JP2013542929A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013542929A5 JP2013542929A5 JP2013530855A JP2013530855A JP2013542929A5 JP 2013542929 A5 JP2013542929 A5 JP 2013542929A5 JP 2013530855 A JP2013530855 A JP 2013530855A JP 2013530855 A JP2013530855 A JP 2013530855A JP 2013542929 A5 JP2013542929 A5 JP 2013542929A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- heterocyclyl
- aryl
- cycloalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 42
- 125000000623 heterocyclic group Chemical group 0.000 claims 41
- 125000003118 aryl group Chemical group 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 28
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 27
- 125000000304 alkynyl group Chemical group 0.000 claims 26
- 125000003342 alkenyl group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 19
- -1 C 6-8 cycloalkynyl Chemical group 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000002207 metabolite Substances 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 229940002612 prodrug Drugs 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 210000003169 central nervous system Anatomy 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 210000001428 peripheral nervous system Anatomy 0.000 claims 5
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 4
- MZAGXDHQGXUDDX-JSRXJHBZSA-N (e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/C(N)=O MZAGXDHQGXUDDX-JSRXJHBZSA-N 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 claims 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- PUJDIJCNWFYVJX-UHFFFAOYSA-N benzyl carbamate Chemical compound NC(=O)OCC1=CC=CC=C1 PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 claims 2
- 230000000035 biogenic effect Effects 0.000 claims 2
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 claims 2
- 229960003638 dopamine Drugs 0.000 claims 2
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 claims 2
- 230000000926 neurological effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229960002748 norepinephrine Drugs 0.000 claims 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 229940076279 serotonin Drugs 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- QPLJYAKLSCXZSF-UHFFFAOYSA-N 2,2,2-trichloroethyl carbamate Chemical compound NC(=O)OCC(Cl)(Cl)Cl QPLJYAKLSCXZSF-UHFFFAOYSA-N 0.000 claims 1
- ZZOKVYOCRSMTSS-UHFFFAOYSA-N 9h-fluoren-9-ylmethyl carbamate Chemical compound C1=CC=C2C(COC(=O)N)C3=CC=CC=C3C2=C1 ZZOKVYOCRSMTSS-UHFFFAOYSA-N 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000004982 aromatic amines Chemical class 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 150000002081 enamines Chemical class 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- OCAAZRFBJBEVPS-UHFFFAOYSA-N prop-2-enyl carbamate Chemical compound NC(=O)OCC=C OCAAZRFBJBEVPS-UHFFFAOYSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2322/DEL/2010 | 2010-09-28 | ||
| IN2322DE2010 | 2010-09-28 | ||
| IN1515DE2011 | 2011-05-26 | ||
| IN1515/DEL/2011 | 2011-05-26 | ||
| PCT/IN2011/000669 WO2012042539A2 (en) | 2010-09-28 | 2011-09-27 | Novel bicyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013542929A JP2013542929A (ja) | 2013-11-28 |
| JP2013542929A5 true JP2013542929A5 (enExample) | 2014-12-04 |
Family
ID=45048157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530855A Pending JP2013542929A (ja) | 2010-09-28 | 2011-09-27 | 新規ビシクロ環化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9133116B2 (enExample) |
| EP (1) | EP2621902B1 (enExample) |
| JP (1) | JP2013542929A (enExample) |
| AR (1) | AR083202A1 (enExample) |
| BR (1) | BR112013007566A2 (enExample) |
| WO (1) | WO2012042539A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2685828A4 (en) * | 2011-03-17 | 2014-08-13 | Merck Sharp & Dohme | SUBSTITUTED 3-AZABICYCLO [3,1,0-] HEXAN DERIVATIVES AS CCR2 ANTAGONISTS |
| JP5936849B2 (ja) * | 2011-11-24 | 2016-06-22 | 東洋ゴム工業株式会社 | 空気入りタイヤの製造方法 |
| WO2015123505A1 (en) * | 2014-02-14 | 2015-08-20 | Takeda Pharmaceutical Company Limited | Pyridopyrazines modulators of gpr6 |
| US9575560B2 (en) | 2014-06-03 | 2017-02-21 | Google Inc. | Radar-based gesture-recognition through a wearable device |
| US9811164B2 (en) | 2014-08-07 | 2017-11-07 | Google Inc. | Radar-based gesture sensing and data transmission |
| US10268321B2 (en) | 2014-08-15 | 2019-04-23 | Google Llc | Interactive textiles within hard objects |
| US11169988B2 (en) | 2014-08-22 | 2021-11-09 | Google Llc | Radar recognition-aided search |
| US9778749B2 (en) | 2014-08-22 | 2017-10-03 | Google Inc. | Occluded gesture recognition |
| US9600080B2 (en) | 2014-10-02 | 2017-03-21 | Google Inc. | Non-line-of-sight radar-based gesture recognition |
| EP3289432B1 (en) | 2015-04-30 | 2019-06-12 | Google LLC | Rf-based micro-motion tracking for gesture tracking and recognition |
| CN107466389B (zh) | 2015-04-30 | 2021-02-12 | 谷歌有限责任公司 | 用于确定类型不可知的rf信号表示的方法和装置 |
| EP3289434A1 (en) | 2015-04-30 | 2018-03-07 | Google LLC | Wide-field radar-based gesture recognition |
| US10088908B1 (en) | 2015-05-27 | 2018-10-02 | Google Llc | Gesture detection and interactions |
| US9693592B2 (en) | 2015-05-27 | 2017-07-04 | Google Inc. | Attaching electronic components to interactive textiles |
| US10817065B1 (en) | 2015-10-06 | 2020-10-27 | Google Llc | Gesture recognition using multiple antenna |
| CN115531553A (zh) * | 2015-12-22 | 2022-12-30 | 武田药品工业株式会社 | 内体g蛋白-偶联的受体的三部分调节剂 |
| US10492302B2 (en) | 2016-05-03 | 2019-11-26 | Google Llc | Connecting an electronic component to an interactive textile |
| WO2017200949A1 (en) | 2016-05-16 | 2017-11-23 | Google Llc | Interactive fabric |
| WO2017200570A1 (en) | 2016-05-16 | 2017-11-23 | Google Llc | Interactive object with multiple electronics modules |
| WO2018053587A1 (en) * | 2016-09-21 | 2018-03-29 | Vectus Biosystems Limited | Compositions for the treatment of hypertension and/or fibrosis |
| US10579150B2 (en) | 2016-12-05 | 2020-03-03 | Google Llc | Concurrent detection of absolute distance and relative movement for sensing action gestures |
| TWI860849B (zh) | 2021-09-14 | 2024-11-01 | 美商美國禮來大藥廠 | Sstr4促效劑鹽 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4435419A (en) | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
| US4438130A (en) | 1981-11-12 | 1984-03-20 | The Upjohn Company | Analgesic 1-oxa-, aza- and thia-spirocyclic compounds |
| US4560767A (en) | 1983-06-17 | 1985-12-24 | The Upjohn Company | N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom |
| WO1991002526A1 (en) | 1989-08-16 | 1991-03-07 | Pfizer Inc. | Azabicyclo quinolone carboxylic acids |
| US5164402A (en) | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
| DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| AU685225B2 (en) | 1994-02-10 | 1998-01-15 | Yamanouchi Pharmaceutical Co., Ltd. | Novel carbamate derivative and medicinal composition containing the same |
| US5475116A (en) * | 1994-04-29 | 1995-12-12 | Pfizer Inc. | Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones |
| GB9524157D0 (en) | 1995-11-25 | 1996-01-24 | Pfizer Ltd | Therapeutic agents |
| HUP9902455A3 (en) | 1996-03-29 | 2000-06-28 | Pfizer | 6-phenylpyridyl-2-amine derivatives, pharmaceutical compositions containing them |
| US5914338A (en) | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
| US5968929A (en) | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB0015562D0 (en) | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| US20030207876A1 (en) | 2000-06-23 | 2003-11-06 | Banks Bernard Joseph | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
| CA2425288A1 (en) | 2000-10-11 | 2002-05-02 | Sander G. Mills | Pyrrolidine modulators of ccr5 chemokine receptor activity |
| US6372919B1 (en) | 2001-01-11 | 2002-04-16 | Dov Pharmaceutical, Inc. | (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent |
| ATE304536T1 (de) | 2001-04-17 | 2005-09-15 | Merck & Co Inc | Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate |
| US20030232739A1 (en) | 2001-08-15 | 2003-12-18 | Pfizer Inc. | Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist |
| EA006708B1 (ru) | 2001-10-22 | 2006-02-24 | Пфайзер Продактс Инк. | Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| GB0208897D0 (en) | 2002-04-18 | 2002-05-29 | Merck Sharp & Dohme | New method of treatment |
| AU2002345266B2 (en) | 2002-07-08 | 2009-07-02 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
| EP1534675B1 (en) | 2002-08-23 | 2009-02-25 | Ranbaxy Laboratories, Ltd. | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| EP1590345A1 (en) | 2002-12-23 | 2005-11-02 | Ranbaxy Laboratories, Ltd. | Xanthine derivatives as muscarinic receptor antagonists |
| JP2006522791A (ja) | 2003-04-09 | 2006-10-05 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗微生物性［３．１．０］ビシクロヘキシルフェニルオキサゾリジノン誘導体および類似体 |
| JP2006522787A (ja) | 2003-04-11 | 2006-10-05 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体 |
| ATE471937T1 (de) | 2003-07-02 | 2010-07-15 | Merck Sharp & Dohme | Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon |
| AU2004256086B2 (en) | 2003-07-02 | 2007-12-06 | Kyorin Pharmaceutical Co., Ltd. | Oxazolidinone antibiotics and derivatives thereof |
| CA2529292A1 (en) | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| US20070185132A1 (en) | 2003-07-02 | 2007-08-09 | Yasumichi Fukuda | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo |
| EP1670759A1 (en) | 2003-09-18 | 2006-06-21 | Ranbaxy Laboratories Limited | PROCESS FOR THE PREPARATION OF (1a, 5a, 6a)-6-AMINOME THYL-3-BENZYL-3-AZABICYCLO 3.1.0 HEXANE |
| US7153976B2 (en) | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
| RS20060190A (sr) | 2003-10-14 | 2008-08-07 | Pfizer Products Inc., | Biciklični /3.1.0/ derivati kao inhibitori transportera glicina |
| JP2007508367A (ja) | 2003-10-16 | 2007-04-05 | ファイザー・プロダクツ・インク | ３−アザビシクロ［３．１．０］ヘキサン誘導体の製造方法 |
| DE602005021760D1 (de) | 2004-02-27 | 2010-07-22 | Schering Corp | Schwefelverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus |
| US20050282859A1 (en) | 2004-06-04 | 2005-12-22 | Thor Karl B | Dual acting SNRI-NMDA antagonists for the treatment of genitourinary disorders |
| MX2007000015A (es) | 2004-06-22 | 2007-03-07 | Schering Corp | Ligandos de receptor de canabinoide. |
| MX2007002136A (es) | 2004-09-01 | 2007-04-02 | Pfizer Prod Inc | Antagonistas amino azabiciclicos del receptor 3 de la histamina. |
| JP4887297B2 (ja) | 2004-09-24 | 2012-02-29 | アクテリオン ファーマシューティカルズ リミテッド | 新規二環式抗生物質 |
| US20100016400A1 (en) | 2004-11-19 | 2010-01-21 | Naresh Kumar | Azabicyclic muscarinic receptor antagonists |
| EP1828126A1 (en) | 2004-12-15 | 2007-09-05 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
| US20060223875A1 (en) | 2005-03-08 | 2006-10-05 | Phil Skolnick | Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0]hexanes |
| GEP20105053B (en) | 2005-04-08 | 2010-07-26 | Pfizer Prod Inc | Bicyclic [3.1.0] heteroaryl amides as type i glycine transport inhibitors |
| WO2006117754A1 (en) | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists |
| GB0510204D0 (en) | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| US20090012116A1 (en) | 2005-07-11 | 2009-01-08 | Naresh Kumar | Muscarinic Receptor Antagonists |
| WO2007006117A1 (en) | 2005-07-13 | 2007-01-18 | Nicogen Inc. | Novel cyp2a6 inhibitors |
| US20070082939A1 (en) | 2005-07-26 | 2007-04-12 | Lippa Arnold S | Methods and compositions for the treatment of neuropathies and related disorders |
| EP1915146A4 (en) | 2005-07-27 | 2010-06-02 | Dov Pharmaceutical Inc | NOVEL 1-ARYL-3-AZABICYCLO [3.1.0] HEXANEES. PREPARATION AND USE FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES |
| WO2007127421A2 (en) | 2006-04-28 | 2007-11-08 | Merck & Co., Inc. | Process for the synthesis of (+) and (-)-1-aryl-3-azabicyclo[3.1.0]hexanes |
| WO2007135527A2 (en) | 2006-05-23 | 2007-11-29 | Pfizer Products Inc. | Benzimidazolyl compounds |
| WO2007135529A2 (en) | 2006-05-23 | 2007-11-29 | Pfizer Products Inc. | Azabenzimidazolyl compounds as mglur2 potentiators |
| WO2007138431A2 (en) | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Azabicyclic ether histamine-3 antagonists |
| US20080058535A1 (en) | 2006-07-25 | 2008-03-06 | Zhengming Chen | Methods and compositions for production, formulation and use of 1 aryl-3-azabicyclo[3.1.0]hexanes |
| EP2059505A2 (en) | 2006-09-04 | 2009-05-20 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| WO2008053131A1 (en) | 2006-10-30 | 2008-05-08 | Chroma Therapeutics Ltd. | Hydroxamates as inhibitors of histone deacetylase |
| WO2008075162A2 (en) | 2006-12-15 | 2008-06-26 | Pfizer Limited | Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction |
| GB0625198D0 (en) | 2006-12-18 | 2007-01-24 | Glaxo Group Ltd | Chemical compounds |
| US20080287479A1 (en) | 2006-12-20 | 2008-11-20 | Pfizer Inc | Inhibitors of serine palmitoyltransferase |
| US20080176860A1 (en) | 2007-01-19 | 2008-07-24 | Lutz Weber | Pyridin-2-one compounds |
| WO2008117229A1 (en) | 2007-03-23 | 2008-10-02 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| EP1980150A1 (en) | 2007-04-13 | 2008-10-15 | Basf Se | Fungicidal mixtures based on triazolopyrimidine compounds |
| EP2167083B1 (en) | 2007-06-06 | 2015-10-28 | Euthymics Bioscience, Inc. | 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| JP2009040709A (ja) | 2007-08-08 | 2009-02-26 | Kyorin Pharmaceut Co Ltd | １２位置換ムチリン誘導体 |
| GB0716632D0 (en) | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Compounds |
| CA2705719C (en) | 2007-09-14 | 2016-10-11 | Janssen Pharmaceutica N.V. | Thieno-and furo-pyrimidine modulators of the histamine h4 receptor |
| WO2009090548A2 (en) | 2008-01-17 | 2009-07-23 | Glenmark Pharmaceuticals, S.A. | 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands |
| US8278311B2 (en) | 2008-04-28 | 2012-10-02 | Abbott Laboratories | Substituted pyrimidine derivatives |
| GB0809479D0 (en) | 2008-05-23 | 2008-07-02 | Glaxo Group Ltd | Novel compounds |
| US20120108565A1 (en) | 2008-07-30 | 2012-05-03 | Lalima Sharma | Pyrrole carboxylic acid derivatives as antibacterial agents |
| EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| KR20120106697A (ko) | 2009-06-26 | 2012-09-26 | 파나세아 바이오테크 리미티드 | 신규 아자비시클로헥산 |
-
2011
- 2011-09-27 BR BR112013007566A patent/BR112013007566A2/pt not_active IP Right Cessation
- 2011-09-27 US US13/876,757 patent/US9133116B2/en not_active Expired - Fee Related
- 2011-09-27 JP JP2013530855A patent/JP2013542929A/ja active Pending
- 2011-09-27 WO PCT/IN2011/000669 patent/WO2012042539A2/en not_active Ceased
- 2011-09-27 EP EP11788589.7A patent/EP2621902B1/en not_active Not-in-force
- 2011-09-28 AR ARP110103576A patent/AR083202A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013542929A5 (enExample) | ||
| RU2014141579A (ru) | Гетероциклические соединения в качестве ингибиторов бета-лактамаз | |
| JP2011515482A5 (enExample) | ||
| EP3138838A1 (en) | Small molecules for the modulation of mcl-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders | |
| JP2014511892A5 (enExample) | ||
| JP2013010793A5 (enExample) | ||
| JP2019520417A5 (enExample) | ||
| CN102762207A (zh) | 用于治疗神经精神疾患的nmda受体拮抗剂 | |
| JP2014518853A5 (enExample) | ||
| JP2021502323A5 (enExample) | ||
| RU2012102094A (ru) | Новые азабициклогексаны | |
| JP2010511626A5 (enExample) | ||
| FI2291080T5 (fi) | Uusia sfingosiinifosfaattireseptorimodulaattoreita | |
| CN107205994A (zh) | 脂肪酸半胱胺缀合物和它们作为自噬的活化剂的用途 | |
| JP2013010792A5 (enExample) | ||
| JP2014051526A5 (enExample) | ||
| JP2017537940A5 (enExample) | ||
| JP2010524975A5 (enExample) | ||
| JP2014503525A5 (enExample) | ||
| RU2005123802A (ru) | Производные адамантана, способы их получения и содержащие их фармацевтические композиции | |
| JP2013528180A5 (enExample) | ||
| RU2015107803A (ru) | Производные дигидроксипиримидинкарбоновой кислоты и их применение в лечении, облегчении или предотвращении вирусного заболевания | |
| JP2020502047A5 (enExample) | ||
| TWI455938B (zh) | 碳酸啶衍生物及其醫藥組成物 | |
| JP2018531289A5 (enExample) |