CN103517904A - α-螺旋模拟物和与其相关的方法 - Google Patents

α-螺旋模拟物和与其相关的方法 Download PDF

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Publication number
CN103517904A
CN103517904A CN201280010189.1A CN201280010189A CN103517904A CN 103517904 A CN103517904 A CN 103517904A CN 201280010189 A CN201280010189 A CN 201280010189A CN 103517904 A CN103517904 A CN 103517904A
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optionally
substituted
optionally substituted
methyl
ylmethyl
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CN201280010189.1A
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Chinese (zh)
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小路弘行
小田上刚直
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PRISM BioLab Corp
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PRISM BioLab Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201280010189.1A 2011-02-25 2012-02-27 α-螺旋模拟物和与其相关的方法 Pending CN103517904A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161446801P 2011-02-25 2011-02-25
US61/446801 2011-02-25
PCT/JP2012/055489 WO2012115286A1 (en) 2011-02-25 2012-02-27 Alpha helix mimetics and methods relating thereto

Publications (1)

Publication Number Publication Date
CN103517904A true CN103517904A (zh) 2014-01-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280010189.1A Pending CN103517904A (zh) 2011-02-25 2012-02-27 α-螺旋模拟物和与其相关的方法

Country Status (5)

Country Link
US (1) US20140051706A1 (https=)
EP (1) EP2678341A1 (https=)
JP (1) JP2014509298A (https=)
CN (1) CN103517904A (https=)
WO (1) WO2012115286A1 (https=)

Cited By (3)

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CN105061315A (zh) * 2015-08-06 2015-11-18 大连理工大学 一类1,5-二苯基吡唑-3-羧酸类化合物及其应用
CN108026104A (zh) * 2015-09-18 2018-05-11 国立大学法人鸟取大学 利用低分子化合物的癌及纤维化的抑制和再生促进的效果
WO2023198076A1 (zh) * 2022-04-11 2023-10-19 中国科学院上海药物研究所 一种环肽类化合物及其应用

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KR102168006B1 (ko) * 2010-10-07 2020-10-20 유니버시티 오브 써던 캘리포니아 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 ｃｂｐ/카테닌 길항제
CA2817975C (en) * 2010-11-16 2020-03-31 Michael Kahn Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells
WO2013052162A1 (en) 2011-10-07 2013-04-11 University Of Southern California Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells
WO2014061828A1 (en) * 2012-10-19 2014-04-24 Hiroyuki Kouji Treatment of scleroderma using an inhibitor of cbp/catenin
WO2014061826A1 (en) * 2012-10-19 2014-04-24 Hiroyuki Kouji Treatment of hyperproliferative and pre-cancerous skin diseases using an inhibitor of cbp/catenin
JP6303112B2 (ja) * 2012-12-12 2018-04-04 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 肝線維症の予防または治療剤
CN105899211A (zh) * 2013-10-18 2016-08-24 小路弘行 使用cbp/连环蛋白的抑制剂治疗肝纤维化
US9174998B2 (en) * 2013-12-25 2015-11-03 Eisai R&D Management Co., Ltd. (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-8-({6-[3-(piperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide compound
MX373231B (es) * 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
CA2986999C (en) 2015-06-23 2023-08-08 Eisai R&D Management Co., Ltd. Crystal of (6s,9as)-n-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxo-2-(prop-2-en-1-yl)hexahydro-2h-pyrazino[2,1-c][1,2,4]triazine-1(6h)-carboxamide
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
EP4051278B1 (en) 2019-10-29 2025-12-17 Eisai R&D Management Co., Ltd. Combination of a pd-1 antagonist, a vegfr/fgfr/ret tyrosine kinase inhibitor and a cbp/beta-catenin inhibitor for treating cancer
US12486275B2 (en) 2020-03-12 2025-12-02 City Of Hope Substituted pyrazino[2,1-c][1,2,4]triazines as Wnt/CBP/catenin signaling pathway inhibitors
AR121544A1 (es) 2020-03-12 2022-06-15 3 2 Pharma Inhibidores de la vía de señalización por cbp / catenina y sus usos
JP7689761B2 (ja) * 2020-07-16 2025-06-09 株式会社 PRISM BioLab 新規ヘテロ環化合物
EP4518866A1 (en) * 2022-05-04 2025-03-12 Athira Pharma, Inc. Methods of treating fibrosis

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CN1585770A (zh) * 2001-10-12 2005-02-23 中外药品株式会社 回折模拟物及其相关的方法
US20050250780A1 (en) * 2002-10-17 2005-11-10 Myriad Genetics, Incorporated Reverse-turn mimetics and compositions and methods relating thereto
WO2005116032A2 (en) * 2004-04-16 2005-12-08 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
WO2009051397A2 (en) * 2007-10-15 2009-04-23 Choongwae Pharma Corporation Novel compounds of reverse turn mimetics and the use thereof (3)
WO2009148192A1 (en) * 2008-06-06 2009-12-10 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
US20100267672A1 (en) * 2009-04-15 2010-10-21 Choongwae Pharma Corporation Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof

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EP2408300B1 (en) * 2009-03-21 2016-05-11 Sunshine Lake Pharma Co., Ltd. Amino ester derivatives, salts thereof and methods of use
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CN1585770A (zh) * 2001-10-12 2005-02-23 中外药品株式会社 回折模拟物及其相关的方法
US20050250780A1 (en) * 2002-10-17 2005-11-10 Myriad Genetics, Incorporated Reverse-turn mimetics and compositions and methods relating thereto
WO2005116032A2 (en) * 2004-04-16 2005-12-08 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
WO2009051397A2 (en) * 2007-10-15 2009-04-23 Choongwae Pharma Corporation Novel compounds of reverse turn mimetics and the use thereof (3)
WO2009148192A1 (en) * 2008-06-06 2009-12-10 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
US20100267672A1 (en) * 2009-04-15 2010-10-21 Choongwae Pharma Corporation Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105061315A (zh) * 2015-08-06 2015-11-18 大连理工大学 一类1,5-二苯基吡唑-3-羧酸类化合物及其应用
CN105061315B (zh) * 2015-08-06 2017-10-24 大连理工大学 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用
CN108026104A (zh) * 2015-09-18 2018-05-11 国立大学法人鸟取大学 利用低分子化合物的癌及纤维化的抑制和再生促进的效果
CN108026104B (zh) * 2015-09-18 2021-06-18 国立大学法人鸟取大学 利用低分子化合物的癌及纤维化的抑制和再生促进的效果
WO2023198076A1 (zh) * 2022-04-11 2023-10-19 中国科学院上海药物研究所 一种环肽类化合物及其应用

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EP2678341A1 (en) 2014-01-01
WO2012115286A1 (en) 2012-08-30
JP2014509298A (ja) 2014-04-17
US20140051706A1 (en) 2014-02-20

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Application publication date: 20140115