JP2014000431A - 脳血流画像化、及びマイクロバブルを用いた血餅溶解をする超音波システム - Google Patents
脳血流画像化、及びマイクロバブルを用いた血餅溶解をする超音波システム Download PDFInfo
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Abstract
【解決手段】トランスデューサヘッドセットは、好ましくはマイクロバブル造影剤により支援され、頭蓋内の血管系の2次元又は3次元画像を生成する。血流マップは、血餅の兆しを診断され得るシステムにより生成される。血餅が検出される場合、マイクロバブルの破壊により血餅を破壊するため、造影剤が存在する間、治療ビームが送信される。ヘッドセットは、卒中の患者の血餅の再発を検出するモニタリング用途にも使用され得る。
【選択図】図7
Description
Claims (20)
- 頭蓋の血管の閉塞を治療するための卒中治療システムであって、
超音波トランスデューサアレイを被検体の頭部と音響的に接触させて保持するトランスデューサアレイヘッドセットと、
前記超音波トランスデューサアレイに結合され、前記被検体の前記頭蓋の血流の画像を生成する画像プロセッサと、
前記画像プロセッサに結合され、前記頭蓋の血管系の画像を生成する画像ディスプレイと
を有するシステム。 - 前記画像プロセッサがドップラプロセッサを有し、
前記ドップラプロセッサが、速度ドップラ画像及びパワードップラ画像のうちの少なくとも1つを生成する、請求項1に記載の卒中治療システム。 - 超音波トランスデューサアレイは、前記被検体の前記頭蓋の閉塞部に治療ビームを向けるため、治療モードで更に動作可能であり、
前記治療ビームが、前記閉塞部においてマイクロバブルを破裂させることができる超音波ビームを含む、請求項1に記載の卒中治療システム。 - 前記トランスデューサアレイヘッドセットが、第1超音波トランスデューサアレイを前記頭部の一方の側と音響的に接触させて保持し、
前記ヘッドセットにより、前記頭部の他方の側と音響的な接触を維持される第2トランスデューサアレイを更に含む、請求項1に記載の卒中治療システム。 - 頭蓋の血管の閉塞を治療する卒中治療システムであって、
超音波トランスデューサアレイを被検体の頭部と音響的に接触させて保持するトランスデューサアレイヘッドセットと、
該超音波トランスデューサアレイに結合され、前記被検体の前記頭蓋の血流の画像を生成する画像プロセッサと、
前記画像プロセッサに結合され、前記頭蓋の血管系の画像を生成する画像ディスプレイと、
前記トランスデューサアレイに結合され、前記超音波トランスデューサアレイに超音波ビームを生成させるように作動する送信機とを有し、
前記超音波ビームの画像化及び供給が共通の超音波トランスデューサアレイによりなされる、システム。 - 前記超音波ビームの画像化及び供給が、ともに被検体に対する診断超音波エネルギー供給の制限内でなされる、請求項5に記載の卒中治療システム。
- 前記送信機が、前記トランスデューサアレイに対するパルス幅変調及びデューティサイクル変調信号のうちの少なくとも1つを適用するように動作する、請求項5に記載の卒中治療システム。
- 前記送信機は、前記超音波トランスデューサアレイがドップラ画像及びBモード画像のうちの少なくとも1つのためにビームを送信するように更に動作する、請求項5に記載の卒中治療システム。
- 前記送信機は、前記頭蓋における所与の側面の次元を示す画像化領域に渡って画像化するビームを送信するように更に動作し、
前記治療ビームが、前記所与の側面の次元以外の側面の次元を示す、請求項8に記載の卒中治療システム。 - 前記送信機は、前記頭蓋における所与の空間的領域を占有する画像化領域に渡って画像化ビームを送信するように動作し、
前記治療ビームが、前記所与の空間的領域の一部に渡って送信される、請求項8に記載の卒中治療システム。 - 前記超音波トランスデューサアレイが2次元アレイのトランスデューサ素子を有し、
前記所与の空間的領域が容積測定の領域である、請求項10に記載の卒中治療システム。 - 前記2次元アレイが、前記頭部の一方の側と音響的に接触して保持され、
前記頭部の他方の側と、前記ヘッドセットにより音響的に接触して保持される第2の2次元アレイを更に有する、請求項11に記載の卒中治療システム。 - 前記第1の2次元アレイが、前記頭部の左側と前記頭蓋の中心との間の頭蓋距離の大部分に渡って画像化ビームをスキャンし、
前記第2の2次元アレイが、前記頭部の右側と前記頭蓋の中心との間の頭蓋距離の大部分に渡って画像化ビームをスキャンする、請求項12に記載の卒中治療システム。 - 第1及び第2のトランスデューサアレイを含むヘッドセットを被検体の頭部に適用し、該トランスデューサアレイを前記頭部の反対側と音響的に接触させるステップと、
前記トランスデューサアレイのうちの少なくとも1つから受信される信号から、頭蓋内のフローの超音波画像を生成するステップと、
前記ヘッドセットが前記トランスデューサアレイを前記頭部と音響的に接触して保持することを確かにするステップと、
前記被検体の前記血流にマイクロバブルを注入するステップと、
マイクロバブルを含む頭蓋内のフローの超音波画像を生成するステップとを含む、卒中を治療する方法。 - 頭蓋内のフローの前記超音波画像における狭窄を検出するステップと、
前記狭窄に近接したマイクロバブルに対して、前記トランスデューサアレイのうちの少なくとも1つからの治療超音波ビームを向けるステップとを更に有する、請求項14に記載の方法。 - 前記治療ビームを向けるステップが、前記狭窄に近接したマイクロバブルに対してペンシルビームを操作するステップを更に含む、請求項15に記載の方法。
- 前記治療ビームを向けるステップが、前記狭窄に近接したマイクロバブルを振動させるステップを更に含む、請求項15に記載の方法。
- 前記治療ビームを向けるステップが、前記狭窄に近接したマイクロバブルを破壊するステップを更に含む、請求項15に記載の方法。
- 前記治療超音波ビームを向けるステップが、治療超音波ビームを診断超音波に対する制限内のエネルギーレベルで前記狭窄に近接したマイクロバブルに送信するステップを更に含む、請求項15に記載の方法。
- 適用するステップが、第1及び第2の二次元トランスデューサアレイを含むヘッドセットを適用するステップを更に含み、
前記超音波画像を生成するステップが3次元超音波画像を生成するステップを更に含む、請求項14に記載の方法。
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EP (1) | EP2051777B1 (ja) |
JP (2) | JP5450065B2 (ja) |
CN (1) | CN101500650B (ja) |
WO (1) | WO2008017997A2 (ja) |
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EP2051777B1 (en) | 2019-01-16 |
JP2010500084A (ja) | 2010-01-07 |
WO2008017997A3 (en) | 2008-05-08 |
EP2051777A2 (en) | 2009-04-29 |
US20170196465A1 (en) | 2017-07-13 |
WO2008017997A2 (en) | 2008-02-14 |
JP5450065B2 (ja) | 2014-03-26 |
JP5684870B2 (ja) | 2015-03-18 |
CN101500650B (zh) | 2012-08-08 |
US10363012B2 (en) | 2019-07-30 |
CN101500650A (zh) | 2009-08-05 |
US9630028B2 (en) | 2017-04-25 |
US20100160779A1 (en) | 2010-06-24 |
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