JP2014506565A - ダイニンのキナゾリノン阻害剤 - Google Patents

ダイニンのキナゾリノン阻害剤 Download PDF

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Publication number
JP2014506565A
JP2014506565A JP2013550547A JP2013550547A JP2014506565A JP 2014506565 A JP2014506565 A JP 2014506565A JP 2013550547 A JP2013550547 A JP 2013550547A JP 2013550547 A JP2013550547 A JP 2013550547A JP 2014506565 A JP2014506565 A JP 2014506565A
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group
alkyl
compound according
formula
hydrogen atom
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JP2013550547A
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Japanese (ja)
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JP2014506565A5 (enExample
Inventor
ジェームズ ケー． チェン
タルン エム． カプーア
アリ ジェー． ファイアストン
ジョシュア エス． ワインガー
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Leland Stanford Junior University
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Leland Stanford Junior University
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Publication of JP2014506565A publication Critical patent/JP2014506565A/ja
Publication of JP2014506565A5 publication Critical patent/JP2014506565A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013550547A 2011-01-20 2012-01-18 ダイニンのキナゾリノン阻害剤 Pending JP2014506565A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161434545P 2011-01-20 2011-01-20
US61/434,545 2011-01-20
PCT/US2012/021639 WO2012099916A1 (en) 2011-01-20 2012-01-18 Quinazolinone inhibitors of dynein

Publications (2)

Publication Number Publication Date
JP2014506565A true JP2014506565A (ja) 2014-03-17
JP2014506565A5 JP2014506565A5 (enExample) 2015-03-12

Family

ID=45774309

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013550547A Pending JP2014506565A (ja) 2011-01-20 2012-01-18 ダイニンのキナゾリノン阻害剤

Country Status (7)

Country Link
US (1) US9145376B2 (enExample)
EP (1) EP2665712A1 (enExample)
JP (1) JP2014506565A (enExample)
AU (1) AU2012207393A1 (enExample)
CA (1) CA2824925A1 (enExample)
IL (1) IL227490A0 (enExample)
WO (1) WO2012099916A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019531263A (ja) * 2016-09-01 2019-10-31 アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ ２，４−ジクロロ−ａ−（３，４−ジヒドロ−４−オキソ−２（１Ｈ）−キナゾリニリデン）−β−オキソ−ベンゼンプロパンニトリルを含むメラニン増進用組成物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015221969A1 (de) * 2015-11-09 2017-05-11 Technische Universität Dresden Verfahren zur automatisierten Detektion einer Aktivität von Wirkstoffen in einer Lösung
US11192893B2 (en) 2017-05-18 2021-12-07 The Rockefeller University Pyrazoloquinazolinone antitumor agents

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0995485A (ja) * 1995-03-16 1997-04-08 Takeda Chem Ind Ltd 複素環化合物、その製造法および剤
WO2003074497A1 (en) * 2002-03-01 2003-09-12 Pintex Pharmaceutical, Inc. Pin1-modulating compounds and methods of use thereof
US20050080138A1 (en) * 1999-09-16 2005-04-14 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
JP2006512315A (ja) * 2002-11-04 2006-04-13 エヌピーエス ファーマスーティカルズ インコーポレイテッド カルシリティックとしてのキナゾリノン化合物
WO2007124171A2 (en) * 2006-04-20 2007-11-01 Massachusetts Institute Of Technology Compositions and methods for treating trinucleotide repeat disorders
WO2008015265A1 (de) * 2006-08-04 2008-02-07 Æterna Zentaris Gmbh Anthracen-derivate und deren verwendung zur behandlung gutartiger und bösartiger tumorerkrankungen
WO2009102864A1 (en) * 2008-02-12 2009-08-20 Stanford University Hedgehog pathway antagonists and methods of use
WO2010077680A2 (en) * 2008-12-08 2010-07-08 Vm Discovery Inc. Compositions of protein receptor tyrosine kinase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2177189B1 (en) 2003-02-12 2015-11-04 The Procter and Gamble Company Absorbent core for an absorbent article
US8686102B2 (en) 2007-11-02 2014-04-01 Momentive Performance Materials Inc. Textiles treated with copolymers of epoxy compounds and amino silanes having enhanced wet-strength
US20090118421A1 (en) 2007-11-02 2009-05-07 Momentive Performance Materials Inc. Copolymer of epoxy compounds and amino silanes

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0995485A (ja) * 1995-03-16 1997-04-08 Takeda Chem Ind Ltd 複素環化合物、その製造法および剤
US20050080138A1 (en) * 1999-09-16 2005-04-14 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
WO2003074497A1 (en) * 2002-03-01 2003-09-12 Pintex Pharmaceutical, Inc. Pin1-modulating compounds and methods of use thereof
JP2006512315A (ja) * 2002-11-04 2006-04-13 エヌピーエス ファーマスーティカルズ インコーポレイテッド カルシリティックとしてのキナゾリノン化合物
WO2007124171A2 (en) * 2006-04-20 2007-11-01 Massachusetts Institute Of Technology Compositions and methods for treating trinucleotide repeat disorders
WO2008015265A1 (de) * 2006-08-04 2008-02-07 Æterna Zentaris Gmbh Anthracen-derivate und deren verwendung zur behandlung gutartiger und bösartiger tumorerkrankungen
WO2009102864A1 (en) * 2008-02-12 2009-08-20 Stanford University Hedgehog pathway antagonists and methods of use
WO2010077680A2 (en) * 2008-12-08 2010-07-08 Vm Discovery Inc. Compositions of protein receptor tyrosine kinase inhibitors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6015036487; Ｃｈｅｍｉｓｔｒｙ　ｏｆ　Ｈｅｔｅｒｏｃｙｃｌｉｃ　Ｃｏｍｐｏｕｎｄｓ ４４（４）, 2008, ｐｐ．４６１-４６５ *
JPN6015036489; Ｚｅｉｔｓｃｈｒｉｆｔ　ｆｕｒ　Ｃｈｅｍｉｅ ２７（９）, 1987, ｐｐ．３３６-３３７ *
JPN6015036490; Ｍｏｌ　Ｐｈａｒｍａｃｏｌ ７７（５）, 2010, ｐｐ．７２４-７３３ *
JPN6015036493; ＳＹＮＴＨＥＳＩＳ １６, 2004, ｐｐ．２６５９-２６６４ *
JPN6015036496; Ｓｙｎｔｈｅｔｉｃ　Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ２６（３）, 1996, ｐｐ．４７５-４８２ *
JPN6015036497; ＰＮＡＳ １０６（３３）, 2009, ｐｐ．１４１３２-１４１３７ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019531263A (ja) * 2016-09-01 2019-10-31 アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ ２，４−ジクロロ−ａ−（３，４−ジヒドロ−４−オキソ−２（１Ｈ）−キナゾリニリデン）−β−オキソ−ベンゼンプロパンニトリルを含むメラニン増進用組成物

Also Published As

Publication number Publication date
AU2012207393A1 (en) 2013-08-08
US9145376B2 (en) 2015-09-29
EP2665712A1 (en) 2013-11-27
IL227490A0 (en) 2013-09-30
CA2824925A1 (en) 2012-07-26
US20130296349A1 (en) 2013-11-07
WO2012099916A1 (en) 2012-07-26

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