JP2014501510A5 - - Google Patents
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- JP2014501510A5 JP2014501510A5 JP2013540387A JP2013540387A JP2014501510A5 JP 2014501510 A5 JP2014501510 A5 JP 2014501510A5 JP 2013540387 A JP2013540387 A JP 2013540387A JP 2013540387 A JP2013540387 A JP 2013540387A JP 2014501510 A5 JP2014501510 A5 JP 2014501510A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid residue
- binding protein
- terminal capping
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10192711.9 | 2010-11-26 | ||
| EP10192711 | 2010-11-26 | ||
| PCT/EP2011/071084 WO2012069655A2 (en) | 2010-11-26 | 2011-11-25 | Improved n-terminal capping modules for designed ankyrin repeat proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501510A JP2014501510A (ja) | 2014-01-23 |
| JP2014501510A5 true JP2014501510A5 (US20090208454A1-20090820-C00047.png) | 2014-11-27 |
| JP6173216B2 JP6173216B2 (ja) | 2017-08-02 |
Family
ID=43858162
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540386A Active JP6105479B2 (ja) | 2010-11-26 | 2011-11-25 | 血清アルブミンに結合する設計リピートタンパク質 |
| JP2013540387A Active JP6173216B2 (ja) | 2010-11-26 | 2011-11-25 | 設計アンキリンリピートタンパク質のための改善されたキャッピングモジュール |
| JP2016211658A Pending JP2017048216A (ja) | 2010-11-26 | 2016-10-28 | 血清アルブミンに結合する設計リピートタンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540386A Active JP6105479B2 (ja) | 2010-11-26 | 2011-11-25 | 血清アルブミンに結合する設計リピートタンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016211658A Pending JP2017048216A (ja) | 2010-11-26 | 2016-10-28 | 血清アルブミンに結合する設計リピートタンパク質 |
Country Status (13)
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| KR101782790B1 (ko) * | 2010-11-26 | 2017-09-28 | 몰리큘라 파트너스 아게 | 혈청 알부민에 결합하는 설계된 반복 단백질 |
| PT2846836T (pt) | 2012-05-07 | 2019-10-29 | Allergan Inc | Método de tratamento de dmi em doentes refratários à terapia anti-vegf |
| EP2867360B1 (en) * | 2012-06-28 | 2019-05-08 | Molecular Partners AG | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| JP2015532306A (ja) * | 2012-10-15 | 2015-11-09 | チューリッヒ大学 | 癌治療のための二重特異性ｈｅｒ２リガンド |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| EP3444278A1 (en) * | 2013-02-26 | 2019-02-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| KR20150097304A (ko) | 2014-02-18 | 2015-08-26 | 삼성전자주식회사 | 항 EGFR DARPin을 포함하는 EGFR/HER2 이중 특이 항체 |
| WO2016005969A1 (en) | 2014-07-07 | 2016-01-14 | Yeda Research And Development Co. Ltd. | Method of computational protein design |
| MY179505A (en) | 2015-04-02 | 2020-11-09 | Molecular Partners Ag | Recombinant binding proteins and their use |
| CA3036301C (en) * | 2016-09-22 | 2021-04-20 | Molecular Partners Ag | Recombinant binding proteins comprising ankyrin repeat domains and their use |
| KR102634762B1 (ko) * | 2016-11-01 | 2024-02-06 | 애로우헤드 파마슈티컬스 인코포레이티드 | 알파-v 베타-6 인테그린 리간드 및 그의 용도 |
| WO2018165046A1 (en) | 2017-03-07 | 2018-09-13 | Igc Bio, Inc. | A computational pipeline for antibody modeling and design |
| US11655293B2 (en) | 2018-02-22 | 2023-05-23 | Universitat Zurich | Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT |
| EP3623382A1 (en) | 2018-09-14 | 2020-03-18 | Universität Zürich | Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct |
| WO2019180243A1 (en) | 2018-03-22 | 2019-09-26 | Charité-Universitätsmedizin Berlin | Crispr associated protein reactive t cell immunity |
| US20210253723A1 (en) | 2018-06-15 | 2021-08-19 | Universität Bern | LIGANDS TO LIGHT OR ITS RECEPTOR LTßR FOR USE IN HAEMATOLOGIC MALIGNANCIES |
| EP3864054A1 (en) | 2018-10-08 | 2021-08-18 | Universität Zürich | Her2-binding tetrameric polypeptides |
| EP3883919A1 (en) | 2018-11-21 | 2021-09-29 | Universität Zürich | Photochemically induced conjugation of radiometals to small molecules, peptides and nanoparticles in a simultaneous one-pot reaction |
| EP3677911A3 (en) | 2019-01-03 | 2020-07-29 | Universität Basel | Use of non-agonist ligands for suppression of metastasis |
| US20220088144A1 (en) | 2019-01-11 | 2022-03-24 | Universitätsspital Basel | Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery |
| WO2020207771A1 (en) | 2019-04-10 | 2020-10-15 | Universität Zürich | A method for determining the likelihood of a patient being responsive to cancer immunotherapy |
| BR112021024231A2 (pt) * | 2019-06-04 | 2022-04-26 | Molecular Partners Ag | Proteínas de ligação fap recombinantes e uso da mesma |
| US20240124535A1 (en) | 2019-06-04 | 2024-04-18 | Molecular Partners Ag | Designed ankyrin repeat domain with improved stability |
| KR20220016945A (ko) | 2019-06-04 | 2022-02-10 | 몰리큘라 파트너스 아게 | 다중특이적 단백질 |
| EP4025693A1 (en) | 2019-09-05 | 2022-07-13 | Genome Biologics UG | Inhibition of mthfd1l for use in hypertrophic heart disease and heart failure |
| WO2021116470A2 (en) | 2019-12-11 | 2021-06-17 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins and their generation and use |
| CA3161326A1 (en) | 2019-12-11 | 2021-06-17 | Molecular Partners Ag | Designed ankyrin repeat domains with altered surface residues |
| WO2021122813A1 (en) | 2019-12-16 | 2021-06-24 | Universität Basel | Angiogenesis promoting agents for prevention of metastatic cancer |
| WO2021176008A1 (en) | 2020-03-04 | 2021-09-10 | Cornell University | Agents targeting baf155 or brg1 for use in treatment of advanced prostate cancer |
| EP4132578A1 (en) | 2020-04-06 | 2023-02-15 | Universität Zürich | Artc1 ligands for cancer treatment |
| WO2021224686A1 (en) | 2020-05-06 | 2021-11-11 | Molecular Partners Ag | Novel ankyrin repeat binding proteins and their uses |
| WO2021229076A1 (en) * | 2020-05-14 | 2021-11-18 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
| TW202208408A (zh) | 2020-05-14 | 2022-03-01 | 瑞士商分子夥伴股份有限公司 | 多特異性蛋白質 |
| AU2021276332A1 (en) | 2020-05-19 | 2022-11-17 | Boehringer Ingelheim International Gmbh | Binding molecules for the treatment of cancer |
| WO2021239844A1 (en) | 2020-05-27 | 2021-12-02 | Universitätsspital Basel | Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia in prediabetes |
| WO2021239999A1 (en) | 2020-05-28 | 2021-12-02 | Universität Zürich | Il-12 pd-l1 ligand fusion protein |
| KR20230048151A (ko) | 2020-08-18 | 2023-04-10 | 유니버시타트 취리히 | Cd25 편향된 항-il-2 항체 |
| EP3957649A1 (en) * | 2020-08-18 | 2022-02-23 | Athebio AG | Improved n-terminal capping modules of ankyrin repeat domains |
| US11981710B2 (en) * | 2020-08-18 | 2024-05-14 | Athebio Ag | N-terminal capping modules of ankyrin repeat domains |
| CN114106194B (zh) * | 2020-08-31 | 2024-01-16 | 中国科学院天津工业生物技术研究所 | 一种用于治疗糖尿病和/或肥胖症的融合蛋白 |
| WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
| WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
| AU2021403658A1 (en) | 2020-12-16 | 2023-06-29 | Molecular Partners Ag | Recombinant cd3 binding proteins and their use |
| AU2021403833A1 (en) | 2020-12-16 | 2023-07-27 | Molecular Partners Ag | Novel slow-release prodrugs |
| WO2022171831A1 (en) | 2021-02-11 | 2022-08-18 | Universität Zürich | Use of markers found on lymph node metastatic samples for the prognosis of breast cancer |
| EP4043481A1 (en) | 2021-02-15 | 2022-08-17 | Affilogic | Compounds and methods for extending half life of biomolecules |
| US20240150475A1 (en) | 2021-03-09 | 2024-05-09 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| CA3211248A1 (en) | 2021-03-09 | 2022-09-15 | Nina RESCHKE | Novel darpin based cd33 engagers |
| US20240156980A1 (en) | 2021-03-09 | 2024-05-16 | Molecular Partners Ag | Protease cleavable prodrugs |
| AU2022234894A1 (en) | 2021-03-09 | 2023-10-05 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
| WO2022219185A1 (en) | 2021-04-16 | 2022-10-20 | Athebio Ag | N-terminal capping modules of ankyrin repeat domains |
| IL310615A (en) | 2021-08-05 | 2024-04-01 | Immunos Therapeutics Ag | Pharmaceutical compositions comprising HLA fusion proteins |
| KR20240045260A (ko) | 2021-08-05 | 2024-04-05 | 이뮤노스 테라퓨틱스 아게 | Hla 융합 단백질을 포함하는 복합 치료제 |
| WO2023021006A1 (en) | 2021-08-16 | 2023-02-23 | Universität Zürich | Il-1 targeting agents for treatment of pitiyriasis rubra pilaris |
| WO2023021050A1 (en) | 2021-08-17 | 2023-02-23 | Athebio Ag | Variants of ankyrin repeat domains |
| EP4137508A1 (en) | 2021-08-17 | 2023-02-22 | Athebio AG | Variants of ankyrin repeat domains |
| WO2023036849A1 (en) | 2021-09-07 | 2023-03-16 | ETH Zürich | Identifying and predicting future coronavirus variants |
| EP4163380A1 (en) | 2021-10-08 | 2023-04-12 | ETH Zurich | Device and method for manipulation of extracellular vesicles |
| WO2023110942A1 (en) | 2021-12-14 | 2023-06-22 | Charité-Universitätsmedizin Berlin | Prevention of impaired fracture healing |
| WO2023110983A1 (en) | 2021-12-14 | 2023-06-22 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| EP4260907A1 (en) | 2022-04-11 | 2023-10-18 | Universität Zürich | Agents for treatment of endometriosis and other benign gynecological neoplasms |
| WO2024002914A1 (en) | 2022-06-27 | 2024-01-04 | Charité-Universitätsmedizin Berlin | Prediction of, and composition to improve, tendon healing |
| WO2024028278A1 (en) | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | Charge modified designed repeat domains and their use |
| WO2024037743A1 (en) | 2022-08-16 | 2024-02-22 | Athebio Ag | Variants of ankyrin repeat domains |
| WO2023194628A2 (en) | 2022-08-16 | 2023-10-12 | Athebio Ag | Variants of ankyrin repeat domains |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
Family Cites Families (38)
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| JP3771253B2 (ja) | 1988-09-02 | 2006-04-26 | ダイアックス コープ． | 新規な結合タンパク質の生成と選択 |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| ATE321849T1 (de) | 1997-04-23 | 2006-04-15 | Univ Zuerich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| IL143238A0 (en) | 1998-12-02 | 2002-04-21 | Phylos Inc | Dna-protein fusions and uses thereof |
| WO2001045746A2 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20060228364A1 (en) | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| AU2002218166A1 (en) | 2000-09-08 | 2002-03-22 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
| RU2299208C2 (ru) * | 2001-05-08 | 2007-05-20 | Шеринг Акциенгезельшафт | Антраниламидпиридинамиды избирательного действия в качестве ингибиторов vegfr-2 и vegfr-3 |
| JP2006512895A (ja) | 2002-06-28 | 2006-04-20 | ドマンティス リミテッド | リガンド |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| ES2655912T3 (es) | 2002-11-08 | 2018-02-22 | Ablynx N.V. | Anticuerpos de dominio simple dirigidos contra factor de necrosis tumoral-alfa y usos para los mismos |
| EP2390268B1 (en) | 2002-11-08 | 2017-11-01 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1732613A2 (en) | 2004-04-06 | 2006-12-20 | Affibody AB | Use of serum albumin binding peptides conjugates for the preparation of a medicament |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| MX363423B (es) | 2005-05-18 | 2019-03-22 | Ablynx Nv | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
| DK1902131T3 (da) | 2005-07-08 | 2010-03-01 | Univ Zuerich | Fag-display under anvendelse af cotranslational translokation af fusionspolypeptider |
| SI2402754T2 (sl) | 2006-03-06 | 2023-09-29 | Amunix Operating Inc. | Nestrukturirani rekombinantni polimeri in njihove uporabe |
| WO2008028977A2 (en) | 2006-09-08 | 2008-03-13 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| EP2086998B1 (en) | 2006-10-11 | 2011-12-07 | Ablynx N.V. | Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the ph, compounds comprising the same, and use thereof |
| US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
| EP2111228B1 (en) | 2007-02-02 | 2011-07-20 | Bristol-Myers Squibb Company | 10Fn3 domain for use in treating diseases associated with inappropriate angiogenesis |
| DE602008005596D1 (de) | 2007-06-21 | 2011-04-28 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
| CN101765608B (zh) | 2007-07-31 | 2015-03-11 | 阿菲博迪公司 | 新白蛋白结合组合物、方法及应用 |
| EP2198022B1 (en) | 2007-09-24 | 2024-03-06 | University Of Zurich | Designed armadillo repeat proteins |
| EP2263088A2 (en) * | 2008-03-19 | 2010-12-22 | Institut Pasteur | Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use |
| EP2358746B1 (en) | 2008-11-03 | 2020-09-16 | Molecular Partners AG | Binding proteins inhibiting the vegf-a receptor interaction |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| US9154968B2 (en) * | 2010-11-03 | 2015-10-06 | Telefonaktiebolaget L M Ericsson (Publ) | Radio base station and a method therein |
| KR101782790B1 (ko) * | 2010-11-26 | 2017-09-28 | 몰리큘라 파트너스 아게 | 혈청 알부민에 결합하는 설계된 반복 단백질 |
| EA201391607A1 (ru) | 2011-04-29 | 2014-04-30 | Янссен Байотек, Инк. | Связывающие il4/il13 белки с повторами и их применение |
| EP2867360B1 (en) | 2012-06-28 | 2019-05-08 | Molecular Partners AG | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
| EP2738180A1 (en) * | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| MY179505A (en) * | 2015-04-02 | 2020-11-09 | Molecular Partners Ag | Recombinant binding proteins and their use |
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2011
- 2011-11-25 KR KR1020137014067A patent/KR101782790B1/ko active IP Right Grant
- 2011-11-25 RU RU2013128895A patent/RU2636552C2/ru active
- 2011-11-25 CA CA2818990A patent/CA2818990C/en active Active
- 2011-11-25 EP EP11788152.4A patent/EP2643348A2/en active Pending
- 2011-11-25 JP JP2013540386A patent/JP6105479B2/ja active Active
- 2011-11-25 AU AU2011333666A patent/AU2011333666B2/en active Active
- 2011-11-25 CA CA2818969A patent/CA2818969C/en active Active
- 2011-11-25 AU AU2011333665A patent/AU2011333665B2/en active Active
- 2011-11-25 BR BR112013013043A patent/BR112013013043A2/pt not_active Application Discontinuation
- 2011-11-25 RU RU2013128896A patent/RU2625882C2/ru active
- 2011-11-25 JP JP2013540387A patent/JP6173216B2/ja active Active
- 2011-11-25 CN CN201180066084.3A patent/CN103403024B/zh active Active
- 2011-11-25 EP EP11788815.6A patent/EP2643349B1/en active Active
- 2011-11-25 DK DK11788815T patent/DK2643349T3/da active
- 2011-11-25 WO PCT/EP2011/071084 patent/WO2012069655A2/en active Application Filing
- 2011-11-25 ES ES11788815T patent/ES2758352T3/es active Active
- 2011-11-25 BR BR122020011428-2A patent/BR122020011428B1/pt active IP Right Grant
- 2011-11-25 EP EP19160342.2A patent/EP3514169B1/en active Active
- 2011-11-25 US US13/989,181 patent/US9221892B2/en active Active
- 2011-11-25 KR KR1020177010815A patent/KR101838037B1/ko active IP Right Grant
- 2011-11-25 PL PL11788815T patent/PL2643349T3/pl unknown
- 2011-11-25 CN CN201180066086.2A patent/CN103459415B/zh active Active
- 2011-11-25 WO PCT/EP2011/071083 patent/WO2012069654A1/en active Application Filing
- 2011-11-25 US US13/989,174 patent/US9284361B2/en active Active
- 2011-11-25 CN CN202110301133.2A patent/CN113278077A/zh active Pending
- 2011-11-25 BR BR112013012786-4A patent/BR112013012786B1/pt active IP Right Grant
- 2011-11-25 KR KR1020137014339A patent/KR20140032356A/ko active Application Filing
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2015
- 2015-11-20 US US14/947,148 patent/US9717802B2/en active Active
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2016
- 2016-02-02 US US15/013,092 patent/US9775912B2/en active Active
- 2016-10-28 JP JP2016211658A patent/JP2017048216A/ja active Pending
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2017
- 2017-06-23 US US15/631,028 patent/US10322190B2/en active Active
