JP2014511680A5 - - Google Patents

Info

Publication number

JP2014511680A5

JP2014511680A5 JP2014501588A JP2014501588A JP2014511680A5 JP 2014511680 A5 JP2014511680 A5 JP 2014511680A5 JP 2014501588 A JP2014501588 A JP 2014501588A JP 2014501588 A JP2014501588 A JP 2014501588A JP 2014511680 A5 JP2014511680 A5 JP 2014511680A5

Authority

JP

Japan

Prior art keywords

immunoglobulin

variable domain

single variable

seq

amino acid

Prior art date

2012-03-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108060003951 Immunoglobulin Proteins 0.000 claims description 174
• 102000018358 immunoglobulin Human genes 0.000 claims description 174
• 125000000539 amino acid group Chemical group 0.000 claims description 19
• 101000678890 Homo sapiens Atypical chemokine receptor 3 Proteins 0.000 claims description 13
• 102100022716 Atypical chemokine receptor 3 Human genes 0.000 claims description 11
• 150000001413 amino acids Chemical class 0.000 claims 54
• 229920001184 polypeptide Polymers 0.000 claims 13
• 102000004196 processed proteins & peptides Human genes 0.000 claims 13
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 125000003275 alpha amino acid group Chemical group 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 201000010536 head and neck cancer Diseases 0.000 claims 4
• 208000014829 head and neck neoplasm Diseases 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 230000004614 tumor growth Effects 0.000 claims 3
• 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims 2
• 101710098272 C-X-C motif chemokine 11 Proteins 0.000 claims 2
• 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 2
• 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 2
• 102000047836 human ACKR3 Human genes 0.000 claims 2
• 150000007523 nucleic acids Chemical group 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000006395 Globulins Human genes 0.000 claims 1
• 108010044091 Globulins Proteins 0.000 claims 1
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 108091006905 Human Serum Albumin Proteins 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 239000002773 nucleotide Chemical group 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1