JP2014193889A5 - - Google Patents

Info

Publication number

JP2014193889A5

JP2014193889A5 JP2014099667A JP2014099667A JP2014193889A5 JP 2014193889 A5 JP2014193889 A5 JP 2014193889A5 JP 2014099667 A JP2014099667 A JP 2014099667A JP 2014099667 A JP2014099667 A JP 2014099667A JP 2014193889 A5 JP2014193889 A5 JP 2014193889A5

Authority

JP

Japan

Prior art keywords

alkyl

independently

substituted

hal

alkoxy

Prior art date

2014-05-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 50
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 48
• 150000001875 compounds Chemical class 0.000 claims 43
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 40
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 39
• 229910052799 carbon Inorganic materials 0.000 claims 30
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 28
• 125000000623 heterocyclic group Chemical group 0.000 claims 22
• 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 20
• 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 20
• -1 C1-C12 alkanoyl Chemical group 0.000 claims 20
• XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 20
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 14
• 235000019152 folic acid Nutrition 0.000 claims 14
• 239000011724 folic acid Substances 0.000 claims 14
• 229960000304 folic acid Drugs 0.000 claims 14
• 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 claims 10
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 10
• 125000000018 nitroso group Chemical group N(=O)* 0.000 claims 10
• 229910000073 phosphorus hydride Inorganic materials 0.000 claims 10
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
• 229920006395 saturated elastomer Polymers 0.000 claims 7
• 238000004519 manufacturing process Methods 0.000 claims 6
• 150000001345 alkine derivatives Chemical class 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 125000003118 aryl group Chemical group 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
• 238000002059 diagnostic imaging Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 238000006736 Huisgen cycloaddition reaction Methods 0.000 claims 2
• 150000001540 azides Chemical class 0.000 claims 2
• 125000002837 carbocyclic group Chemical group 0.000 claims 2
• 239000003638 chemical reducing agent Substances 0.000 claims 2
• 102000006815 folate receptor Human genes 0.000 claims 2
• 108020005243 folate receptor Proteins 0.000 claims 2
• 238000003384 imaging method Methods 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 125000000168 pyrrolyl group Chemical group 0.000 claims 2
• 230000005855 radiation Effects 0.000 claims 2
• 125000000335 thiazolyl group Chemical group 0.000 claims 2
• JOAQINSXLLMRCV-UHFFFAOYSA-N 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid Chemical compound C1=NC2=NC(N)=NC(O)=C2N=C1CNC1=CC=C(C(O)=O)C=C1 JOAQINSXLLMRCV-UHFFFAOYSA-N 0.000 claims 1
• ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
• 229910021626 Tin(II) chloride Inorganic materials 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 239000000032 diagnostic agent Substances 0.000 claims 1
• 229940039227 diagnostic agent Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 150000002224 folic acids Chemical class 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000001678 irradiating effect Effects 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 125000005647 linker group Chemical group 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 230000002194 synthesizing effect Effects 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1