JP2014505015A5 - - Google Patents
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- Publication number
- JP2014505015A5 JP2014505015A5 JP2013537131A JP2013537131A JP2014505015A5 JP 2014505015 A5 JP2014505015 A5 JP 2014505015A5 JP 2013537131 A JP2013537131 A JP 2013537131A JP 2013537131 A JP2013537131 A JP 2013537131A JP 2014505015 A5 JP2014505015 A5 JP 2014505015A5
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- therapeutic agent
- additional therapeutic
- teriflunomide
- fingolimod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- YLOCGHYTXIINAI-XKUOMLDTSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 YLOCGHYTXIINAI-XKUOMLDTSA-N 0.000 claims 1
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 1
- 108010072051 Glatiramer Acetate Proteins 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 108010005716 Interferon beta-1a Proteins 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 229930003827 cannabinoid Natural products 0.000 claims 1
- 239000003557 cannabinoid Substances 0.000 claims 1
- 229960002436 cladribine Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960000556 fingolimod Drugs 0.000 claims 1
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims 1
- 229940042385 glatiramer Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 229960004461 interferon beta-1a Drugs 0.000 claims 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
- 229960001156 mitoxantrone Drugs 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
- 229960000331 teriflunomide Drugs 0.000 claims 1
- UTNUDOFZCWSZMS-YFHOEESVSA-N teriflunomide Chemical compound C\C(O)=C(/C#N)C(=O)NC1=CC=C(C(F)(F)F)C=C1 UTNUDOFZCWSZMS-YFHOEESVSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1018519.7A GB2485169A (en) | 2010-11-03 | 2010-11-03 | (R)-flurbiprofen for use in the treatment of multiple sclerosis |
| GB1018519.7 | 2010-11-03 | ||
| PCT/EP2011/069319 WO2012059541A1 (en) | 2010-11-03 | 2011-11-03 | Novel treatment of multiple sclerosis (ms) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505015A JP2014505015A (ja) | 2014-02-27 |
| JP2014505015A5 true JP2014505015A5 (https=) | 2014-10-23 |
| JP5903438B2 JP5903438B2 (ja) | 2016-04-13 |
Family
ID=43401688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537131A Expired - Fee Related JP5903438B2 (ja) | 2010-11-03 | 2011-11-03 | 多発性硬化症（ｍｓ）の新規の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130309199A1 (https=) |
| EP (1) | EP2635271A1 (https=) |
| JP (1) | JP5903438B2 (https=) |
| KR (1) | KR101877587B1 (https=) |
| CN (1) | CN103209692A (https=) |
| BR (1) | BR112013010883A2 (https=) |
| CA (1) | CA2816911C (https=) |
| GB (1) | GB2485169A (https=) |
| RU (1) | RU2595861C2 (https=) |
| WO (1) | WO2012059541A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017080989A1 (en) | 2015-11-09 | 2017-05-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | (r)-fluriprofen for the prevention and/or treatment of diabetes |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HUE071047T2 (hu) | 2016-08-31 | 2025-07-28 | Mapi Pharma Ltd | Glatiramer-acetátot tartalmazó depórendszerek |
| CN110382052A (zh) | 2017-03-26 | 2019-10-25 | Mapi医药公司 | 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统 |
| EP3709986B1 (en) | 2017-11-14 | 2023-11-01 | Merck Sharp & Dohme LLC | Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| CN111344287B (zh) | 2017-11-14 | 2023-12-19 | 默沙东有限责任公司 | 作为吲哚胺2，3-双加氧酶(ido)抑制剂的新型取代的联芳基化合物 |
| EA035792B1 (ru) * | 2018-06-21 | 2020-08-11 | Государственное Научное Учреждение "Институт Биоорганической Химии Национальной Академии Наук Беларуси" | Лекарственное средство пролонгированного действия для лечения рассеянного склероза (варианты) |
| CN113880899B (zh) * | 2020-10-30 | 2023-06-23 | 杭州拉林智能科技有限公司 | 黄酮苷-有机胺类神经激动剂复盐化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19907895A1 (de) * | 1999-02-24 | 2000-11-16 | Paz Arzneimittelentwicklung | Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen bei Mensch und Tier, welche durch die Hemmung der Aktivierung von NF-kB therapeutisch beeinflußt werden können |
| EP1587798A4 (en) * | 2003-01-14 | 2007-06-27 | Merck & Co Inc | GEMINAL DISUBSTITUTED SODIUM DERIVATIVES AS ABETA 42 SUBSTITUTING AGENTS |
| WO2008036733A2 (en) * | 2006-09-19 | 2008-03-27 | Myriad Genetics, Inc. | Methods for treatment of vesicle transport disorders |
| US20100173960A1 (en) * | 2006-09-21 | 2010-07-08 | Antonio Cruz | The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases |
| US20090162421A1 (en) * | 2007-12-21 | 2009-06-25 | Paz Arzneimittel-Entwicklungsgesellschaft Mbh | Drugs as well as their production and use in the treatment of pain-associated neuropathies |
| MX2010006608A (es) * | 2007-12-21 | 2010-10-05 | Paz Arzneimittelentwicklung | Composiciones farmaceuticas y produccion y uso de las mismas en el tratamiento de neuropatias asociadas con el dolor. |
| RU2565066C2 (ru) * | 2010-04-21 | 2015-10-20 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Производные 1-(2-фторбифенил-4-ил)-алкилкарбоновой кислоты для лечения транстиретинового амилоидоза |
-
2010
- 2010-11-03 GB GB1018519.7A patent/GB2485169A/en not_active Withdrawn
-
2011
- 2011-11-03 WO PCT/EP2011/069319 patent/WO2012059541A1/en not_active Ceased
- 2011-11-03 BR BR112013010883A patent/BR112013010883A2/pt not_active Application Discontinuation
- 2011-11-03 CN CN2011800529378A patent/CN103209692A/zh active Pending
- 2011-11-03 KR KR1020137010891A patent/KR101877587B1/ko not_active Expired - Fee Related
- 2011-11-03 US US13/881,088 patent/US20130309199A1/en not_active Abandoned
- 2011-11-03 CA CA2816911A patent/CA2816911C/en not_active Expired - Fee Related
- 2011-11-03 EP EP11784967.9A patent/EP2635271A1/en not_active Withdrawn
- 2011-11-03 JP JP2013537131A patent/JP5903438B2/ja not_active Expired - Fee Related
- 2011-11-03 RU RU2013125470/15A patent/RU2595861C2/ru active
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