CN103189394B - 利用透明质酸评价肾损伤的方法和组合物 - Google Patents

利用透明质酸评价肾损伤的方法和组合物 Download PDF

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Publication number
CN103189394B
CN103189394B CN201180047897.8A CN201180047897A CN103189394B CN 103189394 B CN103189394 B CN 103189394B CN 201180047897 A CN201180047897 A CN 201180047897A CN 103189394 B CN103189394 B CN 103189394B
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China
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subject
threshold
measured concentration
renal
rifle stage
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Expired - Fee Related
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CN201180047897.8A
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English (en)
Chinese (zh)
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CN103189394A (zh
Inventor
J·安德伯格
J·格雷
P·麦克弗森
K·中村
J·P·坎普夫
K·辛巴提
J·A·小凯勒姆
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University of Pittsburgh
Astute Medical Inc
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University of Pittsburgh
Astute Medical Inc
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Priority to CN201610569328.4A priority Critical patent/CN106248921A/zh
Publication of CN103189394A publication Critical patent/CN103189394A/zh
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Publication of CN103189394B publication Critical patent/CN103189394B/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN201180047897.8A 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物 Expired - Fee Related CN103189394B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610569328.4A CN106248921A (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38642110P 2010-09-24 2010-09-24
US61/386,421 2010-09-24
PCT/US2011/053015 WO2012040592A1 (en) 2010-09-24 2011-09-23 Methods and compositions for the evaluation of renal injury using hyaluronic acid

Related Child Applications (1)

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CN201610569328.4A Division CN106248921A (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物

Publications (2)

Publication Number Publication Date
CN103189394A CN103189394A (zh) 2013-07-03
CN103189394B true CN103189394B (zh) 2016-08-17

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CN201180047897.8A Expired - Fee Related CN103189394B (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物
CN201610569328.4A Pending CN106248921A (zh) 2010-09-24 2011-09-23 利用透明质酸评价肾损伤的方法和组合物

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Country Link
US (1) US20130252264A1 (enExample)
EP (1) EP2619231B1 (enExample)
JP (1) JP2013541005A (enExample)
KR (1) KR20140051099A (enExample)
CN (2) CN103189394B (enExample)
AU (1) AU2011305197B2 (enExample)
BR (1) BR112013006631A2 (enExample)
CA (1) CA2813011A1 (enExample)
EA (1) EA201390294A1 (enExample)
ES (1) ES2619617T3 (enExample)
MX (1) MX348303B (enExample)
NZ (1) NZ609126A (enExample)
WO (1) WO2012040592A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2882767B1 (en) * 2012-08-11 2023-07-12 Astute Medical, Inc. Evaluating renal injury using hyaluronic acid
CN119643878B (zh) * 2024-12-25 2025-07-25 中国人民解放军总医院第一医学中心 一种检测肾脏纤维化相关疾病的生物标志物及其应用

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EP0579767B1 (en) 1991-04-11 2000-08-23 Biosite Diagnostics Inc. Novel conjugates and assays for simultaneous detection of multiple ligands
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Also Published As

Publication number Publication date
BR112013006631A2 (pt) 2017-10-24
NZ609126A (en) 2015-05-29
CN106248921A8 (zh) 2017-07-21
AU2011305197B2 (en) 2015-06-11
EP2619231A4 (en) 2014-04-30
ES2619617T3 (es) 2017-06-26
MX2013003204A (es) 2013-06-05
JP2013541005A (ja) 2013-11-07
EP2619231B1 (en) 2016-12-21
WO2012040592A1 (en) 2012-03-29
AU2011305197A1 (en) 2013-05-02
CN106248921A (zh) 2016-12-21
CA2813011A1 (en) 2012-03-29
CN103189394A (zh) 2013-07-03
EP2619231A1 (en) 2013-07-31
EA201390294A1 (ru) 2013-09-30
KR20140051099A (ko) 2014-04-30
US20130252264A1 (en) 2013-09-26
MX348303B (es) 2017-06-06

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