JP2013544846A5 - - Google Patents
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- JP2013544846A5 JP2013544846A5 JP2013542201A JP2013542201A JP2013544846A5 JP 2013544846 A5 JP2013544846 A5 JP 2013544846A5 JP 2013542201 A JP2013542201 A JP 2013542201A JP 2013542201 A JP2013542201 A JP 2013542201A JP 2013544846 A5 JP2013544846 A5 JP 2013544846A5
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- Japan
- Prior art keywords
- alkyl
- halo
- cycloalkyl
- alkoxyl
- alkylamino
- Prior art date
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- LXFOLMYKSYSZQS-LURJZOHASA-N CC(C)N(C[C@H]([C@H]([C@H]1O)O)O[C@H]1[n]1c(ncnc2N)c2nc1)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 Chemical compound CC(C)N(C[C@H]([C@H]([C@H]1O)O)O[C@H]1[n]1c(ncnc2N)c2nc1)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 LXFOLMYKSYSZQS-LURJZOHASA-N 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41966110P | 2010-12-03 | 2010-12-03 | |
US61/419,661 | 2010-12-03 | ||
PCT/US2011/063044 WO2012075381A1 (en) | 2010-12-03 | 2011-12-02 | Substituted purine and 7 - deazapurine compounds as modulators of epigenetic enzymes |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013544846A JP2013544846A (ja) | 2013-12-19 |
JP2013544846A5 true JP2013544846A5 (US07794700-20100914-C00152.png) | 2015-01-15 |
JP5931905B2 JP5931905B2 (ja) | 2016-06-08 |
Family
ID=45444712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013542201A Active JP5931905B2 (ja) | 2010-12-03 | 2011-12-02 | 置換プリン及び7‐デアザプリン化合物 |
Country Status (19)
Families Citing this family (56)
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JP2016518336A (ja) | 2013-03-14 | 2016-06-23 | エピザイム,インコーポレイティド | Prmt1阻害剤としてのピラゾール誘導体およびその使用 |
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WO2015003131A1 (en) * | 2013-07-03 | 2015-01-08 | Epizyme, Inc. | Substituted purine compounds |
AU2014296532B2 (en) * | 2013-07-29 | 2019-05-16 | Dana-Farber Cancer Institute, Inc. | DOT1L probes |
CA2920252A1 (en) | 2013-08-02 | 2015-02-05 | Memorial Sloan-Kettering Cancer Center | Methods for the detection and treatment of leukemias that are responsive to dot1l inhibition |
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JP6585158B2 (ja) | 2014-08-12 | 2019-10-02 | ファイザー・インク | ヤヌスキナーゼの阻害に有用なピロロ[2,3−d]ピリミジン誘導体 |
EP3180010A4 (en) * | 2014-08-13 | 2018-06-20 | Epizyme, Inc. | Combination therapy for treating cancer |
US9458165B2 (en) | 2014-08-27 | 2016-10-04 | Dana-Farber Cancer Institute, Inc. | DOT1L inhibitors |
US20190083521A1 (en) * | 2014-09-17 | 2019-03-21 | Epizyme, Inc. | Combination therapy for treating cancer |
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WO2016051396A1 (en) * | 2014-09-30 | 2016-04-07 | Susan Eve Vecht-Lifshitz | Pharmaceutical compositions for treating ebola virus disease |
US20180028552A1 (en) * | 2015-01-30 | 2018-02-01 | Epizyme, Inc. | Combination therapy for treating cancer |
US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
US10869868B2 (en) | 2016-01-26 | 2020-12-22 | Memorial Sloan Kettering Cancer Center | Targeting chromatin regulators inhibits leukemogenic gene expression in NPM1 mutant leukemia |
CN109462980B (zh) * | 2016-03-15 | 2022-02-08 | 奥莱松基因组股份有限公司 | 用于治疗血液恶性肿瘤的lsd1抑制剂的组合 |
CN109195593A (zh) | 2016-03-15 | 2019-01-11 | 奥莱松基因组股份有限公司 | 用于治疗实体瘤的lsd1抑制剂的组合 |
CN106432095B (zh) * | 2016-09-09 | 2019-04-16 | 东南大学 | 匹莫苯丹关键中间体6-(3,4-二氨基苯基)-5-甲基-4,5-二氢哒嗪-3(2h)-酮的制备 |
US11944627B2 (en) | 2017-03-24 | 2024-04-02 | Kura Oncology, Inc. | Methods for treating hematological malignancies and Ewing's sarcoma |
CN109748944B (zh) * | 2017-11-03 | 2021-12-10 | 中国科学院上海药物研究所 | 5’-脱氧-5’-异丙基取代氨基核苷类化合物、其制备方法和用途 |
CN109748943A (zh) * | 2017-11-03 | 2019-05-14 | 中国科学院上海药物研究所 | 2’-c-甲基取代核苷类化合物及其制备与用途 |
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KR102118891B1 (ko) | 2018-10-04 | 2020-06-04 | 성균관대학교산학협력단 | 매소니아노사이드 b를 유효성분으로 포함하는 혼합 직계성 백혈병 유전자 재배열 동반 백혈병 예방 및 치료용 약학적 조성물 |
CN118290350A (zh) * | 2019-03-11 | 2024-07-05 | 协同医药发展有限公司 | 治疗铁死亡相关紊乱的杂芳基和双杂环芳基衍生物 |
CN110092804A (zh) * | 2019-03-29 | 2019-08-06 | 广州盈升生物科技有限公司 | 一种含双环基团的嘌呤化合物及其制备方法 |
SG11202110742TA (en) | 2019-04-02 | 2021-10-28 | Aligos Therapeutics Inc | Compounds targeting prmt5 |
CN113024620B (zh) * | 2021-03-11 | 2023-02-28 | 沈阳药科大学 | 一种嘌呤衍生物及其制备方法和用途 |
WO2022271540A1 (en) * | 2021-06-21 | 2022-12-29 | Mayo Foundation For Medical Education And Research | Inhibitors of dot1l |
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WO2023004283A1 (en) * | 2021-07-19 | 2023-01-26 | Dana-Farber Cancer Institute, Inc. | Targeting dot1l and smarca4/2 for the treatment of mllr leukemia |
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CA2819648C (en) * | 2010-12-03 | 2018-05-01 | Epizyme, Inc. | Substituted purine and 7-deazapurine compounds |
EP2646455A4 (en) | 2010-12-03 | 2014-04-02 | Epizyme Inc | MODULATORS OF HISTON METHYLTRANSFERASE AND METHOD OF USE THEREOF |
AU2011336264A1 (en) | 2010-12-03 | 2013-06-20 | Epizyme, Inc. | Carbocycle-substituted purine and 7-deazapurine compounds |
AU2013312319B2 (en) * | 2012-09-06 | 2018-04-19 | Epizyme, Inc. | Method of treating leukemia |
US9446064B2 (en) * | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | Combination therapy for treating cancer |
US9738679B2 (en) * | 2013-03-15 | 2017-08-22 | Epizyme, Inc. | Methods of synthesizing substituted purine compounds |
CA2920252A1 (en) * | 2013-08-02 | 2015-02-05 | Memorial Sloan-Kettering Cancer Center | Methods for the detection and treatment of leukemias that are responsive to dot1l inhibition |
WO2015073706A1 (en) * | 2013-11-13 | 2015-05-21 | Epizyme, Inc. | Methods for treating cancer |
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2011
- 2011-12-02 CA CA2819648A patent/CA2819648C/en active Active
- 2011-12-02 US US13/310,157 patent/US8580762B2/en active Active
- 2011-12-02 DK DK11804836.2T patent/DK2646444T3/da active
- 2011-12-02 CN CN201180066760.7A patent/CN103391939B/zh active Active
- 2011-12-02 ES ES11804836.2T patent/ES2577027T3/es active Active
- 2011-12-02 AU AU2011336415A patent/AU2011336415B2/en active Active
- 2011-12-02 MX MX2013006251A patent/MX2013006251A/es active IP Right Grant
- 2011-12-02 KR KR1020137017337A patent/KR101923746B1/ko active IP Right Grant
- 2011-12-02 EP EP11804836.2A patent/EP2646444B1/en active Active
- 2011-12-02 RU RU2013130250A patent/RU2606514C2/ru active
- 2011-12-02 JP JP2013542201A patent/JP5931905B2/ja active Active
- 2011-12-02 SI SI201130856A patent/SI2646444T1/sl unknown
- 2011-12-02 WO PCT/US2011/063044 patent/WO2012075381A1/en active Application Filing
- 2011-12-02 BR BR112013013659A patent/BR112013013659B8/pt active IP Right Grant
- 2011-12-05 AR ARP110104537A patent/AR084408A1/es active IP Right Grant
- 2011-12-05 TW TW100144669A patent/TWI537271B/zh active
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2013
- 2013-05-30 IL IL226651A patent/IL226651A/en active IP Right Grant
- 2013-10-16 US US14/055,510 patent/US9096634B2/en active Active
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2014
- 2014-03-19 HK HK14102772.4A patent/HK1189596A1/zh unknown
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2015
- 2015-06-26 US US14/752,023 patent/US20150366893A1/en not_active Abandoned
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2016
- 2016-06-10 HR HRP20160655TT patent/HRP20160655T1/hr unknown
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2017
- 2017-11-03 US US15/802,979 patent/US20180280422A1/en not_active Abandoned
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2020
- 2020-06-10 US US16/897,690 patent/US20210252035A1/en not_active Abandoned