JP2014232032A - 化学・物理現象検出方法及びその装置 - Google Patents

化学・物理現象検出方法及びその装置 Download PDF

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Publication number
JP2014232032A
JP2014232032A JP2013112444A JP2013112444A JP2014232032A JP 2014232032 A JP2014232032 A JP 2014232032A JP 2013112444 A JP2013112444 A JP 2013112444A JP 2013112444 A JP2013112444 A JP 2013112444A JP 2014232032 A JP2014232032 A JP 2014232032A
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JP
Japan
Prior art keywords
sensing unit
microparticles
recess
detection target
detection method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013112444A
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English (en)
Japanese (ja)
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JP2014232032A5 (enExample
Inventor
修 滝川
Osamu Takigawa
滝川　　修
海良人 奥野
Arato Okuno
海良人 奥野
立也 吉見
Tatsuya Yoshimi
立也 吉見
澤田　和明
Kazuaki Sawada
和明 澤田
弘一 奥村
Koichi Okumura
弘一 奥村
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyohashi University of Technology NUC
National Center for Geriatrics and Gerontology
Original Assignee
Toyohashi University of Technology NUC
National Center for Geriatrics and Gerontology
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Filing date
Publication date
Application filed by Toyohashi University of Technology NUC, National Center for Geriatrics and Gerontology filed Critical Toyohashi University of Technology NUC
Priority to JP2013112444A priority Critical patent/JP2014232032A/ja
Priority to PCT/JP2014/064177 priority patent/WO2014192830A1/ja
Publication of JP2014232032A publication Critical patent/JP2014232032A/ja
Publication of JP2014232032A5 publication Critical patent/JP2014232032A5/ja
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
JP2013112444A 2013-05-29 2013-05-29 化学・物理現象検出方法及びその装置 Pending JP2014232032A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2013112444A JP2014232032A (ja) 2013-05-29 2013-05-29 化学・物理現象検出方法及びその装置
PCT/JP2014/064177 WO2014192830A1 (ja) 2013-05-29 2014-05-28 化学・物理現象検出方法及びその装置

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013112444A JP2014232032A (ja) 2013-05-29 2013-05-29 化学・物理現象検出方法及びその装置

Publications (2)

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JP2014232032A true JP2014232032A (ja) 2014-12-11
JP2014232032A5 JP2014232032A5 (enExample) 2015-11-05

Family

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JP2013112444A Pending JP2014232032A (ja) 2013-05-29 2013-05-29 化学・物理現象検出方法及びその装置

Country Status (2)

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JP (1) JP2014232032A (enExample)
WO (1) WO2014192830A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017033922A1 (ja) * 2015-08-24 2017-03-02 国立大学法人 東京大学 電界効果トランジスタを用いた目的物質の検出方法
JP2019074461A (ja) * 2017-10-18 2019-05-16 株式会社Ｐｒｏｖｉｇａｔｅ 電荷の遷移差を利用した抗原抗体反応検出装置
JP2020186971A (ja) * 2019-05-13 2020-11-19 アイシン精機株式会社 微小物質検出方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003043010A (ja) * 2001-04-25 2003-02-13 Nikon Corp 有機分子検出素子、有機分子検出装置、および、有機分子検出方法
JP2004361227A (ja) * 2003-06-04 2004-12-24 Tohoku Univ アミロイドβ結合蛋白質の同定方法
JP2007292748A (ja) * 2006-03-31 2007-11-08 Canon Inc センサ素子、ならびにこの素子を用いた磁性粒子の検出方法及び標的物質の検出方法
JP2010243299A (ja) * 2009-04-03 2010-10-28 Sharp Corp バイオセンサ、電荷転送型センサおよび測定方法
JP2011516832A (ja) * 2008-03-17 2011-05-26 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁性粒子によるアッセイ用カートリッジ
JP2011163826A (ja) * 2010-02-05 2011-08-25 Univ Of Tokyo 細胞測定装置
JP2012080873A (ja) * 2010-09-17 2012-04-26 Univ Of Tokyo Ｄｎａ塩基配列解析装置およびｄｎａ塩基配列解析方法
JP2013505438A (ja) * 2009-09-18 2013-02-14 プロビオドルグ エージー アミロイドβペプチドの検出のための新規アッセイ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201102037D0 (en) * 2011-02-07 2011-03-23 Multi Sense Technologies Ltd Microfluidics based assay device
JP2013050426A (ja) * 2011-08-31 2013-03-14 Chiba Univ Ｆｅｔ型センサを用いたインフルエンザウイルスｒｎａの検出方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003043010A (ja) * 2001-04-25 2003-02-13 Nikon Corp 有機分子検出素子、有機分子検出装置、および、有機分子検出方法
JP2004361227A (ja) * 2003-06-04 2004-12-24 Tohoku Univ アミロイドβ結合蛋白質の同定方法
JP2007292748A (ja) * 2006-03-31 2007-11-08 Canon Inc センサ素子、ならびにこの素子を用いた磁性粒子の検出方法及び標的物質の検出方法
JP2011516832A (ja) * 2008-03-17 2011-05-26 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁性粒子によるアッセイ用カートリッジ
JP2010243299A (ja) * 2009-04-03 2010-10-28 Sharp Corp バイオセンサ、電荷転送型センサおよび測定方法
JP2013505438A (ja) * 2009-09-18 2013-02-14 プロビオドルグ エージー アミロイドβペプチドの検出のための新規アッセイ
JP2011163826A (ja) * 2010-02-05 2011-08-25 Univ Of Tokyo 細胞測定装置
JP2012080873A (ja) * 2010-09-17 2012-04-26 Univ Of Tokyo Ｄｎａ塩基配列解析装置およびｄｎａ塩基配列解析方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017033922A1 (ja) * 2015-08-24 2017-03-02 国立大学法人 東京大学 電界効果トランジスタを用いた目的物質の検出方法
JP2019074461A (ja) * 2017-10-18 2019-05-16 株式会社Ｐｒｏｖｉｇａｔｅ 電荷の遷移差を利用した抗原抗体反応検出装置
JP7130223B2 (ja) 2017-10-18 2022-09-05 株式会社Provigate 電荷の遷移差を利用した抗原抗体反応検出装置
JP2020186971A (ja) * 2019-05-13 2020-11-19 アイシン精機株式会社 微小物質検出方法

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