JP2013542241A5 - - Google Patents

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Publication number
JP2013542241A5
JP2013542241A5 JP2013538215A JP2013538215A JP2013542241A5 JP 2013542241 A5 JP2013542241 A5 JP 2013542241A5 JP 2013538215 A JP2013538215 A JP 2013538215A JP 2013538215 A JP2013538215 A JP 2013538215A JP 2013542241 A5 JP2013542241 A5 JP 2013542241A5
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JP
Japan
Prior art keywords
inhibitor
pharmaceutically acceptable
acceptable salt
cancer
alkylating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2013538215A
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English (en)
Japanese (ja)
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JP6382516B2 (ja
JP2013542241A (ja
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Publication date
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Priority claimed from PCT/EP2011/069976 external-priority patent/WO2012062920A1/en
Publication of JP2013542241A publication Critical patent/JP2013542241A/ja
Publication of JP2013542241A5 publication Critical patent/JP2013542241A5/ja
Application granted granted Critical
Publication of JP6382516B2 publication Critical patent/JP6382516B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013538215A 2010-11-12 2011-11-11 抗腫瘍アルカロイドを用いる、組み合わせの治療法 Active JP6382516B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10382300.1 2010-11-12
EP10382300 2010-11-12
PCT/EP2011/069976 WO2012062920A1 (en) 2010-11-12 2011-11-11 Combination therapy with an antitumor alkaloid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016092369A Division JP6723815B2 (ja) 2010-11-12 2016-05-02 抗腫瘍アルカロイドを用いる、組み合わせの治療法

Publications (3)

Publication Number Publication Date
JP2013542241A JP2013542241A (ja) 2013-11-21
JP2013542241A5 true JP2013542241A5 (https=) 2014-12-25
JP6382516B2 JP6382516B2 (ja) 2018-08-29

Family

ID=44936282

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2013538215A Active JP6382516B2 (ja) 2010-11-12 2011-11-11 抗腫瘍アルカロイドを用いる、組み合わせの治療法
JP2016092369A Active JP6723815B2 (ja) 2010-11-12 2016-05-02 抗腫瘍アルカロイドを用いる、組み合わせの治療法
JP2018059776A Active JP6724055B2 (ja) 2010-11-12 2018-03-27 抗腫瘍アルカロイドを用いる、組み合わせの治療法
JP2018059777A Active JP6724056B2 (ja) 2010-11-12 2018-03-27 抗腫瘍アルカロイドを用いる、組み合わせの治療法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2016092369A Active JP6723815B2 (ja) 2010-11-12 2016-05-02 抗腫瘍アルカロイドを用いる、組み合わせの治療法
JP2018059776A Active JP6724055B2 (ja) 2010-11-12 2018-03-27 抗腫瘍アルカロイドを用いる、組み合わせの治療法
JP2018059777A Active JP6724056B2 (ja) 2010-11-12 2018-03-27 抗腫瘍アルカロイドを用いる、組み合わせの治療法

Country Status (24)

Country Link
US (5) US20130266666A1 (https=)
EP (6) EP2786753B1 (https=)
JP (4) JP6382516B2 (https=)
KR (9) KR102301175B1 (https=)
CN (3) CN105664165A (https=)
AU (4) AU2011328004C1 (https=)
BR (4) BR122017028566B1 (https=)
CA (4) CA2995018C (https=)
CY (4) CY1117466T1 (https=)
DK (4) DK2637663T3 (https=)
ES (4) ES2719091T3 (https=)
HK (1) HK1202422A1 (https=)
HR (4) HRP20160361T1 (https=)
HU (4) HUE042801T2 (https=)
LT (3) LT2786756T (https=)
ME (3) ME02395B (https=)
PL (4) PL2786754T3 (https=)
PT (3) PT2786756T (https=)
RS (4) RS54648B1 (https=)
RU (4) RU2605335C2 (https=)
SI (4) SI2786753T1 (https=)
SM (4) SMT201900190T1 (https=)
TR (2) TR201903859T4 (https=)
WO (1) WO2012062920A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8491927B2 (en) * 2009-12-02 2013-07-23 Nimble Epitech, Llc Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
RS54648B1 (sr) * 2010-11-12 2016-08-31 Pharma Mar S.A. Kombinovana terapija sa antitumorskim alkaloidom
KR20160061911A (ko) 2013-04-08 2016-06-01 데니스 엠. 브라운 최적하 투여된 화학 화합물의 치료 효과
KR101588949B1 (ko) * 2014-03-13 2016-01-29 아주대학교산학협력단 플루나리진을 유효성분으로 함유하는 뇌암에 대한 항암 활성 보조제
US11326210B2 (en) * 2015-01-30 2022-05-10 Glax Llc Compositions and methods for monitoring, diagnosis, prognosis, detection, and treatment of cancer
CA3239447A1 (en) * 2016-01-11 2017-07-20 Syndevrx, Inc. Treatment for tumors driven by metabolic dysfunction
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
JP2022512826A (ja) 2018-10-26 2022-02-07 シンデブルックス，インコーポレイティド ＭｅｔＡＰ２阻害剤のバイオマーカーとその応用
CA3148690A1 (en) * 2019-09-03 2021-03-11 Ioannis METAXAS Lurbinectedin in the treatment of malignant mesothelioma
KR20210049403A (ko) * 2019-10-25 2021-05-06 연세대학교 산학협력단 암의 예방 또는 치료용 조성물
PE20252386A1 (es) * 2019-11-21 2025-10-10 Pharma Mar Sa Metodo de tratamiento del cancer de pulmon de celulas pequenas con formulaciones de lurbinectedina
WO2021228414A1 (en) * 2020-05-14 2021-11-18 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations
MA56827B2 (fr) * 2019-11-21 2023-09-27 Pharma Mar Sa Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine
CN111298122B (zh) * 2019-12-04 2021-12-21 哈尔滨商业大学 用于治疗小细胞肺癌的药物组合物及其应用
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
CN113491771A (zh) * 2020-03-18 2021-10-12 苏州大学 小分子化合物在制备glut5摄取转运果糖的抑制剂中的应用
EP4141110A4 (en) 2020-04-24 2025-04-09 Sf Biotech Laboratuvar Danismanlik Anonim Sirketi Method for producing particles of bacteriophages of the genus levivirus
EP4176880A4 (en) * 2020-07-01 2024-07-03 New Cancer Cure - Bio Co., Ltd. PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF CANCER COMPRISING A 3-KETOACYL-COA THIOLASE INHIBITOR AND AN INHIBITOR OF CARNITINE ACYLCARNITINE TRANSPORTERS
CN118576611A (zh) * 2020-10-23 2024-09-03 和记黄埔医药（上海）有限公司 一种药物组合产品在制备用于治疗尤文氏肉瘤的药物中的用途
CN112870194B (zh) * 2021-01-06 2022-06-21 广州医科大学附属肿瘤医院 治疗肝癌的组合物及其应用
CN113633631B (zh) * 2021-06-17 2022-08-09 中国医学科学院医药生物技术研究所 米铂脂质体在抗耐药性肿瘤的应用
CN115246846B (zh) * 2021-11-19 2024-10-01 江苏慧聚药业股份有限公司 卢比替定新晶型及其制备
WO2023165603A1 (en) * 2022-03-03 2023-09-07 Zai Lab (Shanghai) Co., Ltd. Dna-pk inhibitor and combination use thereof
WO2024188978A1 (en) * 2023-03-10 2024-09-19 Pharma Mar, S.A. Lurbinectedin as mcl-1 inhibitor and combinations thereof for use in treating cancer
EP4563149A1 (en) * 2023-11-30 2025-06-04 Pharma Mar, S.A. Lurbinectedin, ecubectedin and a related compound for use in the treatment of skin cancers
WO2025228596A1 (en) 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of pm14 and a topoisomerase i inhibitor in the treatment of cancer
TW202547488A (zh) 2024-04-30 2025-12-16 西班牙商瑪製藥股份有限公司 於癌症的治療中之化合物Ｉａ和拓樸異構酶Ｉ抑制劑的組合

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
EP0309477B1 (en) 1986-06-09 1991-11-06 The Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
BR9909488B1 (pt) 1998-04-06 2011-02-08 ecteinascidinas semi-sintéticas e composição farmacêutica.
CA2331593C (en) 1998-05-11 2008-08-05 Pharma Mar, S.A. Metabolites of ecteinascidin 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
US7311924B2 (en) * 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
CA2397597A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
WO2001077115A1 (en) 2000-04-12 2001-10-18 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
BR0115162A (pt) * 2000-11-06 2003-10-21 Pharma Mar Sa Tratamentos antitumorais eficazes
SE0102232L (sv) 2001-06-25 2003-02-06 Anoto Ab Förfarande och anordning i ett digitalt kommunikationssystem
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
AU2003250483A1 (en) 2002-08-19 2004-03-11 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP1572726B1 (en) 2002-10-18 2010-12-08 Pharma Mar, S.A.U. 4-methylhexanoic kahalalide f compound
FR2856688B1 (fr) 2003-06-25 2008-05-30 Sod Conseils Rech Applic PRODUIT COMPRENANT AU MOINS UN INHIBITEUR DE PHOSPHATASE CDc25 EN ASSOCIATION AVEC AU MOINS UN AUTRE AGENT ANTI-CANCEREUX
US7393277B2 (en) * 2003-08-25 2008-07-01 Igt Horseshoe payline system and games using that system
HRP20080598T3 (en) * 2003-11-13 2009-01-31 Pharma Mar Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
AU2004291037A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
MXPA06013902A (es) * 2004-05-28 2007-01-26 Pfizer Prod Inc Procedimiento para tratar el crecimiento de celulas anormal.
ATE368461T1 (de) 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
CN101080227B (zh) * 2004-12-15 2011-08-31 诺瓦提斯公司 用于治疗癌症的治疗剂的组合
TW200744603A (en) * 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
WO2007101235A2 (en) * 2006-02-28 2007-09-07 Pharma Mar, S.A. Improved antitumoral treatments
JP2011520921A (ja) * 2008-05-16 2011-07-21 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍アルカロイドとの併用療法
RS54648B1 (sr) * 2010-11-12 2016-08-31 Pharma Mar S.A. Kombinovana terapija sa antitumorskim alkaloidom

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