JP2014510185A - 高い嵩密度、良好な流動性及び改善された冷水分散性を有するセルロース誘導体の製造方法。 - Google Patents
高い嵩密度、良好な流動性及び改善された冷水分散性を有するセルロース誘導体の製造方法。 Download PDFInfo
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- JP2014510185A JP2014510185A JP2014503691A JP2014503691A JP2014510185A JP 2014510185 A JP2014510185 A JP 2014510185A JP 2014503691 A JP2014503691 A JP 2014503691A JP 2014503691 A JP2014503691 A JP 2014503691A JP 2014510185 A JP2014510185 A JP 2014510185A
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Abstract
Description
A)湿潤したセルロース誘導体の全重量に対して、25〜95%の含液率を有するセルロース誘導体を提供する工程と、
B)100℃以下のガスが供給される気流式衝撃型粉砕機(gas-swept impact mill)において湿潤したセルロース誘導体を粉砕し、部分乾燥する工程と、
C)気流式衝撃型粉砕機の外側において、前記衝撃型粉砕機に供給されるガスよりも高い温度を有する追加量の乾燥ガスに、前記粉砕及び部分乾燥したセルロース誘導体を接触させる工程と、
を含む、前記方法である。
A)湿潤したセルロース誘導体の全重量に対して、25〜95%の含液率を有するセルロース誘導体を提供する工程と、
B)100℃以下のガスが供給される気流式衝撃型粉砕機において湿潤したセルロース誘導体を粉砕し、部分乾燥する工程と、
C)気流式衝撃型粉砕機の外側において、前記衝撃型粉砕機に供給されるガスよりも高い温度を有する追加量の乾燥ガスに、前記粉砕及び部分乾燥したセルロース誘導体を接触させる工程と、
を含む、前記方法である。
セルロースエーテルの水性組成物からカプセル剤を調製するために用いられるホットピン法は、国際特許公開第2008/050209号において詳細に記載されている。
乾燥したMETHOCELTM E5 Premium LVセルロースエーテルに水を添加するために、市販の加熱及び冷却ジャケット付きの連続混合機を使用した。この混合機のジャケットには、−10℃〜−8℃の流体を供給した。前記混合機のジャケット内の流体は、乾燥及び粉砕する前の前記セルロースエーテルの温度を、約17〜24℃に適合させるために使用したが、前記混合機内の前記セルロースエーテルの水和に用いられる水が約5℃であったため、前記セルロースエーテルの温度を個々に測定すると、該セルロースエーテルの温度は、前記混合機のジャケット内の流体温度には到底及ばなかった。
Claims (15)
- 湿潤したセルロース誘導体を粉砕及び乾燥することによって、粒子状のセルロース誘導体を製造するための方法であって、該方法は、
A)湿潤したセルロース誘導体の全重量に対して、25〜95%の含液率を有するセルロース誘導体を提供する工程と、
B)100℃以下の温度のガスが供給される気流式衝撃型粉砕機において、前記湿潤したセルロース誘導体を粉砕し、部分乾燥する工程と、
C)前記気流式衝撃型粉砕機の外側において、前記衝撃型粉砕機に供給されるガスよりも高い温度を有する追加量の乾燥ガスに、前記粉砕及び部分乾燥したセルロース誘導体を接触させる工程と、
を含む、前記方法。 - 前記気流式衝撃型粉砕機の外側の追加量の乾燥ガスが、前記衝撃型粉砕機に供給されるガスよりも70℃以上高い、請求項1に記載の方法。
- 工程B)の気流式衝撃型粉砕機におけるガス流量と、工程C)の追加量の乾燥ガス流量との比が、1:10〜8:1である、請求項1又は2のいずれかに記載の方法。
- 前記気流式衝撃型粉砕機の周速が100m/s以下である、請求項1〜3のいずれか一項に記載の方法。
- 工程A)における湿潤したセルロース誘導体は、セルロース誘導体の乾燥までセルロース誘導体に残る実質的な量の表面処理添加剤を含まない、請求項1〜4のいずれか一項に記載の方法。
- 工程D)において、粉砕及び乾燥したセルロース誘導体が、125〜400μmのメッシュサイズのふるいを通してふるい掛けされ、前記ふるい上に残る前記セルロース誘導体が取り出される、請求項1〜5のいずれか一項に記載の方法。
- 前記セルロース誘導体がセルロースエーテルである、請求項1〜6のいずれか一項に記載の方法。
- 製造される粒子状のセルロース誘導体が、370g/l以上のアンタップ嵩密度、20以下のCarr指数又はこれら両方を有する、請求項1〜7のいずれか一項に記載の方法。
- 請求項1〜8のいずれか一項に記載の方法によって製造可能な粒子状のセルロース誘導体。
- 粒子状のセルロース誘導体の流動性及び/又は冷水分散性を改善するための方法であって、該方法は、
A)湿潤したセルロース誘導体の全重量に対して、25〜95%の含液率を有するセルロース誘導体を提供する工程と、
B)100℃以下の温度のガスが供給される気流式衝撃型粉砕機において、前記湿潤したセルロース誘導体を粉砕し、部分乾燥する工程と、
C)前記気流式衝撃型粉砕機の外側において、前記衝撃型粉砕機に供給されるガスよりも高い温度を有する追加量の乾燥ガスに、前記粉砕及び部分乾燥したセルロース誘導体を接触させる工程と、
を含む、前記方法。 - 370g/l以上のアンタップ嵩密度、20以下のCarr指数及び200μm以上のメジアン等価投影円直径(EQPC)を有する、粒子状のセルロース誘導体。
- 13以下のCarr指数を有する、請求項11に記載の粒子状のセルロース誘導体。
- 水と、請求項11又は12に記載の粒子状のセルロース誘導体と、1又は複数の任意の添加剤とを混合することによって製造される、水性組成物。
- 請求項13に記載の水性組成物を浸漬ピンに接触させる工程を含む、カプセル剤の製造方法。
- 請求項13に記載の水性組成物を剤形に接触させる工程を含む、剤形のコーティング方法。
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EP2694041B1 (en) | 2019-12-11 |
JP6034365B2 (ja) | 2016-11-30 |
BR112013022418A2 (pt) | 2016-12-06 |
CN105949328A (zh) | 2016-09-21 |
MX2013011688A (es) | 2013-11-04 |
KR20140015446A (ko) | 2014-02-06 |
KR101902751B1 (ko) | 2018-10-02 |
EP2694041A1 (en) | 2014-02-12 |
WO2012138533A1 (en) | 2012-10-11 |
CN103561728B (zh) | 2016-08-10 |
US20140013999A1 (en) | 2014-01-16 |
CN103561728A (zh) | 2014-02-05 |
US9334416B2 (en) | 2016-05-10 |
MX344527B (es) | 2016-12-19 |
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