en) | 2013-03-04 | 2016-09-13 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134772A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134774A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134776A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| TW201534597A (zh) * | 2013-06-20 | 2015-09-16 | Ab Science | 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物 |
| WO2015026683A1 (en) * | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2015057945A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
| WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| CN105980388B (zh) * | 2014-01-29 | 2018-01-16 | 葛兰素史密斯克莱知识产权发展有限公司 | 化合物 |
| SG11201605342UA (en) | 2014-01-29 | 2016-08-30 | Glaxosmithkline Ip Dev Ltd | Compounds |
| SG11201607990QA (en) | 2014-04-25 | 2016-11-29 | Pfizer | Heteroaromatic compounds and their use as dopamine d1 ligands |
| US10004751B2 (en) | 2014-07-10 | 2018-06-26 | The J. David Gladstone Institutes | Compositions and methods for treating Dengue virus infection |
| CN113563342A (zh) * | 2015-02-13 | 2021-10-29 | 达纳－法伯癌症研究所公司 | Lrrk2抑制剂及其制备和使用方法 |
| US10273228B2 (en) | 2015-04-17 | 2019-04-30 | Indiana University Research And Technology Corporation | Hepatitis B viral assembly effectors |
| HK1254835A1 (zh) | 2015-06-26 | 2019-07-26 | 卡德门企业有限公司 | 葡萄糖攝取抑制劑 |
| WO2016210331A1 (en) * | 2015-06-26 | 2016-12-29 | Kadmon Corporation, Llc | Treatment of infectious diseases with glucose uptake inhibitors |
| KR102161364B1 (ko) | 2015-09-14 | 2020-09-29 | 화이자 인코포레이티드 | LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체 |
| US9762007B2 (en) | 2016-02-10 | 2017-09-12 | Dish Network L.L.C. | Push on connector |
| MA46191A (fr) | 2016-09-09 | 2021-04-21 | Incyte Corp | Dérivés de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer |
| US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| US20180072741A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
| MX2019003710A (es) | 2016-09-30 | 2019-06-24 | Asana Biosciences Llc | Compuestos y metodos de p2x3 y/o p2x2/3. |
| CN106620315A (zh) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | 一种用于治疗风湿病的药物组合物 |
| CN106667990A (zh) * | 2016-11-17 | 2017-05-17 | 郑州郑先医药科技有限公司 | 一种治疗风湿病的药物 |
| US20180153922A1 (en) | 2016-12-06 | 2018-06-07 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Inhibition of expansion and function of pathogenic age-associated b cells and use for the prevention and treatment of autoimmune disease |
| CN106580974A (zh) * | 2016-12-06 | 2017-04-26 | 郑州郑先医药科技有限公司 | 一种治疗脊髓损伤的西药组合物及其应用 |
| WO2018147612A1 (ko) * | 2017-02-07 | 2018-08-16 | 주식회사 온코크로스 | 암의 전이 억제 및 치료용 조성물 |
| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| EP3612030B1 (en) | 2017-04-21 | 2025-12-24 | Ikena Oncology, Inc. | Indole ahr inhibitors and uses thereof |
| WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
| CN108178760B (zh) * | 2017-12-27 | 2020-02-18 | 安徽医科大学 | 一种嘧啶并吡唑杂环化合物、制备方法、用途 |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| SMT202200294T1 (it) | 2018-02-20 | 2022-11-18 | Incyte Corp | Derivati di n-(fenil)-2-(fenil)pirimidina-4-carbossammide e composti correlati come inibitori di hpk1 per trattare il cancro |
| WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
| WO2019162964A1 (en) * | 2018-02-23 | 2019-08-29 | Indian Institute Of Science | Anti-tubercular composition, and combinatorial implementations thereof |
| WO2019173500A1 (en) * | 2018-03-07 | 2019-09-12 | Duquesne University Of The Holy Spirit | PYRAZOLO[4,3-d]PYRIMIDINES AS ANTITUMOR AGENTS |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| EP3856348B1 (en) | 2018-09-25 | 2024-01-03 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 and/or fgfr modulators |
| CN109867800B (zh) * | 2019-04-01 | 2021-04-09 | 江西理工大学 | 一种镉基金属-有机框架及其制备方法 |
| KR102702945B1 (ko) | 2019-05-21 | 2024-09-05 | 보로노이 주식회사 | N을 포함하는 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| WO2020247756A1 (en) * | 2019-06-05 | 2020-12-10 | Forcyte Biotechnologies, Inc. | Small molecules to relax uterine smooth muscle contractions |
| EP3993764A4 (en) * | 2019-07-05 | 2023-08-23 | Icahn School of Medicine at Mount Sinai | PREVENTION METHOD AGAINST HAIR LOSS |
| KR20220059480A (ko) | 2019-08-06 | 2022-05-10 | 인사이트 코포레이션 | 고체 형태의 hpk1 억제제 |
| CN110876752B (zh) * | 2019-11-18 | 2021-04-30 | 暨南大学 | 长链非编码rna nron功能基序在制备抑制骨吸收及防治骨质疏松药物中的应用 |
| ES3028099T3 (en) | 2019-11-26 | 2025-06-18 | Ikena Oncology Inc | Polymorphic carbazole derivatives and uses thereof |
| AU2021370946A1 (en) * | 2020-10-26 | 2023-06-08 | Neuron23, Inc. | Methods of treatment and diagnosis of parkinson's disease associated with wild-type lrrk2 |
| WO2023032987A1 (ja) * | 2021-08-31 | 2023-03-09 | 日本たばこ産業株式会社 | ６－アミノピラゾロピリミジン化合物及びその医薬用途 |
| WO2023076404A1 (en) | 2021-10-27 | 2023-05-04 | Aria Pharmaceuticals, Inc. | Methods for treating systemic lupus erythematosus |
| JP2025539787A (ja) * | 2022-11-16 | 2025-12-09 | ヴァーンウィ セラピューティクス，インコーポレイテッド | Ｔｙｋ２阻害剤 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469868A (en) * | 1982-05-24 | 1984-09-04 | Warner-Lambert Company | Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines |
| GB8306481D0 (en) * | 1983-03-09 | 1983-04-13 | Beecham Group Plc | Compounds |
| US5360720A (en) | 1993-10-08 | 1994-11-01 | Alcon Laboratories, Inc. | Method of preparing human conjunctival mast cells for mast cell stabilization assays |
| US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| US6531475B1 (en) * | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| DE19942474A1 (de) * | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| DE10113710A1 (de) | 2001-03-16 | 2002-09-26 | Joerg Rademann | Oxoammoniumsalze sowie deren Verwendung |
| GB0106661D0 (en) * | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
| EP1348707B1 (en) * | 2002-03-28 | 2010-08-25 | Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy |
| US20030139427A1 (en) * | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| DE60326646D1 (de) | 2002-12-18 | 2009-04-23 | Vertex Pharma | Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen |
| EP1752457B1 (en) * | 2004-06-02 | 2014-03-19 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| NZ564187A (en) | 2005-05-12 | 2010-03-26 | Pfizer | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide |
| US20090234117A1 (en) | 2005-05-27 | 2009-09-17 | Toshihiko Kashiwagi | Pyrazolopyrimidine Derivative |
| JP2007055940A (ja) | 2005-08-24 | 2007-03-08 | Astellas Pharma Inc | ピラゾロピリミジン誘導体 |
| NL2000291C2 (nl) | 2005-11-10 | 2009-02-17 | Pfizer Prod Inc | 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. |
| US20100298557A1 (en) * | 2006-12-28 | 2010-11-25 | Taisho Pharmaceutical Co., Ltd | Pyrazolopyrimidine compound |
| US20090221612A1 (en) | 2008-02-13 | 2009-09-03 | Mitchell Scott A | Certain substituted amides, method of making, and method of use thereof |
| WO2010068258A1 (en) | 2008-12-08 | 2010-06-17 | Cgi Pharmaceuticals, Inc. | Imidazopyrazine syk inhibitors |
| WO2010118367A2 (en) | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
| JP5918693B2 (ja) | 2009-05-05 | 2016-05-18 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | Ｅｇｆｒ阻害剤及び疾患の治療方法 |
| WO2012143144A1 (en) | 2011-04-21 | 2012-10-26 | Origenis Gmbh | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors |
| AR090650A1 (es) | 2012-04-12 | 2014-11-26 | Alcon Res Ltd | Tratamiento para respuestas inflamatorias inducidas por microbios en el ojo |
-
2012
- 2012-04-23 WO PCT/EP2012/001737 patent/WO2012143144A1/en not_active Ceased
- 2012-04-23 EA EA201301184A patent/EA029040B1/ru unknown
- 2012-04-23 US US13/506,510 patent/US9802937B2/en active Active
- 2012-04-23 MX MX2013012294A patent/MX363696B/es unknown
- 2012-04-23 EP EP12717198.1A patent/EP2699579B1/en active Active
- 2012-04-23 SG SG2013077920A patent/SG194549A1/en unknown
- 2012-04-23 CN CN201280019429.4A patent/CN103492389B/zh active Active
- 2012-04-23 KR KR1020137030320A patent/KR101649611B1/ko active Active
- 2012-04-23 TW TW101114348A patent/TWI606049B/zh active
- 2012-04-23 CA CA2831634A patent/CA2831634C/en active Active
- 2012-04-23 JP JP2014505544A patent/JP6222776B2/ja active Active
- 2012-04-23 AU AU2012244550A patent/AU2012244550C1/en active Active
- 2012-04-23 BR BR112013026521A patent/BR112013026521A2/pt not_active Application Discontinuation
- 2012-04-23 PE PE2013002376A patent/PE20140928A1/es active IP Right Grant
- 2012-04-23 AP AP2013007253A patent/AP2013007253A0/xx unknown
- 2012-04-23 PH PH1/2013/502185A patent/PH12013502185A1/en unknown
-
2013
- 2013-10-14 TN TNP2013000419A patent/TN2013000419A1/fr unknown
- 2013-10-18 GT GT201300255A patent/GT201300255A/es unknown
- 2013-10-20 IL IL228968A patent/IL228968A/en active IP Right Grant
- 2013-10-21 CL CL2013003051A patent/CL2013003051A1/es unknown
- 2013-10-21 CR CR20130536A patent/CR20130536A/es unknown
- 2013-10-21 EC ECSP13012982 patent/ECSP13012982A/es unknown
- 2013-10-21 CO CO13249372A patent/CO6831982A2/es unknown
- 2013-10-21 CU CU2013000143A patent/CU20130143A7/es unknown
- 2013-10-21 ZA ZA2013/07839A patent/ZA201307839B/en unknown
- 2013-11-14 MA MA36430A patent/MA35124B1/fr unknown
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