JP2014502276A - アミロイドプラーク関連症状の治療のための組成物及び方法 - Google Patents

アミロイドプラーク関連症状の治療のための組成物及び方法 Download PDF

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JP2014502276A
JP2014502276A JP2013542218A JP2013542218A JP2014502276A JP 2014502276 A JP2014502276 A JP 2014502276A JP 2013542218 A JP2013542218 A JP 2013542218A JP 2013542218 A JP2013542218 A JP 2013542218A JP 2014502276 A JP2014502276 A JP 2014502276A
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seq
antibody
amino acid
apoe
acid sequence
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Japanese (ja)
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JP2014502276A5 (cg-RX-API-DMAC7.html
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デーヴィッド ホルツマン,
ジュンス キム,
ホン チァン,
アダム エルトライ,
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Washington University in St Louis WUSTL
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
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  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2013542218A 2010-12-02 2011-12-02 アミロイドプラーク関連症状の治療のための組成物及び方法 Pending JP2014502276A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41906010P 2010-12-02 2010-12-02
US61/419,060 2010-12-02
US201161548542P 2011-10-18 2011-10-18
US61/548,542 2011-10-18
PCT/US2011/063121 WO2012075422A2 (en) 2010-12-02 2011-12-02 Compositions and methods for treating amyloid plaque associated symptoms

Publications (2)

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JP2014502276A true JP2014502276A (ja) 2014-01-30
JP2014502276A5 JP2014502276A5 (cg-RX-API-DMAC7.html) 2015-01-22

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JP2013542218A Pending JP2014502276A (ja) 2010-12-02 2011-12-02 アミロイドプラーク関連症状の治療のための組成物及び方法

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US (2) US20140037638A1 (cg-RX-API-DMAC7.html)
EP (1) EP2646053A4 (cg-RX-API-DMAC7.html)
JP (1) JP2014502276A (cg-RX-API-DMAC7.html)
KR (1) KR20140017513A (cg-RX-API-DMAC7.html)
CN (1) CN103338786A (cg-RX-API-DMAC7.html)
AU (1) AU2011336360A1 (cg-RX-API-DMAC7.html)
BR (1) BR112013013723A2 (cg-RX-API-DMAC7.html)
CA (1) CA2819679A1 (cg-RX-API-DMAC7.html)
MX (1) MX2013006116A (cg-RX-API-DMAC7.html)
NZ (1) NZ611614A (cg-RX-API-DMAC7.html)
RU (1) RU2013130002A (cg-RX-API-DMAC7.html)
SG (1) SG190952A1 (cg-RX-API-DMAC7.html)
WO (1) WO2012075422A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201303996B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020506162A (ja) * 2016-10-28 2020-02-27 ワシントン・ユニバーシティWashington University 抗apoe抗体

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2847218A4 (en) * 2012-05-08 2015-12-30 Univ Ramot APOE4 ANTIBODY FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
CA2962969C (en) 2014-09-30 2023-03-21 Washington University Tau kinetic measurements
WO2017192711A1 (en) * 2016-05-03 2017-11-09 University Of South Florida Compositions and methods of modulating abeta protein
JP7280238B2 (ja) * 2017-07-17 2023-05-23 ヤンセン バイオテツク,インコーポレーテツド フィブロネクチンiii型ドメインに対する抗原結合領域及びその使用方法
AU2020282792B2 (en) * 2019-05-28 2025-12-04 Banner Health ApoE antibodies, fusion proteins and uses thereof
EP4419552A4 (en) * 2021-10-19 2025-09-24 Bioatla Inc CONDITIONALLY ACTIVE PROTEINS FOR NEURODEGENERATIVE DISEASES
AU2023399623A1 (en) * 2022-11-30 2025-07-03 Bio-Techne Corporation Natural killer cell engagers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008502311A (ja) * 2003-11-28 2008-01-31 アストラゼネカ アーベー 抗体
JP2009531299A (ja) * 2006-02-21 2009-09-03 オクラホマ メディカル リサーチ ファウンデーション ApoE受容体へのApoEの結合のインヒビターによるアルツハイマー病の処置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2142300C (en) * 1992-10-13 2005-08-23 Allen D. Roses Methods for detecting alzheimer's disease
AU2005228764A1 (en) * 2004-03-30 2005-10-13 Renomedix Institute Inc. Remedy for prion disease and method of producing the same
CA2672581A1 (en) * 2006-12-14 2008-06-19 Forerunner Pharma Research Co., Ltd. Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same
CL2008002775A1 (es) * 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
CA2791648A1 (en) * 2010-03-01 2011-09-09 The J. David Gladstone Institutes Antibody specific for apolipoprotein and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008502311A (ja) * 2003-11-28 2008-01-31 アストラゼネカ アーベー 抗体
JP2009531299A (ja) * 2006-02-21 2009-09-03 オクラホマ メディカル リサーチ ファウンデーション ApoE受容体へのApoEの結合のインヒビターによるアルツハイマー病の処置

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020506162A (ja) * 2016-10-28 2020-02-27 ワシントン・ユニバーシティWashington University 抗apoe抗体
JP2022191397A (ja) * 2016-10-28 2022-12-27 ワシントン・ユニバーシティ 抗apoe抗体
JP7236737B2 (ja) 2016-10-28 2023-03-10 ワシントン・ユニバーシティ 抗apoe抗体

Also Published As

Publication number Publication date
NZ611614A (en) 2015-07-31
CN103338786A (zh) 2013-10-02
BR112013013723A2 (pt) 2019-09-24
WO2012075422A2 (en) 2012-06-07
US20160355581A1 (en) 2016-12-08
CA2819679A1 (en) 2012-06-07
ZA201303996B (en) 2015-10-28
EP2646053A2 (en) 2013-10-09
EP2646053A4 (en) 2014-05-28
MX2013006116A (es) 2013-10-17
AU2011336360A1 (en) 2013-07-04
KR20140017513A (ko) 2014-02-11
RU2013130002A (ru) 2015-01-10
US20140037638A1 (en) 2014-02-06
WO2012075422A3 (en) 2012-10-04
SG190952A1 (en) 2013-07-31

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