JP2014511395A5 - - Google Patents
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- JP2014511395A5 JP2014511395A5 JP2013557866A JP2013557866A JP2014511395A5 JP 2014511395 A5 JP2014511395 A5 JP 2014511395A5 JP 2013557866 A JP2013557866 A JP 2013557866A JP 2013557866 A JP2013557866 A JP 2013557866A JP 2014511395 A5 JP2014511395 A5 JP 2014511395A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451022P | 2011-03-09 | 2011-03-09 | |
| US61/451,022 | 2011-03-09 | ||
| PCT/US2012/028293 WO2012122383A2 (en) | 2011-03-09 | 2012-03-08 | Pi3 kinase inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014511395A JP2014511395A (ja) | 2014-05-15 |
| JP2014511395A5 true JP2014511395A5 (https=) | 2015-04-30 |
Family
ID=46798805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557866A Pending JP2014511395A (ja) | 2011-03-09 | 2012-03-08 | Ｐｉ３キナーゼインヒビターおよびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120258967A1 (https=) |
| EP (1) | EP2683243A4 (https=) |
| JP (1) | JP2014511395A (https=) |
| CN (1) | CN103501610A (https=) |
| AU (1) | AU2012225382B2 (https=) |
| CA (1) | CA2829558A1 (https=) |
| WO (1) | WO2012122383A2 (https=) |
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| DK2841075T3 (da) | 2012-04-26 | 2020-06-22 | Massachusetts Gen Hospital | Midler og fremgangsmåder til behandling og forebyggelse af seboroisk keratose |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| BR112015022854A2 (pt) | 2013-03-14 | 2017-07-18 | Alkermes Pharma Ireland Ltd | pró-farmacos de fumaratos e uso do mesmo no tratamento de várias doenças |
| MY181020A (en) | 2013-03-15 | 2020-12-16 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| PH12019502378A1 (en) | 2013-05-01 | 2022-05-11 | Hoffmann La Roche | Biheteroaryl compounds and uses thereof |
| CN104140426B (zh) * | 2013-05-07 | 2017-02-01 | 上海汇伦生命科技有限公司 | 嘧啶并咪唑类化合物、其药物组合物及其制备方法和用途 |
| WO2014186663A2 (en) * | 2013-05-17 | 2014-11-20 | The General Hospital Corporation | Methods for detecting and treating variants of seborrheic keratoses |
| CN104651368B (zh) * | 2013-11-15 | 2017-09-29 | 北京大学 | 一种核酸适配体bc15的核心序列及其类似物和应用 |
| JP6337135B2 (ja) | 2014-02-24 | 2018-06-06 | アルカーメス ファーマ アイルランド リミテッド | フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用 |
| MA38393B1 (fr) * | 2014-03-13 | 2018-11-30 | Sanofi Sa | Composés hétéroaryle et utilisations associées |
| WO2016172952A1 (zh) * | 2015-04-30 | 2016-11-03 | 江苏挪贝肽医药科技有限公司 | PI4KIIIα蛋白及相关的膜蛋白复合体在治疗阿尔茨海默病中的应用 |
| GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201712282D0 (en) | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| ES3032793T3 (en) | 2018-04-10 | 2025-07-24 | Neuropore Therapies Inc | Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways |
| WO2019238933A1 (en) * | 2018-06-15 | 2019-12-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity |
| JP7640458B2 (ja) | 2018-10-05 | 2025-03-05 | アンナプルナ バイオ インコーポレイテッド | Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物 |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| WO2020097396A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as janus kinase 2 inhibitors and uses thereof |
| CA3181537A1 (en) | 2020-05-06 | 2021-11-11 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| AU2021324684A1 (en) * | 2020-08-11 | 2023-04-20 | Board Of Trustees Of Michigan State University | Proteasome enhancers and uses thereof |
| EP4267574B1 (en) | 2020-12-23 | 2025-04-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| TW202325289A (zh) | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Ｊａｋ２抑制劑之形式及組合物 |
| JP7782035B2 (ja) | 2021-11-09 | 2025-12-08 | エイジャックス セラピューティクス， インコーポレイテッド | Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール |
| PE20250663A1 (es) * | 2022-02-08 | 2025-03-04 | Theras Inc | Compuestos con estructura en t formada por al menos cuatro ciclos para usar en el tratamiento del cancer y otras indicaciones |
| CN115417789B (zh) * | 2022-09-03 | 2023-08-04 | 郑州大学 | 一种治疗帕金森氏病的化合物、其制备方法以及复方药物组合物和应用 |
| AU2024320375A1 (en) * | 2023-08-08 | 2026-02-19 | Lawrence Livermore National Security, Llc | Fused pyridines for the treatment of cancer and other indications |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200510383A (en) * | 2003-07-16 | 2005-03-16 | Neurogen Corp | Biaryl piperazinyl-pyridine analogues |
| CA2531619A1 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| MY145822A (en) * | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
| CN101080401A (zh) * | 2004-12-13 | 2007-11-28 | 神经能质公司 | 经取代的二芳基类似物 |
| ES2571028T3 (es) * | 2006-12-07 | 2016-05-23 | Genentech Inc | Compuestos inhibidores de fosfoinositida 3-cinasa y métodos de uso |
| WO2008098058A1 (en) * | 2007-02-06 | 2008-08-14 | Novartis Ag | Pi 3-kinase inhibitors and methods of their use |
| US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
| WO2009066084A1 (en) * | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
| WO2009070524A1 (en) * | 2007-11-27 | 2009-06-04 | Wyeth | Pyrrolo[3,2-d]pyrimidine compounds and their use as pi3 kinase and mtor kinase inhibitors |
| AU2008343813B2 (en) * | 2007-12-19 | 2012-04-12 | Amgen Inc. | Inhibitors of PI3 kinase |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| DE102009015255A1 (de) * | 2009-04-01 | 2010-10-14 | GM Global Technology Operations, Inc., Detroit | Tankklappenmodul |
| JP5649643B2 (ja) * | 2009-04-17 | 2015-01-07 | ワイス・エルエルシー | ピリミジン化合物、ｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのそれらの使用、ならびにそれらの合成 |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| EP2475375A4 (en) * | 2009-09-09 | 2013-02-20 | Avila Therapeutics Inc | PI3 KINASE INHIBITORS AND USES THEREOF |
| WO2013033901A1 (en) * | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
-
2012
- 2012-03-08 EP EP12755552.2A patent/EP2683243A4/en not_active Withdrawn
- 2012-03-08 JP JP2013557866A patent/JP2014511395A/ja active Pending
- 2012-03-08 CN CN201280021536.0A patent/CN103501610A/zh active Pending
- 2012-03-08 CA CA2829558A patent/CA2829558A1/en not_active Abandoned
- 2012-03-08 AU AU2012225382A patent/AU2012225382B2/en not_active Expired - Fee Related
- 2012-03-08 WO PCT/US2012/028293 patent/WO2012122383A2/en not_active Ceased
- 2012-03-08 US US13/414,918 patent/US20120258967A1/en not_active Abandoned
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