JP2013537915A5 - - Google Patents
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- Publication number
- JP2013537915A5 JP2013537915A5 JP2013530379A JP2013530379A JP2013537915A5 JP 2013537915 A5 JP2013537915 A5 JP 2013537915A5 JP 2013530379 A JP2013530379 A JP 2013530379A JP 2013530379 A JP2013530379 A JP 2013530379A JP 2013537915 A5 JP2013537915 A5 JP 2013537915A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- oxycodone
- pharmaceutical formulation
- opioid
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims description 110
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 96
- 229960002085 oxycodone Drugs 0.000 claims description 96
- 239000008194 pharmaceutical composition Substances 0.000 claims description 88
- 239000000203 mixture Substances 0.000 claims description 51
- 238000009472 formulation Methods 0.000 claims description 45
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 36
- 238000013270 controlled release Methods 0.000 claims description 20
- 229960005181 morphine Drugs 0.000 claims description 18
- 238000004090 dissolution Methods 0.000 claims description 17
- 230000036470 plasma concentration Effects 0.000 claims description 16
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 12
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims description 12
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 12
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 8
- IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 claims description 6
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims description 6
- 229960004126 codeine Drugs 0.000 claims description 6
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims description 6
- 229960000920 dihydrocodeine Drugs 0.000 claims description 6
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 6
- 229960000240 hydrocodone Drugs 0.000 claims description 6
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 6
- 229960001410 hydromorphone Drugs 0.000 claims description 6
- 229960005118 oxymorphone Drugs 0.000 claims description 6
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims description 6
- 239000002632 kappa opiate receptor agonist Substances 0.000 claims description 4
- 239000002756 mu opiate receptor agonist Substances 0.000 claims description 4
- 229940005483 opioid analgesics Drugs 0.000 claims description 3
- 229940121954 Opioid receptor agonist Drugs 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000003402 opiate agonist Substances 0.000 claims description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 description 5
- 241000282412 Homo Species 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38622710P | 2010-09-24 | 2010-09-24 | |
| US61/386,227 | 2010-09-24 | ||
| US13/024,319 | 2011-02-09 | ||
| US13/024,319 US20110195989A1 (en) | 2010-02-09 | 2011-02-09 | Controlled Release Formulations of Opioids |
| PCT/US2011/053132 WO2012040651A2 (en) | 2010-09-24 | 2011-09-23 | Controlled release formulations of opioids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537915A JP2013537915A (ja) | 2013-10-07 |
| JP2013537915A5 true JP2013537915A5 (OSRAM) | 2014-11-06 |
Family
ID=44741728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530379A Pending JP2013537915A (ja) | 2010-09-24 | 2011-09-23 | オピオイドの制御放出製剤 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2618820A2 (OSRAM) |
| JP (1) | JP2013537915A (OSRAM) |
| CN (1) | CN103476403A (OSRAM) |
| AU (1) | AU2011305161A1 (OSRAM) |
| CA (1) | CA2812570A1 (OSRAM) |
| WO (1) | WO2012040651A2 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
| EP1429739A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer release system |
| ES2570454T3 (es) | 2003-03-26 | 2016-05-18 | Egalet Ltd | Sistema de liberación controlada de morfina |
| EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| CA2766179A1 (en) | 2009-06-24 | 2010-12-29 | Egalet Ltd. | Controlled release formulations |
| WO2013153451A2 (en) * | 2012-04-09 | 2013-10-17 | QRxPharma Ltd. | Controlled release formulations of opioids |
| CN104684548A (zh) | 2012-07-06 | 2015-06-03 | 埃格勒特有限责任公司 | 防止滥用的控释药物组合物 |
| EP3169315B1 (en) * | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| CA3085348A1 (en) | 2017-12-20 | 2019-06-27 | Purdue Pharma L.P. | Abuse deterrent morphine sulfate dosage forms |
| CN114515282B (zh) * | 2020-11-19 | 2023-09-08 | 山东大学 | Sorbic acid在制备抗冠状病毒感染药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
| US6419960B1 (en) * | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
| UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| US20030092724A1 (en) * | 2001-09-18 | 2003-05-15 | Huaihung Kao | Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic |
| JP2005508372A (ja) * | 2001-11-02 | 2005-03-31 | エラン コーポレーシヨン ピーエルシー | 薬剤組成物 |
| US8906413B2 (en) * | 2003-05-12 | 2014-12-09 | Supernus Pharmaceuticals, Inc. | Drug formulations having reduced abuse potential |
| AU2005323534A1 (en) | 2005-01-05 | 2006-07-13 | Philip S. Portoghese | Analgesic conjugates |
| CA2599386A1 (en) * | 2005-03-28 | 2006-10-05 | Orexo Ab | New pharmaceutical compositions useful in the treatment of pain |
| US20090082466A1 (en) | 2006-01-27 | 2009-03-26 | Najib Babul | Abuse Resistant and Extended Release Formulations and Method of Use Thereof |
| CA2667259A1 (en) * | 2006-11-07 | 2008-05-15 | Nektar Therapeutics Al, Corporation | Dosage forms and co-administration of an opioid agonist and an opioid antagonist |
| US20090291975A1 (en) * | 2008-05-20 | 2009-11-26 | Warren Stern | Dual opioid pain therapy |
| US20110195989A1 (en) * | 2010-02-09 | 2011-08-11 | Rudnic Edward M | Controlled Release Formulations of Opioids |
-
2011
- 2011-09-23 EP EP11764653.9A patent/EP2618820A2/en not_active Withdrawn
- 2011-09-23 CA CA2812570A patent/CA2812570A1/en not_active Abandoned
- 2011-09-23 AU AU2011305161A patent/AU2011305161A1/en not_active Abandoned
- 2011-09-23 CN CN2011800562785A patent/CN103476403A/zh active Pending
- 2011-09-23 WO PCT/US2011/053132 patent/WO2012040651A2/en not_active Ceased
- 2011-09-23 JP JP2013530379A patent/JP2013537915A/ja active Pending
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