JP2014506466A5 - - Google Patents
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- JP2014506466A5 JP2014506466A5 JP2013553588A JP2013553588A JP2014506466A5 JP 2014506466 A5 JP2014506466 A5 JP 2014506466A5 JP 2013553588 A JP2013553588 A JP 2013553588A JP 2013553588 A JP2013553588 A JP 2013553588A JP 2014506466 A5 JP2014506466 A5 JP 2014506466A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically modified
- polypeptide
- optionally
- dehydrogenase
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 33
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 15
- 230000000813 microbial effect Effects 0.000 claims 13
- 238000006243 chemical reaction Methods 0.000 claims 11
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 10
- 241000588724 Escherichia coli Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 230000003197 catalytic effect Effects 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 4
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 4
- 241000194035 Lactococcus lactis Species 0.000 claims 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 4
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 3
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 101710177708 Alpha-ketoglutarate semialdehyde dehydrogenase Proteins 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 244000063299 Bacillus subtilis Species 0.000 claims 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 241000588921 Enterobacteriaceae Species 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 108010055471 Phenylacetaldehyde dehydrogenase Proteins 0.000 claims 2
- 241000589776 Pseudomonas putida Species 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 2
- 241000194018 Streptococcaceae Species 0.000 claims 2
- 241000194017 Streptococcus Species 0.000 claims 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 2
- 101150014383 adhE gene Proteins 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- OGKCMUHKYFDVQB-UHFFFAOYSA-N 2-methylpropanal;2-methylpropanoic acid Chemical compound CC(C)C=O.CC(C)C(O)=O OGKCMUHKYFDVQB-UHFFFAOYSA-N 0.000 claims 1
- 102100027278 4-trimethylaminobutyraldehyde dehydrogenase Human genes 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 108010000700 Acetolactate synthase Proteins 0.000 claims 1
- 108010065763 Aminobutyraldehyde dehydrogenase Proteins 0.000 claims 1
- 101100098786 Bacillus subtilis (strain 168) tapA gene Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241001646647 Burkholderia ambifaria Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108700016168 Dihydroxy-acid dehydratases Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101001131614 Escherichia coli (strain K12) NADP/NAD-dependent aldehyde dehydrogenase PuuC Proteins 0.000 claims 1
- 101100108235 Escherichia coli (strain K12) adhP gene Proteins 0.000 claims 1
- 101100321116 Escherichia coli (strain K12) yqhD gene Proteins 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 108010000200 Ketol-acid reductoisomerase Proteins 0.000 claims 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 101100462488 Phlebiopsis gigantea p2ox gene Proteins 0.000 claims 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims 1
- 101100490769 Rattus norvegicus Aldh1a1 gene Proteins 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 241000235344 Saccharomycetaceae Species 0.000 claims 1
- 101100297542 Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) phpC gene Proteins 0.000 claims 1
- 108010084086 Succinate-Semialdehyde Dehydrogenase Proteins 0.000 claims 1
- 102000005566 Succinate-Semialdehyde Dehydrogenase Human genes 0.000 claims 1
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 claims 1
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 108010008221 formate C-acetyltransferase Proteins 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 101150111581 pflB gene Proteins 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 101150060030 poxB gene Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161441939P | 2011-02-11 | 2011-02-11 | |
| US61/441,939 | 2011-02-11 | ||
| PCT/US2012/024640 WO2012109534A2 (en) | 2011-02-11 | 2012-02-10 | Cells and methods for producing isobutyric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014506466A JP2014506466A (ja) | 2014-03-17 |
| JP2014506466A5 true JP2014506466A5 (enExample) | 2015-04-02 |
Family
ID=45722726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553588A Pending JP2014506466A (ja) | 2011-02-11 | 2012-02-10 | イソ酪酸を製造するための細胞及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140065697A1 (enExample) |
| EP (1) | EP2673355A2 (enExample) |
| JP (1) | JP2014506466A (enExample) |
| KR (1) | KR20140061303A (enExample) |
| CN (1) | CN103562375A (enExample) |
| AU (1) | AU2012214255A1 (enExample) |
| SG (1) | SG192706A1 (enExample) |
| WO (1) | WO2012109534A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013055667A2 (en) * | 2011-10-10 | 2013-04-18 | Regents Of The University Of Minnesota | Biocatalysis cells and methods |
| WO2013180810A1 (en) * | 2012-05-29 | 2013-12-05 | Regents Of The University Of Minnesota | Biosynthetic pathways, recombinant cells, and methods |
| US9701948B2 (en) * | 2012-06-18 | 2017-07-11 | The Regents Of The University Of California | Escherichia coli engineered for isobutyraldehyde production |
| US10233467B2 (en) | 2012-08-17 | 2019-03-19 | Easel Biotechnologies, Llc | Two-stage production of higher alcohols |
| CN105705650A (zh) * | 2013-08-28 | 2016-06-22 | 英威达技术有限责任公司 | 用于生物合成异丁烯酸盐的方法 |
| JP2017131111A (ja) * | 2014-06-03 | 2017-08-03 | 味の素株式会社 | Ｌ−アミノ酸の製造法 |
| WO2015191611A1 (en) * | 2014-06-09 | 2015-12-17 | The Regents Of The University Of California | Bacteria engineered for conversion of ethylene to n-butanol |
| JP7203496B2 (ja) | 2015-05-19 | 2023-01-13 | ミツビシ ケミカル ユーケー リミテッド | メタクリル酸およびその誘導体の生物学的製造方法 |
| CN105296410A (zh) * | 2015-10-27 | 2016-02-03 | 中国科学院青岛生物能源与过程研究所 | 一种利用缬氨酸途径合成丙烷的大肠杆菌及其构建方法 |
| WO2017156509A1 (en) | 2016-03-11 | 2017-09-14 | Aemetis, Inc. | α-KETOISOCAPROIC ACID AND α-ΚΕΤΟ-3-METHYLVALERIC ACID DECARBOXYLASES AND USES THEREOF |
| WO2017194696A1 (en) | 2016-05-12 | 2017-11-16 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to isobutyric acid |
| US10849938B2 (en) * | 2017-09-13 | 2020-12-01 | ZBiotics Company | Gene expression system for probiotic microorganisms |
| WO2019139981A1 (en) * | 2018-01-09 | 2019-07-18 | Lygos, Inc. | Recombinant host cells and methods for the production of isobutyric acid |
| JP2023546022A (ja) | 2020-10-08 | 2023-11-01 | ジーバイオティクス カンパニー | 腸内での繊維合成酵素の発現のための操作されたプロバイオティクス |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0031886B1 (de) * | 1979-12-20 | 1984-04-11 | Röhm Gmbh | Verfahren zur Herstellung von Isobuttersäure oder ihrer niederen Alkylester |
| US4754074A (en) | 1986-12-22 | 1988-06-28 | Amoco Corporation | Preparation of dialkyl ketones from aliphatic carboxylic acids |
| BRPI0614990A2 (pt) * | 2005-08-19 | 2011-04-26 | Univ California | células hospedeiras geneticamente modificadas e uso das mesmas para produção de compostos isoprenóides |
| KR100780324B1 (ko) * | 2006-07-28 | 2007-11-29 | 한국과학기술원 | 신규 순수 숙신산 생성 변이 미생물 및 이를 이용한 숙신산제조방법 |
| CN101679187B (zh) * | 2007-06-01 | 2013-06-05 | 赢创罗姆有限责任公司 | 用于制备甲基丙烯酸或甲基丙烯酸酯的方法 |
| WO2010017230A2 (en) * | 2008-08-04 | 2010-02-11 | The Regents Of The University Of Colorado | Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol |
| JP2012506716A (ja) * | 2008-10-28 | 2012-03-22 | ウィリアム マーシュ ライス ユニバーシティ | グリセロールを化学物質に変換するための微好気性培養 |
| WO2011142865A2 (en) * | 2010-02-12 | 2011-11-17 | Gevo, Inc. | Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids |
-
2012
- 2012-02-10 AU AU2012214255A patent/AU2012214255A1/en not_active Abandoned
- 2012-02-10 EP EP12705215.7A patent/EP2673355A2/en not_active Withdrawn
- 2012-02-10 US US13/984,502 patent/US20140065697A1/en not_active Abandoned
- 2012-02-10 WO PCT/US2012/024640 patent/WO2012109534A2/en not_active Ceased
- 2012-02-10 JP JP2013553588A patent/JP2014506466A/ja active Pending
- 2012-02-10 CN CN201280017985.8A patent/CN103562375A/zh active Pending
- 2012-02-10 KR KR1020137023666A patent/KR20140061303A/ko not_active Withdrawn
- 2012-02-10 SG SG2013060769A patent/SG192706A1/en unknown
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