JP2014511686A5 - - Google Patents
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- Publication number
- JP2014511686A5 JP2014511686A5 JP2014502867A JP2014502867A JP2014511686A5 JP 2014511686 A5 JP2014511686 A5 JP 2014511686A5 JP 2014502867 A JP2014502867 A JP 2014502867A JP 2014502867 A JP2014502867 A JP 2014502867A JP 2014511686 A5 JP2014511686 A5 JP 2014511686A5
- Authority
- JP
- Japan
- Prior art keywords
- wing
- compound according
- nucleoside
- modified
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 27
- 239000002777 nucleoside Substances 0.000 claims 27
- 108091034117 Oligonucleotide Proteins 0.000 claims 12
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 10
- 125000003835 nucleoside group Chemical group 0.000 claims 10
- -1 bicyclic nucleoside Chemical class 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000003463 hyperproliferative effect Effects 0.000 claims 3
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161471045P | 2011-04-01 | 2011-04-01 | |
| US201161471001P | 2011-04-01 | 2011-04-01 | |
| US201161471035P | 2011-04-01 | 2011-04-01 | |
| US201161471015P | 2011-04-01 | 2011-04-01 | |
| US61/471,045 | 2011-04-01 | ||
| US61/471,015 | 2011-04-01 | ||
| US61/471,035 | 2011-04-01 | ||
| US61/471,001 | 2011-04-01 | ||
| US201161558308P | 2011-11-10 | 2011-11-10 | |
| US201161558316P | 2011-11-10 | 2011-11-10 | |
| US61/558,308 | 2011-11-10 | ||
| US61/558,316 | 2011-11-10 | ||
| PCT/US2012/031642 WO2012135736A2 (en) | 2011-04-01 | 2012-03-30 | Modulation of signal transducer and activator of transcription 3 (stat3) expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511686A JP2014511686A (ja) | 2014-05-19 |
| JP2014511686A5 true JP2014511686A5 (cg-RX-API-DMAC7.html) | 2015-04-09 |
| JP5943993B2 JP5943993B2 (ja) | 2016-07-05 |
Family
ID=46932413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014502867A Active JP5943993B2 (ja) | 2011-04-01 | 2012-03-30 | 転写のシグナル伝達及び活性化因子３（ｓｔａｔ３）発現の調節 |
Country Status (35)
Families Citing this family (37)
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| BR112013024768B1 (pt) | 2011-04-01 | 2022-02-08 | Ionis Pharmaceuticals, Inc | Composto para inibição da expressão de mrna e proteína stat3, uso do composto e composição farmacêutica |
| JP6587934B2 (ja) | 2012-03-28 | 2019-10-09 | ソマロジック・インコーポレーテッド | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
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| KR102138781B1 (ko) | 2013-05-01 | 2020-07-28 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포지질단백질 c-iii 발현을 조절하는 조성물 및 방법 |
| JP6487913B2 (ja) * | 2013-07-02 | 2019-03-20 | アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 成長ホルモン受容体のモジュレータ |
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| JP6973073B2 (ja) * | 2015-11-06 | 2021-11-24 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
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-
2012
- 2012-03-30 BR BR112013024768-1A patent/BR112013024768B1/pt active IP Right Grant
- 2012-03-30 PL PL12763390T patent/PL2697243T3/pl unknown
- 2012-03-30 SM SM20190060T patent/SMT201900060T1/it unknown
- 2012-03-30 SG SG2013069935A patent/SG193504A1/en unknown
- 2012-03-30 RS RS20190022A patent/RS58489B1/sr unknown
- 2012-03-30 WO PCT/US2012/031642 patent/WO2012135736A2/en not_active Ceased
- 2012-03-30 HR HRP20182169TT patent/HRP20182169T1/hr unknown
- 2012-03-30 CN CN201280026065.2A patent/CN103562215B/zh active Active
- 2012-03-30 EP EP18201757.4A patent/EP3466960A3/en not_active Withdrawn
- 2012-03-30 PE PE2018001314A patent/PE20181518A1/es unknown
- 2012-03-30 ES ES12763390T patent/ES2709495T3/es active Active
- 2012-03-30 CN CN201611204855.1A patent/CN107012144A/zh active Pending
- 2012-03-30 DK DK12763390.7T patent/DK2697243T3/en active
- 2012-03-30 CA CA2831915A patent/CA2831915C/en active Active
- 2012-03-30 MY MYPI2013701834A patent/MY163004A/en unknown
- 2012-03-30 LT LTEP12763390.7T patent/LT2697243T/lt unknown
- 2012-03-30 KR KR1020137028986A patent/KR102050469B1/ko active Active
- 2012-03-30 EA EA201792185A patent/EA201792185A3/ru unknown
- 2012-03-30 SI SI201231497T patent/SI2697243T1/sl unknown
- 2012-03-30 PE PE2013002156A patent/PE20142463A1/es active IP Right Grant
- 2012-03-30 JP JP2014502867A patent/JP5943993B2/ja active Active
- 2012-03-30 MX MX2013011423A patent/MX340086B/es active IP Right Grant
- 2012-03-30 ME MEP-2019-20A patent/ME03317B/me unknown
- 2012-03-30 PT PT12763390T patent/PT2697243T/pt unknown
- 2012-03-30 HU HUE12763390A patent/HUE042173T2/hu unknown
- 2012-03-30 US US13/436,558 patent/US8816056B2/en active Active
- 2012-03-30 KR KR1020197021858A patent/KR20190092590A/ko not_active Abandoned
- 2012-03-30 AU AU2012236206A patent/AU2012236206C1/en active Active
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2013
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- 2013-09-29 IL IL228569A patent/IL228569A/en active IP Right Grant
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2014
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2016
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2017
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2019
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