CN103501610A - Pi3激酶抑制剂和其用途 - Google Patents
Pi3激酶抑制剂和其用途 Download PDFInfo
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- CN103501610A CN103501610A CN201280021536.0A CN201280021536A CN103501610A CN 103501610 A CN103501610 A CN 103501610A CN 201280021536 A CN201280021536 A CN 201280021536A CN 103501610 A CN103501610 A CN 103501610A
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- Prior art keywords
- ring
- nhc
- nitrogen
- compound
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- 0 CC[*+](C(C)C)C=NSC Chemical compound CC[*+](C(C)C)C=NSC 0.000 description 21
- PTBIBRMZPJAVMW-UHFFFAOYSA-N CC(C)(C1)OCCN1[I]1CC1 Chemical compound CC(C)(C1)OCCN1[I]1CC1 PTBIBRMZPJAVMW-UHFFFAOYSA-N 0.000 description 1
- ZACHDISXYXTYFT-UHFFFAOYSA-N CC(C)CN1CC(CNC)OCC1 Chemical compound CC(C)CN1CC(CNC)OCC1 ZACHDISXYXTYFT-UHFFFAOYSA-N 0.000 description 1
- ACIWXTBLKCVFGG-XFFZJAGNSA-N CC(C)SCC[N](C)(C)(/C(/O)=C/C)=C Chemical compound CC(C)SCC[N](C)(C)(/C(/O)=C/C)=C ACIWXTBLKCVFGG-XFFZJAGNSA-N 0.000 description 1
- RZHBKZAQFXVMAA-ALCCZGGFSA-N CCCN(/C=C\C=C)N Chemical compound CCCN(/C=C\C=C)N RZHBKZAQFXVMAA-ALCCZGGFSA-N 0.000 description 1
- YCAWHEDEAOZIFM-UHFFFAOYSA-N CN1CC(CC(N2CCCC2)=O)OCC1 Chemical compound CN1CC(CC(N2CCCC2)=O)OCC1 YCAWHEDEAOZIFM-UHFFFAOYSA-N 0.000 description 1
- AVYFCIWTWQBXQM-UHFFFAOYSA-N CN1CC(CNCC(c2ccccc2)O)OCC1 Chemical compound CN1CC(CNCC(c2ccccc2)O)OCC1 AVYFCIWTWQBXQM-UHFFFAOYSA-N 0.000 description 1
- SQFCBBLSKSECMB-UHFFFAOYSA-O [NH3+]CCCOCCO Chemical compound [NH3+]CCCOCCO SQFCBBLSKSECMB-UHFFFAOYSA-O 0.000 description 1
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451022P | 2011-03-09 | 2011-03-09 | |
| US61/451,022 | 2011-03-09 | ||
| PCT/US2012/028293 WO2012122383A2 (en) | 2011-03-09 | 2012-03-08 | Pi3 kinase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103501610A true CN103501610A (zh) | 2014-01-08 |
Family
ID=46798805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280021536.0A Pending CN103501610A (zh) | 2011-03-09 | 2012-03-08 | Pi3激酶抑制剂和其用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120258967A1 (https=) |
| EP (1) | EP2683243A4 (https=) |
| JP (1) | JP2014511395A (https=) |
| CN (1) | CN103501610A (https=) |
| AU (1) | AU2012225382B2 (https=) |
| CA (1) | CA2829558A1 (https=) |
| WO (1) | WO2012122383A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2724493C2 (ru) * | 2015-04-30 | 2020-06-23 | Цзянсу Нуо-Бета Фармасьютикал Текнолоджи Ко., Лтд. | Изобретение белка pi4kiiia и родственного мембранного белкового комплекса в лечении болезни альцгеймера |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE051096T2 (hu) | 2012-04-26 | 2021-03-01 | Massachusetts Gen Hospital | Ágensek és módszerek a sebészeti keratózis kezelésére és megelõzésére |
| KR102085557B1 (ko) | 2013-03-14 | 2020-03-06 | 엘커메스 파마 아일랜드 리미티드 | 푸마레이트의 프로드럭 및 다양한 질환을 치료하는데 있어서의 이들의 용도 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| EP3943087A1 (en) | 2013-03-15 | 2022-01-26 | Celgene CAR LLC | Heteroaryl compounds and uses thereof |
| US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| CN105307657B (zh) | 2013-03-15 | 2020-07-10 | 西建卡尔有限责任公司 | 杂芳基化合物和其用途 |
| AR096151A1 (es) * | 2013-05-01 | 2015-12-09 | Hoffmann La Roche | Compuestos de biheteroarilo y usos de los mismos |
| CN104140426B (zh) * | 2013-05-07 | 2017-02-01 | 上海汇伦生命科技有限公司 | 嘧啶并咪唑类化合物、其药物组合物及其制备方法和用途 |
| US10508309B2 (en) * | 2013-05-17 | 2019-12-17 | The General Hospital Corporation | Methods for detecting and treating variants of seborrheic keratoses |
| CN104651368B (zh) * | 2013-11-15 | 2017-09-29 | 北京大学 | 一种核酸适配体bc15的核心序列及其类似物和应用 |
| JP6337135B2 (ja) | 2014-02-24 | 2018-06-06 | アルカーメス ファーマ アイルランド リミテッド | フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用 |
| GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201712282D0 (en) | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| KR102803762B1 (ko) | 2018-04-10 | 2025-05-09 | 뉴로포레 테라피스, 인코포레이티드 | Pi3-키나제 및 오토파지 경로의 조절인자로서의 트리-치환된 아릴 및 헤테로아릴 유도체 |
| EP3806833A1 (en) | 2018-06-15 | 2021-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity |
| MX2021003904A (es) | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| AU2021324684A1 (en) * | 2020-08-11 | 2023-04-20 | Board Of Trustees Of Michigan State University | Proteasome enhancers and uses thereof |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| KR20240157788A (ko) * | 2022-02-08 | 2024-11-01 | 테라스, 인크. | 암 및 기타 적응증의 치료에 사용하기 위한 적어도 4개의 환에 의해서 형성된 t 구조를 갖는 화합물 |
| CN115417789B (zh) * | 2022-09-03 | 2023-08-04 | 郑州大学 | 一种治疗帕金森氏病的化合物、其制备方法以及复方药物组合物和应用 |
| AU2024320375A1 (en) * | 2023-08-08 | 2026-02-19 | Lawrence Livermore National Security, Llc | Fused pyridines for the treatment of cancer and other indications |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823057A (zh) * | 2003-07-16 | 2006-08-23 | 神经能质公司 | 二芳基哌嗪基-吡啶类似物 |
| CN101014587A (zh) * | 2004-08-13 | 2007-08-08 | 神经能质公司 | 经取代的二芳基六氢吡基-吡啶类似物 |
| WO2009066084A1 (en) * | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
| US20090149458A1 (en) * | 2007-11-27 | 2009-06-11 | Wyeth | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS |
| US20090163489A1 (en) * | 2007-12-19 | 2009-06-25 | Shon Booker | Inhibitors of PI3 kinase |
| CN101675053A (zh) * | 2006-12-07 | 2010-03-17 | 健泰科生物技术公司 | 磷酸肌醇3-激酶抑制剂化合物及使用方法 |
| WO2010052569A2 (en) * | 2008-11-10 | 2010-05-14 | University Of Basel | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes |
| CN101711241A (zh) * | 2007-02-06 | 2010-05-19 | 诺瓦提斯公司 | Pi3-激酶抑制剂和它们的使用方法 |
| WO2010120998A1 (en) * | 2009-04-17 | 2010-10-21 | Wyeth Llc | Pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| US20100273764A1 (en) * | 2009-04-28 | 2010-10-28 | Amgen Inc. | Inhibitors of pi3 kinase and/or mtor |
| US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
| CN102625708A (zh) * | 2009-09-09 | 2012-08-01 | 阿维拉制药公司 | Pi3激酶抑制剂及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2531619A1 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| CA2590586A1 (en) * | 2004-12-13 | 2006-07-06 | Neurogen Corporation | Substituted biaryl analogues |
| DE102009015255A1 (de) * | 2009-04-01 | 2010-10-14 | GM Global Technology Operations, Inc., Detroit | Tankklappenmodul |
| WO2013033901A1 (en) * | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
-
2012
- 2012-03-08 CA CA2829558A patent/CA2829558A1/en not_active Abandoned
- 2012-03-08 CN CN201280021536.0A patent/CN103501610A/zh active Pending
- 2012-03-08 JP JP2013557866A patent/JP2014511395A/ja active Pending
- 2012-03-08 AU AU2012225382A patent/AU2012225382B2/en not_active Expired - Fee Related
- 2012-03-08 EP EP12755552.2A patent/EP2683243A4/en not_active Withdrawn
- 2012-03-08 US US13/414,918 patent/US20120258967A1/en not_active Abandoned
- 2012-03-08 WO PCT/US2012/028293 patent/WO2012122383A2/en not_active Ceased
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823057A (zh) * | 2003-07-16 | 2006-08-23 | 神经能质公司 | 二芳基哌嗪基-吡啶类似物 |
| CN101014587A (zh) * | 2004-08-13 | 2007-08-08 | 神经能质公司 | 经取代的二芳基六氢吡基-吡啶类似物 |
| CN101675053A (zh) * | 2006-12-07 | 2010-03-17 | 健泰科生物技术公司 | 磷酸肌醇3-激酶抑制剂化合物及使用方法 |
| CN101711241A (zh) * | 2007-02-06 | 2010-05-19 | 诺瓦提斯公司 | Pi3-激酶抑制剂和它们的使用方法 |
| US20100311736A1 (en) * | 2007-10-22 | 2010-12-09 | Glaxosmithkline Llc | Pyridosulfonamide derivatives as p13 kinase inhibitors |
| WO2009066084A1 (en) * | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
| US20090149458A1 (en) * | 2007-11-27 | 2009-06-11 | Wyeth | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS |
| US20090163489A1 (en) * | 2007-12-19 | 2009-06-25 | Shon Booker | Inhibitors of PI3 kinase |
| WO2010052569A2 (en) * | 2008-11-10 | 2010-05-14 | University Of Basel | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes |
| WO2010120998A1 (en) * | 2009-04-17 | 2010-10-21 | Wyeth Llc | Pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| US20100273764A1 (en) * | 2009-04-28 | 2010-10-28 | Amgen Inc. | Inhibitors of pi3 kinase and/or mtor |
| CN102625708A (zh) * | 2009-09-09 | 2012-08-01 | 阿维拉制药公司 | Pi3激酶抑制剂及其用途 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2724493C2 (ru) * | 2015-04-30 | 2020-06-23 | Цзянсу Нуо-Бета Фармасьютикал Текнолоджи Ко., Лтд. | Изобретение белка pi4kiiia и родственного мембранного белкового комплекса в лечении болезни альцгеймера |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014511395A (ja) | 2014-05-15 |
| WO2012122383A3 (en) | 2012-12-27 |
| CA2829558A1 (en) | 2012-09-13 |
| AU2012225382A1 (en) | 2013-10-10 |
| WO2012122383A2 (en) | 2012-09-13 |
| AU2012225382B2 (en) | 2016-10-27 |
| EP2683243A2 (en) | 2014-01-15 |
| US20120258967A1 (en) | 2012-10-11 |
| EP2683243A4 (en) | 2014-12-03 |
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