JP2013541005A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013541005A5 JP2013541005A5 JP2013530362A JP2013530362A JP2013541005A5 JP 2013541005 A5 JP2013541005 A5 JP 2013541005A5 JP 2013530362 A JP2013530362 A JP 2013530362A JP 2013530362 A JP2013530362 A JP 2013530362A JP 2013541005 A5 JP2013541005 A5 JP 2013541005A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- concentration
- threshold
- stage
- measured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 14
- 229920002674 hyaluronan Polymers 0.000 claims 14
- 229960003160 hyaluronic acid Drugs 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 238000003556 assay Methods 0.000 claims 10
- 230000002485 urinary effect Effects 0.000 claims 8
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 6
- 208000033626 Renal failure acute Diseases 0.000 claims 5
- 201000011040 acute kidney failure Diseases 0.000 claims 5
- 210000001124 body fluid Anatomy 0.000 claims 4
- 210000003734 kidney Anatomy 0.000 claims 4
- 238000012959 renal replacement therapy Methods 0.000 claims 4
- 210000002700 urine Anatomy 0.000 claims 4
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 208000012998 acute renal failure Diseases 0.000 claims 3
- 229940109239 creatinine Drugs 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 2
- 230000003907 kidney function Effects 0.000 claims 2
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 claims 2
- 238000013517 stratification Methods 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000036675 Myoglobin Human genes 0.000 claims 1
- 108010062374 Myoglobin Proteins 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 229940126575 aminoglycoside Drugs 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000002296 eclampsia Diseases 0.000 claims 1
- 229940093476 ethylene glycol Drugs 0.000 claims 1
- 229960005102 foscarnet Drugs 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
- 229960001052 streptozocin Drugs 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38642110P | 2010-09-24 | 2010-09-24 | |
| US61/386,421 | 2010-09-24 | ||
| PCT/US2011/053015 WO2012040592A1 (en) | 2010-09-24 | 2011-09-23 | Methods and compositions for the evaluation of renal injury using hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013541005A JP2013541005A (ja) | 2013-11-07 |
| JP2013541005A5 true JP2013541005A5 (enExample) | 2014-11-06 |
Family
ID=45874188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530362A Pending JP2013541005A (ja) | 2010-09-24 | 2011-09-23 | ヒアルロン酸を使用した腎損傷の評価のための方法ならびに組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20130252264A1 (enExample) |
| EP (1) | EP2619231B1 (enExample) |
| JP (1) | JP2013541005A (enExample) |
| KR (1) | KR20140051099A (enExample) |
| CN (2) | CN103189394B (enExample) |
| AU (1) | AU2011305197B2 (enExample) |
| BR (1) | BR112013006631A2 (enExample) |
| CA (1) | CA2813011A1 (enExample) |
| EA (1) | EA201390294A1 (enExample) |
| ES (1) | ES2619617T3 (enExample) |
| MX (1) | MX348303B (enExample) |
| NZ (1) | NZ609126A (enExample) |
| WO (1) | WO2012040592A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2882767B1 (en) * | 2012-08-11 | 2023-07-12 | Astute Medical, Inc. | Evaluating renal injury using hyaluronic acid |
| CN119643878B (zh) * | 2024-12-25 | 2025-07-25 | 中国人民解放军总医院第一医学中心 | 一种检测肾脏纤维化相关疾病的生物标志物及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5939272A (en) | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
| US5028535A (en) | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US5922615A (en) | 1990-03-12 | 1999-07-13 | Biosite Diagnostics Incorporated | Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network |
| WO1992005282A1 (en) | 1990-09-14 | 1992-04-02 | Biosite Diagnostics, Inc. | Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays |
| US5955377A (en) | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
| ATE177841T1 (de) | 1991-04-10 | 1999-04-15 | Biosite Diagnostics Inc | ''crosstalk''- oder übersprech-inhibitoren und ihre verwendung |
| EP0579767B1 (en) | 1991-04-11 | 2000-08-23 | Biosite Diagnostics Inc. | Novel conjugates and assays for simultaneous detection of multiple ligands |
| US5885527A (en) | 1992-05-21 | 1999-03-23 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membrances |
| US6143576A (en) | 1992-05-21 | 2000-11-07 | Biosite Diagnostics, Inc. | Non-porous diagnostic devices for the controlled movement of reagents |
| US5494829A (en) | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
| US5824799A (en) | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
| US6113855A (en) | 1996-11-15 | 2000-09-05 | Biosite Diagnostics, Inc. | Devices comprising multiple capillarity inducing surfaces |
| US5947124A (en) | 1997-03-11 | 1999-09-07 | Biosite Diagnostics Incorporated | Diagnostic for determining the time of a heart attack |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| JP2004208693A (ja) * | 2002-12-17 | 2004-07-29 | Sanyo Chem Ind Ltd | 抗ヒアルロン酸抗体、これを含む試薬キット、抗ヒアルロン酸抗体の製造法及びヒアルロン酸の測定法 |
| WO2005114186A1 (ja) * | 2004-05-20 | 2005-12-01 | Wako Pure Chemical Industries, Ltd. | ヒアルロン酸バインディングプロテインを用いたヒアルロン酸の測定方法 |
| US20090285761A1 (en) * | 2008-04-18 | 2009-11-19 | Pharmacophotonics, Llc D/B/A Fast Diagnostics | Renal Function Analysis Method and Apparatus |
| WO2009146450A2 (en) * | 2008-05-30 | 2009-12-03 | Therapeutic Monitoring Services, L.L.C. | Methods for monitoring immunosuppressant drug levels, renal function, and hepatic function using small volume samples |
| US8673574B2 (en) * | 2008-08-21 | 2014-03-18 | Pxbiosciences Llc | Diagnosis and monitoring of renal failure using peptide biomarkers |
| NZ610356A (en) * | 2008-08-28 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US8501489B2 (en) * | 2008-09-26 | 2013-08-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Urinary biomarkers to predict long-term dialysis |
| EP2393937A4 (en) * | 2009-02-06 | 2012-08-08 | Astute Medical Inc | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE |
| JP5763098B2 (ja) * | 2009-12-20 | 2015-08-12 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
-
2011
- 2011-09-23 JP JP2013530362A patent/JP2013541005A/ja active Pending
- 2011-09-23 CA CA2813011A patent/CA2813011A1/en not_active Abandoned
- 2011-09-23 AU AU2011305197A patent/AU2011305197B2/en not_active Ceased
- 2011-09-23 EP EP11827625.2A patent/EP2619231B1/en not_active Not-in-force
- 2011-09-23 MX MX2013003204A patent/MX348303B/es active IP Right Grant
- 2011-09-23 BR BR112013006631A patent/BR112013006631A2/pt not_active IP Right Cessation
- 2011-09-23 NZ NZ609126A patent/NZ609126A/en not_active IP Right Cessation
- 2011-09-23 ES ES11827625.2T patent/ES2619617T3/es active Active
- 2011-09-23 EA EA201390294A patent/EA201390294A1/ru unknown
- 2011-09-23 WO PCT/US2011/053015 patent/WO2012040592A1/en not_active Ceased
- 2011-09-23 KR KR1020137010404A patent/KR20140051099A/ko not_active Ceased
- 2011-09-23 US US13/825,675 patent/US20130252264A1/en not_active Abandoned
- 2011-09-23 CN CN201180047897.8A patent/CN103189394B/zh not_active Expired - Fee Related
- 2011-09-23 CN CN201610569328.4A patent/CN106248921A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016505143A5 (enExample) | ||
| JP2013503344A5 (enExample) | ||
| JP2013519095A5 (enExample) | ||
| JP2012517594A5 (enExample) | ||
| JP2014529073A5 (enExample) | ||
| JP2013501920A5 (enExample) | ||
| JP2012517592A5 (enExample) | ||
| JP2013531240A5 (enExample) | ||
| JP2015129764A5 (enExample) | ||
| JP2013515243A5 (enExample) | ||
| JP2017533427A5 (enExample) | ||
| HRP20160733T1 (hr) | Postupci i pripravci za postavljanje dijagnoze i prognoze ozljede bubrega i bubrežne insuficijencije | |
| JP2013510321A5 (enExample) | ||
| Husain-Syed et al. | Persistent decrease of renal functional reserve in patients after cardiac surgery-associated acute kidney injury despite clinical recovery | |
| JP2013510322A5 (enExample) | ||
| JP2013539861A5 (enExample) | ||
| JP2013513086A5 (enExample) | ||
| Kurian et al. | Molecular classifiers for acute kidney transplant rejection in peripheral blood by whole genome gene expression profiling | |
| Bagshaw et al. | Urinary biomarkers in septic acute kidney injury | |
| JP2021039112A5 (enExample) | ||
| Maisel et al. | Biomarkers in kidney and heart disease | |
| NZ630277A (en) | Methods and compositions for diagnosis and prognosis of renal injury and renal failure | |
| NZ625423A (en) | Methods and compositions for diagnosis and prognosis of renal injury and renal failure | |
| KR20170107934A (ko) | 동맥경화증 및 이와 관련된 허혈성 심장질환의 진단용 바이오마커 | |
| JP2013519866A5 (enExample) |