JP2014172904A5 - - Google Patents
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- Publication number
- JP2014172904A5 JP2014172904A5 JP2013058954A JP2013058954A JP2014172904A5 JP 2014172904 A5 JP2014172904 A5 JP 2014172904A5 JP 2013058954 A JP2013058954 A JP 2013058954A JP 2013058954 A JP2013058954 A JP 2013058954A JP 2014172904 A5 JP2014172904 A5 JP 2014172904A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- oil
- nonionic surfactant
- water
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FBRAWBYQGRLCEK-AVVSTMBFSA-N [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CCC)[C@@]1(C)CC2=O FBRAWBYQGRLCEK-AVVSTMBFSA-N 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 229960005465 clobetasone butyrate Drugs 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- WNLRTRBMVRJNCN-UHFFFAOYSA-N Adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- 235000011037 adipic acid Nutrition 0.000 claims description 4
- 239000001361 adipic acid Substances 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- -1 polyoxyethylene cetyl ether Polymers 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 210000003491 Skin Anatomy 0.000 claims description 2
- 229950011392 Sorbitan stearate Drugs 0.000 claims description 2
- HVUMOYIDDBPOLL-IIZJTUPISA-N [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)[C@H]1OC[C@@H](O)[C@@H]1O HVUMOYIDDBPOLL-IIZJTUPISA-N 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims 1
- 230000003110 anti-inflammatory Effects 0.000 description 6
- ZDQWESQEGGJUCH-UHFFFAOYSA-N Diisopropyl adipate Chemical compound CC(C)OC(=O)CCCCC(=O)OC(C)C ZDQWESQEGGJUCH-UHFFFAOYSA-N 0.000 description 3
- 229940031578 diisopropyl adipate Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000001052 transient Effects 0.000 description 3
- 239000003246 corticosteroid Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 229940064701 Corticosteroid nasal preparations for topical use Drugs 0.000 description 1
- 229960001334 Corticosteroids Drugs 0.000 description 1
- VIZORQUEIQEFRT-UHFFFAOYSA-N Diethyl adipate Chemical compound CCOC(=O)CCCCC(=O)OCC VIZORQUEIQEFRT-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960001146 clobetasone Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 230000001804 emulsifying Effects 0.000 description 1
- 239000002628 heparin derivative Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003020 moisturizing Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229920001888 polyacrylic acid Polymers 0.000 description 1
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 description 1
- 150000003431 steroids Chemical group 0.000 description 1
- 230000004936 stimulating Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000000699 topical Effects 0.000 description 1
- 229940083878 topical for treatment of hemorrhoids and anal fissures Corticosteroids Drugs 0.000 description 1
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013058954A JP6077350B2 (ja) | 2013-03-05 | 2013-03-05 | 酪酸クロベタゾンを含有するアトピー性皮膚炎用の外用医薬組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013058954A JP6077350B2 (ja) | 2013-03-05 | 2013-03-05 | 酪酸クロベタゾンを含有するアトピー性皮膚炎用の外用医薬組成物 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014172904A JP2014172904A (ja) | 2014-09-22 |
JP2014172904A5 true JP2014172904A5 (fr) | 2016-02-25 |
JP6077350B2 JP6077350B2 (ja) | 2017-02-08 |
Family
ID=51694507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013058954A Active JP6077350B2 (ja) | 2013-03-05 | 2013-03-05 | 酪酸クロベタゾンを含有するアトピー性皮膚炎用の外用医薬組成物 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6077350B2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021133260A1 (fr) * | 2019-12-26 | 2021-07-01 | Agency For Science, Technology And Research | Composition comprenant mir-335 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100151054A1 (en) * | 2005-10-03 | 2010-06-17 | Taisho Pharmaceutical Co., Ltd. | Emulsion lotion |
-
2013
- 2013-03-05 JP JP2013058954A patent/JP6077350B2/ja active Active
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