JP2013542929A5 - - Google Patents
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- Publication number
- JP2013542929A5 JP2013542929A5 JP2013530855A JP2013530855A JP2013542929A5 JP 2013542929 A5 JP2013542929 A5 JP 2013542929A5 JP 2013530855 A JP2013530855 A JP 2013530855A JP 2013530855 A JP2013530855 A JP 2013530855A JP 2013542929 A5 JP2013542929 A5 JP 2013542929A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- heterocyclyl
- aryl
- cycloalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 42
- 125000000623 heterocyclic group Chemical group 0.000 claims 41
- 125000003118 aryl group Chemical group 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 28
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 27
- 125000000304 alkynyl group Chemical group 0.000 claims 26
- 125000003342 alkenyl group Chemical group 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 19
- -1 C 6-8 cycloalkynyl Chemical group 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000002207 metabolite Substances 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 229940002612 prodrug Drugs 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 210000003169 central nervous system Anatomy 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 210000001428 peripheral nervous system Anatomy 0.000 claims 5
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 4
- MZAGXDHQGXUDDX-JSRXJHBZSA-N (e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/C(N)=O MZAGXDHQGXUDDX-JSRXJHBZSA-N 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 claims 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000025966 Neurological disease Diseases 0.000 claims 2
- PUJDIJCNWFYVJX-UHFFFAOYSA-N benzyl carbamate Chemical compound NC(=O)OCC1=CC=CC=C1 PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 claims 2
- 230000000035 biogenic effect Effects 0.000 claims 2
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 claims 2
- 229960003638 dopamine Drugs 0.000 claims 2
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 claims 2
- 230000000926 neurological effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229960002748 norepinephrine Drugs 0.000 claims 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 229940076279 serotonin Drugs 0.000 claims 2
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- QPLJYAKLSCXZSF-UHFFFAOYSA-N 2,2,2-trichloroethyl carbamate Chemical compound NC(=O)OCC(Cl)(Cl)Cl QPLJYAKLSCXZSF-UHFFFAOYSA-N 0.000 claims 1
- ZZOKVYOCRSMTSS-UHFFFAOYSA-N 9h-fluoren-9-ylmethyl carbamate Chemical compound C1=CC=C2C(COC(=O)N)C3=CC=CC=C3C2=C1 ZZOKVYOCRSMTSS-UHFFFAOYSA-N 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000004982 aromatic amines Chemical class 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 150000002081 enamines Chemical class 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- OCAAZRFBJBEVPS-UHFFFAOYSA-N prop-2-enyl carbamate Chemical compound NC(=O)OCC=C OCAAZRFBJBEVPS-UHFFFAOYSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2322DE2010 | 2010-09-28 | ||
| IN2322/DEL/2010 | 2010-09-28 | ||
| IN1515DE2011 | 2011-05-26 | ||
| IN1515/DEL/2011 | 2011-05-26 | ||
| PCT/IN2011/000669 WO2012042539A2 (en) | 2010-09-28 | 2011-09-27 | Novel bicyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013542929A JP2013542929A (ja) | 2013-11-28 |
| JP2013542929A5 true JP2013542929A5 (enExample) | 2014-12-04 |
Family
ID=45048157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530855A Pending JP2013542929A (ja) | 2010-09-28 | 2011-09-27 | 新規ビシクロ環化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9133116B2 (enExample) |
| EP (1) | EP2621902B1 (enExample) |
| JP (1) | JP2013542929A (enExample) |
| AR (1) | AR083202A1 (enExample) |
| BR (1) | BR112013007566A2 (enExample) |
| WO (1) | WO2012042539A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2685828A4 (en) * | 2011-03-17 | 2014-08-13 | Merck Sharp & Dohme | SUBSTITUTED 3-AZABICYCLO [3,1,0-] HEXAN DERIVATIVES AS CCR2 ANTAGONISTS |
| JP5936849B2 (ja) * | 2011-11-24 | 2016-06-22 | 東洋ゴム工業株式会社 | 空気入りタイヤの製造方法 |
| JP6526034B2 (ja) | 2014-02-14 | 2019-06-05 | 武田薬品工業株式会社 | Ｇｐｒ６のピリドピラジンモジュレーター |
| US9575560B2 (en) | 2014-06-03 | 2017-02-21 | Google Inc. | Radar-based gesture-recognition through a wearable device |
| US9811164B2 (en) | 2014-08-07 | 2017-11-07 | Google Inc. | Radar-based gesture sensing and data transmission |
| US10268321B2 (en) | 2014-08-15 | 2019-04-23 | Google Llc | Interactive textiles within hard objects |
| US9778749B2 (en) | 2014-08-22 | 2017-10-03 | Google Inc. | Occluded gesture recognition |
| US11169988B2 (en) | 2014-08-22 | 2021-11-09 | Google Llc | Radar recognition-aided search |
| US9600080B2 (en) | 2014-10-02 | 2017-03-21 | Google Inc. | Non-line-of-sight radar-based gesture recognition |
| KR102236958B1 (ko) | 2015-04-30 | 2021-04-05 | 구글 엘엘씨 | 제스처 추적 및 인식을 위한 rf―기반 마이크로―모션 추적 |
| WO2016176606A1 (en) | 2015-04-30 | 2016-11-03 | Google Inc. | Type-agnostic rf signal representations |
| CN111880650B (zh) | 2015-04-30 | 2024-07-05 | 谷歌有限责任公司 | 基于宽场雷达的手势识别 |
| US10088908B1 (en) | 2015-05-27 | 2018-10-02 | Google Llc | Gesture detection and interactions |
| US9693592B2 (en) | 2015-05-27 | 2017-07-04 | Google Inc. | Attaching electronic components to interactive textiles |
| US10817065B1 (en) | 2015-10-06 | 2020-10-27 | Google Llc | Gesture recognition using multiple antenna |
| EA201891472A1 (ru) * | 2015-12-22 | 2018-12-28 | Такеда Фармасьютикал Компани Лимитед | Тройные модуляторы эндосомальных рецепторов, сопряженных с g-белком |
| US10492302B2 (en) | 2016-05-03 | 2019-11-26 | Google Llc | Connecting an electronic component to an interactive textile |
| US10285456B2 (en) | 2016-05-16 | 2019-05-14 | Google Llc | Interactive fabric |
| WO2017200570A1 (en) | 2016-05-16 | 2017-11-23 | Google Llc | Interactive object with multiple electronics modules |
| WO2018053587A1 (en) * | 2016-09-21 | 2018-03-29 | Vectus Biosystems Limited | Compositions for the treatment of hypertension and/or fibrosis |
| US10579150B2 (en) | 2016-12-05 | 2020-03-03 | Google Llc | Concurrent detection of absolute distance and relative movement for sensing action gestures |
| TWI860849B (zh) | 2021-09-14 | 2024-11-01 | 美商美國禮來大藥廠 | Sstr4促效劑鹽 |
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| RU2012102094A (ru) | 2009-06-26 | 2013-08-10 | Панацеа Биотек Лтд. | Новые азабициклогексаны |
-
2011
- 2011-09-27 BR BR112013007566A patent/BR112013007566A2/pt not_active IP Right Cessation
- 2011-09-27 WO PCT/IN2011/000669 patent/WO2012042539A2/en not_active Ceased
- 2011-09-27 US US13/876,757 patent/US9133116B2/en not_active Expired - Fee Related
- 2011-09-27 JP JP2013530855A patent/JP2013542929A/ja active Pending
- 2011-09-27 EP EP11788589.7A patent/EP2621902B1/en not_active Not-in-force
- 2011-09-28 AR ARP110103576A patent/AR083202A1/es unknown
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