JP2014100148A5 - - Google Patents
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- Publication number
- JP2014100148A5 JP2014100148A5 JP2014045879A JP2014045879A JP2014100148A5 JP 2014100148 A5 JP2014100148 A5 JP 2014100148A5 JP 2014045879 A JP2014045879 A JP 2014045879A JP 2014045879 A JP2014045879 A JP 2014045879A JP 2014100148 A5 JP2014100148 A5 JP 2014100148A5
- Authority
- JP
- Japan
- Prior art keywords
- cell culture
- cell
- culture supernatant
- cells
- heterologous protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 238000004113 cell culture Methods 0.000 claims 12
- 239000012228 culture supernatant Substances 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 210000004962 mammalian cell Anatomy 0.000 claims 5
- 108010054218 Factor VIII Proteins 0.000 claims 4
- 102000001690 Factor VIII Human genes 0.000 claims 4
- 229960000301 factor viii Drugs 0.000 claims 4
- 230000003248 secreting effect Effects 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 2
- 102100032290 A disintegrin and metalloproteinase with thrombospondin motifs 13 Human genes 0.000 claims 1
- 108091005670 ADAMTS13 Proteins 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 102100023804 Coagulation factor VII Human genes 0.000 claims 1
- 108010023321 Factor VII Proteins 0.000 claims 1
- 108090001126 Furin Proteins 0.000 claims 1
- 102000004961 Furin Human genes 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 229940012413 factor vii Drugs 0.000 claims 1
- 239000012737 fresh medium Substances 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 108010047303 von Willebrand Factor Proteins 0.000 claims 1
- 102100036537 von Willebrand factor Human genes 0.000 claims 1
- 229960001134 von willebrand factor Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US932807P | 2007-12-27 | 2007-12-27 | |
| US61/009,328 | 2007-12-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540844A Division JP5727790B2 (ja) | 2007-12-27 | 2008-12-22 | 細胞培養プロセス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015207654A Division JP2016013140A (ja) | 2007-12-27 | 2015-10-22 | 細胞培養プロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014100148A JP2014100148A (ja) | 2014-06-05 |
| JP2014100148A5 true JP2014100148A5 (enExample) | 2015-04-09 |
| JP5890854B2 JP5890854B2 (ja) | 2016-03-22 |
Family
ID=40350258
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540844A Active JP5727790B2 (ja) | 2007-12-27 | 2008-12-22 | 細胞培養プロセス |
| JP2014045879A Active JP5890854B2 (ja) | 2007-12-27 | 2014-03-10 | 細胞培養プロセス |
| JP2015207654A Withdrawn JP2016013140A (ja) | 2007-12-27 | 2015-10-22 | 細胞培養プロセス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540844A Active JP5727790B2 (ja) | 2007-12-27 | 2008-12-22 | 細胞培養プロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015207654A Withdrawn JP2016013140A (ja) | 2007-12-27 | 2015-10-22 | 細胞培養プロセス |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9359629B2 (enExample) |
| EP (4) | EP3255152A1 (enExample) |
| JP (3) | JP5727790B2 (enExample) |
| KR (4) | KR20180005287A (enExample) |
| CN (2) | CN106222220A (enExample) |
| AR (2) | AR069956A1 (enExample) |
| AU (1) | AU2008345231B2 (enExample) |
| BR (1) | BR122019022434B8 (enExample) |
| CA (1) | CA2709890A1 (enExample) |
| DK (3) | DK2235197T3 (enExample) |
| ES (3) | ES2647294T3 (enExample) |
| HK (1) | HK1246827A1 (enExample) |
| HR (3) | HRP20171375T1 (enExample) |
| HU (2) | HUE036712T2 (enExample) |
| MX (2) | MX343269B (enExample) |
| NZ (1) | NZ586250A (enExample) |
| PL (3) | PL2235197T3 (enExample) |
| PT (3) | PT2235197T (enExample) |
| SG (2) | SG10201503304RA (enExample) |
| SI (3) | SI2574676T1 (enExample) |
| WO (1) | WO2009086309A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2527425A1 (en) | 2006-09-13 | 2012-11-28 | Abbott Laboratories | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| SI4269578T1 (sl) | 2008-03-06 | 2024-07-31 | Halozyme, Inc. | Sestava topne hialuronidaze |
| TW201024318A (en) | 2008-10-20 | 2010-07-01 | Abbott Lab | Isolation and purification of antibodies using protein A affinity chromatography |
| NZ592097A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Viral inactivation during purification of il-12 and il-18 antibodies |
| SG178194A1 (en) | 2009-07-31 | 2012-03-29 | Baxter Int | Cell culture medium for adamts protein expression |
| US8580554B2 (en) * | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| HUE11738351T2 (hu) * | 2010-07-08 | 2019-03-28 | Baxalta GmbH | Eljárás rekombináns ADAMTS13 elõállítására sejttenyészetben |
| WO2012122611A1 (en) * | 2011-03-11 | 2012-09-20 | Universidade De São Paulo - Usp | Method for the production of recombinant human factor viii |
| EP2511293A1 (en) | 2011-04-13 | 2012-10-17 | LEK Pharmaceuticals d.d. | A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| EP2890782A1 (en) | 2012-09-02 | 2015-07-08 | AbbVie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| KR20150026024A (ko) * | 2013-08-30 | 2015-03-11 | 한미약품 주식회사 | 인간 혈액응고 7인자 유도체의 대량 생산 방법 |
| WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| MX2016012288A (es) * | 2014-03-25 | 2017-01-23 | Genentech Inc | Metodos para preparar un poloxamero para usar en medio de cultivo celular. |
| WO2015157335A1 (en) * | 2014-04-10 | 2015-10-15 | Bayer Healthcare Llc | Compounded media powder formulation and method of preparation of liquid medium for cell culture |
| MX2016015971A (es) * | 2014-06-03 | 2017-08-08 | Lupin Ltd | Proceso de cultivo celular para la producción de una proteína. |
| PT3926051T (pt) | 2014-06-04 | 2024-06-20 | Amgen Inc | Métodos de colheita de culturas de células de mamíferos |
| RU2017145002A (ru) | 2015-05-22 | 2019-06-24 | Цсл Беринг Ленгнау Аг | Способы получения модифицированного фактора фон виллебранда |
| JP7213180B2 (ja) * | 2016-10-19 | 2023-01-26 | エフ．ホフマン－ラ ロシュ アーゲー | 免疫コンジュゲートを製造するための方法 |
| CN114657118B (zh) * | 2021-12-31 | 2023-12-01 | 广州齐志生物工程设备有限公司 | 一种2bs细胞在生物反应器内的多倍放大方法 |
| EP4584299A2 (en) | 2022-09-07 | 2025-07-16 | Quantitative Biosciences, Inc. | Fentanyl-specific single variable-domain antibodies and use in a continuous agglutination assay |
| CN116064409A (zh) * | 2023-01-06 | 2023-05-05 | 四川阿思科力生物科技有限公司 | 一种大规模高产量细胞连续培养和收获的生产工艺 |
| WO2024226439A1 (en) | 2023-04-24 | 2024-10-31 | Quantitative Biosciences, Inc. | Engineered biosensor strains of e. coli for continuous aerobic detection of analytes |
| WO2025128343A1 (en) | 2023-12-11 | 2025-06-19 | Just-Evotec Biologics, Inc. | Protein expression using trans-splicing and split selectable markers |
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| US4456591A (en) | 1981-06-25 | 1984-06-26 | Baxter Travenol Laboratories, Inc. | Therapeutic method for activating factor VII |
| SE8501050D0 (sv) | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
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| GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
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-
2008
- 2008-12-22 AU AU2008345231A patent/AU2008345231B2/en active Active
- 2008-12-22 DK DK08868009.5T patent/DK2235197T3/en active
- 2008-12-22 KR KR1020187000372A patent/KR20180005287A/ko not_active Ceased
- 2008-12-22 MX MX2015014311A patent/MX343269B/es unknown
- 2008-12-22 JP JP2010540844A patent/JP5727790B2/ja active Active
- 2008-12-22 KR KR1020167025638A patent/KR101798813B1/ko active Active
- 2008-12-22 SI SI200831864T patent/SI2574676T1/sl unknown
- 2008-12-22 CN CN201610625651.9A patent/CN106222220A/zh active Pending
- 2008-12-22 EP EP17175185.2A patent/EP3255152A1/en not_active Withdrawn
- 2008-12-22 HU HUE08868009A patent/HUE036712T2/hu unknown
- 2008-12-22 US US12/341,807 patent/US9359629B2/en active Active
- 2008-12-22 SG SG10201503304RA patent/SG10201503304RA/en unknown
- 2008-12-22 CA CA2709890A patent/CA2709890A1/en not_active Abandoned
- 2008-12-22 PT PT88680095T patent/PT2235197T/pt unknown
- 2008-12-22 KR KR1020177032356A patent/KR101818411B1/ko active Active
- 2008-12-22 SG SG2012095329A patent/SG187397A1/en unknown
- 2008-12-22 HR HRP20171375TT patent/HRP20171375T1/hr unknown
- 2008-12-22 ES ES12198392.8T patent/ES2647294T3/es active Active
- 2008-12-22 PT PT121983928T patent/PT2574676T/pt unknown
- 2008-12-22 KR KR1020107016654A patent/KR101659458B1/ko active Active
- 2008-12-22 SI SI200831865T patent/SI2235197T1/sl unknown
- 2008-12-22 NZ NZ586250A patent/NZ586250A/xx unknown
- 2008-12-22 PT PT121987549T patent/PT2574677T/pt unknown
- 2008-12-22 SI SI200831871T patent/SI2574677T1/sl unknown
- 2008-12-22 BR BR122019022434A patent/BR122019022434B8/pt active IP Right Grant
- 2008-12-22 WO PCT/US2008/088036 patent/WO2009086309A2/en not_active Ceased
- 2008-12-22 DK DK12198754.9T patent/DK2574677T3/da active
- 2008-12-22 EP EP12198754.9A patent/EP2574677B1/en active Active
- 2008-12-22 EP EP12198392.8A patent/EP2574676B1/en active Active
- 2008-12-22 ES ES12198754.9T patent/ES2649094T3/es active Active
- 2008-12-22 ES ES08868009.5T patent/ES2644089T3/es active Active
- 2008-12-22 PL PL08868009T patent/PL2235197T3/pl unknown
- 2008-12-22 DK DK12198392.8T patent/DK2574676T3/en active
- 2008-12-22 EP EP08868009.5A patent/EP2235197B1/en active Active
- 2008-12-22 HU HUE12198392A patent/HUE036496T2/hu unknown
- 2008-12-22 PL PL12198392T patent/PL2574676T3/pl unknown
- 2008-12-22 CN CN2008801232545A patent/CN101910408A/zh active Pending
- 2008-12-22 PL PL12198754T patent/PL2574677T3/pl unknown
- 2008-12-22 MX MX2014003366A patent/MX343271B/es unknown
- 2008-12-23 AR ARP080105692A patent/AR069956A1/es active IP Right Grant
-
2014
- 2014-03-10 JP JP2014045879A patent/JP5890854B2/ja active Active
-
2015
- 2015-10-22 JP JP2015207654A patent/JP2016013140A/ja not_active Withdrawn
-
2016
- 2016-05-03 US US15/145,618 patent/US20160244506A1/en not_active Abandoned
-
2017
- 2017-09-14 HR HRP20171374TT patent/HRP20171374T1/hr unknown
- 2017-10-05 HR HRP20171495TT patent/HRP20171495T1/hr unknown
-
2018
- 2018-01-29 AR ARP180100205A patent/AR110864A2/es unknown
- 2018-05-09 HK HK18105999.0A patent/HK1246827A1/en unknown
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