JP2014509593A5 - - Google Patents
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- Publication number
- JP2014509593A5 JP2014509593A5 JP2013558187A JP2013558187A JP2014509593A5 JP 2014509593 A5 JP2014509593 A5 JP 2014509593A5 JP 2013558187 A JP2013558187 A JP 2013558187A JP 2013558187 A JP2013558187 A JP 2013558187A JP 2014509593 A5 JP2014509593 A5 JP 2014509593A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- pharmaceutical composition
- erbb3
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161452976P | 2011-03-15 | 2011-03-15 | |
| US201161452974P | 2011-03-15 | 2011-03-15 | |
| US61/452,974 | 2011-03-15 | ||
| US61/452,976 | 2011-03-15 | ||
| PCT/US2012/029292 WO2012125864A2 (en) | 2011-03-15 | 2012-03-15 | Overcoming resistance to erbb pathway inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014509593A JP2014509593A (ja) | 2014-04-21 |
| JP2014509593A5 true JP2014509593A5 (https=) | 2014-06-19 |
Family
ID=45953230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558187A Withdrawn JP2014509593A (ja) | 2011-03-15 | 2012-03-15 | ＥｒｂＢ経路阻害剤に対する耐性の克服 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20150231238A1 (https=) |
| EP (2) | EP2815765A1 (https=) |
| JP (1) | JP2014509593A (https=) |
| KR (1) | KR20140023921A (https=) |
| CN (1) | CN103429262A (https=) |
| AU (1) | AU2012229062A1 (https=) |
| BR (1) | BR112013022887A2 (https=) |
| CA (1) | CA2828043A1 (https=) |
| EA (1) | EA201301025A1 (https=) |
| IL (1) | IL228393A0 (https=) |
| MX (1) | MX2013010444A (https=) |
| SG (1) | SG192775A1 (https=) |
| WO (1) | WO2012125864A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG178789A1 (en) * | 2007-02-16 | 2012-03-29 | Merrimack Pharmaceuticals Inc | Antibodies against erbb3 and uses thereof |
| CA2792327C (en) | 2010-03-11 | 2019-09-24 | Merrimack Pharmaceuticals, Inc. | Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| US9828635B2 (en) * | 2011-10-06 | 2017-11-28 | Aveo Pharmaceuticals, Inc. | Predicting tumor response to anti-ERBB3 antibodies |
| JP6180425B2 (ja) | 2011-11-23 | 2017-08-23 | メディミューン，エルエルシー | Ｈｅｒ３に特異的な結合分子及びそれらの使用 |
| WO2013110030A2 (en) * | 2012-01-19 | 2013-07-25 | Duke University | Vaccines against antigens involved in therapy resistance and methods of using same |
| US9180185B2 (en) | 2013-01-11 | 2015-11-10 | Hoffman-La Roche Inc. | Combination therapy of anti-HER3 antibodies |
| US11305012B2 (en) * | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
| WO2015048804A2 (en) * | 2013-09-30 | 2015-04-02 | Daiichi Sankyo Co., Ltd. | Protein biomarker and uses thereof |
| WO2015066543A1 (en) * | 2013-11-01 | 2015-05-07 | Board Of Regents, The University Of Texas System | Targeting her2 and her3 with bispecific antibodies in cancerous cells |
| EP3087394A2 (en) | 2013-12-27 | 2016-11-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| EP3786186A1 (en) | 2014-02-28 | 2021-03-03 | Merus N.V. | Antibodies that bind egfr and erbb3 |
| IL301147A (en) * | 2014-02-28 | 2023-05-01 | Merus Nv | An antibody that binds to ErbB-2 and ErbB-3 |
| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| MX2016014862A (es) * | 2014-05-14 | 2017-02-27 | Hoffmann La Roche | Her3 / her2 anticuerpos biespecificos que se unen a la horquilla beta de her3 y al dominio ii de her2. |
| MA39599A (fr) | 2014-05-14 | 2016-10-05 | Merrimack Pharmaceuticals Inc | Dosage et administration d'agents thérapeutiques anti-egfr |
| EP3166630A4 (en) | 2014-07-07 | 2018-03-28 | Duke University | Vaccines against an oncogenic isoform of esr1 and methods of using the same |
| US20170196953A1 (en) | 2014-07-07 | 2017-07-13 | Duke University | VACCINES AGAINST AN ONCOGENIC ISOFORM OF HER2 (ErbB2) AND METHODS OF USING THE SAME |
| AU2015313811A1 (en) | 2014-09-08 | 2017-04-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (TKI) |
| CA2959716A1 (en) | 2014-09-08 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Anti-her3 antibodies and uses of same |
| CA2983008A1 (en) * | 2015-04-17 | 2016-10-20 | Merrimack Pharmaceuticals, Inc. | Combination treatments with seribantumab |
| WO2016179103A1 (en) | 2015-05-01 | 2016-11-10 | National Taiwan University | Pink1 c-terminal domain polypeptide and methods using the same in cancer treatment |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| WO2017035482A1 (en) * | 2015-08-27 | 2017-03-02 | Merrimack Pharmaceuticals, Inc | Combination therapies for treatment of heregulin positive cancers |
| CA3002957A1 (en) | 2015-10-23 | 2017-04-27 | Koninklijke Nederlandse Akademie Van Wetenschappen | Binding molecules that inhibit cancer growth |
| EP3176183A1 (en) | 2015-12-02 | 2017-06-07 | Yeda Research and Development Co. Ltd | Compositions and methods for treating cancer not resistant to a tyrosine kinase inhibitor (tki) |
| WO2017120576A1 (en) | 2016-01-07 | 2017-07-13 | Duke University | Cancer vaccines and methods of delivery |
| US10487143B2 (en) | 2016-10-05 | 2019-11-26 | Duke University | Vaccines against HER3 antigens and methods of using the same |
| US11224665B2 (en) | 2016-10-05 | 2022-01-18 | Duke University | Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same |
| AU2018246873B2 (en) | 2017-03-31 | 2021-05-06 | Merus B.V. | ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment f cells that have an NRG1 fusion gene |
| WO2018212656A1 (en) | 2017-05-17 | 2018-11-22 | Merus N.V. | Combination of an erbb-2/erbb-3 bispecific antibody with endocrine therapy for breast cancer |
| CN118580366A (zh) | 2017-08-09 | 2024-09-03 | 美勒斯公司 | 结合EGFR和cMET的抗体 |
| WO2019088348A1 (ko) * | 2017-11-06 | 2019-05-09 | 한국과학기술원 | Egfr 저해제 저항성 암 치료제 |
| WO2021080428A1 (en) * | 2019-10-24 | 2021-04-29 | Merus N.V. | Means and methods for treating subjects with her2 and her3 positive cancer |
| EP4434548A1 (en) | 2021-11-15 | 2024-09-25 | Systimmune, Inc. | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
| AR127893A1 (es) * | 2021-12-10 | 2024-03-06 | Servier Lab | Terapia del cáncer dirigida a egfr |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
| US7390632B2 (en) | 1999-09-30 | 2008-06-24 | Tumor Biology Investment Group, Inc. | Soluble ErbB3 receptor isoforms |
| US7612042B2 (en) | 2001-05-31 | 2009-11-03 | Tumor Biology Investment Group, Inc. | Methods for inhibiting heregulin and treating cancer |
| EP1283053A1 (en) | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
| EP2400021B1 (en) | 2002-03-26 | 2016-11-30 | Zensun (Shanghai) Science & Technology, Co., Ltd. | ErbB3 based methods and compositions for treating neoplasms |
| US7332580B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The University Of California | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| AR056857A1 (es) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
| SG178789A1 (en) | 2007-02-16 | 2012-03-29 | Merrimack Pharmaceuticals Inc | Antibodies against erbb3 and uses thereof |
| CN101675075B (zh) | 2007-03-01 | 2014-06-18 | 西福根有限公司 | 重组抗表皮生长因子受体抗体组合物 |
| NZ581201A (en) | 2007-05-11 | 2012-05-25 | Enzon Pharmaceuticals Inc | Rna antagonist compounds for the modulation of her3 |
| CA2721093A1 (en) * | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| CN102282168A (zh) * | 2008-11-18 | 2011-12-14 | 梅里麦克制药股份有限公司 | 人血清白蛋白接头以及其结合物 |
| CN104447995A (zh) | 2009-03-20 | 2015-03-25 | 霍夫曼-拉罗奇有限公司 | 双特异性抗-her抗体 |
| AU2010242914B2 (en) | 2009-04-29 | 2014-11-13 | Trellis Bioscience, Llc | Improved antibodies immunoreactive with heregulin-coupled HER3 |
| MA33892B1 (fr) | 2009-12-22 | 2013-01-02 | Roche Glycart Ag | Anticorps anti-her3, et leurs utilisations |
| CN102884085B (zh) | 2010-04-09 | 2016-08-03 | Aveo制药公司 | 抗erbb3抗体 |
| JP6033783B2 (ja) * | 2010-11-01 | 2016-11-30 | シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ | Ｐａｎ−ｈｅｒ抗体組成物 |
| EP2678359A4 (en) * | 2011-02-24 | 2015-01-28 | Merrimack Pharmaceuticals Inc | COMBINATION THERAPIES WITH ANTI-ERBB3 MEDIUM |
-
2012
- 2012-03-15 SG SG2013061791A patent/SG192775A1/en unknown
- 2012-03-15 EA EA201301025A patent/EA201301025A1/ru unknown
- 2012-03-15 AU AU2012229062A patent/AU2012229062A1/en not_active Abandoned
- 2012-03-15 US US14/004,848 patent/US20150231238A1/en not_active Abandoned
- 2012-03-15 JP JP2013558187A patent/JP2014509593A/ja not_active Withdrawn
- 2012-03-15 CA CA2828043A patent/CA2828043A1/en not_active Abandoned
- 2012-03-15 CN CN201280011820XA patent/CN103429262A/zh active Pending
- 2012-03-15 KR KR1020137026522A patent/KR20140023921A/ko not_active Withdrawn
- 2012-03-15 EP EP14166702.2A patent/EP2815765A1/en not_active Withdrawn
- 2012-03-15 WO PCT/US2012/029292 patent/WO2012125864A2/en not_active Ceased
- 2012-03-15 EP EP12714108.3A patent/EP2686015A2/en not_active Withdrawn
- 2012-03-15 MX MX2013010444A patent/MX2013010444A/es unknown
- 2012-03-15 BR BR112013022887A patent/BR112013022887A2/pt not_active IP Right Cessation
-
2013
- 2013-09-12 IL IL228393A patent/IL228393A0/en unknown
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