JP2014509298A5 - - Google Patents
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- Publication number
- JP2014509298A5 JP2014509298A5 JP2013539024A JP2013539024A JP2014509298A5 JP 2014509298 A5 JP2014509298 A5 JP 2014509298A5 JP 2013539024 A JP2013539024 A JP 2013539024A JP 2013539024 A JP2013539024 A JP 2013539024A JP 2014509298 A5 JP2014509298 A5 JP 2014509298A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- methyl
- substituted
- pyrazino
- ylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC(C)/*=C(\CC(CN(*)C(*)C1[N+](*)*C2)N1C2=O)/C(C)/*=C/C(O*)=C Chemical compound CCC(C)/*=C(\CC(CN(*)C(*)C1[N+](*)*C2)N1C2=O)/C(C)/*=C/C(O*)=C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446801P | 2011-02-25 | 2011-02-25 | |
| US61/446,801 | 2011-02-25 | ||
| PCT/JP2012/055489 WO2012115286A1 (en) | 2011-02-25 | 2012-02-27 | Alpha helix mimetics and methods relating thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014509298A JP2014509298A (ja) | 2014-04-17 |
| JP2014509298A5 true JP2014509298A5 (https=) | 2015-05-07 |
Family
ID=45878996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539024A Pending JP2014509298A (ja) | 2011-02-25 | 2012-02-27 | アルファへリックスミメティック及びその関連の方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140051706A1 (https=) |
| EP (1) | EP2678341A1 (https=) |
| JP (1) | JP2014509298A (https=) |
| CN (1) | CN103517904A (https=) |
| WO (1) | WO2012115286A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102168006B1 (ko) * | 2010-10-07 | 2020-10-20 | 유니버시티 오브 써던 캘리포니아 | 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 ｃｂｐ/카테닌 길항제 |
| CA2817975C (en) * | 2010-11-16 | 2020-03-31 | Michael Kahn | Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells |
| WO2013052162A1 (en) | 2011-10-07 | 2013-04-11 | University Of Southern California | Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells |
| WO2014061828A1 (en) * | 2012-10-19 | 2014-04-24 | Hiroyuki Kouji | Treatment of scleroderma using an inhibitor of cbp/catenin |
| WO2014061826A1 (en) * | 2012-10-19 | 2014-04-24 | Hiroyuki Kouji | Treatment of hyperproliferative and pre-cancerous skin diseases using an inhibitor of cbp/catenin |
| JP6303112B2 (ja) * | 2012-12-12 | 2018-04-04 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | 肝線維症の予防または治療剤 |
| CN105899211A (zh) * | 2013-10-18 | 2016-08-24 | 小路弘行 | 使用cbp/连环蛋白的抑制剂治疗肝纤维化 |
| US9174998B2 (en) * | 2013-12-25 | 2015-11-03 | Eisai R&D Management Co., Ltd. | (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-8-({6-[3-(piperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide compound |
| MX373231B (es) * | 2015-06-16 | 2020-05-08 | Eisai R&D Man Co Ltd | Agente anticancerigeno. |
| CA2986999C (en) | 2015-06-23 | 2023-08-08 | Eisai R&D Management Co., Ltd. | Crystal of (6s,9as)-n-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2h-pyrazino[2,1-c][1,2,4]triazine-1(6h)-carboxamide |
| CN105061315B (zh) * | 2015-08-06 | 2017-10-24 | 大连理工大学 | 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用 |
| WO2017047762A1 (ja) * | 2015-09-18 | 2017-03-23 | 国立大学法人鳥取大学 | 低分子化合物による癌と線維化の抑制と再生促進の効果 |
| US12303505B2 (en) | 2017-02-08 | 2025-05-20 | Eisai R&D Management Co., Ltd. | Tumor-treating pharmaceutical composition |
| RU2019134940A (ru) | 2017-05-16 | 2021-06-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Лечение гепатоцеллюлярной карциномы |
| EP4051278B1 (en) | 2019-10-29 | 2025-12-17 | Eisai R&D Management Co., Ltd. | Combination of a pd-1 antagonist, a vegfr/fgfr/ret tyrosine kinase inhibitor and a cbp/beta-catenin inhibitor for treating cancer |
| US12486275B2 (en) | 2020-03-12 | 2025-12-02 | City Of Hope | Substituted pyrazino[2,1-c][1,2,4]triazines as Wnt/CBP/catenin signaling pathway inhibitors |
| AR121544A1 (es) | 2020-03-12 | 2022-06-15 | 3 2 Pharma | Inhibidores de la vía de señalización por cbp / catenina y sus usos |
| JP7689761B2 (ja) * | 2020-07-16 | 2025-06-09 | 株式会社 PRISM BioLab | 新規ヘテロ環化合物 |
| CN116925081A (zh) * | 2022-04-11 | 2023-10-24 | 中国科学院上海药物研究所 | 一种环肽类化合物及其应用 |
| EP4518866A1 (en) * | 2022-05-04 | 2025-03-12 | Athira Pharma, Inc. | Methods of treating fibrosis |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| WO1992013878A2 (en) | 1991-02-07 | 1992-08-20 | Board Of Trustees Of The University Of Illinois | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| CA2141447A1 (en) | 1992-08-06 | 1994-02-17 | Michael Kahn | Conformationally restricted mimetics of reverse turns and peptides containing the same |
| US6184223B1 (en) | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6013458A (en) | 1995-10-27 | 2000-01-11 | Molecumetics, Ltd. | Reverse-turn mimetics and methods relating thereto |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6117445A (en) * | 1998-01-28 | 2000-09-12 | Link Technology Inc. | Methods for the prevention and treatment of fibrosis and sclerosis |
| US6410245B1 (en) | 1998-04-01 | 2002-06-25 | Affymax, Inc. | Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions |
| US6294525B1 (en) | 1999-09-01 | 2001-09-25 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| DE20119322U1 (de) | 2000-11-21 | 2002-02-21 | Schering Ag, 13353 Berlin | Röhrenförmige Gefäßimplantate (Stents) |
| EP1444235B1 (en) * | 2001-10-12 | 2008-06-11 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7671054B1 (en) * | 2001-10-12 | 2010-03-02 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7576084B2 (en) * | 2001-10-12 | 2009-08-18 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| US7097850B2 (en) | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
| AU2003284120A1 (en) * | 2002-10-17 | 2004-05-04 | Myriad Genetics, Inc. | Reverse-turn mimetics and composition and methods relating thereto |
| CA2537099A1 (en) * | 2003-08-28 | 2005-03-10 | Choongwae Pharma Corporation | Modulation of .beta.-catenin/tcf activated transcription |
| EP1804838A2 (en) * | 2004-09-15 | 2007-07-11 | Drug Discovery Laboratory AS | Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs |
| WO2007056593A2 (en) | 2005-11-08 | 2007-05-18 | Choongwae Pharma Corporation | α-HELIX MIMETICS AND METHOD RELATING TO THE TREATMENT OF CANCER STEM CELLS |
| US20080009500A1 (en) | 2005-11-08 | 2008-01-10 | Michael Kahn | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders |
| JP5530427B2 (ja) * | 2008-06-06 | 2014-06-25 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | アルファへリックスミメティック及び関連の方法 |
| CN102186853A (zh) | 2008-10-14 | 2011-09-14 | 株式会社棱镜生物实验室 | 治疗癌症α-螺旋模拟物 |
| EP2408300B1 (en) * | 2009-03-21 | 2016-05-11 | Sunshine Lake Pharma Co., Ltd. | Amino ester derivatives, salts thereof and methods of use |
| CA2758904C (en) * | 2009-04-15 | 2017-04-04 | Jw Pharmaceutical Corporation | Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof |
| EP2427451B1 (en) | 2009-05-07 | 2019-03-20 | PRISM BioLab Co., Ltd. | Alpha helix mimetics and methods relating thereto |
-
2012
- 2012-02-27 WO PCT/JP2012/055489 patent/WO2012115286A1/en not_active Ceased
- 2012-02-27 CN CN201280010189.1A patent/CN103517904A/zh active Pending
- 2012-02-27 EP EP12710567.4A patent/EP2678341A1/en not_active Withdrawn
- 2012-02-27 US US14/001,470 patent/US20140051706A1/en not_active Abandoned
- 2012-02-27 JP JP2013539024A patent/JP2014509298A/ja active Pending
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