JP2013544078A5 - - Google Patents

Info

Publication number

JP2013544078A5

JP2013544078A5 JP2013534142A JP2013534142A JP2013544078A5 JP 2013544078 A5 JP2013544078 A5 JP 2013544078A5 JP 2013534142 A JP2013534142 A JP 2013534142A JP 2013534142 A JP2013534142 A JP 2013534142A JP 2013544078 A5 JP2013544078 A5 JP 2013544078A5

Authority

JP

Japan

Prior art keywords

antibody

sequence

seq

administration

light chain

Prior art date

2011-10-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000006467 substitution reaction Methods 0.000 claims description 10
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• 239000004475 Arginine Substances 0.000 claims description 6
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• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 4
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• 102000039446 nucleic acids Human genes 0.000 claims description 4
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• 239000004472 Lysine Substances 0.000 claims description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
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