JP2014501246A5 - - Google Patents
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- JP2014501246A5 JP2014501246A5 JP2013544634A JP2013544634A JP2014501246A5 JP 2014501246 A5 JP2014501246 A5 JP 2014501246A5 JP 2013544634 A JP2013544634 A JP 2013544634A JP 2013544634 A JP2013544634 A JP 2013544634A JP 2014501246 A5 JP2014501246 A5 JP 2014501246A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- ring
- methyl
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C**1CN(C)CCC(C)C1 Chemical compound C**1CN(C)CCC(C)C1 0.000 description 94
- HNJOAIYFUCQZAA-UHFFFAOYSA-N Cc1n[o]c(C)n1 Chemical compound Cc1n[o]c(C)n1 HNJOAIYFUCQZAA-UHFFFAOYSA-N 0.000 description 3
- ZRLDBDZSLLGDOX-UHFFFAOYSA-N Cc1c(C)[o]c(C)n1 Chemical compound Cc1c(C)[o]c(C)n1 ZRLDBDZSLLGDOX-UHFFFAOYSA-N 0.000 description 2
- MPBPVACPFBSAFW-UHFFFAOYSA-N Cc1n[s]c(C)n1 Chemical compound Cc1n[s]c(C)n1 MPBPVACPFBSAFW-UHFFFAOYSA-N 0.000 description 2
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- NWGNHPNGCDJCRH-UHFFFAOYSA-N CN(C(CC1)=N)C1=O Chemical compound CN(C(CC1)=N)C1=O NWGNHPNGCDJCRH-UHFFFAOYSA-N 0.000 description 1
- JARWBOSIMBOMRK-UHFFFAOYSA-N CN(C(CC1)=[U])c2c1cccc2 Chemical compound CN(C(CC1)=[U])c2c1cccc2 JARWBOSIMBOMRK-UHFFFAOYSA-N 0.000 description 1
- XRYKNRLGZZNWEE-UHFFFAOYSA-N CN(C(N=N1)=O)C1=O Chemical compound CN(C(N=N1)=O)C1=O XRYKNRLGZZNWEE-UHFFFAOYSA-N 0.000 description 1
- DORVZFVQNUHJNY-UHFFFAOYSA-N CN(C(c1c2cccc1)=S)C2=S Chemical compound CN(C(c1c2cccc1)=S)C2=S DORVZFVQNUHJNY-UHFFFAOYSA-N 0.000 description 1
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- ZXZJJLXBVBPLEZ-UHFFFAOYSA-N CN(CCc1c2cccc1)C2=N Chemical compound CN(CCc1c2cccc1)C2=N ZXZJJLXBVBPLEZ-UHFFFAOYSA-N 0.000 description 1
- FOCZWAAXMRNTNY-UHFFFAOYSA-N CN(Cc(cccc1)c1O1)C1=O Chemical compound CN(Cc(cccc1)c1O1)C1=O FOCZWAAXMRNTNY-UHFFFAOYSA-N 0.000 description 1
- JHMBTUMIVBSJFS-UHFFFAOYSA-N CN(Cc1c2cccc1)C2=O Chemical compound CN(Cc1c2cccc1)C2=O JHMBTUMIVBSJFS-UHFFFAOYSA-N 0.000 description 1
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- CDNHLXOFELOEOL-UHFFFAOYSA-N CN(c(cccc1)c1N1)C1=S Chemical compound CN(c(cccc1)c1N1)C1=S CDNHLXOFELOEOL-UHFFFAOYSA-N 0.000 description 1
- VYFQTZSQRZCAGR-UHFFFAOYSA-N CN(c(cccc1)c1S1)C1=N Chemical compound CN(c(cccc1)c1S1)C1=N VYFQTZSQRZCAGR-UHFFFAOYSA-N 0.000 description 1
- NELNEJVXXHYLSO-ARJAWSKDSA-N CN/C=C\NNC Chemical compound CN/C=C\NNC NELNEJVXXHYLSO-ARJAWSKDSA-N 0.000 description 1
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- MWZDIEIXRBWPLG-UHFFFAOYSA-N C[n]1ncnc1 Chemical compound C[n]1ncnc1 MWZDIEIXRBWPLG-UHFFFAOYSA-N 0.000 description 1
- RUOGLHMRBURIEQ-UHFFFAOYSA-N Cc([n](C)nc1C)c1I Chemical compound Cc([n](C)nc1C)c1I RUOGLHMRBURIEQ-UHFFFAOYSA-N 0.000 description 1
- IFEXEVPFINMYJV-UHFFFAOYSA-N Cc(cc1)c[n]1N Chemical compound Cc(cc1)c[n]1N IFEXEVPFINMYJV-UHFFFAOYSA-N 0.000 description 1
- BDXJANJAHYKTMI-UHFFFAOYSA-N Cc1c(C)[nH]c(C)c1C Chemical compound Cc1c(C)[nH]c(C)c1C BDXJANJAHYKTMI-UHFFFAOYSA-N 0.000 description 1
- BAMPVSWRQZNDQC-UHFFFAOYSA-N Cc1c(C)[s]c(C)n1 Chemical compound Cc1c(C)[s]c(C)n1 BAMPVSWRQZNDQC-UHFFFAOYSA-N 0.000 description 1
- SEBRPHZZSLCDRQ-UHFFFAOYSA-N Cc1c[s]c2c1cccc2 Chemical compound Cc1c[s]c2c1cccc2 SEBRPHZZSLCDRQ-UHFFFAOYSA-N 0.000 description 1
- YUTQRQJTFPEEPB-UHFFFAOYSA-N Cc1c[s]nc1 Chemical compound Cc1c[s]nc1 YUTQRQJTFPEEPB-UHFFFAOYSA-N 0.000 description 1
- VQKFNUFAXTZWDK-UHFFFAOYSA-N Cc1ccc[o]1 Chemical compound Cc1ccc[o]1 VQKFNUFAXTZWDK-UHFFFAOYSA-N 0.000 description 1
- XQQBUAPQHNYYRS-UHFFFAOYSA-N Cc1ccc[s]1 Chemical compound Cc1ccc[s]1 XQQBUAPQHNYYRS-UHFFFAOYSA-N 0.000 description 1
- AGQOIYCTCOEHGR-UHFFFAOYSA-N Cc1ccn[o]1 Chemical compound Cc1ccn[o]1 AGQOIYCTCOEHGR-UHFFFAOYSA-N 0.000 description 1
- AIKUBOPKWKZULG-UHFFFAOYSA-N Cc1cnncc1 Chemical compound Cc1cnncc1 AIKUBOPKWKZULG-UHFFFAOYSA-N 0.000 description 1
- INSUSOZBMWJGDG-UHFFFAOYSA-N Cc1n[o]c(C)c1N Chemical compound Cc1n[o]c(C)c1N INSUSOZBMWJGDG-UHFFFAOYSA-N 0.000 description 1
- GAUKCDPSYQUYQL-UHFFFAOYSA-N Cc1n[o]c2c1cccc2 Chemical compound Cc1n[o]c2c1cccc2 GAUKCDPSYQUYQL-UHFFFAOYSA-N 0.000 description 1
- XYYXDARQOHWBPO-UHFFFAOYSA-N Cc1nc(C)n[nH]1 Chemical compound Cc1nc(C)n[nH]1 XYYXDARQOHWBPO-UHFFFAOYSA-N 0.000 description 1
- LDZYRENCLPUXAX-UHFFFAOYSA-N Cc1nc(cccc2)c2[nH]1 Chemical compound Cc1nc(cccc2)c2[nH]1 LDZYRENCLPUXAX-UHFFFAOYSA-N 0.000 description 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N Cc1nc(cccc2)c2[s]1 Chemical compound Cc1nc(cccc2)c2[s]1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 description 1
- DJRVNXDTTXOZRZ-UHFFFAOYSA-N Cc1ncc(CN[IH]I)[n]1N Chemical compound Cc1ncc(CN[IH]I)[n]1N DJRVNXDTTXOZRZ-UHFFFAOYSA-N 0.000 description 1
- VZWOXDYRBDIHMA-UHFFFAOYSA-N Cc1ncc[s]1 Chemical compound Cc1ncc[s]1 VZWOXDYRBDIHMA-UHFFFAOYSA-N 0.000 description 1
- YIUOAAUFVBZQPM-UHFFFAOYSA-N Cc1ncncn1 Chemical compound Cc1ncncn1 YIUOAAUFVBZQPM-UHFFFAOYSA-N 0.000 description 1
- YVDWFZIVIIKYBQ-UHFFFAOYSA-N Cc1nnc(C)[o]1 Chemical compound Cc1nnc(C)[o]1 YVDWFZIVIIKYBQ-UHFFFAOYSA-N 0.000 description 1
- JXQGICFGPUAVLJ-UHFFFAOYSA-N Cc1nnc(C)[s]1 Chemical compound Cc1nnc(C)[s]1 JXQGICFGPUAVLJ-UHFFFAOYSA-N 0.000 description 1
- VJRHHVGPZXCQSS-UHFFFAOYSA-N Cc1nnc(NC)[s]1 Chemical compound Cc1nnc(NC)[s]1 VJRHHVGPZXCQSS-UHFFFAOYSA-N 0.000 description 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N O=C(CC1)NC1=O Chemical compound O=C(CC1)NC1=O KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 1
- BLHSDXZNFGDHNB-UHFFFAOYSA-N O=C(CN1)NC1=[U] Chemical compound O=C(CN1)NC1=[U] BLHSDXZNFGDHNB-UHFFFAOYSA-N 0.000 description 1
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- HOBCFUWDNJPFHB-UHFFFAOYSA-N c1c[n](cccc2)c2c1 Chemical compound c1c[n](cccc2)c2c1 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 description 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N c1c[s]c2ccccc12 Chemical compound c1c[s]c2ccccc12 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424228P | 2010-12-17 | 2010-12-17 | |
| US61/424,228 | 2010-12-17 | ||
| PCT/US2011/064324 WO2012082580A2 (en) | 2010-12-17 | 2011-12-12 | Fungicidal azocyclic amides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014501246A JP2014501246A (ja) | 2014-01-20 |
| JP2014501246A5 true JP2014501246A5 (cg-RX-API-DMAC7.html) | 2015-01-15 |
Family
ID=45446208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544634A Pending JP2014501246A (ja) | 2010-12-17 | 2011-12-12 | 殺菌・殺カビ性アゾ環式アミド |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130261154A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2651219A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2014501246A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140017520A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103384470A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011344161A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013015166A2 (cg-RX-API-DMAC7.html) |
| CL (1) | CL2013001722A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2013006936A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012082580A2 (cg-RX-API-DMAC7.html) |
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| TW201036966A (en) * | 2008-12-02 | 2010-10-16 | Du Pont | Fungicidal heterocyclic compounds |
| KR102000301B1 (ko) | 2010-12-17 | 2019-07-15 | 리아타 파마슈티컬즈, 아이엔씨. | 산화방지성 염증 조절제로서의 피라졸릴 및 피리미디닐 트리사이클릭 엔온 |
| EP3121171B1 (en) | 2010-12-17 | 2018-08-15 | Novartis Ag | Crystalline forms of 5-chloro-n2-(2-isopropoxy-5-methyl-4-piperidin-4-yl-phenyl)-n4[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine |
| CN104987330B (zh) * | 2011-02-01 | 2019-04-05 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物 |
| US10004232B2 (en) | 2011-09-15 | 2018-06-26 | Bayer Intellectual Property Gmbh | Piperidine pyrazoles as fungicides |
| DK2921492T3 (en) | 2011-12-27 | 2017-12-11 | Bayer Ip Gmbh | HETEROARYLPIPERIDINE AND ¿PIPERAZINE DERIVATIVES |
| CA2861020C (en) | 2012-02-02 | 2018-07-17 | Actelion Pharmaceuticals Ltd | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives and their use as cxcr3 receptor modulators |
| CN104583207A (zh) * | 2012-06-22 | 2015-04-29 | 杜邦公司 | 杀真菌杂环化合物 |
| EP2801575A1 (en) | 2013-05-07 | 2014-11-12 | Bayer CropScience AG | Heteroaryldihydropyridine derivatives as fungicides |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| CN105473585B (zh) | 2013-06-24 | 2018-04-13 | 拜耳作物科学股份公司 | 作为杀真菌剂的哌啶羧酸衍生物 |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US10259807B2 (en) | 2013-07-22 | 2019-04-16 | Idorsia Pharmaceuticals Ltd. | 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives |
| CN105705503B (zh) * | 2013-08-28 | 2019-07-09 | 拜耳作物科学股份公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪的丙二酸酯衍生物 |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| CN106459028A (zh) * | 2014-03-24 | 2017-02-22 | 拜耳作物科学股份公司 | 作为杀真菌剂的苯基哌啶羧酰胺衍生物 |
| WO2016024350A1 (ja) * | 2014-08-13 | 2016-02-18 | 株式会社エス・ディー・エス バイオテック | 縮合１１員環化合物及びそれらを含有する農園芸用殺菌剤 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| CA2972952C (en) | 2015-01-15 | 2021-01-05 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
| US11274076B2 (en) | 2016-02-08 | 2022-03-15 | Gowan Company, L.L.C. | Process for preparing 1, 2-benzenedimethanol compound |
| CN108601353B (zh) * | 2016-02-08 | 2024-04-05 | 高文作物保护公司 | 杀菌性组合物 |
| CN110381738B (zh) * | 2016-10-14 | 2021-07-16 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的乙烯基异噁唑啉化合物 |
| KR20200105652A (ko) | 2017-09-08 | 2020-09-08 | 피아이 인더스트리스 엘티디. | 새로운 살균성 헤테로시클릭 화합물 |
| WO2019048988A1 (en) * | 2017-09-08 | 2019-03-14 | Pi Industries Ltd. | Novel fungidal heterocyclic compounds |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| PH12022550361A1 (en) | 2019-08-14 | 2023-02-27 | Incyte Corp | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| MX2022004390A (es) | 2019-10-11 | 2022-08-08 | Incyte Corp | Aminas biciclicas como inhibidores de la cinasa dependiente de ciclina 2 (cdk2). |
| CN114644634B (zh) * | 2020-12-21 | 2023-06-20 | 深圳市祥根生物医药有限公司 | 一种吡咯衍生物及其制备方法和用途 |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
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| CL2007002867A1 (es) | 2006-10-04 | 2008-06-27 | Pharmacopeia Inc | Compuestos derivados de 2-(bencimidazolil)purina, inhibidores de janus quinasa 3; composicion farmaceutica que los contiene; y su uso para tratar enfermedades autoinmune, inflamatorias, cardiovasculares, rechazo de implante, entre otras. |
| WO2008103615A1 (en) | 2007-02-21 | 2008-08-28 | Kalypsys, Inc. | Isoquinolines useful as inducible nitric oxide synthase inhibitors |
| TWI428091B (zh) * | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
| CN103965187A (zh) * | 2008-01-25 | 2014-08-06 | 杜邦公司 | 杀真菌杂环化合物 |
| US20100286147A1 (en) * | 2008-01-25 | 2010-11-11 | E.I. Dupont De Nemours And Company | Fungicidal amides |
| TW201036966A (en) * | 2008-12-02 | 2010-10-16 | Du Pont | Fungicidal heterocyclic compounds |
| US20120122928A1 (en) * | 2010-08-11 | 2012-05-17 | Bayer Cropscience Ag | Heteroarylpiperidine and -Piperazine Derivatives as Fungicides |
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2011
- 2011-12-12 JP JP2013544634A patent/JP2014501246A/ja active Pending
- 2011-12-12 MX MX2013006936A patent/MX2013006936A/es unknown
- 2011-12-12 AU AU2011344161A patent/AU2011344161A1/en not_active Abandoned
- 2011-12-12 CN CN2011800678071A patent/CN103384470A/zh active Pending
- 2011-12-12 US US13/990,542 patent/US20130261154A1/en not_active Abandoned
- 2011-12-12 BR BR112013015166A patent/BR112013015166A2/pt not_active IP Right Cessation
- 2011-12-12 EP EP11805311.5A patent/EP2651219A2/en not_active Withdrawn
- 2011-12-12 KR KR1020137018596A patent/KR20140017520A/ko not_active Withdrawn
- 2011-12-12 WO PCT/US2011/064324 patent/WO2012082580A2/en not_active Ceased
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2013
- 2013-06-14 CL CL2013001722A patent/CL2013001722A1/es unknown