JP2013541502A5 - - Google Patents
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- JP2013541502A5 JP2013541502A5 JP2013523342A JP2013523342A JP2013541502A5 JP 2013541502 A5 JP2013541502 A5 JP 2013541502A5 JP 2013523342 A JP2013523342 A JP 2013523342A JP 2013523342 A JP2013523342 A JP 2013523342A JP 2013541502 A5 JP2013541502 A5 JP 2013541502A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- dione
- independently
- composition according
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 73
- 239000000203 mixture Substances 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 31
- 239000001257 hydrogen Substances 0.000 claims description 31
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 14
- 239000012453 solvate Substances 0.000 claims description 14
- 208000012268 mitochondrial disease Diseases 0.000 claims description 10
- 208000024412 Friedreich ataxia Diseases 0.000 claims description 8
- 208000011580 syndromic disease Diseases 0.000 claims description 8
- 150000004677 hydrates Chemical class 0.000 claims description 7
- 230000004065 mitochondrial dysfunction Effects 0.000 claims description 6
- FRASJONUBLZVQX-UHFFFAOYSA-N 1,4-naphthoquinone Chemical compound C1=CC=C2C(=O)C=CC(=O)C2=C1 FRASJONUBLZVQX-UHFFFAOYSA-N 0.000 claims description 5
- 206010058799 Mitochondrial encephalomyopathy Diseases 0.000 claims description 4
- 201000002169 Mitochondrial myopathy Diseases 0.000 claims description 4
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims description 4
- 201000009028 early myoclonic encephalopathy Diseases 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 4
- 208000023692 inborn mitochondrial myopathy Diseases 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 208000010444 Acidosis Diseases 0.000 claims description 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims description 2
- 206010011878 Deafness Diseases 0.000 claims description 2
- 208000023105 Huntington disease Diseases 0.000 claims description 2
- 201000009623 Myopathy Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000012202 Pervasive developmental disease Diseases 0.000 claims description 2
- 208000034189 Sclerosis Diseases 0.000 claims description 2
- 230000007950 acidosis Effects 0.000 claims description 2
- 208000026545 acidosis disease Diseases 0.000 claims description 2
- 208000029560 autism spectrum disease Diseases 0.000 claims description 2
- 230000010370 hearing loss Effects 0.000 claims description 2
- 231100000888 hearing loss Toxicity 0.000 claims description 2
- 208000016354 hearing loss disease Diseases 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- QDUAOKYKHMKPTA-UHFFFAOYSA-N 2-methyl-3-nonylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCC)=C(C)C(=O)C2=C1 QDUAOKYKHMKPTA-UHFFFAOYSA-N 0.000 claims 2
- -1 R 3c is Chemical group 0.000 claims 2
- LGFDNUSAWCHVJN-UHFFFAOYSA-N 2,3-dimethyl-1,4-naphthoquinone Chemical compound C1=CC=C2C(=O)C(C)=C(C)C(=O)C2=C1 LGFDNUSAWCHVJN-UHFFFAOYSA-N 0.000 claims 1
- ZYZWUEIPVNFQQC-UHFFFAOYSA-N 2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCC(C)(O)CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 ZYZWUEIPVNFQQC-UHFFFAOYSA-N 0.000 claims 1
- PFCSRGNFXBREEI-UHFFFAOYSA-N 2-(3-hydroxy-3,7-dimethyloct-6-enyl)naphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCC(C)(O)CCC=C(C)C)=CC(=O)C2=C1 PFCSRGNFXBREEI-UHFFFAOYSA-N 0.000 claims 1
- BXRGMKVTCTWHRD-UHFFFAOYSA-N 2-butyl-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCC)=C(C)C(=O)C2=C1 BXRGMKVTCTWHRD-UHFFFAOYSA-N 0.000 claims 1
- JZCYOZPRLAGWSS-UHFFFAOYSA-N 2-decyl-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCCC)=C(C)C(=O)C2=C1 JZCYOZPRLAGWSS-UHFFFAOYSA-N 0.000 claims 1
- DTGKPFYIFROSOP-UHFFFAOYSA-N 2-heptadecyl-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCCCCCCCCCC)=C(C)C(=O)C2=C1 DTGKPFYIFROSOP-UHFFFAOYSA-N 0.000 claims 1
- YAKBITAXCOOTRG-UHFFFAOYSA-N 2-heptyl-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCC)=C(C)C(=O)C2=C1 YAKBITAXCOOTRG-UHFFFAOYSA-N 0.000 claims 1
- DIIHNBLSXDGYNT-UHFFFAOYSA-N 2-hexyl-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCC)=C(C)C(=O)C2=C1 DIIHNBLSXDGYNT-UHFFFAOYSA-N 0.000 claims 1
- FATIXBDICXNSAQ-UHFFFAOYSA-N 2-icosyl-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCCCCCCCCCCCCC)=C(C)C(=O)C2=C1 FATIXBDICXNSAQ-UHFFFAOYSA-N 0.000 claims 1
- MOYPRYFRIDZWHC-UHFFFAOYSA-N 2-methyl-3-(3,7,11-trimethyldodecyl)naphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MOYPRYFRIDZWHC-UHFFFAOYSA-N 0.000 claims 1
- JCSUQQOAHQRPBF-UHFFFAOYSA-N 2-methyl-3-(3-methylbutyl)naphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCC(C)C)=C(C)C(=O)C2=C1 JCSUQQOAHQRPBF-UHFFFAOYSA-N 0.000 claims 1
- SUVLFHKXBHCAKS-UHFFFAOYSA-N 2-methyl-3-nonadecylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCCCCCCCCCCCC)=C(C)C(=O)C2=C1 SUVLFHKXBHCAKS-UHFFFAOYSA-N 0.000 claims 1
- ANJYWYTXJPIQLS-UHFFFAOYSA-N 2-methyl-3-octylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCC)=C(C)C(=O)C2=C1 ANJYWYTXJPIQLS-UHFFFAOYSA-N 0.000 claims 1
- ONKIICPFVVQPJA-UHFFFAOYSA-N 2-methyl-3-pentadecylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCCCCCCCC)=C(C)C(=O)C2=C1 ONKIICPFVVQPJA-UHFFFAOYSA-N 0.000 claims 1
- XTMWDFCOWHNAPA-UHFFFAOYSA-N 2-methyl-3-pentylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCC)=C(C)C(=O)C2=C1 XTMWDFCOWHNAPA-UHFFFAOYSA-N 0.000 claims 1
- GIQISUKKXZTPJV-UHFFFAOYSA-N 2-methyl-3-propylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCC)=C(C)C(=O)C2=C1 GIQISUKKXZTPJV-UHFFFAOYSA-N 0.000 claims 1
- PUURYLDVOHSJSZ-UHFFFAOYSA-N 2-methyl-3-tetradecylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCCCCCCC)=C(C)C(=O)C2=C1 PUURYLDVOHSJSZ-UHFFFAOYSA-N 0.000 claims 1
- MVFUHAWRIKCIAB-UHFFFAOYSA-N 2-methyl-3-tridecylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(CCCCCCCCCCCCC)=C(C)C(=O)C2=C1 MVFUHAWRIKCIAB-UHFFFAOYSA-N 0.000 claims 1
- 229930192627 Naphthoquinone Natural products 0.000 claims 1
- 150000002791 naphthoquinones Chemical class 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 6
- 235000017471 coenzyme Q10 Nutrition 0.000 description 6
- 102000018832 Cytochromes Human genes 0.000 description 4
- 108010052832 Cytochromes Proteins 0.000 description 4
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 4
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000002861 ventricular Effects 0.000 description 3
- HCAJQHYUCKICQH-VPENINKCSA-N 8-Oxo-7,8-dihydro-2'-deoxyguanosine Chemical compound C1=2NC(N)=NC(=O)C=2NC(=O)N1[C@H]1C[C@H](O)[C@@H](CO)O1 HCAJQHYUCKICQH-VPENINKCSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 1
- 0 C*C(C(c1cc(I)c(*=C)cc11)=N)=C(**(*)[I-])C1=Cl Chemical compound C*C(C(c1cc(I)c(*=C)cc11)=N)=C(**(*)[I-])C1=Cl 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 229950007002 phosphocreatine Drugs 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40104410P | 2010-08-06 | 2010-08-06 | |
| US61/401,044 | 2010-08-06 | ||
| PCT/US2011/046630 WO2012019029A2 (en) | 2010-08-06 | 2011-08-04 | Treatment of mitochondrial diseases with naphthoquinones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000265A Division JP2016041772A (ja) | 2010-08-06 | 2016-01-04 | ナフトキノンによるミトコンドリア病の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541502A JP2013541502A (ja) | 2013-11-14 |
| JP2013541502A5 true JP2013541502A5 (OSRAM) | 2015-04-02 |
| JP6045494B2 JP6045494B2 (ja) | 2016-12-14 |
Family
ID=45560075
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523342A Expired - Fee Related JP6045494B2 (ja) | 2010-08-06 | 2011-08-04 | ナフトキノンによるミトコンドリア病の処置 |
| JP2016000265A Pending JP2016041772A (ja) | 2010-08-06 | 2016-01-04 | ナフトキノンによるミトコンドリア病の処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016000265A Pending JP2016041772A (ja) | 2010-08-06 | 2016-01-04 | ナフトキノンによるミトコンドリア病の処置 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20130345312A1 (OSRAM) |
| EP (1) | EP2600857A4 (OSRAM) |
| JP (2) | JP6045494B2 (OSRAM) |
| AU (1) | AU2011285619B2 (OSRAM) |
| BR (1) | BR112013002877A2 (OSRAM) |
| CA (1) | CA2807507A1 (OSRAM) |
| EA (1) | EA201300215A1 (OSRAM) |
| MX (1) | MX2013001469A (OSRAM) |
| SG (1) | SG187744A1 (OSRAM) |
| WO (1) | WO2012019029A2 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2583087C (en) | 2003-09-19 | 2012-07-10 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| WO2006130775A2 (en) | 2005-06-01 | 2006-12-07 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomakers |
| JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| EP3456707B1 (en) | 2007-11-06 | 2020-04-15 | PTC Therapeutics, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| EA023618B1 (ru) | 2008-01-08 | 2016-06-30 | Эдисон Фармасьютикалз, Инк. | Производные (гет)арил-п-хинона для лечения митохондриальных болезней |
| CA2717734A1 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc | 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases |
| WO2009158348A1 (en) | 2008-06-25 | 2009-12-30 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| EP3827815B1 (en) | 2008-09-10 | 2023-09-06 | PTC Therapeutics, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| WO2010045220A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| TR201819154T4 (tr) | 2008-10-28 | 2019-01-21 | Bioelectron Tech Corp | Alfa-tokotrienol kuinone ve ara ürünlerini içeren bileşim. |
| WO2010126911A1 (en) | 2009-04-28 | 2010-11-04 | Edison Pharmaceuticals, Inc. | Treatment of leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones |
| US9464016B2 (en) | 2011-06-14 | 2016-10-11 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| JP2014520894A (ja) | 2011-07-19 | 2014-08-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法 |
| SMT201700195T1 (it) | 2012-07-12 | 2017-05-08 | Khondrion Ip B V | Derivati di cromanile per il trattamento di malattie mitocondriali |
| CA2883882A1 (en) * | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
| CN115990242A (zh) | 2013-03-01 | 2023-04-21 | 康德生物医疗有限公司 | 预防或治疗巴斯综合征的方法和组合物 |
| CN110339339A (zh) * | 2013-03-01 | 2019-10-18 | 康德生物医疗技术公司 | 治疗线粒体疾病的方法 |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| EP2970158B1 (en) | 2013-03-15 | 2019-02-20 | BioElectron Technology Corporation | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| CA2916977A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| WO2015103577A1 (en) * | 2014-01-06 | 2015-07-09 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating dominant optic atrophy |
| EP3233786B1 (en) | 2014-12-16 | 2022-03-16 | PTC Therapeutics, Inc. | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| EP3359521B1 (en) | 2015-10-08 | 2025-04-16 | Khondrion Ip B.V. | Novel compounds for treating mitochondrial disease |
| EP3390377A1 (en) | 2015-12-16 | 2018-10-24 | BioElectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| MX2019011692A (es) | 2017-04-05 | 2020-02-10 | Khondrion Ip B V | Nuevo tratamiento de enfermedades mitocondriales. |
| MX388592B (es) * | 2017-04-21 | 2025-03-20 | Univ Tasmania | Compuestos y metodos terapeuticos. |
| CN112770735A (zh) | 2018-07-29 | 2021-05-07 | Musc研究发展基金会 | 用于治疗神经或线粒体疾病的化合物 |
| PL3866772T3 (pl) | 2018-10-17 | 2024-04-08 | Ptc Therapeutics, Inc. | 2,3,5-trimetylo-6-nonylocykloheksa-2,5-dieno-1,4-dion do hamowania i leczenia alfa-synukleinopatii, tauopatii i innych zaburzeń |
| WO2020152336A1 (en) | 2019-01-25 | 2020-07-30 | Universitat Autonoma De Barcelona | Cannabidiol and/or derivatives thereof for use in the treatment of mitochondrial diseases |
| KR20220078644A (ko) | 2019-10-04 | 2022-06-10 | 스텔스 바이오테라퓨틱스 인코포레이티드 | 미토콘드리아 질환 치료를 위한 바티퀴논의 퀴논-, 히드로퀴논- 및 나프토퀴논-유사체 |
| JP2023520462A (ja) | 2020-04-03 | 2023-05-17 | ステルス バイオセラピューティクス インコーポレイテッド | フリードライヒ運動失調症を含むミトコンドリア病の予防および／または治療のための組成物および方法 |
| IT202100006065A1 (it) * | 2021-03-15 | 2022-09-15 | Univ Degli Studi Padova | Composto per l’uso nel metodo di trattamento delle malattie mitocondriali da disfunzione dei complessi i, ii, iii della catena respiratoria |
| KR20240032997A (ko) | 2021-07-08 | 2024-03-12 | 피티씨 테라퓨틱스, 인크. | 2,3,5-트리메틸-6-노닐사이클로헥사-2,5-디엔-1,4-디온을 포함하는 약제학적 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117326D0 (en) * | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| JP2003226639A (ja) * | 2002-01-31 | 2003-08-12 | Hisamitsu Pharmaceut Co Inc | 神経成長因子活性増強剤としてのビタミンｋ類を含む医薬組成物およびその使用 |
| US20040087527A1 (en) * | 2002-10-31 | 2004-05-06 | Day Brian J. | Methods for treatment of thiol-containing compound deficient conditions |
| WO2006130775A2 (en) * | 2005-06-01 | 2006-12-07 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomakers |
| RU2318500C2 (ru) * | 2005-10-18 | 2008-03-10 | Общество С Ограниченной Ответственностью "Митотехнология" | Способ воздействия на организм путем адресной доставки биологически активных веществ в митохондрии, фармацевтическая композиция для его осуществления и соединение, применяемое для этой цели |
| JP5374162B2 (ja) * | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| KR20080047956A (ko) * | 2006-11-27 | 2008-05-30 | 주식회사 엠디바이오알파 | 발기부전의 치료 및 예방을 위한 약제 조성물 |
| CA2717734A1 (en) * | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc | 2-substituted-p-quinone derivatives for treatment of oxidative stress diseases |
| EP3827815B1 (en) * | 2008-09-10 | 2023-09-06 | PTC Therapeutics, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| EP2519232A1 (en) * | 2009-12-31 | 2012-11-07 | Edison Pharmaceuticals, Inc. | Treatment of leigh syndrome and leigh-like syndrome with tocotrienol quinones |
| JP2013538799A (ja) * | 2010-08-06 | 2013-10-17 | アンペア ライフ サイエンシーズ，インコーポレイテッド | ビタミンｋを用いたミトコンドリア病の処置 |
| WO2012170773A1 (en) * | 2011-06-08 | 2012-12-13 | Edison Pharmaceuticals, Inc. | Adjunctive therapy for the treatment of mitochondrial disorders with quinones and naphthoquinones |
-
2011
- 2011-08-04 MX MX2013001469A patent/MX2013001469A/es unknown
- 2011-08-04 EP EP11815334.5A patent/EP2600857A4/en not_active Withdrawn
- 2011-08-04 US US13/814,721 patent/US20130345312A1/en not_active Abandoned
- 2011-08-04 SG SG2013009212A patent/SG187744A1/en unknown
- 2011-08-04 AU AU2011285619A patent/AU2011285619B2/en not_active Ceased
- 2011-08-04 EA EA201300215A patent/EA201300215A1/ru unknown
- 2011-08-04 WO PCT/US2011/046630 patent/WO2012019029A2/en not_active Ceased
- 2011-08-04 JP JP2013523342A patent/JP6045494B2/ja not_active Expired - Fee Related
- 2011-08-04 CA CA2807507A patent/CA2807507A1/en not_active Abandoned
- 2011-08-04 BR BR112013002877A patent/BR112013002877A2/pt not_active Application Discontinuation
-
2016
- 2016-01-04 JP JP2016000265A patent/JP2016041772A/ja active Pending
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