JP2014098049A5 - - Google Patents
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- Publication number
- JP2014098049A5 JP2014098049A5 JP2014040226A JP2014040226A JP2014098049A5 JP 2014098049 A5 JP2014098049 A5 JP 2014098049A5 JP 2014040226 A JP2014040226 A JP 2014040226A JP 2014040226 A JP2014040226 A JP 2014040226A JP 2014098049 A5 JP2014098049 A5 JP 2014098049A5
- Authority
- JP
- Japan
- Prior art keywords
- peaks
- furan
- acetyl
- dione
- diffraction pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000004519 manufacturing process Methods 0.000 claims 11
- 239000013078 crystal Substances 0.000 claims 9
- DPHUWDIXHNQOSY-UHFFFAOYSA-N napabucasin Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1OC(C(=O)C)=C2 DPHUWDIXHNQOSY-UHFFFAOYSA-N 0.000 claims 9
- 238000002441 X-ray diffraction Methods 0.000 claims 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- ALOLHIXWHIWOHM-UHFFFAOYSA-N 2-acetyl-2,3,4,9-tetrahydronaphtho[2,3-b]furan-4,9-dione Natural products O=C1C2=CC=CC=C2C(=O)C2=C1OC(C(=O)C)C2 ALOLHIXWHIWOHM-UHFFFAOYSA-N 0.000 claims 2
- AGHIQBRPBAHPMV-UHFFFAOYSA-N 3-bromobut-3-en-2-one Chemical compound CC(=O)C(Br)=C AGHIQBRPBAHPMV-UHFFFAOYSA-N 0.000 claims 2
- CSFWPUWCSPOLJW-UHFFFAOYSA-N lawsone Chemical compound C1=CC=C2C(=O)C(O)=CC(=O)C2=C1 CSFWPUWCSPOLJW-UHFFFAOYSA-N 0.000 claims 2
- KUJTUBMARVZCNB-UHFFFAOYSA-N 1-(4,9-dihydrobenzo[f][1]benzofuran-2-yl)ethanone Chemical compound C(C)(=O)C1=CC2=C(O1)CC1=CC=CC=C1C2 KUJTUBMARVZCNB-UHFFFAOYSA-N 0.000 claims 1
- DRSZTATWOSZRAK-UHFFFAOYSA-N 3,4-dibromobutan-2-one Chemical compound CC(=O)C(Br)CBr DRSZTATWOSZRAK-UHFFFAOYSA-N 0.000 claims 1
- -1 3-bromo-3,4-dibromobutan-2-one Chemical compound 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31588610P | 2010-03-19 | 2010-03-19 | |
| US31589010P | 2010-03-19 | 2010-03-19 | |
| US61/315,890 | 2010-03-19 | ||
| US61/315,886 | 2010-03-19 | ||
| US32581410P | 2010-04-19 | 2010-04-19 | |
| US61/325,814 | 2010-04-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500246A Division JP5602935B2 (ja) | 2010-03-19 | 2011-03-21 | がん幹細胞を標的とするための新規の化合物および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014098049A JP2014098049A (ja) | 2014-05-29 |
| JP2014098049A5 true JP2014098049A5 (OSRAM) | 2014-11-27 |
Family
ID=50940329
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014040226A Withdrawn JP2014098049A (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2014040225A Expired - Fee Related JP5993390B2 (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2014040227A Withdrawn JP2014098050A (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015035285A Pending JP2015098489A (ja) | 2010-03-19 | 2015-02-25 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015179115A Expired - Fee Related JP6246169B2 (ja) | 2010-03-19 | 2015-09-11 | がん幹細胞を標的とするための新規の方法 |
| JP2016194176A Withdrawn JP2016222723A (ja) | 2010-03-19 | 2016-09-30 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2017199380A Withdrawn JP2018002744A (ja) | 2010-03-19 | 2017-10-13 | がん幹細胞を標的とするための新規の方法 |
| JP2018081329A Withdrawn JP2018115209A (ja) | 2010-03-19 | 2018-04-20 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020014705A Withdrawn JP2020063308A (ja) | 2010-03-19 | 2020-01-31 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020082479A Pending JP2020114888A (ja) | 2010-03-19 | 2020-05-08 | がん幹細胞を標的とするための新規の方法 |
| JP2021197732A Pending JP2022020002A (ja) | 2010-03-19 | 2021-12-06 | がん幹細胞を標的とするための新規の化合物および組成物 |
Family Applications After (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014040225A Expired - Fee Related JP5993390B2 (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2014040227A Withdrawn JP2014098050A (ja) | 2010-03-19 | 2014-03-03 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015035285A Pending JP2015098489A (ja) | 2010-03-19 | 2015-02-25 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2015179115A Expired - Fee Related JP6246169B2 (ja) | 2010-03-19 | 2015-09-11 | がん幹細胞を標的とするための新規の方法 |
| JP2016194176A Withdrawn JP2016222723A (ja) | 2010-03-19 | 2016-09-30 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2017199380A Withdrawn JP2018002744A (ja) | 2010-03-19 | 2017-10-13 | がん幹細胞を標的とするための新規の方法 |
| JP2018081329A Withdrawn JP2018115209A (ja) | 2010-03-19 | 2018-04-20 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020014705A Withdrawn JP2020063308A (ja) | 2010-03-19 | 2020-01-31 | がん幹細胞を標的とするための新規の化合物および組成物 |
| JP2020082479A Pending JP2020114888A (ja) | 2010-03-19 | 2020-05-08 | がん幹細胞を標的とするための新規の方法 |
| JP2021197732A Pending JP2022020002A (ja) | 2010-03-19 | 2021-12-06 | がん幹細胞を標的とするための新規の化合物および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP3108750B1 (OSRAM) |
| JP (11) | JP2014098049A (OSRAM) |
| CN (3) | CN107311969B (OSRAM) |
| CA (3) | CA2993363A1 (OSRAM) |
| DK (1) | DK3108750T3 (OSRAM) |
| ES (1) | ES2689928T3 (OSRAM) |
| HU (1) | HUE066482T2 (OSRAM) |
| NZ (2) | NZ712826A (OSRAM) |
| PT (1) | PT2547205T (OSRAM) |
| RU (2) | RU2015142279A (OSRAM) |
| SG (3) | SG10201704745UA (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE027443T2 (en) | 2007-09-10 | 2016-10-28 | Boston Biomedical Inc | A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors |
| SG10201704745UA (en) * | 2010-03-19 | 2017-07-28 | Boston Biomedical Inc | Novel compounds and compositions for targeting cancer stem cells |
| CN103025159A (zh) * | 2010-03-19 | 2013-04-03 | 波士顿生物医学公司 | 靶向癌症干细胞的新方法 |
| JP6433085B2 (ja) | 2013-04-09 | 2018-12-05 | ボストン バイオメディカル， インコーポレイテッド | がんの処置に使用するための２−アセチルナフト［２，３−ｂ］フラン−４，９−ジオン |
| EA201792623A1 (ru) * | 2015-06-03 | 2018-04-30 | Бостон Биомедикал, Инк. | Композиции, содержащие ингибитор стволовости рака и иммунотерапевтический агент, для применения в лечении рака |
| GB201515391D0 (en) * | 2015-08-28 | 2015-10-14 | Amazentis Sa | Compositions |
| GB201515387D0 (en) * | 2015-08-28 | 2015-10-14 | Amazentis Sa | Compositions |
| JP6751658B2 (ja) | 2016-11-15 | 2020-09-09 | クラリオン株式会社 | 音声認識装置、音声認識システム |
| US11299469B2 (en) | 2016-11-29 | 2022-04-12 | Sumitomo Dainippon Pharma Oncology, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| WO2018213424A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61205257A (ja) * | 1985-03-08 | 1986-09-11 | Ishihara Sangyo Kaisha Ltd | ベンゾイルウレア系化合物、その製法及びそれを含有する抗ガン剤 |
| EP0945131A1 (de) * | 1998-03-27 | 1999-09-29 | Boehringer Ingelheim Pharma KG | Perorale Wirkstoff-Suspension |
| EP1146869A2 (en) * | 1999-01-27 | 2001-10-24 | University Of South Florida | Inhibition of stat3 signal transduction for human cancer therapy |
| US20060142271A1 (en) * | 2002-09-17 | 2006-06-29 | Klaus Muller | Novel lapacho compounds and methods of use thereof |
| AR042052A1 (es) * | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| JP5288791B2 (ja) * | 2005-01-28 | 2013-09-11 | 武田薬品工業株式会社 | 難水溶性物質含有微細化組成物 |
| JP2006290871A (ja) * | 2005-03-16 | 2006-10-26 | Taheebo Japan Kk | 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法 |
| AR058676A1 (es) * | 2005-09-30 | 2008-02-20 | Smithkline Beecham Corp | Composicion farmaceutica que contiene (s) -(-)-n-( alfa- etilbencil) -3- hidroxi- 2- fenilquinolina-4-carboxamida ( talnetant), povidona , manitol y tensioactivo, procedimiento para prepararla y forma de dosificacion que la comprende |
| EP1860126A1 (en) * | 2006-05-26 | 2007-11-28 | INEOS Manufacturing Belgium NV | Polyolefin powder |
| HUE027443T2 (en) * | 2007-09-10 | 2016-10-28 | Boston Biomedical Inc | A novel class of Stat3 pathway inhibitors and tumor stem cell inhibitors |
| JP5719770B2 (ja) * | 2008-07-08 | 2015-05-20 | ベータ・ファーマ・インコーポレイテッドＢｅｔａ Ｐｈａｒｍａ， Ｉｎｃ． | 塩酸イコチニブ、合成物、結晶学的形態、併用薬及びその用途 |
| SG10201704745UA (en) * | 2010-03-19 | 2017-07-28 | Boston Biomedical Inc | Novel compounds and compositions for targeting cancer stem cells |
| CN103002890A (zh) * | 2010-03-19 | 2013-03-27 | 波士顿生物医学公司 | 靶向癌症干细胞的新的化合物和组合物 |
| CN103025159A (zh) * | 2010-03-19 | 2013-04-03 | 波士顿生物医学公司 | 靶向癌症干细胞的新方法 |
-
2011
- 2011-03-21 SG SG10201704745UA patent/SG10201704745UA/en unknown
- 2011-03-21 CN CN201710613672.3A patent/CN107311969B/zh active Active
- 2011-03-21 RU RU2015142279A patent/RU2015142279A/ru not_active Application Discontinuation
- 2011-03-21 CN CN201410101861.9A patent/CN104016951B/zh active Active
- 2011-03-21 SG SG10201502079VA patent/SG10201502079VA/en unknown
- 2011-03-21 ES ES16182813.2T patent/ES2689928T3/es active Active
- 2011-03-21 HU HUE11757135A patent/HUE066482T2/hu unknown
- 2011-03-21 CN CN201710134235.3A patent/CN106860443A/zh active Pending
- 2011-03-21 CA CA2993363A patent/CA2993363A1/en not_active Abandoned
- 2011-03-21 DK DK16182813.2T patent/DK3108750T3/en active
- 2011-03-21 SG SG10201706265PA patent/SG10201706265PA/en unknown
- 2011-03-21 CA CA2959951A patent/CA2959951A1/en not_active Abandoned
- 2011-03-21 CA CA2959931A patent/CA2959931A1/en not_active Abandoned
- 2011-03-21 RU RU2016123004A patent/RU2657750C1/ru active
- 2011-03-21 EP EP16182813.2A patent/EP3108750B1/en active Active
- 2011-03-21 NZ NZ712826A patent/NZ712826A/en unknown
- 2011-03-21 PT PT117571356T patent/PT2547205T/pt unknown
- 2011-03-21 EP EP17196754.0A patent/EP3295796A1/en active Pending
- 2011-03-21 NZ NZ701237A patent/NZ701237A/en not_active IP Right Cessation
-
2014
- 2014-03-03 JP JP2014040226A patent/JP2014098049A/ja not_active Withdrawn
- 2014-03-03 JP JP2014040225A patent/JP5993390B2/ja not_active Expired - Fee Related
- 2014-03-03 JP JP2014040227A patent/JP2014098050A/ja not_active Withdrawn
-
2015
- 2015-02-25 JP JP2015035285A patent/JP2015098489A/ja active Pending
- 2015-09-11 JP JP2015179115A patent/JP6246169B2/ja not_active Expired - Fee Related
-
2016
- 2016-09-30 JP JP2016194176A patent/JP2016222723A/ja not_active Withdrawn
-
2017
- 2017-10-13 JP JP2017199380A patent/JP2018002744A/ja not_active Withdrawn
-
2018
- 2018-04-20 JP JP2018081329A patent/JP2018115209A/ja not_active Withdrawn
-
2020
- 2020-01-31 JP JP2020014705A patent/JP2020063308A/ja not_active Withdrawn
- 2020-05-08 JP JP2020082479A patent/JP2020114888A/ja active Pending
-
2021
- 2021-12-06 JP JP2021197732A patent/JP2022020002A/ja active Pending
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